Tag: M.W:100-200

Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. In an article, author is Benharref, Ahmed, once mentioned the application of 455-14-1, Name is 4-(Trifluoromethyl)aniline, molecular formula is C7H6F3N, molecular weight is 161.1245, MDL number is MFCD00064396, category is thiomorpholine. Now introduce a scientific discovery about this category, Application In Synthesis of 4-(Trifluoromethyl)aniline.

The title compound, C19H29NO4S, was synthesised from 9 alpha-hydroxyparthenolide (9 alpha-hydroxy-4,8-dimethyl-12-methylene-3,14-dioxatricyclo[9.3.0.0(2,4)]tetradec-7-en-13-one), which was isolated from the chloroform extract of the aerial parts of the plant Anvillea radiata. The molecule is built up from two fused five-and ten-membered rings, with an additional epoxy ring system and a thiomorpholine group as a substituent. The ten-membered ring adopts an approximate chair-chair conformation, while the thiomorpholine ring displays a chair conformation and the five-membered ring has an envelope conformation, with the C atom closest to the hydroxy group forming the flap. An intramolecular O-H center dot center dot center dot N hydrogen bond closes an S(8) ring. The crystal structure features weak C-H center dot center dot center dot O hydrogen-bonding interactions, which link the molecules into [010] chains.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In an article, author is Aridoss, G., once mentioned the application of 585-32-0, Name is 2-Phenylpropan-2-amine, molecular formula is C9H13N, molecular weight is 135.2062, MDL number is MFCD00134680, category is thiomorpholine. Now introduce a scientific discovery about this category, Quality Control of 2-Phenylpropan-2-amine.

In the title compound, C(27)H(32)N(2)O(4)S, the thiomorpholine ring adopts a chair conformation and the tetrahydropyridine ring is in a distorted envelope conformation. The molecular structure is stabilized by an intramolecular O-H center dot center dot center dot O interaction and the crystal packing is stabilized by an intermolecular C-H center dot center dot center dot O interaction, generating an S(6) motif and a dimer of the type R(2)(2)(18), respectively.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. In an article, author is Kralova, Petra, once mentioned the application of 455-14-1, Name is 4-(Trifluoromethyl)aniline, molecular formula is C7H6F3N, molecular weight is 161.1245, MDL number is MFCD00064396, category is thiomorpholine. Now introduce a scientific discovery about this category, Recommanded Product: 455-14-1.

Herein, we report the stereoselective synthesis of trisubstituted benzoxazino[4,3-b]{1,2,5}thiadiazepinone 6,6-dioxides from polymer-supported Fmoc-Ser(tBu)-OH and Fmoc-Thr(tBu)-OH. After the solid-phase synthesis of N-alkylated-Nsulfonylated intermediates using various 2-nitrobenzenesulfonyl chlorides and bromoketones, the target compounds were obtained via trifluoroacetic acid (TFA)-mediated cleavage from the resin, followed by cyclization of the diazepinone scaffold. Except for the threonine-based intermediates, the inclusion of triethylsilane (TES) in the cleavage cocktail yielded a specific configuration of the newly formed C-3 chiral center. The final cyclization resulted in minor or no inversion of the C-12a stereocenter configuration.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. In an article, author is Al-Trawneh, Salah A., once mentioned the application of 455-14-1, Name is 4-(Trifluoromethyl)aniline, molecular formula is C7H6F3N, molecular weight is 161.1245, MDL number is MFCD00064396, category is thiomorpholine. Now introduce a scientific discovery about this category, Synthetic Route of 455-14-1.

Fungal infection is a significant global health challenge in part due to the emergence of strains exhibiting resistance to nearly all classes of antifungals. This underscores the urgent need for the development of new antifungal agents that can circumvent this burgeoning problem. For the present research, a new selected set of pyrazolo[5,1-c][1,2,4]triazine derivatives 3a-g was prepared in high yield via the reaction of N1-(5-methylpyrazol-3-yl)hydrazonoyl chloride 1 with morpholine, thiomorpholine, 4-phenylpiperidine and N-(substituted)piperazines. The new compounds were evaluated for their in vitro antifungal and antibacterial activities. The screening revealed compounds with specific activity against pathogenic fungi, including Candida albicans, Candida auris, and Cryptococcus. Compound 3d, which incorporated N-phenylpiperazine moiety, exhibited the highest growth inhibition against C. albicans with a minimum inhibitory concentration of 16 mu g/mL. The compounds were superior to fluconazole in inhibiting Candida biofilm mass at sub-inhibitory concentration. Furthermore, the MTS assay confirmed that compounds 1 and 3d exhibited an excellent toxicity profile (not toxic, up to 256 mu g/mL, for mammalian cells). Collectively, the presented results demonstrate that the synthesized pyrazolo-triazines warrant further exploration for potential use as antifungal agents.

Synthetic Route of 455-14-1, You can get involved in discussing the latest developments in this exciting area about 455-14-1.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 90-15-3 in 2021. Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 90-15-3, Name is 1-Naphthol, molecular formurla is C10H8O. In a document, author is El-Abadelah, MM, introducing its new discovery. Quality Control of 1-Naphthol.

A series of 5-fluoro-6-(N-heterocyclyl) benzofuroxans (3b-e) have been prepared by hypochlorite oxidative cyclization of the respective 4-fluoro-5-(N-heterocyclyl)-2-nitroanilines (2b-e). The heterocyclyls include piperazine, N-(2-hydroxyerhyl)piperazine, morpholine and thiomorpholine. Some bio-properties and spectral data of these new derivatives are presented.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Related Products of 5428-54-6, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects.5428-54-6, Name is 2-Methyl-5-nitrophenol, SMILES is C1=C([N+]([O-])=O)C=CC(=C1O)C, belongs to thiomorpholine compound. In a article, author is Clegg, Jack K., introduce new discover of the category.

The sequential interaction of preformed [Cu-2(L-1)(2)(THF)(2)] (where H2L1 is 1,1-(1,3-phenylene)-bis(4,4-dimethylpentane-1,3-dione incorporating a 1,3-phenylene linker between its two beta-diketone domains) and [Cu-2(L-4)(2)]center dot 2H(2)O (where H2L4 is 1,1-(4,4′-oxybiphenylene)-bis(4,4-dimethylpentane-1,3-dione) incorporating a flexible oxybiphenylene linkage between the two beta-diketone groups) with the potentially difunctional aliphatic non-planar co-ligands, N-methylpiperazine (mpip), N,N’-dimethylpiperazine (dmpip) and 1,4-thiomorpholine (thiomorph) is reported. A series of extended molecular assemblies exhibiting a range of di- and tetranuclear assemblies were obtained and their X-ray structures determined. Dinuclear [Cu-2(L-1)(2)(mpip)(2)]center dot 2mpip incorporates two 5-coordinate, square pyramidal metal centres as does tetranuclear [{Cu-2(L-1)(2)}(2)(dmpip)(2)]center dot 2dmpip. In contrast, dinuclear [Cu-2(L-1)(2)(dmpip)(4)]center dot dmpip and [{Cu-2(L-1)(2)}(2)(thiomorph)(4)]center dot 3thiomorph each contain two 5-coordinate and two 6-coordinate centres. Each of [Cu-2(L-4)(2)(THF)(2)]center dot 2THF and Cu-2(L-4)(2)(mpip)(2)]center dot H2O incorporate only 5-coordinate metal centres, with the latter complex forming a one-dimensional hydrogen bonded ribbon-like structure directed along the crystallographic a-axis. In keeping with the documented tendency for the smallest, least strained assembly to form in supramolecular self-assembly processes, the incorporation of the flexible oxy linkage between the 4,4′-linked phenylene rings of H2L3 results in generation of a dinuclear [Cu2L2] species rather than a trinuclear (triangular) [Cu3L3] species of the type formed by the more rigid bis-beta-diketonato ligand analogue in which the biphenylene rings separating the beta-diketone domains are directly coupled in their 4,4′ positions.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. In an article, author is Srivastava, Stuti, once mentioned the application of 657-84-1, Name is Sodium p-toluenesulfonate, molecular formula is C7H7NaO3S, molecular weight is 194.18, MDL number is MFCD00064388, category is thiomorpholine. Now introduce a scientific discovery about this category, Related Products of 657-84-1.

The three component reaction of alpha-aminoacids, mercaptoacetaldehyde and an isocyanide smoothly and stereoselectively yields the novel scaffold 1,2-disubstituted N-alkyl(aryl)-6-oxo thiomorpholine-3-carboxamide. In this communication we present our preliminary results on six compounds derived from this unprecedented reaction.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In an article, author is Freitas, Vera L. S., once mentioned the application of 88-05-1, Name is 2,4,6-Trimethylaniline, molecular formula is C9H13N, molecular weight is 135.2062, MDL number is MFCD00007740, category is thiomorpholine. Now introduce a scientific discovery about this category, Category: thiomorpholine.

The influence of the heteroatoms in the conformational, energetic, and reactivity trends exhibited by morpholine and thiomorpholine isosteres was obtained from computational and experimental thermochemical studies. For those purposes, the gas-phase standard (p = 0.1 MPa) molar enthalpies of formation of the compounds, at T = 298.15 K, were determined from the experimental values of the standard molar. enthalpies of formation, in the liquid phase, and of the standard molar: enthalpies of vaporization, obtained by calorimetric techniques, and also from composite G3(MP2)// B3LYP calculations making use of appropriate working reactions. A very good agreement was found between the calculated and the experimental gas-phase enthalpies of formation. The computational study was further extended to the calculation of other gas-phase thermodynamic properties these compounds, namely, the N-H or C-H bond dissociation enthalpies, gas-phase acidities and basicitics, proton affinities and adiabatic ionization enthalpies, and the energies and structures of the conformational stereoisomers of morpholine and thiomorpholine.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. In an article, author is Theodosis-Nobelos, Panagiotis, once mentioned the application of 90-05-1, Name is Guaiacol, molecular formula is C7H8O2, molecular weight is 124.1372, MDL number is MFCD00002185, category is thiomorpholine. Now introduce a scientific discovery about this category, Related Products of 90-05-1.

Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), alpha-lipoic acid and indole-3-acetic acid with thiomorpholine were synthesised by a simple method and at high yields (60-92%). All the NSAID derivatives highly decreased lipidemic indices in the plasma of Triton treated hyperlipidemic rats. The most potent compound was the indomethacin derivative, which decreased total cholesterol, triglycerides and LDL cholesterol by 73%, 80% and 83%, respectively. They reduced acute inflammation equally or more than most parent acids. Hence, it could be concluded that amides of common NSAIDs with thiomorpholine acquire considerable hypolipidemic potency, while they preserve or augment their anti-inflammatory activity, thus addressing significant risk factors for atherogenesis. (C) 2015 Elsevier Ltd. All rights reserved.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 3-Tolualdehyde, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more.620-23-5, Name is 3-Tolualdehyde, SMILES is O=CC1=CC=CC(C)=C1, belongs to thiomorpholine compound. In a article, author is Dkhar, Lincoln, introduce new discover of the category.

A series of cationic complexes [(Cp/Ind)Ru(kappa(2)((SS))-L)(PPh3)]PF6 (1-6) are obtained by the reaction of [CpRu(PPh3)(2)Cl] or [(Ind)Ru(PPh3)(2)Cl] (Cp = eta(5)-C5H5, Ind = eta(5)-C9H7) with respective dithione derivatives 1,2-di(piperidin-1-yl)ethane-1,2-dithione (L1), 1,2-dimorpholinoethane-1,2-dithione (L2) and 1,2-dithiomorpholinoethane-1,2-dithione (L3). All the compounds are characterized using spectroscopic techniques. The molecular structures of complexes 1, 2 and 4 are established by single-crystal X-ray diffraction studies. Antimicrobial studies were tested against three strains of bacterial microorganisms Staphylococcus aureus (gram + ve), Bacillus subtilis (gram + ve), Klebsiella pneumoniae (gram -ve) and one strain of fungal microorganism Candida albicans. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem