In 2021 J MOL STRUCT published article about AGENTS in [Mohammadi, Ali Asghar; Taheri, Salman; Ghaderi, Peghman; Ahdenov, Reza] Dept Chem & Chem Engn, Res Ctr Iran, POB 14115-175, Tehran, Iran; [Azizian, Homa] Iran Univ Med Sci, Dept Med Chem, Sch Pharm, Int Campus, Tehran, Iran; [Mohammadi-Khanaposhtani, Maryam] Babol Univ Med Sci, Cellular & Mol Biol Res Ctr, Hlth Res Inst, Babol, Iran; [Faramarzi, Mohammad Ali] Univ Tehran Med Sci, Fac Pharm & Biotechnol Res Ctr, Dept Pharmaceut Biotechnol, Tehran, Iran; [Larijani, Bagher; Mahdavi, Mohammad] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran in 2021, Cited 30. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6. Category: thiomorpholine
In this study, new tri-amides 5a-1 have been synthesized via a one-pot four-component Ugi reaction between repaglinide, aniline derivatives, aldehyde derivatives, and cyclohexyl isocyanide in good yields. These compounds were evaluated against yeast alpha-glucosidase. Obtained in vitro alpha-glucosidase results demonstrated that all the synthesized compounds 5a-1 were more potent than standard inhibitor acarbose. Among them, the most potent compounds were compounds 5j, 5k, and 5h. The kinetic analysis of the most potent compound 5j revealed that this compound is a competitive inhibitor for alpha-glucosidase (K-i = 24 mu M). Furthermore, docking study of the most potent compounds was also performed in the alpha-glucosidase active site to find interaction modes and binding energies of these compounds. (C) 2020 Elsevier B.V. All rights reserved.
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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem