Costa, J; Streich, L; Pinto, S; Pronto-Laborinho, A; Nimtz, M; Conradt, HS; de Carvalho, M in [Costa, Julia] Univ Nova Lisboa, Lab Glycobiol, Inst Tecnol Quim & Biol Antonio Xavier, Ave Republ, P-2780157 Oeiras, Portugal; [Streich, Linda; Conradt, Harald S.] Glyco Thera GmbH, Feodor Lynen Str 35, D-30625 Hannover, Germany; [Pinto, Susana; Pronto-Laborinho, Ana; de Carvalho, Mamede] Univ Lisbon, Inst Physiol, Inst Med Mol, Fac Med, Lisbon, Portugal; [Nimtz, Manfred] Helmholtz Zentrum Infekt Forsch, D-38124 Braunschweig, Germany; [de Carvalho, Mamede] Hosp Santa Maria CHLN, Dept Neurosci & Mental Hlth, Lisbon, Portugal published Exploring Cerebrospinal Fluid IgG N-Glycosylation as Potential Biomarker for Amyotrophic Lateral Sclerosis in 2019, Cited 41. COA of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which the existing candidate biomarkers (neurofilaments) have low specificity. Changes in blood IgG N-glycosylation have been observed in several diseases, including ALS, whereas cerebrospinal fluid (CSF) IgG has been less studied. Here, we characterized N-glycans of CSF IgG from ALS patients in comparison with a control group of other neurological diseases. Cerebrospinal fluid was collected from patients with ALS (n=26) and other neurological diseases (n=10). N-Glycans were released from CSF purified IgG with peptide N-glycosidase F, labeled with 2-aminobenzamide and analyzed by NP-HPLC chromatography in combination with exoglycosidase digestion and MALDI-TOF mass spectrometry. The N-glycosylation profile of ALS CSF IgG consisted of diantennary N-glycans predominantly with proximal fucose and some bisecting GlcNAc; agalacto-, mono-, and digalactosylated as well as alpha 2,6-sialylated structures were detected. Differences between ALS and control patients were observed; most relevant was the increase in ALS CSF IgG of the level of galactosylated structures defined here as Gal-index (median 46.87 and 40.50% for ALS and controls, respectively; p=0.006). The predictive value of the Gal-index (AUC=0.792, p=0.007) considering ROC analysis had potential utility as a diagnostic test for ALS and was comparable to that of phosphoneurofilament heavy chain (AUC=0.777, p=0.011), which was used as benchmark marker for our group of patients. The results provide the basis to further explore the potential of IgG N-glycan galactosylation as biomarker for ALS by using larger cohorts of patients and controls.
Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C7H8N2O
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem