Month: November 2021

I found the field of Chemistry very interesting. Saw the article CuI/I-2-Catalyzed Concise Synthesis of Substituted 6-Aminoisoquinolinoquinazoline Carboxylates from Anthranilamide published in 2020. Name: 2-Aminobenzamide, Reprint Addresses Alla, M (corresponding author), Indian Inst Chem Technol, CSIR, Div Fluoro & Agro Chem, Hyderabad 500007, Andhra Pradesh, India.; Alla, M (corresponding author), Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A one pot sequential addition protocol for synthesis of polycyclic quinazolines with beta-amino acid motifs has been achieved starting from anthranilamide. Initialin situformation of 2-(2-bromophenyl)quinazolin-4(3H)-one followed by addition of alkyl cyanoacetates catalyzed by copper (I) salts gives the target compound in good to excellent yields. The expedient and facile cascade protocol involves nucleophilic alpha-arylation, intramolecular cycloamidation of nitriles followed by 1,3-hydrogen shift allowing direct access to 6-amino-8-oxo-8H-isoquinolino[1,2-b]quinazoline-5-carboxylates.

Name: 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Reddy, PG; Indukuri, DR; Alla, M or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Ansari, SA; Deshmukh, SU; Patil, RB; Damale, MG; Patil, RH; Alkahtani, HM; Almehizia, AA; Al-Tuwajiri, HM; Aleanizy, FS; Alqahtani, FY; Pathan, SK; Sangshetti, JN in [Ansari, Siddique A.; Alkahtani, Hamad M.; Almehizia, Abdulrahman A.; Al-Tuwajiri, Hanaa M.] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, POB 2454, Riyadh 11451, Saudi Arabia; [Deshmukh, Satish U.] Deogiri Coll, Dept Chem, Aurangabad 431005, Maharashtra, India; [Patil, Rajesh B.] Smt Kashibai Navale Coll Pharm, Sinhgad Tech Educ Societys, Pune 411048, Maharashtra, India; [Damale, Manoj G.] Srinath Coll Pharm, Dept Pharmaceut Med Chem, Aurangabad 431136, Maharashtra, India; [Patil, Rajendra H.] Savitribai Phule Pune Univ, Dept Biotechnol, Pune 411007, Maharashtra, India; [Aleanizy, Fadilah S.; Alqahtani, Fulwah Y.] King Saud Univ, Dept Pharmaceutcs, Coll Pharm, POB 2454, Riyadh 11451, Saudi Arabia; [Pathan, Shahebaaz K.; Sangshetti, Jaiprakash N.] YB Chavan Coll Pharm, Dr Rafiq Zakaria Campus, Aurangabad 431001, Maharashtra, India published Identification of Promising Biofilm Inhibitory and Cytotoxic Quinazolin-4-one Derivatives: Synthesis, Evaluation, Molecular Docking and ADMET Studies in 2019, Cited 35. COA of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A library of 2,3-dihydroquinazolin-4(1H)-one derivatives (5 a-k) were synthesized in good yield by using 1-Ethyl-3-Methylimidazolium hydrogen sulphate (10 mol %) as a catalyst and were evaluated for their anti-biofilm, antimicrobial and cytotoxicity potential. Among the synthesized compounds, 2-(4-(1H-1,2,4-triazol-1-yl)phenyl)-2,3-dihydroquinazolin-4(1H)-one (5d) and 2,3-dihydro-2-(2,4,6-trimethoxyphenyl) quinazolin-4(1H)-one (5j) displayed better anti-biofilm activity than fluconazole (IC50 = 40 mu M) with IC50 values less than 30 mu M. Compound 5d also appeared to be fungicidal against C. Albicans having MIC=33.5 mu g/ml comparable with standard fluconazole (50 mu g/ml). All the synthesized compounds were also evaluated for cytotoxic activity by using MTT assay against HeLa, A-549 and MDA-MB-231 cell lines. The compound 5d was found to be more potent against MDA-MB-231 and A549 cell lines (IC50 = 11 +/- 2 mu M and 34 +/- 8 mu M respectively) than 5-fluorouracil (IC50 = 19 +/- 3 mu M and 51 +/- 5 mu M respectively). The compounds substituted with 6-methyl-4-oxo-4H-chromen-3-yl (5a), biphenyl (5c) and 2-hydroxy-5-bromophenyl (5e) were also found to be more potent against MDA-MB-231 cell lines (IC50 = 13 +/- 3 – 14 +/- 4 mu M) than 5-fluorouracil. Molecular docking simulations were also carried out using secreted aspartyl protease (SAP5), pepA enzyme of C. albicans for biofilm inhibition and EGFR tyrosine kinase for cyto-toxicity studies. The study reveals that the compounds 5d and 5e can serve as an important lead moiety for biofilm inhibition and cyto-toxicity against MDA-MB-231 and A549 cancer cell-lines indicating their potential in the treatment of tougher fungal infections and breast and lung cancer.

Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Long, J; Selikhov, AN; Mamontova, E; Lyssenko, KA; Guari, Y; Larionova, J; Trifonov, AA in [Long, Jerome; Mamontova, Ekaterina; Guari, Yannick; Larionova, Joulia] Univ Montpellier, CNRS, Inst Charles Gerhardt, ENSCM,Equipe Ingenierie Mol & Nanoobjets, F-34095 Montpellier 5, France; [Selikhov, Alexander N.; Trifonov, Alexander A.] Russian Acad Sci, Inst Organometall Chem, 49 Tropinina Str,GSP-445, Nizhnii Novgorod 630950, Russia; [Selikhov, Alexander N.; Lyssenko, Konstantin A.; Trifonov, Alexander A.] Russian Acad Sci, Inst Organoelement Cpds, 28 Vavilova Str, Moscow, Russia; [Lyssenko, Konstantin A.] Moscow MV Lomonosov State Univ, Chem Dept, Moscow 119991, Russia published Synthesis, structure, magnetic and luminescence properties of two dysprosium single-molecule magnets based on phenoxide dye ligands in 2020, Cited 34. Formula: C14H10O. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

We report here two dysprosium complexes based on phenoxide-based emissive ligands 1-(2,4-dimetylphenylazo)-2-naphtholate (L1) and anthracenolate (L2). While 1 is a dinuclear homoleptic complex [Dy-2(L1)(6)].2C(7)H(8) exhibiting zero-field slow relaxation of magnetization, 2 is a mononuclear complex [Dy(L2)(3)(py)(3)] (py = pyridine) showing field-induced relaxation.

Bye, fridends, I hope you can learn more about C14H10O, If you have any questions, you can browse other blog as well. See you lster.. Formula: C14H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Li, Z; Zhang, JH; Jing, XT; Dong, J; Liu, HF; Lv, HJ; Chi, YN; Hu, CW in ROYAL SOC CHEMISTRY published article about in [Li, Zhen; Zhang, Junhao; Jing, Xiaoting; Dong, Jing; Liu, Huifang; Lv, Hongjin; Chi, Yingnan; Hu, Changwen] Beijing Inst Technol, Key Lab Cluster Sci, Beiing Key Lab Photoelectro Electrophoton Convers, Minist Educ,Sch Chem & Chem Engn, Beijing 100081, Peoples R China in 2021.0, Cited 58.0. Recommanded Product: 119-61-9. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Electrocatalytic oxidation has been proven as a sustainable and promising alternative to traditional chemical transformation, but its further development is limited by the use of noble-metal electrocatalysts. Herein, a polyoxometalate-based electrode material, H5PMo10V2O40@CTF (denoted as PMo10V2@CTF), has been successfully fabricated through electrostatic assembly of a molecular polyoxometalate catalyst, PMo10V2, with a porous cationic covalent triazine framework (CTF), which, to our knowledge, represents the first combination of polyoxometalate with a cationic CTF. The resulting PMo10V2@CTF exhibits high activity for the selective electrocatalytic oxidation of alcohols to aldehydes, achieving 99% conversion of benzyl alcohol, over 99% selectivity of benzyl aldehyde, and at the same time near unity H-2 production. Notably, the reported electrocatalytic system presents good atom economy, high energy conversion (96% faradaic efficiency), remarkable catalytic activity and robustness for at least eight recycles. Based on the various experimental and spectroscopic analyses, a possible catalytic mechanism was proposed, revealing that such excellent electrocatalytic performance is attributed to the versatile redox ability of PMo10V2 and the good porosity and adsorption property of the CTF in the constructed PMo10V2@CTF composite.

About Benzophenone, If you have any questions, you can contact Li, Z; Zhang, JH; Jing, XT; Dong, J; Liu, HF; Lv, HJ; Chi, YN; Hu, CW or concate me.. Recommanded Product: 119-61-9

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Anthropogenic contaminants in freshwater from the northern Antarctic Peninsula region WOS:000583510100001 published article about MINNOW GOBIOCYPRIS-RARUS; PERSONAL CARE PRODUCTS; ORGANIC UV FILTERS; WASTE-WATER; ULTRAVIOLET FILTERS; PYRETHROID INSECTICIDES; PROTEOMIC RESPONSES; ESTROGENIC ACTIVITY; AQUATIC ECOSYSTEMS; IN-VITRO in [Dominguez-Morueco, Noelia; Valcarcel, Yolanda] Univ Rey Juan Carlos, Grp Invest & Docencia Toxicol Ambiental & Evaluac, Avda Tulipan Sn, Madrid, Spain; [Dominguez-Morueco, Noelia; Valcarcel, Yolanda] Rey Juan Carlos Univ, Fac Hlth Sci, Dept Prevent Med Publ Hlth Immunol & Med Microbio, Avda Atenas S-N, Madrid 28922, Spain; [Moreno-Merino, Luis; Duran Valsero, Juan Jose] Inst Geol & Minero Espana IGME, C Rios Rosas 23, Madrid 28003, Spain; [Molins-Delgado, Daniel; Diaz-Cruz, M. Silvia; Aznar-Alemany, Oscar; Eljarrat, Ethel; Farre, Marinella; Lopez de Alda, Miren] CSIC, Inst Environm Assessment & Water Res IDAEA, Dept Environm Chem, Water Environm & Food Chem Unit ENFO CHEM, C Jordi Girona 18-26, Barcelona 08034, Spain; [Lopez-Martinez, Jeronimo] Univ Autonoma Madrid, Dept Geol & Geoquim, Fac Ciencias, Madrid 28049, Spain; [Silva, Adrian] Inst Nacl Agua, Empalme J Newbery Km 1 620, Buenos Aires, DF, Argentina in 2021.0, Cited 66.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Product Details of 119-61-9

This study aimed to evaluate the presence of ultraviolet filters (UV-Fs), benzotriazoles, pyrethroids and per- and polyfluoroalkyl substances (PFASs) in freshwater and wastewater from the northern Antarctic Peninsula region. All water samples analyzed contained UV-Fs residues and high concentrations were detected in anthropogenic impacted sites (< LOD up to 1300 ng/L). Likewise, benzotriazoles were detected in all water samples (< LOQ-920 ng/L). Regarding suspended particulate matter, almost all UV-Fs and all benzotriazoles were measured at concentrations ranging from < LOQ to 33 mu g/g dry weight. Pyrethroids were also detected (< LOQ-250 ng/L) and their presence implies the existence of a gateway to the Antarctica Peninsula from other regions. The data confirmed the presence of PFASs (< LOD-7500 ng/L) in this area, in agreement with previous studies. In light of these results, extended monitoring in Antarctica should be carried out to perform a reliable environmental risk assessment leading to propose recommendations to minimize the anthropic impact. About Benzophenone, If you have any questions, you can contact Dominguez-Morueco, N; Moreno-Merino, L; Molins-Delgado, D; Diaz-Cruz, MS; Aznar-Alemany, O; Eljarrat, E; Farre, M; Lopez-Martinez, J; de Alda, ML; Silva, A; Valsero, JJD; Valcarcel, Y or concate me.. Product Details of 119-61-9

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 2-Aminobenzamide. In 2020 J HETEROCYCLIC CHEM published article about AZIDE-ALKYNE CYCLOADDITION; ONE-POT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; CATALYST; ANTIBACTERIAL; DENDRIMERS; CHEMISTRY; COPPER(I); ANALOGS in [Keivanloo, Ali; Bakherad, Mohammad; Mokhtarei, Lotfollah] Shahrood Univ Technol, Fac Chem, Shahrood 3619995161, Iran in 2020, Cited 42. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Water soluble sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate ligand was used successfully for the preparation of 1,2,3-triazoles pharmacophore linked-quinazolinone scaffold. The reaction of ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate and related amide compounds with propargyl bromide afforded ethyl 4-oxo-3-(prop-2-yn-1-yl)-3,4-dihydroquinazoline-2-carboxylate and its amide derivatives. The reaction of propargylated compounds with azides catalyzed by copper (II) salt, in the presence of Sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate as a ligand in water produced novel 1,2,3-triazole pharmacophore linked-quinazolinone-4-one scaffold with high-to-excellent yields. The ligand assisted in the click reaction and reduced loading of copper salt to 2 mol%. Simplicity, short reaction times, use of water as green solvent, and low catalyst loading are the main advantages of this procedure.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Keivanloo, A; Bakherad, M; Mokhtarei, L or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021.0 MONATSH CHEM published article about HANTZSCH 1,4-DIHYDROPYRIDINES; POLYMER MICROSPHERES; SELECTIVE OXIDATION; MOLECULAR-OXYGEN; GRAPHENE OXIDE; EFFICIENT; ALCOHOLS; BENZIMIDAZOLES; AROMATIZATION; SURFACE in [Sharma, Sukanya; Choudhary, Anu; Sharma, Shally; Shamim, Tahira; Paul, Satya] Univ Jammu, Dept Chem, Jammu 180006, India in 2021.0, Cited 48.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6. Category: thiomorpholine

The present protocol uncover a new strategy to synthesize highly efficient solid TEMPO based catalyst in which 4-oxo-TEMPO was covalently tethered to the surface of amine functionalized magnetic titania. The chemical nature and structure of the synthesized catalyst was authenticated by various techniques such as Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray powder diffraction, field emission gun scanning electron microscopy, high resolution transmission electron microscopy, energy dispersive X-ray spectroscopy, elemental analysis, and vibrating sample magnetometer. FT-IR confirmed the immobilization of titania, APTES, and TEMPO on the magnetic nanoparticles. Thermal behaviour of the catalyst was studied by TGA. Morphology of the catalyst was investigated by FEG-SEM and HR-TEM analysis. Furthermore, loading content of TEMPO on the catalyst was quantified by elemental analysis and found to be 0.61 mmol/g. Magnetic properties of the catalyst were investigated by VSM analysis. The catalytic performance of the synthesized catalyst has been investigated for the oxidative synthesis of benzimidazoles, oxidative aromatization of 1,4-dihydropyridines, and oxidative trimerization of indoles using molecular oxygen. In addition, the catalyst could be successfully recycled and reused up to five times without the prominent loss of catalytic activity.

Category: thiomorpholine. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Sharma, S; Choudhary, A; Sharma, S; Shamim, T; Paul, S or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Liu, CX; Cui, J; Wang, YF; Zhang, MJ in ROYAL SOC CHEMISTRY published article about in [Liu, Chengxin; Zhang, Mingjie] Tianjin Univ, Sch Sci, Dept Chem, Tianjin 30035, Peoples R China; [Cui, Jin] Tianjin Prod Qual Inspect Technol Res Inst, Natl Foodstuff Inspect Ctr, Tianjin 300384, Peoples R China; [Wang, Yufang] Shijiazhuang Univ Appl Technol, Sci Res Dept, Shijiazhuang 050081, Hebei, Peoples R China in 2021.0, Cited 40.0. Computed Properties of C7H5NO3. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

A novel metal-organic framework (MOF) with two-dimensional (2D) crystal structure was developed using Cu(NO3)(2)center dot 3H(2)O and 2,2 ‘,5,5 ‘-tetramethoxy-[1,1 ‘-biphenyl]-4,4 ‘-dicarboxylic acid. Further, its structure was characterized using infrared spectroscopy, thermogravimetry, X-ray diffraction, and X-ray crystallography. The activated Cu-MOF was used to catalyze the dehydrogenative oxidation of alcohol and N-arylation of azole compounds. Furthermore, it could be easily recovered and reused.

Computed Properties of C7H5NO3. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Liu, CX; Cui, J; Wang, YF; Zhang, MJ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of 1-Phenylurea. In 2019.0 J MED CHEM published article about ANDROGEN RECEPTOR; HISTONE H3; COACTIVATOR; CARM1; METHYLATION; DISCOVERY; TRANSCRIPTION; EXPRESSION in [Guo, Zuhao; Cao, Danyan; Chen, Danqi; Wang, Qi; Li, Yanlian; Li, Jian; Du, Zhiyan; Wang, Xin; Chen, Lin; Shen, Jingkang; Xiong, Bing] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Zhang, Zhuqing; Yang, Hong; Xu, Xiaowei; Zheng, Xineng; Ding, Jian; Geng, Meiyu; Huang, Xun] Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Zhang, Zhuqing; Xu, Xiaowei; Zheng, Xineng; Wang, Qi; Ding, Jian; Geng, Meiyu; Huang, Xun; Xiong, Bing] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China in 2019.0, Cited 46.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

PRMT4 is a type I protein arginine methyltransferase and plays important roles in various cellular processes. Overexpression of PRMT4 has been found to be involved in several types of cancers. Selective and in vivo effective PRMT4 inhibitors are needed for demonstrating PRMT4 as a promising therapeutic target. On the basis of compound 6, a weak dual PRMT4/6 inhibitor, we constructed a tetrahydroisoquinoline scaffold through a cut-and-sew scaffold hopping strategy. The subsequent SAR optimization efforts employed structure-based approach led to the identification of a novel PRMT4 inhibitor 49. Compound 49 exhibited prominently high potency and selectivity, moderate pharmacokinetic profiles, and good antitumor efficacy in acute myeloid leukemia xenograft model via oral administration, thus demonstrating this compound as a useful pharmacological tool for further target validation and drug development in cancer therapy.

Quality Control of 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Guo, ZH; Zhang, ZQ; Yang, H; Cao, DY; Xu, XW; Zheng, XN; Chen, DQ; Wang, Q; Li, YL; Li, J; Du, ZY; Wang, X; Chen, L; Ding, J; Shen, JK; Geng, MY; Huang, X; Xiong, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Electrophilic Substitution of Asymmetrically Distorted Benzenes within Triptycene Derivatives WOS:000649477300061 published article about REACTIVITY in [Ueno, Keisuke; Nishii, Yuji; Miura, Masahiro] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan in 2021, Cited 46. HPLC of Formula: C14H10O. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

Herein, we disclose a unique directing effect of 9-substituted triptycenes in electrophilic substitution to achieve the regioselective functionalization of the triptycene core. The Hirshfeld population analysis was adopted to predict the selectivity in electrophilic substitution. TMS and t-Bu groups were found to considerably accelerate the reaction at C2 positions to produce C3symmetric isomers. Correlation between distortion and charge distribution within benzene rings was systematically examined.

About Anthrone, If you have any questions, you can contact Ueno, K; Nishii, Y; Miura, M or concate me.. HPLC of Formula: C14H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem