Tag: M.W=100-150

Computed Properties of C7H8N2O. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Styryl quinazolinones and its ethynyl derivatives induce myeloid differentiation published in 2019, Reprint Addresses Radhakrishnan, S; Tenen, DG; Kobayashi, SS (corresponding author), Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide.

The tumor suppressor transcription factor CCAAT enhancer-binding protein alpha (C/EBP alpha) expression is down-regulated in myeloid leukemias and enhancement of C/EBP alpha expression induces granulocytic differentiation in leukemic cells. Previously we reported that Styryl quinazolinones induce myeloid differentiation in HL-60 cells by upregulating C/EBP alpha expression. To identify more potent molecule that can induce leukemic cell differentiation we synthesized and evaluated new series of styryl quinazolinones, ethynyl styryl quinazolinones, styryl quinolinones and thienopyrimidinones. Thienopyrimidinones were found toxic and styryl quinolinones were found inactive. Ethynyl styryl quinazolinone 39 and styryl quinazolinone 5 were found active on par with the earlier reported analogues 1 and 2 suggesting that the 5-nitro furan-2-yl styryl quinazolinones find a real promise in leukemic cell differentiation. The improved potency of 5 suggested that further modifications in the 5-nitro furan-2-yl styryl quinazolinones can be at the phenyl substitution at the 3-position of the quinazolinone ring apart from the 5-position of the heteroaryl ring.

Computed Properties of C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Radhakrishnan, S; Syed, R; Takei, H; Kobayashi, IS; Nakamura, E; Sultana, F; Kamal, A; Tenen, DG; Kobayashi, SS or send Email.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 1-Phenylurea. Authors Abdourahime, H; Anastassiadou, M; Brancato, A; Brocca, D; Cabrera, LC; De Lentdecker, C; Ferreira, L; Greco, L; Jarrah, S; Kardassi, D; Leuschner, R; Lostia, A; Lythgo, C; Medina, P; Miron, I; Molnar, T; Nave, S; Pedersen, R; Raczyk, M; Reich, H; Ruocco, S; Sacchi, A; Santos, M; Stanek, A; Sturma, J; Tarazona, J; Theobald, A; Vagenende, B; Verani, A; Villamar-Bouza, L in EUROPEAN FOOD SAFETY AUTHORITY-EFSA published article about in in 2019.0, Cited 16.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

According to Article 12 of Regulation (EC) No396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance fluometuron. To assess the occurrence of fluometuron residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Commission Regulation (EC) No33/2008 as well as the European authorisations reported by Member States (including the supporting residues data). Based on the assessment of the available data, an MRL proposal was derived and a consumer risk assessment was carried out. All information required by the regulatory framework was present and a risk to consumers was not identified. In addition, EFSA identified some data gaps which are not expected to impact on the validity of the MRL derived but which might have an impact on national authorisations.

Recommanded Product: 1-Phenylurea. Welcome to talk about 64-10-8, If you have any questions, you can contact Abdourahime, H; Anastassiadou, M; Brancato, A; Brocca, D; Cabrera, LC; De Lentdecker, C; Ferreira, L; Greco, L; Jarrah, S; Kardassi, D; Leuschner, R; Lostia, A; Lythgo, C; Medina, P; Miron, I; Molnar, T; Nave, S; Pedersen, R; Raczyk, M; Reich, H; Ruocco, S; Sacchi, A; Santos, M; Stanek, A; Sturma, J; Tarazona, J; Theobald, A; Vagenende, B; Verani, A; Villamar-Bouza, L or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Shamanth, S; Nagarakere, SC; Sagar, KS; Narayana, Y; Mamatha, M; Rangappa, KS; Kempegowda, M in [Shamanth, Sadashivamurthy; Sagar, Kunigal S.; Narayana, Yatheesh; Rangappa, Kanchugarakoppal S.; Kempegowda, Mantelingu] Univ Mysore, DOS Chem, Manasagangotri, Mysuru 570006, Karnataka, India; [Nagarakere, Sandhya C.] St Philomenas Coll, PG Dept Studies Chem, Mysuru, India; [Nagarakere, Sandhya C.] St Philomenas Coll, Res Ctr, Mysuru, India; [Mamatha, Mahesha] SRSMN Govt First Grade Coll, Barkur, India published T3P mediated intramolecular rearrangement of o-aminobenzamide to o-ureidobenzonitrile using isothiocyanates in 2021, Cited 38. Category: thiomorpholine. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Current work describes the environmentally benign approach for the synthesis of o-ureidobenzonitriles, from o-aminobenzamides and isothiocyanates using T3P. Here, the conversion of thiourea to urea and amide to nitrile take place simultaneously via unprecedented intramolecular rearrangement. This protocol is operationally facile and offers wide variety of o-ureidobenzonitriles at room temperature in good to excellent yields.

About 2-Aminobenzamide, If you have any questions, you can contact Shamanth, S; Nagarakere, SC; Sagar, KS; Narayana, Y; Mamatha, M; Rangappa, KS; Kempegowda, M or concate me.. Category: thiomorpholine

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article A mechanistic insight into the acid catalyzed, one-pot synthesis of isoindole-fused quinazolin 4-ones WOS:000528568400001 published article about EFFICIENT in [Mondal, Mohabul A.; Mondal, Sudipta; Khan, Abdul A.] Jadavpur Univ, Dept Chem, Kolkata 700032, W Bengal, India in 2020, Cited 11. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Safety of 2-Aminobenzamide

One-pot synthesis of isoindole fused quinazolin 4-ones via intramolecular 1,3 hydride transfer in the presence of acid catalyst has been described. Substrate scope and mechanistic insights were investigated. Substituents on the amide side have a negligible influence on the key step and therefore the method have wide scope for accessing various bicyclic core structure.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of 2-Aminobenzamide. Keivanloo, A; Bakherad, M; Mokhtarei, L in [Keivanloo, Ali; Bakherad, Mohammad; Mokhtarei, Lotfollah] Shahrood Univ Technol, Fac Chem, Shahrood 3619995161, Iran published Sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate an efficient ligand for click reaction in water: Synthesis of 1,2,3-triazole pharmacophore linked-quinazolinone scaffold in 2020, Cited 42. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Water soluble sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate ligand was used successfully for the preparation of 1,2,3-triazoles pharmacophore linked-quinazolinone scaffold. The reaction of ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate and related amide compounds with propargyl bromide afforded ethyl 4-oxo-3-(prop-2-yn-1-yl)-3,4-dihydroquinazoline-2-carboxylate and its amide derivatives. The reaction of propargylated compounds with azides catalyzed by copper (II) salt, in the presence of Sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate as a ligand in water produced novel 1,2,3-triazole pharmacophore linked-quinazolinone-4-one scaffold with high-to-excellent yields. The ligand assisted in the click reaction and reduced loading of copper salt to 2 mol%. Simplicity, short reaction times, use of water as green solvent, and low catalyst loading are the main advantages of this procedure.

Quality Control of 2-Aminobenzamide. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Chemistry very interesting. Saw the article Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines published in 2019. Safety of 2-Aminobenzamide, Reprint Addresses Yi, CS (corresponding author), Marquette Univ, Dept Chem, Milwaukee, WI 53201 USA.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines led to the efficient formation of quinazolinone products. The catalytic coupling method provides an efficient synthesis of quinazoline and quinazolinone derivatives without using any reactive reagents or forming any toxic byproducts.

Safety of 2-Aminobenzamide. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Pismataro, MC; Felicetti, T; Bertagnin, C; Nizi, MG; Bonomini, A; Barreca, ML; Cecchetti, V; Jochmans, D; De Jonghe, S; Neyts, J; Loregian, A; Tabarrini, O; Massari, S in [Pismataro, Maria Chiara; Felicetti, Tommaso; Nizi, Maria Giulia; Barreca, Maria Letizia; Cecchetti, Violetta; Tabarrini, Oriana; Massari, Serena] Univ Perugia, Dept Pharmaceut Sci, Via Del Liceo 1, I-06123 Perugia, Italy; [Bertagnin, Chiara; Bonomini, Anna; Loregian, Arianna] Univ Padua, Dept Mol Med, Via Gabelli 63, I-35121 Padua, Italy; [Jochmans, Dirk; De Jonghe, Steven; Neyts, Johan] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Rega Inst Med Res, Lab Virol & Chemotherapy, Herestr 49,Box 1043, B-3000 Leuven, Belgium published 1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors in 2021, Cited 46. Category: thiomorpholine. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

In the search for new anti-influenza virus (IV) compounds, we have identified the 1,2,4-triazolo[1,5-a] pyrimidine (TZP) as a very suitable scaffold to obtain compounds able to disrupt IV RNA-dependent RNA polymerase (RdRP) PA-PB1 subunits heterodimerization. In this work, in order to acquire further SAR insights for this class of compounds and identify more potent derivatives, we designed and synthesized additional series of analogues to investigate the role of the substituents around the TZP core. To this aim, we developed four facile and efficient one-step procedures for the synthesis of 5-phenyl-, 6- phenyl- and 7-phenyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidines, and 2-amino-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol. Two analogues having the ethyl carboxylate moiety at the C-2 position of the TZP were also prepared in good yields. Then, the scaffolds herein synthesized and two previous scaffolds were functionalized and evaluated for their anti-IAV activity, leading to the identification of compound 22 that showed both anti-PA-PB1 (IC50 = 19.5 mM) and anti-IAV activity (EC50 = 16 mM) at non-toxic concentrations, thus resulting among the most active TZP derivatives reported to date by us. A selection of the synthesized compounds, along with a set of in-house available analogues, was also tested against SARS-CoV-2. The most promising compound 49 from this series displayed an EC50 value of 34.47 mM, high-lighting the potential of the TPZ scaffold in the search for anti-CoV agents. (C) 2021 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 88-68-6, If you have any questions, you can contact Pismataro, MC; Felicetti, T; Bertagnin, C; Nizi, MG; Bonomini, A; Barreca, ML; Cecchetti, V; Jochmans, D; De Jonghe, S; Neyts, J; Loregian, A; Tabarrini, O; Massari, S or send Email.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

HPLC of Formula: C7H8N2O. I found the field of Chemistry very interesting. Saw the article DMAP-Catalyzed One-Pot Synthesis of Quinazoline-2,4-diones from 2-Aminobenzamides and Di-tert-butyl Dicarbonate published in 2020, Reprint Addresses Li, G; Huang, HH (corresponding author), Peking Union Med Coll & Chinese Acad Med Sci, Beijing Key Lab Act Subst Discovery & Druggabil E, Inst Mat Med, Beijing 100050, Peoples R China.; Li, G; Huang, HH (corresponding author), Peking Union Med Coll & Chinese Acad Med Sci, Chinese Acad Med Sci, Key Lab AntiDR TB Innovat Drug Res, Inst Mat Med, Beijing 100050, Peoples R China.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide.

The one-pot synthesis of quinazoline-2,4-diones was developed in the presence of 4-dimethylaminopyridine (DMAP) by metal-free catalysis. The commercially available (Boc)(2)O acted as a key precursor in the construction of the 2-position carbonyl of quinazolinediones. The p-methoxybenzyl (PMB)-activated hetero- cyclization could smoothly proceed at room temperature instead of the microwave condition. This strategy is compatible with a variety of substrates with different functional groups. Furthermore, this protocol was utilized to smoothly prepare Zenarestat with a total yield of 70%.

HPLC of Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Chen, H; Li, P; Qin, RF; Yan, H; Li, G; Huang, HH or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article N-Phenylbenzamide derivatives as alternative oxidase inhibitors: Synthesis, molecular properties, H-1-STD NMR, and QSAR WOS:000519189500051 published article about PURIFICATION; PERFORMANCE; INSIGHTS; FEATURES; PATHWAY; ENZYMES; BINDING; IMPACT in [Costa, Paulo C. S.; Evangelista, Joel S.; Miranda, Paulo C. M. L.] Univ Estadual Campinas, UNICAMP, Inst Chem, BR-13083970 Campinas, SP, Brazil; [Barsottini, Mario R. O.; Pires, Barbara A.; Carazzolle, Marcelo F.; Pereira, Goncalo A. G.] Univ Estadual Campinas, UNICAMP, Inst Biol, Lab Genom & BioEnergy, BR-13083862 Campinas, SP, Brazil; [Barsottini, Mario R. O.] Univ Sussex, Biochem & Biomed, Falmer BN1 9QG, England; [Vieira, Maria L. L.; Silva, Jaqueline S.; Sforca, Mauricio L.; Rocco, Silvana A.] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, BR-13083970 Campinas, SP, Brazil; [Zeri, Ana C. M.; Nascimento, Andrey F. Z.] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Synchrotron Light Lab LNLS, BR-13083970 Campinas, SP, Brazil in 2020, Cited 47. Recommanded Product: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

In the present work, 117 N-phenylbenzamides (NPDs) were prepared and evaluated against recombinant AOX from the fungal pathogen Moniliophthora perniciosa. H-1, C-13 NMR, FTIR, and mass spectra provided structural information on NPDs. The library compounds were tested as Alternative Oxidase inhibitors in two different assays using the model yeast Pichia pastoris: cell growth and oxygen consumption assays. The most active compound, 3(FH), was further characterized by DRX and 1H-NMR-STD. Single crystal X-ray diffraction showed intra- and intermolecular interactions of 3(FH) in solid-state and elucidated its 3D structural configuration. 1H-NMR-STD allowed us to derive protein-ligand interactions in a membranemimetic system and evidenced an outstanding interaction of 3(FH) with this enzyme. Results of both biological assays were used as input to Quantitative Structure-Activity Relationship models, which highlighted the more important molecular fragments contributions for protein-ligand interaction. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C7H8N2O. In 2019 CHINESE J ORG CHEM published article about PRIMARY ALCOHOLS; DERIVATIVES; INHIBITORS; ANTITUMOR; CYCLIZATION; CLEAVAGE; BEARING; AGENTS in [Ju, Huanhuan; Sun, Jiajing; Li, Xiaoliu; Chen, Hua] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China in 2019, Cited 35. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A series of aldo-quinazolinones were synthesized by a one-pot iodine-induced oxidative condensation of the unprotected mono-/di-saccharides and o-aminobenzamides in the yields of 30%similar to 80%, providing an effective protocol for the preparation of aldo-quinazolinones. The amount of iodine has an important effect on the reaction.

Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.. Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem