Tag: M.W=100-150

An article Selective Toll-like receptor 7 agonists with novel chromeno[3,4-d] imidazol-4(1H)-one and 2-(trifluoromethyl)quinoline/quinazoline-4-amine scaffolds WOS:000486133100009 published article about BIOLOGICAL EVALUATION; RECOGNITION; DERIVATIVES; ANTAGONISTS; ACTIVATION; DISCOVERY in [Dolsak, Ana; Svajger, Urban; Gobec, Stanislav; Sova, Matej] Univ Ljubljana, Fac Pharm, Askerceva 7, SI-1000 Ljubljana, Slovenia; [Svajger, Urban] Blood Transfus Ctr Slovenia, Slajmerjeva 6, SI-1000 Ljubljana, Slovenia; [Lesnik, Samo; Konc, Janez] Natl Inst Chem, Hajdrihova 19, SI-1000 Ljubljana, Slovenia in 2019, Cited 40. HPLC of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Toll-like receptors (TLRs) are promising targets for treatment of viral infections, autoimmune diseases, and cancers. Here, two new series of selective small-molecule TLR7 agonists with novel scaffolds and good selectivity over TLR8 are described, some with potencies in the low micromolar range. 8-Hydroxy-1-isobutylchromeno[3,4-d]imidazol-4(1H)-one (26) from the first series was designed and synthesized on the basis of previously described TLR7 antagonist 2, and is shown to be a selective TLR7 agonist (EC50, 1.8 mu M). The second series was based on 2-(trifluoromethyl)quinolin-4-amine and 2-(trifluoromethyl) quinazolin-4-amine scaffolds, which were defined according to our in-house ligand-based virtual screening protocol. Further synthesis of a focused library of analogs, biological evaluation, and docking studies provided systematic exploration of the structure-activity relationships, which indicate that a secondary or tertiary amine with smaller flexible alkyl substituents up to three carbon atoms in length, or bulkier rigid aliphatic rings is required at position 4 on 2-(trifluoromethyl)quinoline/quinazoline scaffold for potent TLR7 agonist activity. The influence of selected TLR7 agonists on cytokine production is also reported showing that N-cyclopropyl-2-(trifluoromethyl)quinazolin-4-amine (46) is able to induce increased levels of IL-6 and IL-8. These data demonstrate successful in-silico definition of novel TLR7 versus TLR8-selective compounds as promising chemical probes for further development of potent small-molecule immunomodulators. (C) 2019 Elsevier Masson SAS. All rights reserved.

HPLC of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Dolsak, A; Svajger, U; Lesnik, S; Konc, J; Gobec, S; Sova, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 88-68-6. Torano, JS; Gagarinov, IA; Vos, GM; Broszeit, F; Srivastava, AD; Palmer, M; Langridge, JI; Aizpurua-Olaizola, O; Somovilla, VJ; Boons, GJ in [Torano, Javier Sastre; Gagarinov, Ivan A.; Vos, Gael M.; Broszeit, Frederik; Srivastava, Apoorva D.; Aizpurua-Olaizola, Oier; Somovilla, Victor J.; Boons, Geert-Jan] Univ Utrecht, Dept Chem Biol & Drug Discovery, Univ Weg 99, NL-3584 CG Utrecht, Netherlands; [Palmer, Martin; Langridge, James, I] Waters Corp, Stamford Ave,Altrincham Rd, Wilmslow SK9 4AX, Cheshire, England; [Boons, Geert-Jan] Univ Georgia, Complex Carbohydrate Res Ctr, 315 Riverbend Rd, Athens, GA 30602 USA; [Boons, Geert-Jan] Univ Georgia, Dept Chem, 315 Riverbend Rd, Athens, GA 30602 USA published Ion-Mobility Spectrometry Can Assign Exact Fucosyl Positions in Glycans and Prevent Misinterpretation of Mass-Spectrometry Data After Gas-Phase Rearrangement in 2019, Cited 36. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The fucosylation of glycans leads to diverse structures and is associated with many biological and disease processes. The exact determination of fucoside positions by tandem mass spectrometry (MS/MS) is complicated because rearrangements in the gas phase lead to erroneous structural assignments. Here, we demonstrate that the combined use of ion-mobility MS and well-defined synthetic glycan standards can prevent misinterpretation of MS/MS spectra and incorrect structural assignments of fucosylated glycans. We show that fucosyl residues do not migrate to hydroxyl groups but to acetamido moieties of N-acetylneuraminic acid as well as N-acetylglucosamine residues and nucleophilic sites of an anomeric tag, yielding specific isomeric fragment ions. This mechanistic insight enables the characterization of unique IMS arrival-time distributions of the isomers which can be used to accurately determine fucosyl positions in glycans.

Product Details of 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Torano, JS; Gagarinov, IA; Vos, GM; Broszeit, F; Srivastava, AD; Palmer, M; Langridge, JI; Aizpurua-Olaizola, O; Somovilla, VJ; Boons, GJ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 TETRAHEDRON LETT published article about CATALYZED DENITROGENATIVE ANNULATION; TERT-BUTYL NITRITE; NEMATOCIDAL ACTIVITIES; SELECTIVE SYNTHESIS; DERIVATIVES; 1,2,3-BENZOTRIAZINE-4-(3H)-ONES; ACID in [Barak, Dinesh S.; Mukhopadhyay, Sushobhan; Dahatonde, Dipak J.; Batra, Sanjay] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Batra, Sanjay] CSIR HRDC, Postal Staff Coll Area, Sect 19, Ghaziabad 201002, India in 2019, Cited 39. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Application In Synthesis of 2-Aminobenzamide

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I-2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization. (C) 2018 Elsevier Ltd. All rights reserved.

Application In Synthesis of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Barak, DS; Mukhopadhyay, S; Dahatonde, DJ; Batra, S or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Improvement of pesticide removal in contaminated media using aqueous extracts from contaminated biopurification systems WOS:000504009600071 published article about BIOREMEDIATION SYSTEMS; BACTERIAL COMMUNITY; INCP-1 PLASMIDS; DEGRADATION; DIURON; SOIL; BIODEGRADATION; MINERALIZATION; HYDROLASE; IMPACTS in [Aguilar Romero, Ines; van Dillewijn, Pieter; Romero, Esperanza] CSIC, EEZ, Dept Environm Protect, C Prof Albareda 1, E-18008 Granada, Spain; [Nesme, Joseph; Sorensen, Soren J.] Univ Copenhagen, Dept Biol, Sect Microbiol, DK-2100 Copenhagen, Denmark in 2019.0, Cited 44.0. Category: thiomorpholine. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

Despite certain limitations, bioaugmentation enhances the efficiency of bioremediation systems. In this study, three aqueous extracts (APE, ACE and APE) from aged residual biomixtures in three biopurification systems (BPSs) exposed to pesticides at a pilot scale were found to improve pesticide removal. The addition of ACEs and AVEs to solutions containing the model compound diuron increased removal rates 6- and 17-fold, respectively, as compared to APEs. These extracts also increased the removal of the metabolite 3,4-dichloroaniline, while AVEs, in particular, were found to remove all pesticides within 9 days. Three metabolites less hazardous than 3,4-dichloroaniline were identified by SPME/GC/MS. AVEs, which also enhance linuron removal in liquid media, were found to increase diuron removal 6-fold in BPSs. We observed an increase in the relative abundance of taxa, such as Chloroflexi, Acidobacteria, Gemmatimonadetes, Firmicutes, Deinococcus-Thermus and especially Proteobacteria (10%), in AV biomixtures, as well as an enrichment of gamma-proteobacteria and the actinobacterial genus Dokdonella in AVEs with respect to initial noncontaminated IV biomixture. We demonstrate that extracts containing a pollutant-acclimatized microbiome could be used as part of a bioaugmentation strategy to improve the functioning of on-farm BPSs and contaminated systems. (c) 2019 Elsevier B.V. All rights reserved.

Category: thiomorpholine. About 1-Phenylurea, If you have any questions, you can contact Romero, IA; van Dillewijn, P; Nesme, J; Sorensen, SJ; Romero, E or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article An expeditious synthesis of 2,3-dihydroquinozoline-4(1H)-ones using graphene-supported sulfonic acid WOS:000501404400001 published article about ONE-POT SYNTHESIS; IONIC-LIQUID; HIGHLY EFFICIENT; ENANTIOSELECTIVE SYNTHESIS; QUINAZOLINONE DERIVATIVES; HETEROGENEOUS CATALYSIS; OXIDE NANOSHEETS; GREEN; ADSORPTION; WATER in [Gajare, Shivanand; Jagadale, Megha; Naikwade, Altafhusen; Bansode, Prakash; Patil, Pradnya; Rashinkar, Gajanan] Shivaji Univ, Dept Chem, Kolhapur 416004, Maharashtra, India in 2020, Cited 86. Computed Properties of C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Graphene-supported sulfonic acid (Gr@SO3H) has been prepared by covalent grafting of (3-mercaptopropyl)trimethoxysilane in the matrix of graphene followed by treatment with sulfuric acid and hydrogen peroxide. Gr@SO3H has been successfully characterized by Fourier transform infrared (FT-IR) spectroscopy, Fourier transform Raman (FT-Raman) spectroscopy, CP-MAS C-13 NMR spectroscopy, thermogravimetric analysis (TGA), energy dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) analysis, and X-ray diffractometer (XRD) analysis. Gr@SO3H served as a robust heterogeneous catalyst for the synthesis of bioactive 2,3-dihydroquinazolin-4(1H)-ones from anthranilamide and aryl aldehydes in ethanol. Recyclability experiments were executed successfully for six consecutive runs.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Gajare, S; Jagadale, M; Naikwade, A; Bansode, P; Patil, P; Rashinkar, G or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Viti, ML; Mendes, KF; dos Reis, FC; Guimaraes, ACD; Soria, MTM; Tornisielo, VL in [Viti, Marcela Lembi; dos Reis, Fabricia Cristina; Tornisielo, Valdemar Luiz] Univ Sao Paulo, Ctr Nucl Energy Agr, Piracicaba, SP, Brazil; [Mendes, Kassio Ferreira] Univ Fed Vicosa, Vicosa, MG, Brazil; [Dias Guimaraes, Ana Carolina] Univ Mato Grosso State, Alta Floresta, Mato Grosso, Brazil; [Martinez Soria, Maria Teresa] Univ La Rioja, Logrono, La Rioja, Spain published Characterization and Metabolism of Bound Residues of Three Herbicides in Soils Amended with Sugarcane Waste in 2021.0, Cited 47.0. Computed Properties of C7H8N2O. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

This study evaluated the remobilization, mineralization, and metabolism of herbicide-bound residues in soils amended with various types of sugarcane waste. Soil with bound residues of three herbicides and fresh soil samples were added to the biometric flasks, followed by the addition of vinasse, filter cake, or sugarcane straw in order to reactivate the microbial activity. In sandy loam soil, higher mineralization was observed where filter cake was added, and the maximum mineralized percentage was 7.7, 46.7, and 8.1% of diuron-, hexazinone-, and metribuzin-bound residues, respectively. Conversely, this soil presented a greater percentage of re-extractable hexazinone and metribuzin residues when vinasse was added. Among the examined herbicides, a higher percentage of bound metribuzin residues remained in the soil (57.5-75.6%). It was possible to identify both metabolites and parent compounds in the re-extracted residues, implying either species could bind to the soil. Therefore, this study has shown that bound residues of three herbicides and their metabolites can become bioavailable, and mineralized or returned to the soil solution, which could adversely affect subsequent crops or non-target organisms. Hence, the remobilization of bound residues must be taken into account when assessing the environmental risk of herbicides in soils in registration processes.

About 1-Phenylurea, If you have any questions, you can contact Viti, ML; Mendes, KF; dos Reis, FC; Guimaraes, ACD; Soria, MTM; Tornisielo, VL or concate me.. Computed Properties of C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Devaraj, K; Ingner, FJL; Sollert, C; Gates, PJ; Orthaber, A; Pilarski, LT in AMER CHEMICAL SOC published article about BENZYNE; INSERTION; GENERATION; PHENOLS in [Devaraj, Karthik; Ingner, Fredric J. L.; Sollert, Carina; Pilarski, Lukasz T.] Uppsala Univ, Dept Chem BMC, Box 576, S-75123 Uppsala, Sweden; [Gates, Paul J.] Univ Bristol, Sch Chem, Cantocks Close, Bristol BS8 1TS, Avon, England; [Orthaber, Andreas] Uppsala Univ, Dept Chem, Angstrom Labs, Box 523, S-75120 Uppsala, Sweden in 2019, Cited 90. Quality Control of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A new, operationally simple approach is presented to access arynes and their fluoride-activated precursors based on Ru-catalyzed C-H silylation of arylboronates. Chromatographic purification may be deferred until after aryne capture, rendering the arylboronates de facto precursors. Access to various new arynes and their derivatives is demonstrated, including, for the first time, those based on a 2,3-carbazolyne and 2,3-fluorenyne core, which pave the way for novel derivatizations of motifs relevant to materials chemistry.

Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Devaraj, K; Ingner, FJL; Sollert, C; Gates, PJ; Orthaber, A; Pilarski, LT or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. In 2019 ACTA CRYSTALLOGR C published article about ENANTIOSELECTIVE TOTAL-SYNTHESIS; ASYMMETRIC-SYNTHESIS; NATURAL-PRODUCTS; DERIVATIVES; ACID; CYCLOADDITION; QUINAZOLINONE; CONSTRUCTION; ANALOGS; SET in [Chernyshov, Vladimir V.; Gatilov, Yuri, V; Yarovaya, Olga, I; Koskin, Igor P.; Salakhutdinov, Nariman F.] NN Vorozhtsov Novosibirsk Inst Organ Chem SB RAS, 9 Acad Lavrentiev Ave, Novosibirsk 630090, Russia; [Chernyshov, Vladimir V.; Gatilov, Yuri, V; Yarovaya, Olga, I; Brylev, Konstantin A.] Novosibirsk State Univ, Pirogova St 2, Novosibirsk 630090, Russia; [Yarovoy, Spartak S.; Brylev, Konstantin A.] Nikolaey Inst Inorgan Chem SB RAS, 3 Acad Lavrentiev Ave, Novosibirsk 630090, Russia in 2019, Cited 41. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The possibility of a single-stage solvent-free stereoselective synthesis of a spirocyclic compound from the natural bicyclic monoterpenoid (-)-fenchone and anthranilamide has been shown for the first time. The molecular and crystal structure of (1R,2S,4S)-1,3,3-trimethyl-10H-spiro[bicyclo[2.2.1]heptane-2,2′-quinazolin]-4′(3’H)-one, C17H22N2O, was established by X-ray diffraction though the chirality was assumed via the known reactant connectivity and H-1 and C-13 NMR spectroscopy. It has shown that in the molecule, for steric reasons, there is an elongation of the Me2C-C(N)N bond to 1.603 (5) A degrees. The formation of dimers via N-H center dot center dot center dot O C hydrogen bonds with an interaction energy of 93.30 kJ mol(-1) and through cavities (33.7% of the unit-cell volume) was established in the packing of the molecules. There are no pi-stacking interactions in the structure.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Chernyshov, VV; Gatilov, YV; Yarovaya, OI; Koskin, IP; Yarovoy, SS; Brylev, KA; Salakhutdinov, NF or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article CuI/I-2-Catalyzed Concise Synthesis of Substituted 6-Aminoisoquinolinoquinazoline Carboxylates from Anthranilamide WOS:000575923400032 published article about ALPHA-ARYLATION; CATALYZED SYNTHESIS; DERIVATIVES; TRYPTANTHRIN; QUINAZOLINE; CYCLIZATION; COMPLEXES; KETONES; ACCESS; ARYL in [Reddy, Potuganti Gal; Indukuri, Divakar Reddy; Alla, Manjula] Indian Inst Chem Technol, CSIR, Div Fluoro & Agro Chem, Hyderabad 500007, Andhra Pradesh, India; [Reddy, Potuganti Gal; Indukuri, Divakar Reddy; Alla, Manjula] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2020, Cited 40. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Category: thiomorpholine

A one pot sequential addition protocol for synthesis of polycyclic quinazolines with beta-amino acid motifs has been achieved starting from anthranilamide. Initialin situformation of 2-(2-bromophenyl)quinazolin-4(3H)-one followed by addition of alkyl cyanoacetates catalyzed by copper (I) salts gives the target compound in good to excellent yields. The expedient and facile cascade protocol involves nucleophilic alpha-arylation, intramolecular cycloamidation of nitriles followed by 1,3-hydrogen shift allowing direct access to 6-amino-8-oxo-8H-isoquinolino[1,2-b]quinazoline-5-carboxylates.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Reddy, PG; Indukuri, DR; Alla, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of 1-Phenylurea. Sakakibara, K; Moriki, Y; Tsujn, Y in [Sakakibara, Keita; Moriki, Yoshihito; Tsujn, Yoshinobu] Kyoto Univ, Inst Chem Res, Uji, Kyoto 6110011, Japan published Preparation of High-Performance Polyethylene Composite Materials Reinforced with Cellulose Nanofiber: Simultaneous Nanofibrillation of Wood Pulp Fibers during Melt-Compounding Using Urea and Diblock Copolymer Dispersant in 2019.0, Cited 57.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

Production of nanocomposites from macro-scale materials in situ in a melting compounder is highly desirable yet challenging. In this study, we develop a highly efficient approach for the preparation of cellulose nanofiber (CNF)-reinforced high-density polyethylene (HDPE) composite materials from as-received wood pulp fibers, in which nanofibrillation-assisting plasticizers (urea and urea derivatives) and a diblock copolymer dispersant are used. The most effective plasticizer is urea, which plays a crucial role in producing CNF with less fragmentation during the kneading step, owing to the plasticization/nanofibrillation and the reaction with hydroxyl groups of cellulose fibers into a carbamate. The diblock copolymer as a dispersant enables the stabilization of the appropriate dispersion of the produced CNF in nonpolar HDPE. The resulting composites exhibit significantly improved mechanical properties, including a 6.9-fold increase in the Youngs modulus with 10 wt % loading of wood pulp fibers over that of neat HDPE.

Safety of 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Sakakibara, K; Moriki, Y; Tsujn, Y or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem