Tag: M.W:100-200

Reference of 114-83-0, Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 114-83-0, Name is 1-Acetyl-2-phenylhydrazine, SMILES is CC(NNC1=CC=CC=C1)=O, belongs to thiomorpholine compound. In a article, author is Efimenko, I. A., introduce new discover of the category.

Binary alpha-unsaturated palladium carboxylates have been synthesized by substitution of alpha-unsaturated acids RCOOH (R is CH2=C(Me), MeCH=CH, PhCH=CH) for the acetate ion in Pd-3(mu-MeCOO)(6). These carboxylates react with amines A (A is morpholine (M), methylmorpholine (MM), or thiomorpholine (MS)) to give trans-Pd(A)(2)(RCOO)(2) similar to trans-A(2)(MeCO2)(2). The structures of the trans-Pd(A)(2)(RCOO)(2) complexes (R is MeCH=CH; A is M, MM, MS) have been determined by X-ray crystallography. The effect of solvent on the crystal structure of the complexes has been demonstrated for trans-(MeCH=CHCO2)(2)Pd(C4H9NO)(2) as an example. The amination reaction of palladium carbonyl crotonate with a secondary amine, morpholine, has been studied for the first time. The reaction involves disproportionation of Pd(I) into Pd(0) and Pd(II) and leads to the first unsaturated palladium(II) carbamoyl carboxylate-palladium carbamoyl crotonate trans-(OC4H8NH)(2)Pd[OC4H8NC(=O)](MeCH=CHCO2) center dot H2O, as well as to trans-M2Pd(MeCH=CHCO2)(2) and (C4H10NO)(+)(MeCH=CHCO2)(-). The structures of these compounds have been proved by X-ray crystallography.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. In an article, author is Starosta, Radoslaw, once mentioned the application of 585-32-0, Name is 2-Phenylpropan-2-amine, molecular formula is C9H13N, molecular weight is 135.2062, MDL number is MFCD00134680, category is thiomorpholine. Now introduce a scientific discovery about this category, Related Products of 585-32-0.

Herein, a series of CuI or CuNCS complexes with neocuproine (2,9-dimethyl-1,10-phenanthroline: dmp) and two tris(aminomethyl)phosphines derived from morpholine (P(CH2N(CH2CH2)(2)O)(3)) or thiomorpholine (P(CH2N(CH2CH2)(2)S)(3)) were tested as cytotoxic agents in vitro towards mouse colon carcinoma (CT26) and human lung adenocarcinoma (A549). The studies showed that the complexes exhibit potential antitumor properties, displayed by IC50 values below 10m towards the tested cell lines, in the case of 4-h incubation time with the examined compounds. Moreover, a high antimicrobial activity of all the complexes was observed against Staphylococcus aureus and Candida albicans with minimal inhibitory concentrations equal to 1-2g/mL. To gain insight into the molecular mechanism of biological activity of the complexes, we investigated also their interactions with plasmid DNA (pUC18) and the human and bovine serum albumins. Gel electrophoresis experiments demonstrated that all the compounds were comparably efficient in DNA degradation process; however, luminescence quenching showed surprising dependence on the interactions strength of the used compounds with the albumins. Apart from exceptionally effective [CuI(dmp)P(CH2N(CH2CH2)(2)O)(3)], the complexes with P(CH2N(CH2CH2)(2)O)(3) quenched more strongly luminescence of bovine serum albumin, while the complexes with P(CH2N(CH2CH2)(2)S)(3) were more active in the quenching of human serum albumin luminescence.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

You could be based in a university, combining chemical research with teaching; or in a public-sector research center, helping to ensure national healthcare provision keeps pace with new discoveries. In an article, author is Sovilj, SP, once mentioned the application of 103-30-0, Name is (E)-1,2-Diphenylethene, molecular formula is C14H12, molecular weight is 180.2451, MDL number is MFCD00064300, category is thiomorpholine. Now introduce a scientific discovery about this category, Related Products of 103-30-0.

Four new cobalt(III) complexes of the general formula [Co(Rdtc)cyclam](ClO4)(2), where cyclam and Rdtc(-) refer to 1,4,8,11-tetraazacyclotetradecane and 2-, 3-, 4-methylpiperidine (2-, 3-, 4-wMeepipdtc(-)) or 4-thiomorpholine (Timdtc(-)) dithiocarbamates, respectively, have been prepared. Elemental and thermal analyses, VIS, IR and H-1 and C-13 NMR spectroscopy have been used to characterized them. In the complexes, cobalt is hexa-coordinated in an octahedral geometry of a folded macrocyclic ligand and dithiocarbamates are bound as bidentates. As regards to the influence of the position of the methyl group on the piperidine ring, the nu(C – N) and nu(C – S) values increase in the order 2-Mepipdtc(-) < 3-Mepipdtc(-) < 4-Mepipdtc(-). Furthermore, the position of the methyl substituent also influences the thermal stability of the complexes and the order of stability decreases in the opposite order. In the meantime we’ve collected together some recent articles in this area about 103-30-0 to whet your appetite. Happy reading! Related Products of 103-30-0.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 98-03-3 in 2021. Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 98-03-3, Name is Thiophene-2-aldehyde, molecular formurla is C5H4OS. In a document, author is Urello, Morgan A., introducing its new discovery. Product Details of 98-03-3.

Synthetic gene delivery systems employ multiple functions to enable safe and effective transport of DNA to target cells. Here, we describe metabolite-based poly(L-lysine) (PLL) modifiers that improve transfection by imparting both pH buffering and nanoparticle stabilization functions within a single molecular unit. PLL modifiers were based on morpholine (M), morpholine and niacin (MN), or thiomorpholine (TM). PLL modification with (MN) or (TM) imparted buffering function over the pH range of 57 both in solution and live cells and enhanced the stability of PLL DNA nanoparticles, which exhibited higher resistance to polyanion exchange and prolonged blood circulation. These properties translated into increased transfection efficiency in vitro coupled with reduced toxicity compared to unmodified PLL and PLL(M). Furthermore, PEG-PLL(MN) DNA nanoparticles transfected muscle tissue in vivo for >45 days following intramuscular injection. These polymer modifiers demonstrate the successful design of multifunctional units that improve transfection of synthetic gene delivery systems while maintaining biocompatibility.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of (3,4-Dimethoxyphenyl)methanol, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more.93-03-8, Name is (3,4-Dimethoxyphenyl)methanol, SMILES is OCC1=CC=C(OC)C(OC)=C1, belongs to thiomorpholine compound. In a article, author is Michalska, Katarzyna, introduce new discover of the category.

Sutezolid is a new oxazolidinone derivative currently in clinical trials to determine its safety and efficacy towards highly drug-resistant tuberculosis. The aim of the study was the spectroscopic identification of selected key intermediate products of the chiral pool synthesis of sutezolid: (S1) (4-(2-fluoro-4-nitrophenyl)thiomorpholine), (S2) 4-[2-fluoro-4-(benzyloxycarbonyl)aminophenyl] thiomorpholine, (S4) (R)-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-p-toluenesulfonate, (S5) (R)-[[3-(3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]azide, as well as (S6) sutezolid, the final synthesis product. Spectroscopic identification was carried out based on infrared spectra analysis (FT-IR) and Raman scattering. This part of the analysis was supported by quantum chemical calculations based on the density functional theory (DFT) utilizing the B3LYP hybrid functional and the 6-31G(d,p) basis set to obtain reference standards for intermediates and sutezolid. Additionally, the sutezolid configuration was confirmed by analysing the electronic circular dichroism (ECD) spectra of (S)-and (R)-isomers, combined with the time-dependent DFT calculations to simulate ECD spectra depending on the solvent and type of conformers. (C) 2020 Elsevier B.V. All rights reserved.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. You can also check out more blogs about 93-03-8. Safety of (3,4-Dimethoxyphenyl)methanol.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards., Electric Literature of 492-37-5, 492-37-5, Name is 2-Phenylpropionic acid, molecular formula is C9H10O2, belongs to thiomorpholine compound. In a document, author is El-Abadelah, MM, introduce the new discover.

A series of 5-fluoro-6-(N-heterocyclyl) benzofuroxans (3b-e) have been prepared by hypochlorite oxidative cyclization of the respective 4-fluoro-5-(N-heterocyclyl)-2-nitroanilines (2b-e). The heterocyclyls include piperazine, N-(2-hydroxyerhyl)piperazine, morpholine and thiomorpholine. Some bio-properties and spectral data of these new derivatives are presented.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 90-01-7, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more.90-01-7, Name is Salicyl Alcohol, SMILES is C1=CC=CC(=C1O)CO, belongs to thiomorpholine compound. In a article, author is Yan, Shanshan, introduce new discover of the category.

A series of novel oxazolidinone antibiotics having [2.2.1] and [2.2.2] bicyclic oxazine moieties at the C-5 side chain of the A-ring was synthesized by nitroso Diels-Alder reactions, from three linezolid analogs containing morpholine, piperazine and thiomorpholine, respectively, as the C-ring components. Subsequent N-O bond cleavage generated oxazolidinones with 4-amino cyclo-2-en-1-ol substituents. The in vitro antibacterial activities of these oxazolidinone analogs were evaluated. (C) 2009 Elsevier Ltd. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Reference of 86-48-6, Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 86-48-6, Name is 1-Hydroxy-2-naphthoic acid, SMILES is O=C(O)C1=CC=C2C=CC=CC2=C1O, belongs to thiomorpholine compound. In a article, author is Mirzaei, Javad, introduce new discover of the category.

Synthesis and in vitro anti-Helicobacter pylori activity of N-[5-(5-nitro-2-heteroaryl)-1,3,4-thiadiazol-2-yl]thiomorpholines 5-7(a-c) and some related compounds 8a-c and 9a-c were described. The anti-H. pylori activity of target compounds along with commercially available antibiotics such as metronidazole and amoxicillin was evaluated by comparing the inhibition zone diameters determined by the paper disc diffusion bioassay. From our bioassay results against 20 clinical isolates, it is evident that most compounds still had strong activity at 4 and 2 mu g/disc (average of inhibition zone > 20 mm) while metronidazole had little activity at these doses. Nitrofuran analog 7b containing thiomorpholine S,S-dioxide moiety was the most potent compound tested. (c) 2007 Elsevier Masson SAS. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. In an article, author is Besse, P, once mentioned the application of 489-84-9, Name is Guaiazulene, molecular formula is C15H18, molecular weight is 198.3034, MDL number is MFCD00003811, category is thiomorpholine. Now introduce a scientific discovery about this category, Reference of 489-84-9.

A strain of Mycobacterium sp. RP1 was isolated from a contaminated activated sludge. It was capable of utilizing morpholine, a waste of chemical industry, as sole source of carbon, nitrogen and energy. The kinetic of biodegradation of morpholine was followed directly on the incubation medium using in situ H-1 NMR. This technic allowed to identify two intermediates of the degradative pathway: glycolate and 2-(2-aminoethoxy)acetate. The inhibitory effects of metyrapone on the degradative abilities of the strain RP1 indicated the involvement of a cytochrome P450. This observation was confirmed by spectrophotometric analysis and H-1 NMR. Metyrapol, a known metabolite of metyrapone, was also found to be an inhibitor. The same study of degradation of thiomorpholine showed the formation of sulfoxide, which confirmed the presence of a cytochrome P450. (C) 1998 Elsevier Science B.V. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of 3,4-Dimethoxybenzoic acid, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects.93-07-2, Name is 3,4-Dimethoxybenzoic acid, SMILES is O=C(O)C1=CC=C(OC)C(OC)=C1, belongs to thiomorpholine compound. In a article, author is Li, YX, introduce new discover of the category.

A chelating ligand, 2,6-bis(thiomorpholinomethyl)pyridine (L), was synthesised. Its palladium(II), copper(II) and nickel(II) complexes of the formula ML(NO3)(2), (M = Pd, Cu and Ni), were prepared and characterised. The molecular structures of the three complexes were determined by X-ray diffraction. In all the compounds prepared the ligand acts in a tridentate fashion using its three N atoms while the two S atoms remain free. The Pd complex possesses a distorted square planar coordination geometry with one of the two nitrate groups coordinating as a unidentate ligand and the other ionic. The Pd-N(pyridine) bond length is 1.857(4) Angstrom, which is believed to be the shortest Pd-N separation ever observed. In the Cu complex, the copper atom is five-coordinated in a distorted square planar arrangement with the two nitrate groups acting as unidentate ligands and occupying the apex and one equatorial position. The Ni complex has a distorted octahedral coordination sphere; one nitrate group behaves in a chelating fashion and the other unidentate. (C) 1998 Elsevier Science S.A. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem