Tag: M.W=100-150

Recently I am researching about QUINAZOLINONE; MECHANOSYNTHESIS; CHEMISTRY; GREEN; COMPLEXES; HYDROXIDE; EFFICIENT; PROTOCOL; BENIGN; UREAS, Saw an article supported by the TEQIP-III; DST-SERB; CSIRCouncil of Scientific & Industrial Research (CSIR) – India; CoE-PI; DSTDepartment of Science & Technology (India) [YSS/2015/000934]; CSIRCouncil of Scientific & Industrial Research (CSIR) – India [02(0253)/16/EMR-II)]; ICT Golden Jubilee Research Fund (2018); UGC-FRP [F.4-5(128)/2014(BSR)]. Category: thiomorpholine. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Yashwantrao, G; Jejurkar, VP; Kshatriya, R; Saha, S. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

Although the synthesis of novel N-heterocyclic molecules is extremely demanding as well as challenging, the involvement of toxic solvents often triggers environmental safety concerns, resulting in process-engineering challenges. Herein, we have demonstrated a rapid, environmentally benign and energy efficient scalable method for the synthesis of 2,3-dihydroquinazolin-4(1H)-one by grinding in a mortar pestle as well as mechanochemically via ball milling using p-TSA catalyst. The ability to accomplish the reaction in the absence of solvent via grinding or milling with p-TSA catalyst, with an immediate reduction in the cost and operational procedures, features the significant advantages of this protocol. The scalability and significance of the operational parameters during mechanochemical milling in the tubular ball mill were also demonstrated. Excellent yield in short duration, large substrate scope, product scalability, and easy recoverability are the prime features of this mechanochemical solvent-free protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-one. The study also demonstrated the significant role of ball diameter to improve the efficiency of the milling operation in this mechanochemical synthesis.

Welcome to talk about 88-68-6, If you have any questions, you can contact Yashwantrao, G; Jejurkar, VP; Kshatriya, R; Saha, S or send Email.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about ONE-POT SYNTHESIS; MAGNETICALLY-RECOVERABLE CATALYST; ECO-FRIENDLY SYNTHESIS; IONIC LIQUIDS; AEROBIC OXIDATION; CASCADE SYNTHESIS; FRIEDLANDER; QUINAZOLIN-4(3H)-ONES; NANOPARTICLES; QUINAZOLINONES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21572156, 21777111]. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Xiao, J; Xu, G; Wang, L; Li, PY; Zhang, WQ; Ma, N; Tao, ML. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. HPLC of Formula: C7H8N2O

Four categories of sulfonic acid functionalized fiber catalysts with different surface microenvironments were synthesized by covalent grafting using polyacrylonitrile fiber (PANF) as the support. After the effect of acid structure on catalytic activity has been investigated by Friedlander reaction, PAN(EOS)F was chosen for the synthesis of quinolines and coumarin derivatives with high yields and extensive substrate scope (51 examples) in ethanol or water. The effect of electrostatic microenvironment and solvent has been discussed, and a release-catch-release-catch catalytic pattern was proposed accordingly. PAN(EOS)F can be easily recycled for 20 times without any decrease of catalytic activity. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

HPLC of Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Xiao, J; Xu, G; Wang, L; Li, PY; Zhang, WQ; Ma, N; Tao, ML or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Coumarin-Quinazolinone conjugate with large two photon action cross-section assisted by intramolecular hydrogen bond for bioimaging WOS:000478562700026 published article about RATIOMETRIC FLUORESCENT-PROBE; LIVING CELLS; NITROREDUCTASE ACTIVITY; SULFANE SULFUR; DESIGN; ABSORPTION; FLUORIDE; DERIVATIVES; SENSOR; FLUOROPHORES in [Yang, Jihuan; Zhang, Yaya; Li, Guorui; Liu, Song; Huang, Jing] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, ICBN,Coll Biol, Changsha 410082, Hunan, Peoples R China; [Yang, Jihuan; Zhang, Yaya; Li, Guorui; Liu, Song; Huang, Jing] Hunan Univ, Hunan Prov Key Lab Biomacromol Chem Biol, Changsha 410082, Hunan, Peoples R China; [Bai, Xuejiao; Xing, Zhiming; Zhou, Jia; Song, Zhibin] Jiangxi Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China; [Zhong, Cheng] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China in 2019, Cited 78. HPLC of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Two photon (TP) fluorescence bioimaging proves to be a powerful tool for biomarker detection and disease diagnosis. However, the probes possessing both good optical properties and biocompatibility are limited. Herein a novel scaffold based on the conjugate of coumarin and quinazolinone (CQ) exhibited brilliant TP fluorescence properties (action cross-section value Phi delta(max) = 299 GM and TP action cross section per molecular weight Phi delta(max)/MW = 0.83) in water. The fluorescence properties are mainly attributed to the enlarged conjugate structure by intramolecular hydrogen bond. The TP fluorescence can be easily switched via amide group modification-deprotection strategy to regulate the formation of hydrogen bond. As a proof of concept, CQ was further engineered with p-nitrobenzyl moiety to afford 2-(7-(diethylamino)-2-oxo-2H-chromen-3-yl)-3-(4-nitrobenzyl) quinazolin-4(3H)-one (NBCQ) for mitochondria nitroreductase (NTR) imaging in normoxia and hypoxia, which proved to be a sensitive and selective off-on NTR fluorescent probe.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about BIOLOGICAL EVALUATION; DERIVATIVES; PI3K/AKT/MTOR; GEFITINIB; PATHWAY; DESIGN; GROWTH, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81430085]; Natural Science Foundation of Henan [182300410321]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Li, ED; Lin, Q; Meng, YQ; Zhang, LY; Song, PP; Li, N; Xin, JC; Yang, P; Bao, CN; Zhang, DQ; Zhang, Y; Wang, JK; Zhang, QR; Liu, HM. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Computed Properties of C7H8N2O

A series of novel 2,4-disubstituted quinazolines were synthesized and evaluated for their anti-tumor activity against five human cancer cells (MDA-MB-231, MCF-7, PC-3, HGC-27 and MGC-803) using MIT assay. Among them, compound 9n showed the most potent cytotoxicity against breast cancer cells. Compound 9n also significantly inhibited the colony formation and migration of MDA-MB-231 and MCF-7 cells. Meanwhile, compound 9n induced cell cycle arrest at G1 phase and cell apoptosis, as well as increased accumulation of intracellular ROS. Furthermore, compound 9n exerted anti-tumor effects in vitro via decreasing the expression of anti-apoptotic protein Bcl-2 and increasing the pro-apoptotic protein Bax and p53. Mechanistically, compound 9n markedly decreased p-EGFR and p-PI3K expression, which revealed that compound 9n targeted breast cancer cells via interfering with EGFR-PI3K signaling pathway. Molecular docking suggested that compound 9n could indeed bind into the active pocket of EGFR. All the findings suggest that compound 9n might be a valuable lead compound for anti-tumor agents targeting breast cancer cells. (C) 2019 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 88-68-6, If you have any questions, you can contact Li, ED; Lin, Q; Meng, YQ; Zhang, LY; Song, PP; Li, N; Xin, JC; Yang, P; Bao, CN; Zhang, DQ; Zhang, Y; Wang, JK; Zhang, QR; Liu, HM or send Email.. Computed Properties of C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 CHEMISTRYSELECT published article about MIXED-METAL OXIDES; OXIDATIVE SYNTHESIS; FACILE; QUINAZOLIN-4(3H)-ONES in [Hase, Dattatraya, V; Jayaram, Radha, V] Inst Chem Technol, Dept Chem, Mumbai 400019, Maharashtra, India; [Thirumalai, Kuppulingam; Swaminathan, Meenakshisundaram] Annamalai Univ, Photocatalysis Lab, Dept Chem, Annamalainagar 608002, Tamil Nadu, India; [Swaminathan, Meenakshisundaram] Kalasalingam Univ, Int Res Ctr, Dept Chem, Nanomat Lab, Krishnan Kovil 626126, Tamil Nadu, India in 2019, Cited 35. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Computed Properties of C7H8N2O

In the present study, ZnO modified with rare earth oxides GdxMn; M=Mo, V, W) were synthesized by hydrothermal process and their catalytic activity was tested in an oxidative cyclization reaction for the selective synthesis of quinazolinones. The catalysts were characterized by various techniques such as BET surface area analysis, XRD, SEM-EDX, DSC-TGA, ICP-MS and elemental color mapping. 5 wt% Gd2MoO6/ZnO exhibited good catalytic activity and gave 60-91% of Quinazolin-4(3H) ones in toluene. The catalysts could be reused at least four times without loss of catalytic activity.

Welcome to talk about 88-68-6, If you have any questions, you can contact Hase, DV; Jayaram, RV; Thirumalai, K; Swaminathan, M or send Email.. Computed Properties of C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C7H8N2O. Authors Dan, YT; Ji, MY; Tao, SP; Luo, G; Shen, Z; Zhang, YL; Sang, WJ in ELSEVIER published article about in [Dan, Yitong; Ji, Mengyuan; Sang, Wenjing] Donghua Univ, Coll Environm Sci & Engn, Text Pollut Controlling Engn Ctr, Minist Environm Protect, Shanghai 201620, Peoples R China; [Tao, Shuping; Shen, Zheng; Zhang, Yalei] Tongji Univ, Natl Engn Res Ctr Protected Agr, Inst New Rural Dev, Shanghai 200092, Peoples R China; [Luo, Gang] Fudan Univ, Dept Environm Sci & Engn, Shanghai Key Lab Atmospher Particle Pollut & Prev, Shanghai 200433, Peoples R China in 2021.0, Cited 76.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

The application of phenylurea herbicides (PUHs) may lead to the extensive distribution in soils, while the role of straw biochar as a soil amendment on the transport and sorption of PUHs are still unclear. Thus, the transport and sorption behavior of three typical PUHs with rice straw biochar (RSB) was studied in both adsorption simulation experiments of aqueous solution and packed column experiments:the sorption mechanism of RSB to herbicides was investigated through batch sorption studies with three influencing factors including dosage of RSB, pH, and ionic strength (IS) with orthogonal test. The sorption coeff icients were improved significantly by increasing the dosage of RSB, while there was no obvious influence by enhancing the pH and IS value. The optimal sorption conditions (pH value at 3, IS at 0.1 M, and RSB dosage at 60 mg) of three herbicides were set and the maximum removal rates of Monuron, Diuron, and Linuron were 41.9%, 25%, and 56.8%, respectively. The co-transport process of RSB and PUHs were investigated under different RSB dosage, pH value, and IS value. The retention effect increased greatly with enhancing the RSB dosage and pH value. However, IS did not have a significant influence on the retention of RSB, and therefore it had little effect on the adsorption capacity, which was consistent with the results of sorption experiments. The breakthrough curves (BTCs) for co-transport were well simulated by the two-site non-equilibrium convection-dispersion equation (CDE). Most of the regression coefficients (R-2) were above 0.99, which uncovered the co-transport in packed column were affected by physical absorption and chemical forces. According to the fitting parameters analysis, the RSB particles and PUHs were subjected to a greater resistance and a stronger stability by reducing pH value in porous media. The presence of RSB increased the amount of dynamic sorption sites in the entire co-transport system, which led to a significant promotion of the PUHs’ sorption and interception. (C) 2021 Elsevier B.V. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 2-Aminobenzamide. Authors Nguyen, TTT; Nguyen, L; Ngo, QA; Koleski, M; Nguyen, TB in ROYAL SOC CHEMISTRY published article about in [Nguyen, Thi Thu Tram] Can Tho Univ Med & Pharm, Dept Chem, Fac Sci, Can Tho, Vietnam; [Nguyen, Le Anh; Ngo, Quoc Anh] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet, Hanoi, Vietnam; [Nguyen, Le Anh; Ngo, Quoc Anh] Grad Univ Sci & Technol, Vietnam Acad Sci & Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam; [Koleski, Marina; Nguyen, Thanh Binh] Univ Paris Saclay, Univ Paris Sud, CNRS UPR 2301, Inst Chim Subst Nat, 1 Av Terrasse, F-91198 Gif Sur Yvette, France in 2021, Cited 57. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Thioamides could be conveniently synthesized in good to excellent yields via DMSO-promoted oxidative coupling of methylhetarenes with amines in the presence of a near stoichiometric amount of sulfur (1.25 equiv.). Both aliphatic and aromatic amines were found to be competent substrates. When anilines o-substituted by cyclizable groups such as OH, NH2, NHPh, SH and CONH2 were used as amine substrates, the corresponding hybrid bis-aza-heterocycles were formed in high yields even with a sulfur loading as low as 0.5 equiv.

Application In Synthesis of 2-Aminobenzamide. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Photocatalyst-free visible-light-promoted quinazolinone synthesis at room temperature utilizing aldehydes generated in situ via C=C bond cleavage WOS:000632575900022 published article about MOLECULAR-OXYGEN; EFFICIENT; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES; OXIDATION; ALKENES; DERIVATIVES; DESIGN; FACILE; CYCLIZATION; OZONOLYSIS in [Xie, Zongbo; Lan, Jin; Yan, Liyuan; Chen, Xuehua; Li, Qian; Meng, Jia; Le, Zhanggao] East China Univ Technol, Jiangxi Prov Key Lab Synthet Chem, Nanchang 330013, Jiangxi, Peoples R China; [Xie, Zongbo; Lan, Jin; Yan, Liyuan; Chen, Xuehua; Li, Qian; Meng, Jia; Le, Zhanggao] East China Univ Technol, Sch Chem Biol & Mat Sci, Nanchang 330013, Jiangxi, Peoples R China in 2021, Cited 62. Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

This is the first report on a facile tandem route for synthesizing quinazolinones at room temperature from various aminobenzamides and in situ-generated aldehydes. The latter was formed via C=C bond cleavage, and the overall reaction proceeded using molecular oxygen as a clean oxidant in the absence of a photocatalyst. Visible light, which was indispensable for the entire course of the reaction, played multiple roles. It initially cleaved styrene to an aldehyde, then facilitated its cyclization with an o-substituted aniline, and finally promoted the dehydrogenation of the cyclized intermediate. The previous step provided the feedstock for the next step in the reaction, thereby preventing volatilization, oxidation, and polymerization of the aldehyde. Thus, the overall process is simple, environmentally benign, and economically feasible.

About 2-Aminobenzamide, If you have any questions, you can contact Xie, ZB; Lan, J; Yan, LY; Chen, XH; Li, Q; Meng, J; Le, ZG or concate me.. Formula: C7H8N2O

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Competing HB acceptors: an extensive NMR investigations corroborated by single crystal XRD and DFT calculations WOS:000648718400034 published article about INTRAMOLECULAR HYDROGEN-BONDS; ORGANIC FLUORINE; DERIVATIVES; ANTHRANILAMIDES; INHIBITORS; COUPLINGS; STRENGTH; GEOMETRY in [Tiwari, Surbhi; Arya, Neeru; Suryaprakash, N.] Indian Inst Sci, NMR Res Ctr, Bangalore 560012, Karnataka, India; [Tiwari, Surbhi; Arya, Neeru; Suryaprakash, N.] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India; [Mishra, Sandeep Kumar] Indian Inst Sci Educ & Res, Dept Phys, Pune 411008, Maharashtra, India; [Mishra, Sandeep Kumar] Indian Inst Sci Educ & Res, NMR Res Ctr, Pune 411008, Maharashtra, India in 2021, Cited 57. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Computed Properties of C7H8N2O

A series of N-benzoylanthranilamide derivatives have been synthesized with the substitution of competitive HB acceptors and investigated by NMR spectroscopy and single crystal XRD. The interesting rivalry for HB acceptance between (sic)C= and X (F or OMe) is observed in the investigated molecules which leads to an unusual increase in the electron density at the site of one of the NH protons, reflecting in the high field resonance in the H-1 NMR spectrum. The NMR experimental findings and single crystal XRD are further reinforced by the DFT studies.

Computed Properties of C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Tiwari, S; Arya, N; Mishra, SK; Suryaprakash, N or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Rohokale, RS; Kalshetti, RG; Ramana, CV in [Rohokale, Rajendra S.; Kalshetti, Rupali G.; Ramana, Chepuri V.] CSIR Natl Chem Lab, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Kalshetti, Rupali G.; Ramana, Chepuri V.] Acad Sci & Innovat Res, New Delhi 110025, India published Iridium(III)-Catalyzed Alkynylation of 2-(Hetero)arylquinazolin-4-one Scaffolds via C-H Bond Activation in 2019, Cited 80. HPLC of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The directed C-H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as -F, -Cl, -Br, -CF3, -OMe, -NO2, and alkyl, etc.

Welcome to talk about 88-68-6, If you have any questions, you can contact Rohokale, RS; Kalshetti, RG; Ramana, CV or send Email.. HPLC of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem