Tag: M.W:100-200

Related Products of 766-98-3, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 766-98-3, Name is 1-Ethynyl-4-fluorobenzene, SMILES is FC1=CC=C(C#C)C=C1, molecular formula is C8H5F, belongs to thiomorpholine compound. In a article, author is Marvadi, Sandeep Kumar, introduce new discover of the category.

5-Chloro-2-thiophenyl-1,2,3-triazolylmethyldihydroquinolines as dual inhibitors of Mycobacterium tuberculosis and influenza virus: Synthesis and evaluation

This study describes synthesis and evaluation of novel 5-Chloro-2-thiophenyl-1,2,3-triazolylmethyldihydroquinolines 7a-o as dual inhibitors of Mycobacterium tuberculosis and influenza virus. Huisgen’s [ 3+ 2] dipolar cycloaddition of 6-(azidomethyl)-5-chloro-2-(thiophen-2-yl)-7,8-dihydroquinoline 5 with various alkynes 6a-o using sodium ascorbate and copper sulphate gave new dihydroquinoline-1,2,3-triazoles 7a-o in good to excellent yields. The new compounds were evaluated for in vitro antimycobacterial against M. tuberculosis H37Rv (Mtb) and antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1). Among the fifteen new analogs, compounds 7a (MIC: 3.12 mu g/mL), 7j and 7k (MIC: 6.25 mu g/mL) were identified as potent antitubercular agents. The virus-inhibiting activity of all the fifteen compounds was found to be moderate, and among them the compound 7l, bearing thiophene moiety appeared the most active with good selectivity index (IC50 = 19.5 mu g/mL; SI = 15). The results presented here will help developing newer dual inhibitors of tuberculosis and influenza virus.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. 766-98-3, you can contact me at any time and look forward to more communication. Related Products of 766-98-3.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. , Product Details of 93-07-2, 93-07-2, Name is 3,4-Dimethoxybenzoic acid, molecular formula is C9H10O4, belongs to thiomorpholine compound. In a document, author is Ganou, C. A., introduce the new discover.

Docking analysis targeted to the whole enzyme: an application to the prediction of inhibition of PTP1B by thiomorpholine and thiazolyl derivatives

PTP1b is a protein tyrosine phosphatase involved in the inactivation of insulin receptor. Since inhibition of PTP1b may prolong the action of the receptor, PTP1b has become a drug target for the treatment of type II diabetes. In the present study, prediction of inhibition using docking analysis targeted specifically to the active or allosteric site was performed on 87 compounds structurally belonging to 10 different groups. Two groups, consisting of 15 thiomorpholine and 10 thiazolyl derivatives exhibiting the best prediction results, were selected for in vitro evaluation. All thiomorpholines showed inhibitory action (with IC50 = 4-45 M, Ki = 2-23 M), while only three thiazolyl derivatives showed low inhibition (best IC50 = 18 M, Ki = 9 M). However, free binding energy (E) was in accordance with the IC50 values only for some compounds. Docking analysis targeted to the whole enzyme revealed that the compounds exhibiting IC50 values higher than expected could bind to other peripheral sites with lower free energy, E-o, than when bound to the active/allosteric site. A prediction factor, E- (sigma(Eo) x 0.16), which takes into account lower energy binding to peripheral sites, was proposed and was found to correlate well with the IC50 values following an asymmetrical sigmoidal equation with r(2) = 0.9692.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. 93-07-2, you can contact me at any time and look forward to more communication. Product Details of 93-07-2.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. , Category: thiomorpholine, 119-61-9, Name is Benzophenone, molecular formula is C13H10O, belongs to thiomorpholine compound. In a document, author is Battula, Kumara Swamy, introduce the new discover.

Synthesis and Biological Evaluation of (N-(3-methoxyphenyl)-4-((aryl-1H-1,2,3-triazol-4-yl)methyl) thiomorpholine-2-carboxamide 1,1-Dioxide Hybrids as Antiproliferative Agents

A series of new thirteen N-(3-Methoxyphenyl)thiomorpholine-2-carboxamide 1, 1-dioxide derived 1, 4-disubtituted 1, 2, 3-triazole hybrids (7a-7m) were synthesized by Cu (I) catalyzed cycloaddition reaction and well characterized by (HNMR)-H-1, (CNMR)-C-13, FTIR, mass spectral and elemental analysis data. All the hybrid compounds were subjected to invitro anticancer activity against three human cancer cell lines MCF-7, Hela and A-549 and 2-hydroxy phenyl, 2-methoxy phenyl and 3-methoxy phenyl substituted (7f, 7g and 7h) derivatives were found to possess potential antiproliferative activity.

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.If you are interested in 119-61-9, you can contact me at any time and look forward to more communication. Category: thiomorpholine.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Kaplanek, Robert, once mentioned the application of 705-31-7, Name is 4-(Trifluoromethyl)phenylacetylene, molecular formula is C9H5F3, molecular weight is 170.1312, MDL number is MFCD01861903, category is thiomorpholine. Now introduce a scientific discovery about this category, COA of Formula: C9H5F3.

Amphiphilic perfluoroalkylated sulfones and sulfonate betaines

Two types of perfluoro alkyl-containing amphiphilic sulfones 7-9 and 13-15, respectively, and sulfonate betaines 23-32 were prepared using 2-[(perfluoroalkyl)methyl]oxiranes (1-3, R-F = C4F9, C6F13, C8F17) or 3-(perfluoroalkyl)propyl iodides (16 and 17, R-F = C6F13, C8F17) as the starting compounds. The overall yields of two-step syntheses were above 90%. The compounds 7-9 were prepared by the reaction of oxiranes 1-3 with 2-sulfanylethan-1-of and subsequent oxidation of intermediate sulfides. Similarly, the amphiphiles 13-15 were obtained by analogous reaction of oxiranes 1-3 with thiomorpholine and subsequent oxidation of the sulfur atom in the morpholine ring. In the syntheses of betaines 23-32, the starting compounds 1-3 or 16 and 17 were first reacted with dimethylamine followed by the ring-opening reaction of the intermediate fluoroalkyl(dimethyl)amines with propane-1,3- or butane-1,4-sultones. (c) 2007 Elsevier B.V. All rights reserved.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.If you’re interested in learning more about 705-31-7. The above is the message from the blog manager. COA of Formula: C9H5F3.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The main research directions are chemical synthesis, new energy materials, nano-ceramics, nano-hybrid composite materials, preparation and modification of special coatings, and research on the structure and performance of functional materials. 579-75-9, Name is 2-Methoxybenzoic acid, molecular formurla is C8H8O3. In a document, author is Theodosis-Nobelos, Panagiotis, introducing its new discovery. SDS of cas: 579-75-9.

Anti-inflammatory and Hypolipidemic Effect of Novel Conjugates with Trolox and Other Antioxidant Acids

Objectives: A series of esters and amides, incorporating an antioxidant residue, such as trolox or caffeic acid, and various moieties with different biological activities, were synthesised. Results: The obtained compounds demonstrated considerable anti-inflammatory, radical scavenging and antioxidant action. Thus, they could reduce carrageenan-induced rat paw oedema by 31-60% at 150 mu mol/kg and inhibit rat microsomal membrane lipid peroxidation with IC50 values as low as 1.4 mu M which is much lower than that of trolox. Most of them could also inhibit soybean lipoxygenase. The thiomorpholine derivatives decreased significantly all lipidemic indices of Triton-induced hyper-lipidemia in rats. The most active, the caffeic acid derivative (6), decreases triglycerides, total cholesterol and low density lipoprotein, in the plasma of hyperlipidemic rats, by 70%, 67%, and 73%, respectively, at 150 mu mol/kg (i.p.). Conclusion: The synthesised compounds, designed to exhibit two or more pharmacological actions, may be considered useful in the study of agents addressed to conditions involving inflammation and oxidative stress.

SDS of cas: 579-75-9, In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts.you can also check out more blogs about 579-75-9.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application of 64-10-8, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 64-10-8, Name is 1-Phenylurea, SMILES is OC(=N)NC1=CC=CC=C1, molecular formula is C7H8N2O, belongs to thiomorpholine compound. In a article, author is Ajibade, Peter A., introduce new discover of the category.

Synthesis and crystal structure of bis(thiomorpholinyldithiocarbamato) Zn(II): structural, optical, and photocatalytic studies of ZnS nanoparticles from the complex

Bis(thiomorpholinyldithiocarbamato) Zn(II) complex was synthesized and characterized by single crystal X-ray crystallography and spectroscopic techniques. The molecular structure of the compound revealed a dimeric Zn(II) complex in which each Zn(II) ion is bound to one chelating and two bridging thiomorpholine ligands. The compound was thermolyzed at 130 degrees C in octadecylamine (ODA), hexadecylamine (HDA), and oleylamine (OLA) to prepare ZnS nanoparticles. Powder X-ray diffraction (PXRD) of the ZnS nanoparticles indicates mixtures of hexagonal and cubic crystalline phases depending on thermolysis temperature. HRTEM micrographs showed well-defined nanoparticles with particle size of 3.3-4.8 nm for ODA-ZnS, 2.5-4.2 nm for OLA-ZnS, while HDA-ZnS shows slightly bigger nanoparticles with particle size of 3.3-5.4 nm. Estimated optical band gaps are 3.58 eV for ODA-ZnS, 3.69 eV for HDA-ZnS and 3.72 eV for OLA-ZnS which indicate blue shift of the absorption band edges with respect to bulk ZnS (3.56 eV). The as-prepared ZnS nanoparticles were used as photocatalysts for the degradation of methylene blue dye. The degradation efficiency of the as-prepared ZnS nanoparticles are 58% for ODA-ZnS, 53% for OLA-ZnS, and 43% for HDA-ZnS. ODA-ZnS nanoparticles were used for the recycling test and showed good photostability and recyclability with 57% recovery percentage.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Welcome to check out more blogs about 64-10-8, in my other articles. Application of 64-10-8.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. In homogeneous catalysis, catalysts are in the same phase as the reactants. 3171-45-7, Name is 4,5-Dimethylbenzene-1,2-diamine, molecular formurla is C8H12N2. In a document, author is Dellinger, Douglas J., introducing its new discovery. Recommanded Product: 3171-45-7.

Streamlined Process for the Chemical Synthesis of RNA Using 2 ‘-O-Thionocarbamate-Protected Nucleoside Phosphoramidites in the Solid Phase

An improved method for the chemical synthesis of RNA was developed utilizing a streamlined method for the preparation of phosphoramidite monomers and a single-step deprotection of the resulting oligoribo-nucleotide product using 1,2-diamines under anhydrous conditions. The process is compatible with most standard heterobase protection and employs a 2′-O-(1,1-dioxo-1 lambda(6)-thiomorpholine-4-carbothioate) as a unique 2’-hydroxyl protective group. Using this approach, it was demonstrated that the chemical synthesis of RNA can be as simple and robust as the chemical synthesis of DNA.

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.If you are interested in 3171-45-7, you can contact me at any time and look forward to more communication. Recommanded Product: 3171-45-7.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. In homogeneous catalysis, catalysts are in the same phase as the reactants. 114-83-0, Name is 1-Acetyl-2-phenylhydrazine, molecular formurla is C8H10N2O. In a document, author is Babic-Samardzija, K, introducing its new discovery. HPLC of Formula: C8H10N2O.

Investigation of the inhibiting action of O-, S- and N-dithiocarbamato(1,4,8,11-tetraazacyclotetradecane)cobalt(III) 1 complexes on the corrosion of iron in HClO4 acid

The inhibiting properties of four macrocyclic cobalt(III) complexes of the general formula [Co-III(Rdtc)cyclam](ClO2)(2), where cyclam and Rdtc(-) refer to 1.4.8,11-tetraazacyclotetradecane and morpholine-, thiomorpholine-, piperazine, N-methyipiperazine-dithiocarbamates. respectively. has been studied on the corrosion of iron in aerated 0.1 M HClO2 solutions by potentiodynamic polarization (dc) technique and electrochemical impedance spectroscopy (ac), Inhibitor efficiency for the corrosion of iron is found to be better for cobalt complexes then for related amino-ligands. The impedance increases with inhibitor concentration. Polarization curves indicate that the inhibitors are predominantly mixed-type. Better protection by the complex inhibitors was obtained with longer immersion time. The best fit for inhibitors adsorption is obtained using the Langmuir isotherm model. Molecular modeling calculations were used to correlate structural properties of the complex species and their inhibition efficiency. (C) 2004 Elsevier B.V. All rights reserved.

HPLC of Formula: C8H10N2O, In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts.you can also check out more blogs about 114-83-0.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. In homogeneous catalysis, catalysts are in the same phase as the reactants. 938-18-1, Name is 2,4,6-Trimethylbenzoyl Chloride, molecular formurla is C10H11ClO. In a document, author is Mitra, S, introducing its new discovery. Recommanded Product: 938-18-1.

Synthesis, characterization and thermal studies of nickel (II), copper (II), zinc (II) and cadmium (II) complexes with some mixed ligands

Dichloro – (DCA) and trichloroacetate (TCA) -cyclic ligand morpholine (Morph)/thiomorpholine (Tmorph)/methylmorpholine (Mmorph)/ dimethyl-piperazine (DMP) complexes of nickel (II), copper (II), zinc (II) and cadmium (II) with the compositions [Ni(tmorph)(2) (DCA)(2)], [Ni(tmorph)(2) (TCA)(2)]. 2H(2)O, [Cu (DMP)(2) (TCA)(2)], [ML2X2]. nH(2)O where M = Zn-II or Cd-II, L = Morph, DMP or tmorph and X = DCA or TCA and n = O except in case of [Cd(Morph)(2) (TCA)(2)] where n = 1 have been synthesised. Some intermediate complexes have been isolated by temperature arrest technique (pyrolysis) and characterised. Configurational and conformational changes have been studied by elemental analyses. IR and electronic spectra, magnetic moment data (in the case of Ni(II) and Cu(II) complexes) and thermal analysis. E-a*, Delta H and Delta S for the decomposition reaction of these complexes are evaluated and the stability of the complexes with respect to activation energy has also been compared. A linear correlation has been found between E-a* and Delta S for the decomposition of the complexes.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. I hope my blog about 938-18-1 is helpful to your research. Recommanded Product: 938-18-1.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The main research directions are chemical synthesis, new energy materials, nano-ceramics, nano-hybrid composite materials, preparation and modification of special coatings, and research on the structure and performance of functional materials. 99-10-5, Name is 3,5-Dihydroxybenzoic acid, molecular formurla is C7H6O4. In a document, author is Zelenkova, N. F., introducing its new discovery. HPLC of Formula: C7H6O4.

Chromatographic determination of morpholine and products of its microbiological degradation

A combination of thin-layer chromatography (TLC) with high-performance liquid chromatography (HPLC) was shown to be efficient in determining the intermediate products of the utilization of thiomorpholine with ligninolytic basidiomycete fungus Bjerkandera adusta VKM F-3477. The chromatographic mobility of the products of microbiological degradation of thiomorpholine was studied on Sorbfil PTSKh-P-V plates in the systems of chloroform-methanol-25% aqueous ammonia (80: 20: 2) for determining cyclic amines and isopropanol-25% aqueous ammonia (70: 30) for determining thio acids. The optimum conditions were selected for the separation of thiomorpholine and the formed metabolites by ion-exchange chromatography and reversed-phase chromatography.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Welcome to check out more blogs about 99-10-5, in my other articles. HPLC of Formula: C7H6O4.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem