New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Battula, Kumaraswamy, once mentioned the application of 100-21-0, Name is Terephthalic acid, molecular formula is C8H6O4, molecular weight is 166.1308, MDL number is MFCD00002558, category is thiomorpholine. Now introduce a scientific discovery about this category, Application of 100-21-0.
A convenient synthesis of novel 1,4-disubstituted 1,2,3-triazoles (4a-j and 5a-j) is reported via copper(I)-catalyzed one pot [3+ 2] cycloaddition of various alkyl halides, sodium azide with 4-(prop-2-yn-1-yl) thiomorpholine and 4-(prop-2-yn-1-yl) thiomorpholine 1,1-dioxide. All the synthesized compounds were investigated for their antimicrobial activity. Compounds 4a, 4b, 4c, 4g, 5a and 5j against Staphylococcus epidermidis, 4a, 5a and 5d against Pseudomonas aeruginosa, 4a, 4b and 4g against Klebsiella pneumoniae, 4b, 5a and 5d against S. aureus and 5b, 5e and 5j against Bacillus subtilis showed excellent antibacterial activity compared to the standard drugs penicillin and streptomycin. Compounds 4c, 4e, 4f, 4j, 5c, 5d, 5g and 5j registered moderate antifungal activity as compared with the standard drug amphotericin B.
Application of 100-21-0, You can get involved in discussing the latest developments in this exciting area about 100-21-0.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem