Tag: M.W:100-200

Thiomorpholine 1,1-dioxide, cas is 39093-93-1, it is a common heterocyclic compound, the Thiomorpholine compound, its synthesis route is as follows.

General procedure: Under nitrogen atmosphere, a mixture of bromide 19 (208mg, 0.58mmol), piperidine (165muL, 1.67mmol), and triethylamine (234muL, 1.68mmol) in DMF (3mL) was subjected to microwave irradiation at 90¡ãC for 5min. The mixture was allowed to cool to room temperature, and the organic solvents were evaporated in vacuo. The residue was purified on a Biotage? KP-NH cartridge (amino-modified silica gel) using cyclohexane/EtOAc in different proportions to afford to give the title compound as a clear yellowish oil (202mg, 100percent), which darkened on standing.

39093-93-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,39093-93-1 ,Thiomorpholine 1,1-dioxide, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Petrov, Ravil R.; Knight, Lindsay; Chen, Shao-Rui; Wager-Miller, Jim; McDaniel, Steven W.; Diaz, Fanny; Barth, Francis; Pan, Hui-Lin; Mackie, Ken; Cavasotto, Claudio N.; Diaz, Philippe; European Journal of Medicinal Chemistry; vol. 69; (2013); p. 881 – 907;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem

Name is Thiomorpholine 1,1-dioxide, as a common heterocyclic compound, it belongs to Thiomorpholine compound, and cas is 39093-93-1, its synthesis route is as follows.

1-tert-Butoxycarbonyl-3-oxocyclobutanamine (lg, 5mm0l) and 1,1-dioxythiomorpholine (0.8g, 5mmol) were dissolved in 1,2-dichloroethane (30mL) Sodium triacetoxyborohydride (lg, 20 mmOl) was added and stirred at room temperature for 8 hours. The reaction solution was concentrated to dryness.Purified by silica gel column chromatography,A white solid (0.92 g, 92percent) was obtained.

39093-93-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,39093-93-1 ,Thiomorpholine 1,1-dioxide, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Shanghai Xiangjin Biological Technology Co., Ltd.; Sun Fang; Zhan Youni; (53 pag.)CN108341814; (2018); A;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem

20196-21-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Thiomorpholin-3-one, cas is 20196-21-8,the Thiomorpholine compound, it is a common compound, a new synthetic route is introduced below.

Preparation 5 4-(4-Trifluoromethylphenyl)-thiomorpholin-3-one A mixture of thiomorpholin-3-one (500 mg, 4.27 mmol), 4-trifluoromethyl-1-iodobenzene (1.25 mL, 8.5 mmol) and copper metal (814 mg, 12.8 mmol) was heated in a sealed glass tube at 185-200 C. for 18 hours. The residue was then purified by flash chromatography to give 260 mg of the title product as a white solid. M.p. 85-87 C. Mass spectrum 262 (M+1). 1H-NMR (CDCl3, 400 MHz) d 7.62 (2H, d), 7.37 (2H, d), 3.97 (2H, t), 3.43 (2H, s), 3.01 (2H, t).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Thiomorpholin-3-one, 20196-21-8

Reference£º
Patent; Pfizer INC; US6423708; (2002); B1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem

As a common heterocyclic compound, it belongs to Thiomorpholine compound, name is Thiomorpholine 1,1-dioxide, and cas is 39093-93-1, its synthesis route is as follows.

Synthesis of the Compound of the Invention and Comparative ExamplesCompound 1 (the Compound of the Invention); Step 1: 2-(4-Bromomethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (1 eq) and DIPEA (2 eq) were dissolved in DCM/MeOH (5:1 v:v) under N2 and thiomorpholine 1,1-dioxide (2 eq) was added portionwise. The resulting solution was stirred at room temperature for 16 h. After this time, the reaction was complete. The solvent was evaporated. The compound was extracted with EtOAc and water, washed with brine and dried over anhyd. MgSO4. Organic layers were filtered and evaporated. The final compound was isolated without further purification.

39093-93-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,39093-93-1 ,Thiomorpholine 1,1-dioxide, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; MENET, Christel Jeanne Marie; SMITS, Koen Kurt; US2010/331319; (2010); A1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem

59801-62-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Thiomorpholine 1,1-dioxide hydrochloride, cas is 59801-62-6,the Thiomorpholine compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 4-chloro-l-methyl-ljH-pyrrolo[3,2-c]pyridine-7-carboxylic acid (726mg) in dimethylformamide (12ml) was added 1-[3-(diemethylamino)propyl]-3-ethylcarbodiimide (0.73g) , 1- hydroxybenzotriazole (0.52g), N-ethylmorpholine (0.48ml) and thiomorpholine 1,1-dioxide hydrochloride (0.66g). The solution was stirred at room temperature overnight. The reaction was diluted with water and extracted three times with ethyl acetate. The ethyl acetate layers were combined, washed with saturated sodium chloride solution and dried (MgS04) then evaporated. The residue was triturated with diethyl ether/n-hexane and filtered to afford the title compound as an off- white solid (0.907g). LC/MS [MH+] 328 consistent with molecular formula C13H1435C1IV303S.

The chemical industry reduces the impact on the environment during synthesis,59801-62-6,Thiomorpholine 1,1-dioxide hydrochloride,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2005/121140; (2005); A1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem

39093-93-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Thiomorpholine 1,1-dioxide, cas is 39093-93-1,the Thiomorpholine compound, it is a common compound, a new synthetic route is introduced below.

4-bromomethylboronic acid pinacol ester 50.00 g (16.84 mmol), 1,1-dioxide thiomorpholine 27.36 g (20.24 mmol), potassium carbonate 27.92 g (20.20 mmol) were added to the reaction flask,250ml of N,N-dimethylformamide was added and the reaction was stirred at 80C for 4h.After cooling to room temperature, the reaction solution was poured into 1250 ml of ice water, stirred for 30 minutes, and the title product was collected by suction filtration. The white solid was 47.2 g. The yield was 79.7%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Thiomorpholine 1,1-dioxide, 39093-93-1

Reference£º
Patent; China Pharmaceutical Research And Development Center Co., Ltd.; Yin Huijun; Yan Xu; Zong Libin; Dong Liuxin; Han Yachao; Xi Qingchuan; Dou Haoshuai; Mi Zhen; Yang Yan; (30 pag.)CN107880038; (2018); A;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem

39093-93-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Thiomorpholine 1,1-dioxide, cas is 39093-93-1,the Thiomorpholine compound, it is a common compound, a new synthetic route is introduced below.

A mixture isopropyl 4-((lr,4r)-4-(5-chloropyrazin-2-yloxy)cyclohexyloxy)piperidine-l- carboxylate (50 mg, 0.126 mmol), diacetoxypalladium (2.8 mg, 0.013 mmol), thiomorpholine- 1 ,1-dioxide (17 mg, 0.126 mmol), sodium 2-methylpropan-2-olate (29 mg, 0.302 mmol), and l ,l’-3/4w(di-t-butylphosphino)ferrocene (12 mg, 0.025 mmol) in 1 ,4-dioxane (0.8 mL) was heated at 100 ¡ãC for 1 h under microwave irradiation. LCMS showed product had formed and no starting material remained. Water was added to the reaction mixture and it was extracted with DCM (3 x 15 mL). The organic layer was rinsed with brine, dried with Na2S04 and concentrated to give a brown oil. The brown oil was purified using Biotage.(TM). flash chromatography and a 25 g SNAP.(TM). column, 20-100percent EtOAc-hexanes, 15 column volumes. Fractions containing product were combined and concentrated to give the title compound (25 mg, 0.050 mmol, 40.1 percent yield) as a light brown solid. ‘H NMR (CDCI3 , 400 MHz) delta 1.23 (d, J = 4 Hz, 6H), 1.46-1.55 (m, 6H), 1.77-1.82 (m, 2H), 1.96-2.01 (m, 2H), 2.09-2.14 (m, 2H), 3.06 (t, J = 4Hz , 4H), 3.09-3.16 (m, 2H), 3.48-3.52 (m, 1H), 3.54-3.59 (m, 1H), 3.78-3.84 (m, 2H), 4.06 (t, J = 4Hz , 4H), 4.85-4.94 (m, 2H), 7.73 (s, 1H), 7.82 (s, 1H), LCMS m/z: 497.6 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis,39093-93-1,Thiomorpholine 1,1-dioxide,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; BUZARD, Daniel J.; LEHMANN, Juerg; NARAYANAN, Sanju; YUE, Dawei; WO2011/127051; (2011); A1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem

39093-93-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Thiomorpholine 1,1-dioxide, cas is 39093-93-1,the Thiomorpholine compound, it is a common compound, a new synthetic route is introduced below.

To a solution of (1R,3aS,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-3a-(aziridin-1-yl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)octadecahydro-1H-cyclopenta[a]chrysen-9(5bH)-one (4.0 g, 8.85 mmol) and thiomorpholine 1,1-dioxide (4.79 g, 35.4 mmol) in toluene (30 mL) was added boron trifluoride diethyl etherate (1 mL in 100 mL of toluene, mL) forming a yellow suspension. The mixture was sonicated for 2 min, then stirred at RT for 5 days. The reaction mixture was diluted with EtOAc (200 mL), washed with NaHCO3 (200 mL), dried over Na2SO4, filtered and concentrated in vacuo. The crude product was purified by a silica gel column (160 gm) eluted with 20-50percent of EtOAc/Hexane to give desired ketone (2.95 g, 57percent) as a solid. MS: m/e 587.5 (M+H)+, 2.39 min (method 4). 1H NMR (400 MHz, CHLOROFORM-d) delta 4.74-4.70 (m, 1H), 4.62-4.59 (m, 1H), 3.11-2.99 (m, 7H), 2.72-2.36 (m, H), 1.98-0.82 (m. 23H), 1.69 (s, 3H), 1.08 (s, 6H), 1.04 (s, 3H), 0.98 (s, 3H), 0.95 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis,39093-93-1,Thiomorpholine 1,1-dioxide,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; Swidorski, Jacob; Chen, Yan; Sit, Sing-Yuen; Meanwell, Nicholas A.; Regueiro-Ren, Alicia; Chen, Jie; US2014/243298; (2014); A1;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem

It is a common heterocyclic compound, the Thiomorpholine compound, Thiomorpholine 1,1-dioxide, cas is 39093-93-1 its synthesis route is as follows.

Example 5; l-(5-tert-Butyl-3-(thiomorpholine-l,l-dioxide-4-carbonyl)thiophen-2-yl)-3-(4-(2- (methylcarbamoyl)pyridin-4-yloxy)phenyl)urea [0228] To a solution of 6-tert-butyl-l/f-thieno[2,3-cTj[l,3]oxazine-2,4-dione (3.7 g, 15 mmol) in dioxane (30 mL) was added 4-(4-aminophenoxy)-N-methylpicolinamide (3.4 g, 14 mmol), and the reaction mixture was heated at 90 0C for 4 h. The volatiles were evaporated under reduced pressure to give the crude product which was used in the next step without further purification. EPO [0229] To a solution of 5-tert-butyl-2-(3-(4-(rhoyridin-4-yloxy)rhohenyl)ureido)thiorhohene-3- carboxylic acid (ca 14 mmol) in THF (70 mL) were added thiomorpholine 1,1 -dioxide (2.27 g, 16.8 mmol, 1.2 eq), HOBt (2.08 g, 15,4 mmol, 1.1 eq), EDCI (3.22 g, 16.8 mmol, 1.2 eq), and the mixture was stirred at room temperature for 16 h. The volatiles were evaporated under reduced pressure to give the crude product which was extracted with saturated sodium bicarbonate (3 x 40 mL) and ethyl acetate (150 mL). The organic layer was dried and diluted with ethanol (40 mL). Upon concentration of the solution using rotary evaporator, precipitation of solid occurred. The solid was digested with ethanol (70 mL), filtered, washed with ethanol to give the product which was dried under vacuum at 70 0C for 24 h. (yield = 7.2 g, 82percent). 1H NMR (400 MHz, DMSOd6) delta 9.89 (s, IH), 9.63 (s, IH), 8.73 (m, IH), 8.47 (d, J = 6.8 Hz, IH), 7.54 (d, J = 8.8 Hz, 2H), 7.35 (d, J = 2.8 Hz, IH), 7.13 (d, J = 8.8 Hz, 2H), 7.11 (m, IHO, 6.65 (s, IH), 3.93 (m, 4H), 3.27 (m, 4H), 2.75 (d, J = 5.2 Hz3 3H), 1.30 (s, 9H).

39093-93-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,39093-93-1 ,Thiomorpholine 1,1-dioxide, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; LOCUS PHARMACEUTICALS, INC.; MOORE, JR., William, R.; SPRINGMAN, Eric; MICHELOTTI, Enrique; WO2006/62984; (2006); A2;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem

39093-93-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Thiomorpholine 1,1-dioxide, cas is 39093-93-1,the Thiomorpholine compound, it is a common compound, a new synthetic route is introduced below.

[3740] A solution of methyl 3-fluoiO-4-((( l-methyl- l H-indazol-4-yl)amino)methyl)benzoate (0.384 g, 1.225 mmol), N,N-diisopropylethylamine ( 1.280 mL, 7.351 mmol) and triphosgene (0.182 g, 0.61 mmol) in dichloromethane (5 mL) was stirred at the room temperature for 30 min, and mixed with thiomorpholine 1 , 1 -dioxide (0.166 g, 1.225 mmol). The reaction mixture was stirred at the same temperature for additional 1 8 hr. Then, water was added to the reaction mixture, followed by extraction with dichloromethane. The bi-phasic mixture was passed through a plastic frit to remove the solid residues and aqueous layer, and the organic layer collected was concentrated in vacuo. The residue was chromatographed (Si02, 12 g cartridge; methanol / dichloromethane = 0 percent to 5 percent ) to give methyl 3-fluoro-4-((N-( l-methyl- l H-indazol-4-yl)- l , l-dioxidothiomorpholine-4-carboxamido )methyl)benzoate as pale yellow oil (0.531 g, 91.3 percent).

The chemical industry reduces the impact on the environment during synthesis,39093-93-1,Thiomorpholine 1,1-dioxide,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; KIM, Yuntae; LEE, Chang Sik; SONG, Hyeseung; GWAK, Dal-Yong; LEE, Jaeyoung; OH, Jung Taek; LEE, Chang Gon; KIM, II Hyang; (1041 pag.)WO2017/23133; (2017); A2;,
Thiomorpholine – Wikipedia
Thiomorpholine | C4H9NS – PubChem