Tag: M.W:100-200

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process., Related Products of 90-15-3, 90-15-3, Name is 1-Naphthol, molecular formula is C10H8O, belongs to thiomorpholine compound. In a document, author is Pulipati, Lokesh, introduce the new discover.

A series of novel piperidine, piperazine, morpholine and thiomorpholine appended dibenzo[b,d] thiophene-1,2,3-triazoles were designed and synthesized utilizing azide-alkyne click chemistry in the penultimate step. The required azide building block 6a-e was synthesized from commercial dibenzo[b, d] thiophene in good yields following five step reaction sequence. All the new analogues 8a-f, 9a-f, 10a-f, 11a-f & 12a-f were characterized by their NMR and mass spectral analysis. Screening all thirty new compounds for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv, resulted 8a, 8f and 11e as potent analogues with MIC 0.78 mu g/mL, 0.78 mu g/mL & 1.56 mu g/mL, respectively, and has shown lower cytotoxicity. Interestingly, all six piperazine appended dibenzo[b, d] thiophene-1,2,3-triazoles 11a-f exhibited Mtb inhibition activity with MIC 1.56-12.5 mu g/mL. To some extent, the data observed here indicated Mycobacterium tuberculosis inhibition among the appendages is in the order, piperazine > thiomorpholine > morpholine. (C) 2016 Elsevier Ltd. All rights reserved.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New Advances in Chemical Research, May 2021. The prevalence of solvent effects has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates. In an article, author is Shimozu, Yuuki, once mentioned the application of 611-19-8, Name is 1-Chloro-2-(chloromethyl)benzene, molecular formula is C7H6Cl2, molecular weight is 161.03, MDL number is MFCD00000893, category is thiomorpholine. Now introduce a scientific discovery about this category, Safety of 1-Chloro-2-(chloromethyl)benzene.

4-Oxo-2-nonenal (ONE), an aldehyde originating from the peroxidation of omega 6 polyunsaturated fatty acids, preferentially reacts with the cysteine residues of protein. Despite the fact that there has been significant recent interest in the protein reactivity and biological activity of ONE, the structural basis of the ONE-cysteine adducts remain to be established. In the present study, to gain a structural insight into the sulfhydryl modification by ONE, we characterized reaction products that originated from the initial ONE-cysteine Michael adducts. N-Acetyl-L-cysteine (10 mM) was incubated with an equimolar concentration of ONE in 0.1 M phosphate buffer (pH 7.4) at 37 degrees C. Within I h of incubation, the reaction of N-acetyl-L-Cysteine with ONE resulted in the formation of two (C-2 and C-3) Michael addition products possessing a carbonyl functionality. Subsequent incubation of the reaction mixture resulted in their disappearance and concomitant formation of advanced reaction products, including a minor product III and major products IVa, IVb, and V. Product III was identified to be a thiomorpholine derivative, 4-acetyl-5-hydroxyl-6-(2-oxoheptyl)thiomorpholine-3-carboxylic acid, which might have originated from the C-2 Michael addition product. The major products were identified to be the novel 2-cyclopentenone derivatives, that is, 2-(acetylamino)-3-[(3-butyl-4-oxocyclopent-2-en-1-yl)sulfanyl] propionic acid (IVa and its isomer IVb) and 2-(acetylamino)-3-[(4-butyl-5-oxocyclopent-3-en-1-yl)sulfanyl]propionic acid (V), which might be generated through the base-catalyzed cyclization of the C-2 and C-3 Michael addition products, respectively. The furan derivative, which has been reported as the end product of the Michael adducts, was found to be formed only under acidic conditions. Thus, this study identified the novel ONE-cysteine adducts, including the most prominent 2-cyclopentenone derivatives, that originated from the initial Michael adducts.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Reference of 103-67-3, New discoveries in chemical research and development in 2021.Chemistry can be defined as the study of matter and the changes it undergoes. 103-67-3, Name is N-Methyl-1-phenylmethanamine, SMILES is CNCC1=CC=CC=C1, belongs to thiomorpholine compound. In a article, author is Fernandes, Debra, introduce new discover of the category.

Carbamate formation is one of the major chemical reactions that can occur in solution in the capture of CO2 by amine-based solvents, and carbamate formation makes a significant enthalpy contribution to the absorption-desorption of CO2 that occurs in the absorber/stripper columns of the PCC process. Consequently, the formation of carbamates of selected series of primary and secondary amines over the temperature range (288 to 318) K has been investigated by equilibrium H-1 NMR studies, and the stability constants (K-9) for the equilibrium: RNH2 + HCO3- reversible arrow(K9) RNHCOO- + H2O are reported. van’t Hoff analyses have resulted in standard molar enthalpies, Delta H-m(o), and entropies, Delta S-m(o), of carbamate formation. A Delta H-m(o) – Delta S-m(o) plot generates a linear correlation for carbamate formation (providing a mean standard molar free energy, Delta G(m)(o), for carbamate formation of about -7 kJ . mol (1)), and this relationship helps provide a guide to the selection of an amine(s) solvent for CO2 capture, in terms of enthalpy considerations. A linear Delta H-m(o) – Delta S-m(o) plot also occurs for carbamate protonation. The formation of the carbamates has been correlated with systematic changes in composition and structure, and steric effects have been identified by comparing molecular geometries obtained using density functional B3LYP/6-311++G(d,p) calculations. Trends in steric effects have been identified in the series of compounds monoethanolamine (MEA), 1-amino-2-propanol, 2-amino-1-propanol (AP) and 2-amino-2-methyl-1-propanol (AMP). In the case of 2-piperidinemethanol, 2-piperidineethanol and 3-piperidinemethanol, strong intramolecular hydrogen bonding is shown to be the likely cause for lack of carbamate formation, and in the ring systems of pyrrolidine, morpholine, piperidine and thiomorpholine trends in carbamate formation (as given by K-9) have been correlated with the internal ring angle at the amine nitrogen, as well as the planarity of the environment around the nitrogen atom. (C) 2012 Elsevier Ltd. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. In homogeneous catalysis, catalysts are in the same phase as the reactants. 446-32-2, Name is 2-Amino-4-fluorobenzoic acid, molecular formurla is C7H6FNO2. In a document, author is Marcaccini, S, introducing its new discovery. Computed Properties of https://www.ambeed.com/products/446-32-2.html.

The Ugi four-component condensation between 5-oxo-3-thiacarboxylic acids, benzylamines and cyclohexyl isocyanide gave 5-oxothiomorpholine-3-carboxamides. The configuration of bicyclic thiomorpholine derivatives was established by NOESY experiments. (C) 2002 Elsevier Science Ltd. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In an article, author is Schindler, U, once mentioned the application of 103-67-3, Name is N-Methyl-1-phenylmethanamine, molecular formula is C8H11N, molecular weight is 121.1796, MDL number is MFCD00008289, category is thiomorpholine. Now introduce a scientific discovery about this category, Recommanded Product: N-Methyl-1-phenylmethanamine.

The heme-enzyme soluble guanylyl cyclase (sGC) is an ubiquitous NO receptor, which mediates NO downstream signaling by the generation of cGMP. We studied the mechanism of action of the anthranilic acid derivatives 5-chloro-2-(5-chloro-thiophene-2-sulfonylamino-N-(4-(morpholine-4-sulfonyl)-phenyl)-benzamide sodium salt (HMR1766) (proposed international nonproprietary name, ataciguat sodium) and 2-(4-chloro-phenylsulfonylamino)4,5- dimethoxy-N-(4-(thiomorpholine-4-sulfonyl)-phenyl)-benzamide (S3448) as a new class of sGC agonists. Both compounds activated different sGC preparations (purified from bovine lung, or crude from human corpus cavernosum) in a concentration-dependent and quickly reversible fashion (EC50 = 0.5-10 mu M), with mixed-type activation kinetics. Activation of sGC by these compounds was additive to activation by NO donors, but instead of being inhibited, it was potentiated by the heme-iron oxidants 1H-[1,2,4]-oxdiazolo[3,4-a]quinoxalin-1-one (ODQ) and 4H-8-bromo-1,2,4-oxadiazolo(3,4-d) benz(b)(1,4) oxazin-1-one (NS2028), suggesting that the new compounds target the ferric heme sGC isoform. Protoporphyrin IX acted as a competitive activator, and zinc-protoporphyrin IX inhibited activation of heme-oxidized sGC by HMR1766 and S3448, whereas heme depletion of sGC by Tween 20 treatment reduced activation. Both compounds increased cGMP levels in cultured rat aortic smooth muscle cells; induced vasorelaxation of isolated endothelium-denuded rat aorta, porcine coronary arteries, and human corpus cavernosum (EC50 1 to 10 mu M); and elicited phosphorylation of the cGMP kinase substrate vasodilator-stimulated phosphoprotein at Ser239. HMR1766 intravenous bolus injection decreased arterial blood pressure in anesthetized pigs. All of these pharmacological responses to the new compounds were enhanced by ODQ and NS2028. Our findings suggest that HMR1766 and S3448 preferentially activate the NO-insensitive heme-oxidized form of sGC, which exists to a variable extent in vascular tissues, and is a pharmacological target for these new vasodilator drugs.

Recommanded Product: N-Methyl-1-phenylmethanamine, The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, spectroscopic. I hope my blog about 103-67-3 is helpful to your research.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. , Name: 2-Amino-5-methylphenol, 2835-98-5, Name is 2-Amino-5-methylphenol, molecular formula is C7H9NO, belongs to thiomorpholine compound. In a document, author is Diao, Peng-Cheng, introduce the new discover.

Based on our previous screening hit compound 1, a series of novel indole-pyrimidine hybrids possessing morpholine or thiomorpholine moiety were synthesized via an efficient one-pot multistep synthetic method. The antiproliferative activities of the synthesized compounds were evaluated in vitro against four cancer cell lines including HeLa, MDA-MB-231, MCF-7, and HCT116. The results revealed that most compounds possessed moderate to excellent potency. The IC50 values of the most promising compound 15 are 0.29, 4.04, and 9.48 mu M against MCF-7, HeLa, and HCI116 cell lines, respectively, which are 48.0, 4.9, and 1.8 folds more active than the lead compound 1. Moreover, fluorescence-activated cell sorting analysis revealed that compound 14 showing the highest activity against HeLa (IC50 = 2.51 mu M) displayed a significant effect on G(2)/M cell-cycle arrest in a concentration-dependent manner in HeLa cell line. In addition, representative nine active hybrids were evaluated for tubulin polymerization inhibitory activities, and compound 15 exhibited the most potent anti-tubulin activity showing 42% inhibition at 10 mu M. These preliminary results encourage a further investigation on indole-pyrimidine hybrids for the development of potent anticancer agents that inhibit tubulin polymerization. (C) 2017 Elsevier Masson SAS. All rights reserved.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Welcome to check out more blogs about 2835-98-5, in my other articles. Name: 2-Amino-5-methylphenol.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

The main research directions are chemical synthesis, new energy materials, nano-ceramics, nano-hybrid composite materials, preparation and modification of special coatings, and research on the structure and performance of functional materials. 492-37-5, Name is 2-Phenylpropionic acid, molecular formurla is C9H10O2. In a document, author is Vijay, Murugan, introducing its new discovery. SDS of cas: 492-37-5.

A domino Bi-catalysed C-N/C-S bond formation of N-sulfonylaziridines is developed with 1,4-dithiane-2,5-diol to give 3,4-dihydro-1,4-thiazines at room temperature. The use of Bi(OTf)(3) as a catalyst, atom economy and regioselectivity are the important practical features.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. In homogeneous catalysis, catalysts are in the same phase as the reactants. 489-84-9, Name is Guaiazulene, molecular formurla is C15H18. In a document, author is Sreerama, Rakesh, introducing its new discovery. Category: thiomorpholine.

A one-pot procedure for the synthesis of novel 1,2,3-triazole derivatives (5a-5l) in good yields (63 to 77%) using different sulfonic acids and 4-(prop-2-yn-1-yl)thiomorpholine 1,1-dioxide through the in situ generated sulfonyl azides was developed. The structures of the newly synthesized compounds were confirmed by H-1 NMR, C-13 NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were screened for in vitro antibacterial activity and free radical scavenging activity in terms of hydrogen donating or radical scavenging ability by the DPPH method. Among all, the compound N-(4-((4-((1,1-dioxidothiomorpholino) methyl)-1H-1,2,3-triazol-1-yl)sulfonyl)phenyl) acetamide (5l) was found to exhibit potent activity as compared to the standard drugs.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Welcome to check out more blogs about 489-84-9, in my other articles. Category: thiomorpholine.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. , Computed Properties of https://www.ambeed.com/products/3171-45-7.html, 3171-45-7, Name is 4,5-Dimethylbenzene-1,2-diamine, molecular formula is C8H12N2, belongs to thiomorpholine compound. In a document, author is Xie, Lei, introduce the new discover.

Base-mediated [3 + 3] cycloaddition reaction of in-situ formed aza-oxyallyl cations and 1,4-dithiane-2,5-diols has been achieved under mild reaction conditions. This strategy provides direct and efficient access to prepare desired thiomorpholin-3-one derivatives in moderate-to-high yields. The approach features broad substrates scope and short reaction time. Moreover, the resulting products can be readily converted into other useful heterocyclic compounds including 2H-1,4-thiazin-3(4H)-ones and thiomorpholine-3,5-diones.

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.If you are interested in 3171-45-7, you can contact me at any time and look forward to more communication. Computed Properties of https://www.ambeed.com/products/3171-45-7.html.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Reference of 657-84-1, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 657-84-1, Name is Sodium p-toluenesulfonate, SMILES is O=S(C1=CC=C(C)C=C1)([O-])=O.[Na+], molecular formula is C7H7NaO3S, belongs to thiomorpholine compound. In a article, author is Ristic, Predrag, introduce new discover of the category.

Four silver-based coordination polymers, {[Ag(L)(2)](BF4)}(infinity) (1), {[Ag(H2BTC)(L)]center dot(H3BTC)}(infinity) (2), {[Ag-2(H2BTEC)(L)(2)]..3.33H(2)O}(infinity) (3), and [Ag(H(25)SSA)(L)](infinity) (4), were synthesized using thiomorpholine-4-carbonitrile (L) as the primary ligand and three aromatic polyoxoacids as coligands: trimesic (H3BTC), pyromellitic (H4BTEC), and 5-sulfosalicylic acid (H(35)SSA). Compounds 1 and 3 are two-dimensional, while 2 and 4 are one-dimensional. L acts as a bis-monodentate ligand, while the Ag(I) ion is three-coordinated in 2 and four-coordinated in all of the other compounds. The tetrahedral coordination of Ag(I) in 3 leads to an almost complete absence of intermolecular interactions with the metal center. All compounds show reasonable photocatalytic activity for photocatalytic degradation of mordant blue 9 dye, with reaction rates in the 0.036-0.056 min(-1) range. Changes in the reaction rates can be correlated with the type and coordination of the coligand. Complex 3 exhibits photoluminescence at 77 K, while 4 exhibits photoluminescence at both room temperature and 77 K. Luminescence lifetimes indicate electronic transitions of singlet parentage, where transitions are allowed. A TD-DFT study determined the contributions of individual singlet-singlet electronic excitations to the fluorescence, indicating that metal- intraligand transitions are responsible for luminescence in both complexes.

Reference of 657-84-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 657-84-1 is helpful to your research.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem