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Preparation method of (by machine translation)

The method of the invention widens the substrate range 1 by directly conducting 4 – coupling suzuki and,formyl phenylboronic acid to carry out reductive amination reaction 4, with thiomorpholine 1,1 – dioxides or the hydrochloride thereof through reductive amination reaction, to obtain the phenetinib product 9; and reduces the process cost 1 and routes the route through improving the crystallization property, of the intermediate to obtain the phenanthrenitiamide product, and the route is easy 4 – to obtain a product with higher total yield, 1,1 – The method of the invention is favorable for improving the purity 9. of the final finished products . The method of the invention is favorable for improving the purity, of the final finished product; through a reductive amination reaction step, The method of the invention is favorable for, increasing the production . of finished products. (by machine translation)

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Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

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Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents

A series of linezolid analogues containing a hydrazone moiety were designed, synthesized and evaluated for their antibacterial activity. Most compounds exhibited more potent antibacterial activity against S.aureus, MRSA, MSSA, LREF and VRE pathogens as compared with linezolid and radezolid. Compounds 9a, 9c, 9f, 9g, 10m and 10t were more potent against tested clinical isolates of MRSA, MSSA, VRE and LREF as compared to linezolid. Compound 9a exhibited comparable activity with linezolid against human MAO-A for safety evaluation and showed moderate metabolism in human liver microsome. The most promising compound 9a showed remarkable antibacterial activity against S.aureus, MRSA, MSSA, LREF and VRE pathogens with MIC value of 0.0675 mg/mL, respectively, which was 15- to 30-fold more potent than linezolid.

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Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Some scientific research about 3-(4-Fluorophenyl)thiomorpholine

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887344-28-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.887344-28-7, Name is 3-(4-Fluorophenyl)thiomorpholine, molecular formula is C10H12FNS. In a article£¬once mentioned of 887344-28-7

SnAP reagents for the transformation of aldehydes into substituted thiomorpholines – An alternative to cross-coupling with saturated heterocycles

It’s a SnAP! The transformation of aldehydes into N-unsubstituted 3-thiomorpholines provides a convenient alternative to metal-catalyzed cross-coupling reactions, which are generally unsuited to the functionalization of saturated N-heterocycles. A copper-mediated radical cyclization is the key to the mild conditions, high functional group tolerance, and broad substrate scope offered by these reagents. Copyright

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Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 6007-55-2, molecular formula is C6H11NO2S, introducing its new discovery. 6007-55-2

COMPOSITIONS AND METHODS FOR ENHANCING SURVIVAL AND REDUCING INJURY UNDER ISCHEMIC OR HYPOXIC CONDITIONS

The present invention is directed to compositions and methods for enhancing the survivability of, and/or reducing damage to, cells, tissues, organs, and organisms, particularly under ischemic or hypoxic conditions.

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Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 39093-93-1, name is Thiomorpholine 1,1-dioxide, introducing its new discovery. 39093-93-1

JAK2 INHIBITORS AND THEIR USE FOR THE TREATMENT OF MYELOPROLIFERATIVE DISEASES AND CANCER

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity of JAK2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

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Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 39093-93-1. In a patent£¬Which mentioned a new discovery about 39093-93-1, molcular formula is C4H9NO2S, introducing its new discovery.

(R)-3-(N,N-DIMETHYLAMINO)PYRROLIDINE DERIVATIVES

(R)-3-(N,N-Dimethyiamino)pyrrolidine derivatives of formula (I), wherein the meaning for Cy1 is as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors

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Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

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INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

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Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

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Pharmaceutical compositions (by machine translation)

[Problem] imidazole compound or its pharmacologically acceptable salt in the melanocortin receptor activity that operates as an active ingredient of a pharmaceutical composition comprising. “I” general formula [a]” Formula, the aryl group may be substituted A ring represents a; R1 Represents a hydrogen atom, or an alkyl group which may be substituted represented; R2 Represents a hydrogen atom, a halogen atom or represents a; R3 The alkyl group may be substituted ” represented by the imidazole compound, its pharmacologically acceptable salt as an active ingredient in a pharmaceutical composition. [Drawing] no (by machine translation)

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Thiomorpholine – Wikipedia,
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Synthesis and antileishmanial activity of 6-methoxy-4-methyl-N-[6-(substituted-1-piperazinyl)hexyl]-8-quinolinami nes and related compounds

The 8-quinolinamine, 4-[6-[(6-methoxy-4-methyl-8-quinolinyl)amino]hexyl]-1-piperazineethanol (1b), has been shown to be highly effective against Leishmania donovani infections in hamsters. In an effort to obtain a more potent, less toxic 8-quinolinamine, a series of analogues (2) was prepared that examined particularly the structural requirements of the terminal of the terminal piperazine moiety. Of the substituted piperazines and alternative heterocycles prepared, as well as those quinoline analogues with ring insertion of a methyl group in the 2-position or an aryloxy substituent in the 5-position, an increase in potency was achieved only with the 2-hydroxypropyl analogue (2f).

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Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

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PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of Formula (0), Formula (I), and Formula (II) and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

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Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem