Month: November 2021

I found the field of Chemistry very interesting. Saw the article Mukaiyama’s reagent promoted mild protocol for one-pot metal-free synthesis of dihydro quinazolinones published in 2021. Product Details of 88-68-6, Reprint Addresses Rajput, CS (corresponding author), Jubilant Biosys Ltd, B-34,Sect 58, Noida 201301, UP, India.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

We have developed a fast and convenient method to prepare dihydroquinazolin-4(1H)-ones from anthranilamide and different aromatic aldehydes by using the Mukaiyama reagent. The reactions proceeded smoothly with a broad scope of substrates providing the expected products in good to excellent yields under with a low environmental factor and high atom economy. The metal-free condition and the ease of product isolation are the highlighted advantages in solving the issue of trace metal contamination in synthesized pharmaceuticals. (C) 2021 Elsevier Ltd. All rights reserved.

Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 3-Nitrobenzaldehyde. Authors Liu, CX; Cui, J; Wang, YF; Zhang, MJ in ROYAL SOC CHEMISTRY published article about in [Liu, Chengxin; Zhang, Mingjie] Tianjin Univ, Sch Sci, Dept Chem, Tianjin 30035, Peoples R China; [Cui, Jin] Tianjin Prod Qual Inspect Technol Res Inst, Natl Foodstuff Inspect Ctr, Tianjin 300384, Peoples R China; [Wang, Yufang] Shijiazhuang Univ Appl Technol, Sci Res Dept, Shijiazhuang 050081, Hebei, Peoples R China in 2021.0, Cited 40.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

A novel metal-organic framework (MOF) with two-dimensional (2D) crystal structure was developed using Cu(NO3)(2)center dot 3H(2)O and 2,2 ‘,5,5 ‘-tetramethoxy-[1,1 ‘-biphenyl]-4,4 ‘-dicarboxylic acid. Further, its structure was characterized using infrared spectroscopy, thermogravimetry, X-ray diffraction, and X-ray crystallography. The activated Cu-MOF was used to catalyze the dehydrogenative oxidation of alcohol and N-arylation of azole compounds. Furthermore, it could be easily recovered and reused.

Welcome to talk about 99-61-6, If you have any questions, you can contact Liu, CX; Cui, J; Wang, YF; Zhang, MJ or send Email.. Application In Synthesis of 3-Nitrobenzaldehyde

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 119-61-9. Authors Das, P; Ganguly, S; Margel, S; Gedanken, A in AMER CHEMICAL SOC published article about in [Das, Poushali; Ganguly, Sayan; Margel, Shlomo; Gedanken, Aharon] Bar Ilan Univ, Bar Ilan Inst Nanotechnol & Adv Mat BINA, Dept Chem, IL-5290002 Ramat Gan, Israel in 2021.0, Cited 69.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

This work presents the facile synthesis of heteroatom-doped fluorescent carbon quantum dots (C-dots), which could serve as an antioxidant. Herein, nitrogen, phosphorous, and sulfur codoped carbon dots (NPSC-dots) have been synthesized by a single-step hydrothermal strategy. Owing to the radical scavenging activity of the NPSC-dots, they were tested against several methods as well as in practical applications. The antioxidant ability of the NPSC-dots was efficiently utilized on plastic films by coating with these NPSC-dots. For the very first time, NPSC-dots were immobilized onto nonpolar plastic films (polypropylene) via photochemical covalent grafting to extend the shelf life of food items or storage without affecting the quality of plastic films. The NPSC-dot-coated PP film with negligible deterioration of transparency was extensively studied using scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared (FTIR) analysis, X-ray photoelectron spectroscopy (XPS), contact angle measurement, and thermogravimetric analysis (TGA). The fluorescent character, antioxidant ability, and durability under different solvent systems of the coated film were examined. Also, the coated films were extensively and rigorously evaluated against simulated drastic environmental conditions to ensure the durability and antifogging application.

Product Details of 119-61-9. Bye, fridends, I hope you can learn more about C13H10O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Oncology; Urology & Nephrology very interesting. Saw the article Polymorphisms in androgen metabolism genes with serum testosterone levels and prognosis in androgen-deprivation therapy published in 2020.0. Quality Control of 1-Phenylurea, Reprint Addresses Shiota, M (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Urol, Fukuoka, Japan.. The CAS is 64-10-8. Through research, I have a further understanding and discovery of 1-Phenylurea

Objective: Androgen metabolism is a key component in therapeutic resistance to androgen deprivation therapy (ADT). This study aimed to reveal the significance of genetic polymorphisms in genes involved in androgen metabolism, including CYP17A1, AKR1C3, and HSD17B, on serum testosterone levels during ADT, as well as the prognosis of men undergoing ADT for metastatic prostate cancer (CaP). Materials and methods: This study included 104 Japanese patients with metastatic CaP, for whom serum testosterone data during ADT were available for 80 patients. The association of CYP17A1 (rs743572), AKR1C3 (rs12529), HSD17B1 (rs605059), HSD17B3 (rs2066479), and HSD17B4 (rs7737181) with serum testosterone levels during ADT and prognosis (progression-free survival and overall survival) was examined. Enzymatic activity in AKR1C3 H5Q was examined using recombinant protein. Results: Homozygous wild-type (GG allele; median [interquartile range], 12.0 ng/ml [8.0-19.0 ng/ml]) AKR1C3 rs12529 was associated with higher serum testosterone levels during ADT compared with variant-type (GC/CC alleles; median [interquartile range], 9.0 ng/ml [6.4-10.8 ng/ml]). Consistently, variant-type (GC/CC alleles) AKR1C3 rs12529 showed significantly lower risk of progression (hazard ratio [95% confidence interval], 0.47 [0.24-0.96], P = 0.039) compared with homozygous wild-type (GG allele) on multivariate analysis. Meanwhile, other genetic variations were associated with neither serum testosterone during ADT nor prognosis. Enzyme activity of wild-type AKR1C3 was comparable to the H5Q mutant. Conclusions: Taken together, this study demonstrated that AKR1C3 polymorphism, which was associated with serum testosterone levels during ADT, may be a prognostic factor of the progression to castration-resistant prostate cancer in Japanese men with metastatic CaP. (C) 2020 Elsevier Inc. All rights reserved.

Quality Control of 1-Phenylurea. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Erfan, MA; Akhlaghinia, B; Ghodsinia, SSE in [Erfan, Mohammad Anwar; Akhlaghinia, Batool; Ghodsinia, Sara S. E.] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad 9177948974, Razavi Khorasan, Iran published An Efficient Green Protocol for Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Using SBA-16/GPTMS-TSC-Cu-I under Solvent-Free Conditions in 2020, Cited 87. Product Details of 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Herein a rapid, efficient, facile and environmentally benign synthesis of 2,3-dihydroquinazolin-4(1H)-ones using SBA-16/GPTMS-TSC-Cu-I (Cu-I anchored onto mesoporous SBA-16 functionalized by aminated 3-glycidyloxypropyltrimethoxysilane with thiosemicarbazid) is reported. The aforesaid mesostructured catalyst with a unique super-cage structure and narrow particle size distribution (3-7 nm) exhibited excellent catalytic activity in high yielding preparation of 2,3 dihydroquinazolin-4(1H)-ones from the condensation of 2-aminobenzamide and an aldehyde in solvent-free conditions. Furthermore, SBA-16/GPTMS-TSC-Cu-I as a heterogeneous catalyst was stable under reaction conditions and can be recycled at least five times without any loss of its catalytic efficiency.

Product Details of 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Erfan, MA; Akhlaghinia, B; Ghodsinia, SSE or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Shiota, M; Endo, S; Fujimoto, N; Tsukahara, S; Ushijima, M; Kashiwagi, E; Takeuchi, A; Inokuchi, J; Uchiumi, T; Eto, M in [Shiota, Masaki; Tsukahara, Shigehiro; Ushijima, Miho; Kashiwagi, Eiji; Takeuchi, Ario; Inokuchi, Junichi; Eto, Masatoshi] Kyushu Univ, Grad Sch Med Sci, Dept Urol, Fukuoka, Japan; [Endo, Satoshi] Gifu Pharmaceut Univ, Dept Biopharmaceut Sci, Lab Biochem, Gifu, Japan; [Fujimoto, Naohiro] Univ Occupat & Environm Hlth, Sch Med, Dept Urol, Kitakyushu, Fukuoka, Japan; [Tsukahara, Shigehiro; Uchiumi, Takeshi] Kyushu Univ, Grad Sch Med Sci, Dept Clin Chem & Lab Med, Fukuoka, Japan published Polymorphisms in androgen metabolism genes with serum testosterone levels and prognosis in androgen-deprivation therapy in 2020.0, Cited 36.0. Quality Control of 1-Phenylurea. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

Objective: Androgen metabolism is a key component in therapeutic resistance to androgen deprivation therapy (ADT). This study aimed to reveal the significance of genetic polymorphisms in genes involved in androgen metabolism, including CYP17A1, AKR1C3, and HSD17B, on serum testosterone levels during ADT, as well as the prognosis of men undergoing ADT for metastatic prostate cancer (CaP). Materials and methods: This study included 104 Japanese patients with metastatic CaP, for whom serum testosterone data during ADT were available for 80 patients. The association of CYP17A1 (rs743572), AKR1C3 (rs12529), HSD17B1 (rs605059), HSD17B3 (rs2066479), and HSD17B4 (rs7737181) with serum testosterone levels during ADT and prognosis (progression-free survival and overall survival) was examined. Enzymatic activity in AKR1C3 H5Q was examined using recombinant protein. Results: Homozygous wild-type (GG allele; median [interquartile range], 12.0 ng/ml [8.0-19.0 ng/ml]) AKR1C3 rs12529 was associated with higher serum testosterone levels during ADT compared with variant-type (GC/CC alleles; median [interquartile range], 9.0 ng/ml [6.4-10.8 ng/ml]). Consistently, variant-type (GC/CC alleles) AKR1C3 rs12529 showed significantly lower risk of progression (hazard ratio [95% confidence interval], 0.47 [0.24-0.96], P = 0.039) compared with homozygous wild-type (GG allele) on multivariate analysis. Meanwhile, other genetic variations were associated with neither serum testosterone during ADT nor prognosis. Enzyme activity of wild-type AKR1C3 was comparable to the H5Q mutant. Conclusions: Taken together, this study demonstrated that AKR1C3 polymorphism, which was associated with serum testosterone levels during ADT, may be a prognostic factor of the progression to castration-resistant prostate cancer in Japanese men with metastatic CaP. (C) 2020 Elsevier Inc. All rights reserved.

Welcome to talk about 64-10-8, If you have any questions, you can contact Shiota, M; Endo, S; Fujimoto, N; Tsukahara, S; Ushijima, M; Kashiwagi, E; Takeuchi, A; Inokuchi, J; Uchiumi, T; Eto, M or send Email.. Quality Control of 1-Phenylurea

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Downs, CA; DiNardo, JC; Stien, D; Rodrigues, AMS; Lebaron, P in AMER CHEMICAL SOC published article about PERSONAL CARE PRODUCTS; UV-FILTER OCTOCRYLENE; ESTROGENIC POTENCY; METABOLITES; INGREDIENTS; DERIVATIVES; SAFETY in [Downs, C. A.; Stien, Didier; Rodrigues, Alice M. S.; Lebaron, Philippe] Sorbonne Univ, CNRS, Lab Biodiversite & Biotechnol Microbiennes, USR3579,Observ Oceanol, F-66650 Banyuls Sur Mer, France; [Downs, C. A.] Haereticus Environm Lab, Clifford, VA 24533 USA in 2021.0, Cited 65.0. Formula: C13H10O. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Benzophenone is a mutagen, carcinogen, and endocrine disruptor. Its presence in food products or food packaging is banned in the United States. Under California Proposition 65, there is no safe harbor for benzophenone in any personal care products, including sunscreens, anti-aging creams, and moisturizers. The purpose of this study was to determine (1) if benzophenone was present in a wide variety of commercial sun protection factor (SPF)/sunscreen products, (2) whether benzophenone concentration in the product increased over time, and (3) if the degradation of octocrylene was the likely source for benzophenone contamination. Benzophenone concentration was assayed in nine commercial sunscreen products from the European Union and eight from the United States (in triplicate), including two single ingredient sources of octocrylene. These same SPF items were subjected to the United States Food and Drug Administration (U.S. FDA)-accelerated stability aging protocol for 6 weeks. Benzophenone was measured in the accelerated-aged products. Sixteen octocrylene-containing product lines that were recently purchased had an average concentration of 39 mg/kg benzophenone, ranging from 6 mg/kg to 186 mg/kg. Benzophenone was not detectable in the product that did not contain octocrylene. After subjecting the 17 products to the U.S. FDA-accelerated stability method, the 16 octocrylene-containing products had an average concentration of 75 mg/kg, ranging from 9.8 mg/kg to 435 mg/kg. Benzophenone was not detectable in the product that did not contain octocrylene. Benzophenone was detected in the pure octocrylene manufactured ingredient. Octocrylene generates benzophenone through a retro-aldol condensation. In vivo, up to 70% of the benzophenone in these sunscreen products may be absorbed through the skin. U.S. FDA has established a zero tolerance for benzophenone as a food additive. In the United States, there were 2999 SPF products containing octocrylene in 2019. The safety of octocrylene as a benzophenone generator in SPF or any consumer products should be expeditiously reviewed by regulatory agencies.

Welcome to talk about 119-61-9, If you have any questions, you can contact Downs, CA; DiNardo, JC; Stien, D; Rodrigues, AMS; Lebaron, P or send Email.. Formula: C13H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 2-Aminobenzamide. In 2019 CHINESE CHEM LETT published article about BIOLOGICAL-ACTIVITIES; MANNICH-BASES; DESIGN; ANTIFUNGAL; FLUORINE; PRODUCT; ANALOGS in [Chen, Xiulei; Jia, Haowu; Li, Zhong; Xu, Xiaoyong] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China; [Li, Zhong; Xu, Xiaoyong] Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai 200237, Peoples R China in 2019, Cited 24. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

To explore new skeleton with nematicidal activity, a series of novel 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker were synthesized and varied fragments were also introduced to increase structure diversity of the new skeleton. Their inhibitory activities in vivo were evaluated against Meloidogyne incognita. The newly prepared compounds A6, A8, A21, A28 and A38 exhibited more than 50% inhibition at the concentration of 20 mg/L. Especially compound A6 displayed 71.4% inhibition against Meloidogyne incognita at the concentration of 20 mg/L. The nematicidal activities varied significantly depending on the types and positions of the substituents, which provided guidance for further structure modification. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Welcome to talk about 88-68-6, If you have any questions, you can contact Chen, XL; Jia, HW; Li, Z; Xu, XY or send Email.. Application In Synthesis of 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Iridium(III)-Catalyzed Alkynylation of 2-(Hetero)arylquinazolin-4-one Scaffolds via C-H Bond Activation WOS:000460491600052 published article about CROSS-COUPLING REACTION; TERMINAL ALKYNES; ETHYNYL BENZIODOXOLONES; CATALYZED ALKYNYLATION; SONOGASHIRA REACTIONS; ARENES; QUINAZOLINONE; AMIDATION; ACETYLENE; AMINATION in [Rohokale, Rajendra S.; Kalshetti, Rupali G.; Ramana, Chepuri V.] CSIR Natl Chem Lab, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Kalshetti, Rupali G.; Ramana, Chepuri V.] Acad Sci & Innovat Res, New Delhi 110025, India in 2019, Cited 80. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Computed Properties of C7H8N2O

The directed C-H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as -F, -Cl, -Br, -CF3, -OMe, -NO2, and alkyl, etc.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Rohokale, RS; Kalshetti, RG; Ramana, CV or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of Anthrone. In 2020 J MACROMOL SCI A published article about LOW-DIELECTRIC-CONSTANT; T-G; IMIDE)S; DIANHYDRIDE; POLYAMIDES; DIAMINE; PROPANE in [Kuang, Lu; Zhong, Ming; Sang, Xiao-Yan; Huang, Zhen-Zhong] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China in 2020, Cited 30. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

10,10-Bis[4-(4-aminophenoxy)-3-methylphenyl]-9(10H)-anthrone, as a novel aromatic diamine, was synthesized from anthrone by three-step process. A series of polyimides containing methyl substituents and 9(10H)-anthrone pendant groups was prepared from this diamine with various aromatic dianhydridesviathe poly(amic acid) (PAA) precursors and subsequent thermal or chemical imidization procedure. Inherent viscosities of PAAs are between 0.87 and 1.58 dL/g, and the corresponding polyimides have the weight-average molecular weight and number-average molecular weight in the range of 49,400-64,200 and 28,700-37,700, respectively. Most of the polyimides obtained through the chemical cyclodehydration method are soluble in NMP, DMF, DMAc, Py andm-cresol at room temperature. These polyimides have glass transition temperatures of 289-313 degrees C, 10% weight loss temperatures of 484-524 degrees C, char yields of 55-63% at 800 degrees C, and temperature at the maximum-rate degradation of 560-584 degrees C in nitrogen, respectively. The polyimide films obtained through the thermal imidization have tensile strength of 76.43-119.74 MPa, elongation at break of 6.93-12.33%, and tensile modulus of 1.91-2.38 GPa.

Application In Synthesis of Anthrone. Welcome to talk about 90-44-8, If you have any questions, you can contact Kuang, L; Zhong, M; Sang, XY; Huang, ZZ or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem