Tag: M.W:100-200

Reference of 90-01-7, New discoveries in chemical research and development in 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 90-01-7, Name is Salicyl Alcohol, SMILES is C1=CC=CC(=C1O)CO, molecular formula is C7H8O2, belongs to thiomorpholine compound. In an article, author is Mancy, Ahmed, introduce new discover of the category.

Bacterial resistance to antibiotics is presently one of the most pressing healthcare challenges and necessitates the discovery of new antibacterials with unique chemical scaffolds. However, the determination of the optimal balance between structural requirements for pharmacological action and pharmacokinetic properties of novel antibacterial compounds is a significant challenge in drug development. The incorporation of lipophilic moieties within a compound’s core structure can enhance biological activity but have a deleterious effect on drug-like properties. In this Article, the lipophilicity of alkynylphenylthiazoles, previously identified as novel antibacterial agents, was reduced by introducing cyclic amines to the lipophilic side chain. In this regard, substitution with methylpiperidine (compounds 14-16) and thiomorpholine (compound 19) substituents significantly enhanced the aqueous solubility profile of the new compounds more than 150-fold compared to the first-generation lead compound 1b. Consequently, the pharmacokinetic profile of compound 15 was significantly enhanced with a notable improvement in both half-life and the time the compound’s plasma concentration remained above its minimum inhibitory concentration (MIC) against methicillin-resistant Staphylococcus aureus (MRSA). In addition, compounds 14-16 and 19 were found to exert a bactericidal mode of action against MRSA and were not susceptible to resistance formation after 14 serial passages. Moreover, these compounds (at 2X MIC) were superior to the antibiotic vancomycin in the disruption of the mature MRSA biofilm. The modifications to the alkynylphenylthiazoles reported herein successfully improved the pharmacokinetic profile of this new series while maintaining the compounds’ biological activity against MRSA.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New Advances in Chemical Research, May 2021. We’ll be discussing some of the latest developments in chemical about CAS: 119-61-9. In an article, author is Peter, A, once mentioned the application of 119-61-9, Name is Benzophenone, molecular formula is C13H10O, molecular weight is 182.2179, MDL number is MFCD00003076, category is thiomorpholine. Now introduce a scientific discovery about this category, HPLC of Formula: https://www.ambeed.com/products/119-61-9.html.

A new chiral derivatizing, agent, (S)-N-(4-nitrophenoxycarbonyl)phenylalanine methoxyethyl ester, (S)-NIFE, was applied for the high-performance liquid chromatographic separation of enantiomers of 19 unnatural secondary amino acids: proline, pipecolic acid analogues, piperazine-2-carboxylic acid, morpholine-3-carboxylic acid, thiomorpholine-3-carboxylic acid and analogues containing the 1,2,3,4-tetrahydroisoquinoline, 1,2,3,4-tetrahydronorharmane, 1,2,3,4-tetrahydro-2-carboline and 2-benzazepine skeletons. Excellent resolutions were achieved for most of the investigated compounds by using a reversed-phase mobile phase system. The conditions of separation were optimized by variation of the mobile phase composition. (C) 2002 Elsevier Science B.V. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. In an article, author is Biava, M, once mentioned the application of 23676-09-7, Name is Ethyl 4-ethoxybenzoate, molecular formula is C11H14O3, molecular weight is 194.23, MDL number is MFCD00009116, category is thiomorpholine. Now introduce a scientific discovery about this category, Computed Properties of https://www.ambeed.com/products/23676-09-7.html.

During the course of our investigations in the field of azole antimicrobial agents, we have identified BM 212, a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 1-10 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria. (C) 2002 Elsevier Science Ltd. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 3,4-Dimethoxybenzoic acid, New discoveries in chemical research and development in 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 93-07-2, Name is 3,4-Dimethoxybenzoic acid, SMILES is O=C(O)C1=CC=C(OC)C(OC)=C1, molecular formula is C9H10O4, belongs to thiomorpholine compound. In an article, author is Ganou, C. A., introduce new discover of the category.

PTP1b is a protein tyrosine phosphatase involved in the inactivation of insulin receptor. Since inhibition of PTP1b may prolong the action of the receptor, PTP1b has become a drug target for the treatment of type II diabetes. In the present study, prediction of inhibition using docking analysis targeted specifically to the active or allosteric site was performed on 87 compounds structurally belonging to 10 different groups. Two groups, consisting of 15 thiomorpholine and 10 thiazolyl derivatives exhibiting the best prediction results, were selected for in vitro evaluation. All thiomorpholines showed inhibitory action (with IC50 = 4-45 M, Ki = 2-23 M), while only three thiazolyl derivatives showed low inhibition (best IC50 = 18 M, Ki = 9 M). However, free binding energy (E) was in accordance with the IC50 values only for some compounds. Docking analysis targeted to the whole enzyme revealed that the compounds exhibiting IC50 values higher than expected could bind to other peripheral sites with lower free energy, E-o, than when bound to the active/allosteric site. A prediction factor, E- (sigma(Eo) x 0.16), which takes into account lower energy binding to peripheral sites, was proposed and was found to correlate well with the IC50 values following an asymmetrical sigmoidal equation with r(2) = 0.9692.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 93-07-2, you can contact me at any time and look forward to more communication. Application In Synthesis of 3,4-Dimethoxybenzoic acid.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 90-44-8 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 90-44-8, Name is Anthrone, molecular formurla is C14H10O. In a document, author is Theodosis-Nobelos, Panagiotis, introducing its new discovery. Formula: https://www.ambeed.com/products/90-44-8.html.

Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), alpha-lipoic acid and indole-3-acetic acid with thiomorpholine were synthesised by a simple method and at high yields (60-92%). All the NSAID derivatives highly decreased lipidemic indices in the plasma of Triton treated hyperlipidemic rats. The most potent compound was the indomethacin derivative, which decreased total cholesterol, triglycerides and LDL cholesterol by 73%, 80% and 83%, respectively. They reduced acute inflammation equally or more than most parent acids. Hence, it could be concluded that amides of common NSAIDs with thiomorpholine acquire considerable hypolipidemic potency, while they preserve or augment their anti-inflammatory activity, thus addressing significant risk factors for atherogenesis. (C) 2015 Elsevier Ltd. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New Advances in Chemical Research, May 2021. We’ll be discussing some of the latest developments in chemical about CAS: 827-95-2. In an article, author is Jovanovic, VM, once mentioned the application of 827-95-2, Name is Sodium 3-nitrobenzoate, molecular formula is C7H4NNaO4, molecular weight is 189.1, MDL number is MFCD00051097, category is thiomorpholine. Now introduce a scientific discovery about this category, Synthetic Route of 827-95-2.

Electrochemical stability of eight complexes of the general formula [Co(III)Rdtc(1-8)cyclam](ClO4)(2), where cyclam = 1,4,8,11-tetraazacyclotetradecane and Rdtc(-) (1-8) = 4-morpholine (Morphdtc), 4-thiomorpholine (Timdtc), 4-piperazine (Pzdtc), N-methyl piperazine (N-Mepzdtc), piperidine (Pipdtc), 2-, 3- or 4-methylpiperidine (2-, 3- or 4-Mepipdtc) dithiocarbamates, respectively, were studied. The substances were examined in aqueous NaClO4 solution and nonaqueous LiClO4 in CH3CN solution by cyclic voltammetry. In aqueous solution, macrocyclic ligand cyclam is characterized by the anodic peak at 0.95 V. The Rdtc(-) ligands have two anodic peaks, one in the region 0.25-0.30 V and the other in the 0.78-0.95 V region. Absence of these anodic peaks in the case of the complexes indicates that coordination to cobalt(III) stabilizes both cyclam and Rdtc(-) ligands, but reversible peaks in the range -0.68 to -0.78 V support the Co(III) redox reaction. In nonaqueous solutions cyclam has one anodic peak at 1.75 V. The ligands with heteroatom in the ring (Morphdtc, Timdtc, Pzdtc, N-Mepzdtc) have two anodic peaks, while the other four ligands (Pipdtc, 2-, 3- and 4-Mepipdtc) have only one anodic peak. In nonaqueous solution again, coordination to Co(III) ion stabilizes the Rdtc(-) ligands and contrary to aqueous solution no Co(III) redox reaction occurs, indicating a greater stability of the complexes in this media. Finally, the electrochemical results are compared with spectroscopic data obtained previously.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Prabhakar, V., once mentioned the application of 2835-06-5, Name is H-DL-Phg-OH, molecular formula is C8H9NO2, molecular weight is 151.16, MDL number is MFCD00064402, category is thiomorpholine. Now introduce a scientific discovery about this category, Recommanded Product: 2835-06-5.

Heterocyclic Chemistry comprises at least half of all organic chemistry research worldwide. Quinazoline and its derivatives constitute an important class of heterocyclic compounds. The chemistry of quinazoline compounds has more than centuries old history, however the intense search for biologically active substances in quinazoline series began only in the last few cascades. In this present communication an attempt is made to cover the medicinally active compounds, along with the recent synthesis, which were reported to possess antimicrobial and antifungal activity.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process., HPLC of Formula: https://www.ambeed.com/products/2835-98-5.html, 2835-98-5, Name is 2-Amino-5-methylphenol, molecular formula is C7H9NO, belongs to thiomorpholine compound. In a document, author is Samzadeh-Kermani, Alireza, introduce the new discover.

An efficient one-pot reaction of nitromethane, isothiocyanates, and three-membered heterocyclic rings (oxiranes and aziridines) for the synthesis of 1,4-oxathiane and 1,4-thiomorpholine derivatives is reported. This procedure is carried out in the presence of K2CO3 in DMF at 60 degrees C.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 83-56-7 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 83-56-7, Name is Naphthalene-1,5-diol, molecular formurla is C10H8O2. In a document, author is Mantelingu, Kempegowda, introducing its new discovery. Synthetic Route of 83-56-7.

Azomethine ylides are accessed under mild conditions via benzoic acid catalyzed condensations of 1,2,3,4-tetrahydroisoquinolines or tryptolines with aldehydes bearing a pendent dipolarophile. These intermediates undergo intramolecular [3 + 2]-cycloadditions in a highly diastereoselective fashion to form polycyclic amines with four new stereogenic centers. Challenging substrates such as piperidine, morpholine, and thiomorpholine undergo the corresponding reactions at elevated temperatures.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application of 30379-55-6, New discoveries in chemical research and development in 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 30379-55-6, Name is 2-(Benzyloxy)acetic acid, SMILES is O=C(O)COCC1=CC=CC=C1, molecular formula is C9H10O3, belongs to thiomorpholine compound. In an article, author is Battula, Kumara Swamy, introduce new discover of the category.

In this report, we describe the synthesis and biological evaluation of a new series of (4-((1-(aryl)-1H-1,2,3-triazol-4-yl) methoxy) phenyl)(1,1-dioxidothiomorpholino) methanone derivatives (6a-6n). All the new derivatives were well analyzed by (HNMR)-H-1, (CNMR)-C-13, FTIR, mass spectral and elemental data. The synthesized compounds were screened for in vitro anticancer activity against three cancer cell lines (MCF-7, HeLa, and HEK293) and compared with standard drug cisplatin. Three (6b, 6g and 6i) out of fourteen derivatives exhibited potent anticancer activity against MCF-7, HeLa, and HEK293. Two ( 6b and 6g) potent hybrids were screened for in vivo studies against EAC bearing mice and found to possess potential anticancer activity.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem