Tag: M.W:100-200

New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Martynov, Alexander V., once mentioned the application of 90-01-7, Name is Salicyl Alcohol, molecular formula is C7H8O2, molecular weight is 124.1372, MDL number is MFCD00004617, category is thiomorpholine. Now introduce a scientific discovery about this category, Safety of Salicyl Alcohol.

An efficient method for preparation of earlier unknown S-oxide of 2(E),6(E)-bis(chloromethylidene)-4-thiomorpholinamine by oxidation of 2(E), 6(E)-bis(chloromethylidene)-4-thiomorpholinamine hydrochloride with hydrogen peroxide in H2O or EtOH/H2O followed by the reaction mixture neutralization with Na2CO3 has been described. Interaction of the S-oxide with acetaldehyde, butanal, benzaldehyde, 4-methoxybenzaldehyde and 4-pyridinecarboxaldehyde in EtOH, C6H6, in the mixture of acetonitrile and ethanol or ethanol and benzene affords the unknown hydrazones, N-organylmethylidene-2(E), 6(E)-bis(chloromethylidene)-4-thiomorpholinamine-1-oxides. [GRAPHICS] .

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Pulipati, Lokesh, once mentioned the application of 135-02-4, Name is 2-Methoxybenzaldehyde, molecular formula is C8H8O2, molecular weight is 136.15, MDL number is MFCD00003308, category is thiomorpholine. Now introduce a scientific discovery about this category, Quality Control of 2-Methoxybenzaldehyde.

A series of novel piperidine, piperazine, morpholine and thiomorpholine appended dibenzo[b,d] thiophene-1,2,3-triazoles were designed and synthesized utilizing azide-alkyne click chemistry in the penultimate step. The required azide building block 6a-e was synthesized from commercial dibenzo[b, d] thiophene in good yields following five step reaction sequence. All the new analogues 8a-f, 9a-f, 10a-f, 11a-f & 12a-f were characterized by their NMR and mass spectral analysis. Screening all thirty new compounds for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv, resulted 8a, 8f and 11e as potent analogues with MIC 0.78 mu g/mL, 0.78 mu g/mL & 1.56 mu g/mL, respectively, and has shown lower cytotoxicity. Interestingly, all six piperazine appended dibenzo[b, d] thiophene-1,2,3-triazoles 11a-f exhibited Mtb inhibition activity with MIC 1.56-12.5 mu g/mL. To some extent, the data observed here indicated Mycobacterium tuberculosis inhibition among the appendages is in the order, piperazine > thiomorpholine > morpholine. (C) 2016 Elsevier Ltd. All rights reserved.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 705-31-7 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 705-31-7, Name is 4-(Trifluoromethyl)phenylacetylene, molecular formurla is C9H5F3. In a document, author is Savinov, Alexei Y., introducing its new discovery. HPLC of Formula: https://www.ambeed.com/products/705-31-7.html.

This study tested the hypothesis that membrane-tethered type-1 matrix metalloproteinase (MT1-MMP)-induced proteolysis of T cell CD44 is important for defining the migration and function of autoreactive T cells, including diabetogenic, insulin-specific and K-d-restricted IS-CD8(+) cells. To confirm the importance of MT1-MMP proteolysis of CD44 in type 1 diabetes (T1D), the anti-diabetic effects of three MMP inhibitors (3(S)-2,2-dimethyl-4[4-pyridin-4-yloxy-benzenesulfonyl]-thiomorpholine-3 -carboxylic acid hydroxamate [AG3340], 2-(4-phenoxyphenylsulfonylmethyl) thiirane [SB-3CT] and epigallocatechin-3-gallate [EGCG]) were compared using an adoptive diabetes transfer model in non-obese diabetic (NOD) mice. Only AG3340 was capable of inhibiting both the activity of MT1-MMP and the shedding of CD44 in T cells; and the transendothelial migration and homing of IS-CD8(+) T cells into the pancreatic islets. SB-3CT and EGCG were incapable of inhibiting T cell MT1-MMP efficiently. As a result, AG3340 alone, but not SB-3CT or EGCG, delayed the onset of transferred diabetes in NOD mice. In summary, the results of the present study emphasize that the MT1-MMP-CD44 axis has a unique involvement in T1D development. Accordingly, we suggest that a potent small-molecule MT1-MMP antagonist is required for the design of novel therapies for T1D.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New Advances in Chemical Research, May 2021. We’ll be discussing some of the latest developments in chemical about CAS: 7311-34-4. In an article, author is Shainyan, BA, once mentioned the application of 7311-34-4, Name is 3,5-Dimethoxybenzaldehyde, molecular formula is C9H10O3, molecular weight is 166.17, MDL number is MFCD00003366, category is thiomorpholine. Now introduce a scientific discovery about this category, Safety of 3,5-Dimethoxybenzaldehyde.

Reactions of secondary cyclic amines (piperidine, morpholine, thiomorpholine, 1lambda(6), 4-thiazinane-1,1-dione) with trifluoromethanesulfonic anhydride or with N-phenyltriflimide both in the presence and in the absence of a base (Et3N) result in formation of corresponding triflamides and triflates of the initial amines. The triflates and triflamides can be distinguished by their F-19 and N-15 NMR spectra and the presence in the IR spectra of salts of absorption bands in the region 3270-3000 cm(-1) lacking in the spectra of triflamides.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New Advances in Chemical Research, May 2021. The prevalence of solvent effects has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates. In an article, author is Bieniek, Michal, once mentioned the application of 2835-98-5, Name is 2-Amino-5-methylphenol, molecular formula is C7H9NO, molecular weight is 123.15, MDL number is MFCD00007693, category is thiomorpholine. Now introduce a scientific discovery about this category, Reference of 2835-98-5.

Catalytic cross-metathesis of commercial divinyl sulfone allowed direct access to novel (E)-alkenylvinyl sulfones and (E, E)- dialkenyl sulfones with excellent stereoselectivity. These compounds are useful building blocks, e. g., in the synthesis of substituted thiomorpholine 1,1-dioxide derivatives.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is da Frota, Livia C. R. M., once mentioned the application of 72235-52-0, Name is (2,4-Difluorophenyl)methanamine, molecular formula is C7H7F2N, molecular weight is 143.134, MDL number is MFCD00010142, category is thiomorpholine. Now introduce a scientific discovery about this category, Reference of 72235-52-0.

The reaction between iodo and N-methyl-piperazine or thiomorpholine in water, in the presence of KI, led to the formation of stable and easy to handle amine-iodine complexes, as the complex morpholine-iodo previously reported in the literature. However, the complex obtained using N,N-tetrametylethylenediamine proved less stable, while no complex was formed when piperidine was used as base. These results show that the presence of a second heteroatom in the structure of amines is of fundamental importance for the formation and stability of these complexes. In this work we describe, for the first time, the use of complexes morpholine-iodo, N-methyl-piperazine-iodo and thiomorpholine-iodo as iodinating reagents of several substituted phenols, leading to iodinated products in good to excellent yields.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process., Related Products of 1074-36-8, 1074-36-8, Name is 4-Mercaptobenzoic acid, molecular formula is C7H6O2S, belongs to thiomorpholine compound. In a document, author is Nuzhdin, KB, introduce the new discover.

The radical cations of piperazine, morpholine, thiomorpholine, and thioxane were investigated by electron paramagnetic resonance (EPR) and electron-nuclear double resonance (ENDOR) spectroscopy in a solid Freon matrix. Optimized geometry and magnetic parameters of the radical cations were calculated using a density functional theory (DFT)/Perdew-Burke-Ernzerhof (PBE) method. Both experimental and theoretical results suggest that all the studied species adopt chair (or distorted chair) conformations. No evidence for the boat conformers with intramolecular sigma*-bonding between heteroatoms were obtained. In the cases of morpholine and thioxane, the oxygen atoms are characterized by relatively small spin populations, whereas a major part of spin density is located at N and S atoms, respectively. The thiomorpholine radical cation exhibits nearly equal spin population of N and S atoms. In most cases (except for thioxane), the calculated magnetic parameters agree with the experimental data reasonably well.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New Advances in Chemical Research, May 2021. We’ll be discussing some of the latest developments in chemical about CAS: 586-38-9. In an article, author is Combourieu, B, once mentioned the application of 586-38-9, Name is 3-Methoxybenzoic acid, molecular formula is C8H8O3, molecular weight is 152.1473, MDL number is MFCD00002499, category is thiomorpholine. Now introduce a scientific discovery about this category, Electric Literature of 586-38-9.

One- and two-dimensional H-1 NMR spectroscopy were used to study the biotransformation of two dietary glucosinolates, sinigrin (SIN), and glucotropaeolin (GTL) by the human digestive microflora in vitro. The molecular structures of the new metabolites issued from the aglycone moiety of the glucosinolate were identified, and the modulation of carbon metabolism was studied by quantifying bacterial metabolites issued from the xenobiotic incubation in the presence or absence of a source of free glucose. Unambiguously and for the first time, it was shown that SIN and GTL were transformed quantitatively into allylamine and benzylamine, respectively. The comparison of the kinetics of transformation of SIN and GTL with and without glucose clearly showed that the presence of glucose did not modify either the nature of the metabolites or the rate of transformation of the glucosinolates (complete degradation within 30 h). The main end products of the glucose moiety of glucosinolates were characteristic of anaerobic carbon metabolism in the digestive tract (acetate, lactate, ethanol, propionate, formate, and butyrate) and similar to those released from free glucose. This work represents the first application of H-1 NMR spectroscopy to the study of xenobiotic metabolism by the human digestive microflora, demonstrating allyl- and benzylamine production from glucosinolates. Whether these amines are produced in vivo from dietary glucosinolates remains to be established. This would reduce the availability of other glucosinolate metabolites, notably cancer-protective isothiocyanates.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 3886-70-2 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 3886-70-2, Name is (R)-1-(Naphthalen-1-yl)ethanamine, molecular formurla is C12H13N. In a document, author is Starosta, Radoslaw, introducing its new discovery. Application of 3886-70-2.

Herein, a series of CuI or CuNCS complexes with neocuproine (2,9-dimethyl-1,10-phenanthroline: dmp) and two tris(aminomethyl)phosphines derived from morpholine (P(CH2N(CH2CH2)(2)O)(3)) or thiomorpholine (P(CH2N(CH2CH2)(2)S)(3)) were tested as cytotoxic agents in vitro towards mouse colon carcinoma (CT26) and human lung adenocarcinoma (A549). The studies showed that the complexes exhibit potential antitumor properties, displayed by IC50 values below 10m towards the tested cell lines, in the case of 4-h incubation time with the examined compounds. Moreover, a high antimicrobial activity of all the complexes was observed against Staphylococcus aureus and Candida albicans with minimal inhibitory concentrations equal to 1-2g/mL. To gain insight into the molecular mechanism of biological activity of the complexes, we investigated also their interactions with plasmid DNA (pUC18) and the human and bovine serum albumins. Gel electrophoresis experiments demonstrated that all the compounds were comparably efficient in DNA degradation process; however, luminescence quenching showed surprising dependence on the interactions strength of the used compounds with the albumins. Apart from exceptionally effective [CuI(dmp)P(CH2N(CH2CH2)(2)O)(3)], the complexes with P(CH2N(CH2CH2)(2)O)(3) quenched more strongly luminescence of bovine serum albumin, while the complexes with P(CH2N(CH2CH2)(2)S)(3) were more active in the quenching of human serum albumin luminescence.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New Advances in Chemical Research, May 2021. We’ll be discussing some of the latest developments in chemical about CAS: 4760-34-3. In an article, author is Aridoss, G., once mentioned the application of 4760-34-3, Name is N1-Methylbenzene-1,2-diamine, molecular formula is C7H10N2, molecular weight is 122.1677, MDL number is MFCD00192314, category is thiomorpholine. Now introduce a scientific discovery about this category, Quality Control of N1-Methylbenzene-1,2-diamine.

In the title compound, C26H30N2O4S, the thiomorpholine ring adopts a chair conformation whereas the tetrahydropyridine ring is in a half-chair conformation. The dihedral angle between the two phenyl rings is 33.3 (2)degrees. A strong intramolecular O-H…O hydrogen bond generates an S(6) motif. In the crystal, molecules are linked by intermolecular C-H…O hydrogen bonds, generating a ribbon-like structure propagating along the a axis.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 4760-34-3, you can contact me at any time and look forward to more communication. Quality Control of N1-Methylbenzene-1,2-diamine.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem