Tag: M.W:200-300

Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. In an article, author is Shainyan, Bagrat A., once mentioned the application of 1591-31-7, Name is 4-Iodo-1,1′-biphenyl, molecular formula is C12H9I, molecular weight is 280.1, MDL number is MFCD00019028, category is thiomorpholine. Now introduce a scientific discovery about this category, Recommanded Product: 1591-31-7.

The stereodynamic behaviour of 1-(trifluoromethylsulfonyl)piperidine 1, 4-(trifluoromethylsulfonyl) morpholine 2, 1,4-bis(trifluoromethylsulfonyl)piperazine 3 and 4-(trifluoromethylsulfonyl)thiomorpholine 1,1-dioxide 4 was studied by low-temperature H-1, C-13 and F-19 NMR spectroscopies. In acetone solution, compounds 1, 2 and 4 were found to exist as mixtures of two conformers in the ratio of 4:1,4:1 and 8:1, respectively, differing by orientation of the CF3 group with respect to the ring. Compound 3 exists as a mixture of three conformers in the ratio of 3:28:69 also differing by the orientation of the two CF3 groups. Unlike the previously studied N-trifyl substituted 1,3,5-triheterocyclohexanes, the preferred conformers of compound 1 and of 1,4-diheterocyclohexanes 2-4 are those with the CF3 group directed outward from the ring, which is caused by intramolecular interactions of the oxygen atoms of the CF3SO2N groups with the equatorial hydrogens in the a-position. B3LYP/6-311+G(d,p) calculations of the energy, geometry and NMR parameters corroborate the experimental data. The calculated Perlin effects for all conformers of compounds 1-4 as well as those measured for the major conformers of compounds 3 and 4 were analyzed by the use of the NBO analysis. (c) 2008 Elsevier Ltd. All rights reserved.

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New research progress on 93-11-8 in 2021. Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. 93-11-8, Name is Naphthalene-2-sulfonyl chloride, molecular formurla is C10H7ClO2S. In a document, author is Mezil, Lynda, introducing its new discovery. Synthetic Route of 93-11-8.

Background: Targeted therapies, associated with standard chemotherapies, have improved breast cancer care. However, primary and acquired resistances are frequently observed and the development of new concepts is needed. High-throughput approaches to identify new active and safe molecules with or without an a priori” are currently developed. Also, repositioning already-approved drugs in cancer therapy is of growing interest. The thiomorpholine hydroxamate compound TMI-1 has been previously designed to inhibit metalloproteinase activity for the treatment of rheumatoid arthritis. We present here the repositioning of TMI-1 drug in breast cancer. Methodology/Principal Findings: We tested the effect of TMI-1 on luminal, basal and ERBB2-overexpressing breast tumor cell lines and on MMTV-ERBB2/neu tumor evolution. We measured the effects on i) cell survival, ii) cell cycle, iii) extrinsic and intrinsic apoptotic pathways, iv) association with doxorubicin, docetaxel and lapatinib, v) cancer stem cells compartment. In contrast with conventional cytotoxic drugs, TMI-1 was highly selective for tumor cells and cancer stem cells at submicromolar range. All non-malignant cells tested were resistant even at high concentration. TMI-1 was active on triple negative (TN) and ERBB2-overexpressing breast tumor cell lines, and was also highly efficient on human and murine primary” ERBB2-overexpressing cells. Treatment of transgenic MMTV-ERBB2/neu mice with 100 mg/kg/day TMI-1 alone induced tumor apoptosis, inhibiting mammary gland tumor occurrence and development. No adverse effects were noticed during the treatment. This compound had a strong synergistic effect in association with docetaxel, doxorubicin and lapatinib. We showed that TMI-1 mediates its selective effects by caspase-dependent apoptosis. TMI-1 was efficient in 34/40 tumor cell lines of various origins (ED50: 0.6 mu M to 12.5 mu M). Conclusions/Significance: This is the first demonstration of the tumor selective cytotoxic action of a thiomorpholin hydroxamate compound. TMI-1 is a novel repositionable drug not only for the treatment of adverse prognosis breast cancers but also for other neoplasms.

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New research progress on 94569-84-3 in 2021. Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. 94569-84-3, Name is 2-Bromo-5-fluorobenzaldehyde, molecular formurla is C7H4BrFO. In a document, author is Lima, LM, introducing its new discovery. Application In Synthesis of 2-Bromo-5-fluorobenzaldehyde.

This paper describes the synthesis and anti-inflammatory activity of new N-phenyl-phthalimide sulfonamides (3a-e) and the isosters N-phenyl-phthalimide amides (4a-e), designed as hybrids of thalidomide (1) and aryl sulfonamide phosphodiesterase inhibitor (2), In these series, compound 3e (LASSBio 468). having a sulfonyl-thiomorpholine moiety, showed potent inhibitory activity on LPS-induced neutrophil recruitment with ED50 = 2.5 mg kg(-1), which was correlated with its inhibitory effect on TNF-alpha level. (C) 2002 Elsevier Science Ltd. All rights reserved.

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As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves., Synthetic Route of 90-14-2, 90-14-2, Name is 1-Iodonaphthalene, molecular formula is C10H7I, belongs to thiomorpholine compound. In a document, author is Levin, Jeremy I., introduce the new discover.

A variety of heterocyclic ring systems have been prepared as scaffolds for butynyloxyphenyl sulfonamide and sulfone hydroxamic acid inhibitors of TACE enzyme. All scaffolds provided highly active TACE inhibitors, but selectivity, and cellular activity was highly scaffold dependent.

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Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 177034-57-0, Name is 4-((2-Isopropoxyethoxy)methyl)phenol, molecular formurla is C12H18O3. In a document, author is Duarte, CD, introducing its new discovery. HPLC of Formula: https://www.ambeed.com/products/177034-57-0.html.

We describe herein the structural optimization of new piperamide analogues, designed from two natural prototypes, piperine 1 and piper-dardine 2, obtained from Piper tuberculatum Jacq. (Piperaceae). Molecular modeling studies using semiempirical AMI method were made in order to establish rational modifications to optimize them by molecular simplification. The targeted compounds (10) and (11) were respectively obtained using benzaldehyde (12) and para-anisaldehyde (13) as starting materials. H-1 NMR spectra showed that the target compounds were diastereoselectively obtained as the (E)-isomer, the same geometry of the natural prototypes. These new synthetic amides presented significant hypotensive effects in cardiovascular essays using in vivo methodologies. Compound 11 (N-[5-(4′-methoxyphenyl)2(E)-pentenoyl]thiomorpholine) showed a potency 10,000 times greater than its prototype 5, evidencing an optimization of the molecular architecture for this class of hypotensive drug candidates. (C) 2004 Elsevier B.V. All rights reserved.

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Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. In an article, author is Chan, Wing Chi, once mentioned the application of 76-83-5, Name is (Chloromethanetriyl)tribenzene, molecular formula is C19H15Cl, molecular weight is 278.7754, MDL number is MFCD00000813, category is thiomorpholine. Now introduce a scientific discovery about this category, HPLC of Formula: https://www.ambeed.com/products/76-83-5.html.

10-Alkylamino-artemisinins including artemiside and artemisone display enhanced activities against malaria. Earlier, dihydroartemisinin (DHA) TMS ether was converted by trimethylsilyl bromide into the 10-beta-bromide that with amine nucleophiles provided the amino-artemisinins. In an attempt to develop more economic approaches, direct N-glycosylation of DHA was examined but 2-deoxyartemisinin was invariably obtained. However, hydroxyl group activation by conversion into the 10 beta-halide in non-polar solvents with anhydrous HCl and Group I and II metal halides, oxalyl chloride or thionyl chloride with catalytic DMSO, and oxalyl bromide did succeed. The beta-halides were converted in situ by thiomorpholine into artemiside, and by thiomorpholine-1,1-dioxide into artemisone respectively in scalable reactions. Hydrogen peroxide-acetonitrile or the urea-hydrogen peroxide complex efficiently oxidized the sulfide artemiside to the sulfone artemisone. Overall, a generalized approach to 10-alkylamino-artemisinins is now available. (C) 2018 Elsevier Ltd. All rights reserved.

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In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In an article, author is Fathalla, Magda F., once mentioned the application of 607-81-8, Name is Diethyl benzylmalonate, molecular formula is C14H18O4, molecular weight is 250.29, MDL number is MFCD00009166, category is thiomorpholine. Now introduce a scientific discovery about this category, SDS of cas: 607-81-8.

The kinetic of the nucleophilic substitution of methyl 2,4-dichloro-3,5-dinitrobenzoate with piperidine, piperazine, morpholine and thiomorpholine in methanol and benzene were determined spectrophotometrically at different amine concentrations and at temperatures ranging from 25 to 45 degrees C. The second order rate constants and the thermodynamic parameters show that the reactions are not amine catalysed and are greatly dependent of the nature of solvent and amine. UV, IR, H-1 NMR, and elemental analysis are used to prove the aminodechlorination at C-2.

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Thiomorpholine – Wikipedia,
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Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. In an article, author is Cindric, Marina, once mentioned the application of 1591-31-7, Name is 4-Iodo-1,1′-biphenyl, molecular formula is C12H9I, molecular weight is 280.1, MDL number is MFCD00019028, category is thiomorpholine. Now introduce a scientific discovery about this category, Formula: https://www.ambeed.com/products/1591-31-7.html.

Eight mononuclear [Ni(sal 4-Phtsc)center dot D] thiosemicarbazonato complexes [sal4-Phtsc = salicylaldehyde 4-phenylthiosemicarbazonato ligand; D = imidazole (1), methylimidazole (2), pyridine (3), 4-aminopyridine (4), 4-methylpyridine (6), morpholine (7), thiomorpholine (8), 2-aminophenol (9)] and one dinuclear {[Ni(sal 4-Phtsc)](2)center dot D} center dot 2DMSO [D = 4,4′-bipyridine (5)] complex have been prepared by adding the corresponding Lewis base to the methanol suspension of the parent complex [Ni(sal 4-Phtsc)(H(2)sal4-Phtsc)]center dot CH3OH. The exchange of the neutral salicylaldehyde 4-phenylthiosemicarbazone (H(2)sal4-Phtsc) ligand in the parent complex for the appropriate Lewis base has been confirmed by IR spectroscopy and powder X-ray diffraction (PXRD) in the solid state. The single-crystal X-ray diffraction of seven complexes 1 and 3-8 confirmed the formation of the complexes with the Ni-II ion, coordinated through O,N,S-donor atoms from the dibasic salicylaldehyde 4-phenylthiosemicarbazonato ligand and endocyclic N-donor atom from the neutral ligand D in the form of a distorted square-planar coordination. NMR spectroscopy in DMF or DMSO and quantum mechanical calculations have been performed in order to explain and compare the stability of the complexes in solution, depending on the polarity of solvents in the context of donor properties and the nucleophilicity of the heterocyclic Lewis base. The single-crystal X-ray data enables a comparison with calculated standard Gibbs energies of binding in the context of crystal packing forces, leading to a general conclusion that the stability of the mononuclear complexes results in the formation of more stable hydrogen-bonded cyclic dimers as a crystal packing pattern.

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Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Synthetic Route of 120-46-7, 120-46-7, Name is 1,3-Diphenylpropane-1,3-dione, molecular formula is C15H12O2, belongs to thiomorpholine compound. In a document, author is Marvadi, Sandeep Kumar, introduce the new discover.

A series of novel morpholine, thiomorpholine and N-substituted piperazine coupled 2-(thiophen-2-yl)dihydroquinolines 7a-p was designed and synthesized from 2-acetyl thiophene in six step reaction sequence involving modified Bohlmann-Rahtz and Vilsmeier-Haack-Arnold reactions as key transformations. 2-(Thiophen-2-yl)dihydroquinoline was formylated and subsequently chlorinated using DMF-POCl3. The resulting aldehyde was reduced to give an alcohol and then converted to bromide using PBr3. Further coupling of bromide with morpholine, thiomorpholine and N-substituted piperazines resulted in the desired quinolines 7a-p in very good yields. All the new derivatives 7a-p were characterized by their NMR and mass spectral analysis. In vitro screening of new compounds for anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB), resulted in two derivatives 7f and 7p as most potent antitubercular agents (MIC:1.56 mu g/mL) with lower cytotoxicity profiles. (C) 2018 Elsevier Masson SAS. All rights reserved.

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New research progress on 125464-42-8 in 2021. Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formurla is C9H12ClNO3S. In a document, author is Basoglu, Serap, introducing its new discovery. Recommanded Product: 125464-42-8.

Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)-4-{[(4-methoxyphenyl)methylidene]amino}-4H-1,2,4-triazole-3-thiol (XIII) was performed starting from furan-2-carbohydrazide by three steps. The structures of the synthesized compounds were well characterized by elemental analyses, IR, H-1 NMR, C-13 NMR and mass spectral studies. Newly synthesized compounds were screened for their antimicrobial activities and some of them displayed activity against the tested microorganisms.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 125464-42-8, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/125464-42-8.html.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem