Tag: M.W=100-150

I found the field of Chemistry very interesting. Saw the article Cu@U-g-C3N4 Catalyzed Cyclization of o-Phenylenediamines for the Synthesis of Benzimidazoles by Using CO2 and Dimethylamine Borane as a Hydrogen Source published in 2019. HPLC of Formula: C7H8N2O, Reprint Addresses Bhanage, BM (corresponding author), ICT, Dept Chem, Mumbai 400019, India.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

This work reports a green and sustainable route for the synthesis of benzimidazoles via C-N bond formation using carbon dioxide (CO2) as a C-1 carbon source. In this work, Cu@U-g-C3N4 catalyst was prepared from urea derived porous graphitic carbonnitride (U-g-C3N4) and CuCl2 and characterized by FT-IR, XRD, XPS, SEM, TPD etc. The Cu@U-g-C3N4 as a heterogeneous recyclable catalyst has been employed first time for the cyclization of o-phenylenediamines (OPD) with CO2 to benzimidazoles using dimethylamine borane (DMAB). The proposed protocol becomes sustainable and efficient due to the use of propylene carbonate/water as a suitable biodegradable, economical and environmentally benign solvent system. The proposed catalytic system showed a wide range of substrate scope for the synthesis of benzimidazoles in good to excellent yields. [GRAPHICS] .

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Thiomorpholine – Wikipedia,
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An article Experimental enthalpies of formation and sublimation of urea compounds: An accuracy assessment WOS:000454515300026 published article about THERMODYNAMIC PROPERTIES; ALKYL DERIVATIVES; VAPOR-PRESSURES; STANDARD ENTHALPIES; COMBUSTION; THERMOCHEMISTRY; CRYSTALS; GAS in [Dorofeeva, Olga, V; Suchkova, Taisiya A.] Lomonosov Moscow State Univ, Fac Chem, 1-3 Leninskie Gory, Moscow 119991, Russia in 2019.0, Cited 38.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Recommanded Product: 64-10-8

The thermochemical network of 91 isodesmic and other balanced reactions was used to adjust simultaneously the enthalpies of formation of 14 urea compounds. The experimental enthalpies of formation of these compounds were treated as unknowns in the least-squares minimization of deviations between the theoretically predicted enthalpies of reaction and experimental values. A result of a least-squares fit confirms the accuracy of experimental enthalpies of formation of 8 ureas, whereas the experimental measurements for 6 urea compounds require re-examination. The gas-phase standard enthalpies of formation of 8 ureas were used as a consistent basis to obtain values for other 15 ureas through isodesmic reactions. To estimate the enthalpies of formation in crystalline state, the sublimation enthalpies were predicted using the molecular electrostatic potential model. (C) 2018 Elsevier Ltd.

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Jabbour, SA; Frias, JP; Ahmed, A; Hardy, E; Choi, J; Sjostrom, CD; Guja, C in [Jabbour, Serge A.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA; [Frias, Juan P.] Natl Res Inst, Los Angeles, CA USA; [Ahmed, Azazuddin] Apex Med Res, Chicago, IL USA; [Hardy, Elise] AstraZeneca, Gaithersburg, MD USA; [Choi, Jasmine] Statum Res, Irvine, CA USA; [Sjostrom, C. David] AstraZeneca, Gothenburg, Sweden; [Guja, Cristian] Carol Davila Univ Med & Pharm, Bucharest, Romania published Efficacy and Safety Over 2 Years of Exenatide Plus Dapagliflozin in the DURATION-8 Study: A Multicenter, Double-Blind, Phase 3, Randomized Controlled Trial in 2020.0, Cited 17.0. Application In Synthesis of 1-Phenylurea. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

OBJECTIVE In patients with type 2 diabetes uncontrolled with metformin, exenatide once weekly (QW) plus dapagliflozin produced greater reductions in glycemic parameters (glycated hemoglobin [HbA(1c)], fasting plasma glucose [FPG], and 2-h postprandial glucose [2-h PPG]), weight, and systolic blood pressure (SBP) than exenatide QW or dapagliflozin alone after 28 weeks of treatment in DURATION-8. Following a 24-week extension period, improvements were sustained at 52 weeks. In this study, we investigated efficacy and safety at 104 weeks after randomization. RESEARCH DESIGN AND METHODS DURATION-8 was a 104-week, multicenter, double-blind, randomized, active-controlled, phase 3 trial. In total, 695 adults (aged >= 18 years) with type 2 diabetes and inadequate glycemic control (HbA(1c)8.0-12.0% [64-108 mmol/mol]) despite stable metformin monotherapy (>= 1,500 mg/day) were randomly assigned (1:1:1) to receive exenatide 2 mg QW plus once-daily dapagliflozin 10 mg, exenatide QW plus placebo, or dapagliflozin plus placebo. All 104-week evaluations were exploratory. RESULTS At week 104, 431 (62.0%) patients completed treatment. The adjusted least squares mean change (SE) from baseline to week 104 in HbA(1c)was greater with exenatide QW plus dapagliflozin (-1.70% [0.11]) versus exenatide QW plus placebo (-1.29% [0.12];P= 0.007) and dapagliflozin plus placebo (-1.06% [0.12];P< 0.001). Clinically relevant changes in FPG, 2-h PPG, weight, and SBP were also observed with exenatide QW plus dapagliflozin. There were no unexpected safety findings, and exenatide QW plus dapagliflozin was well tolerated, with no episodes of major hypoglycemia. CONCLUSIONS In this exploratory analysis, among those individuals who completed the trial without rescue therapy, there was clinically relevant efficacy over 2 years with exenatide QW plus dapagliflozin, with no unexpected safety findings. Welcome to talk about 64-10-8, If you have any questions, you can contact Jabbour, SA; Frias, JP; Ahmed, A; Hardy, E; Choi, J; Sjostrom, CD; Guja, C or send Email.. Application In Synthesis of 1-Phenylurea

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Thiomorpholine – Wikipedia,
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An article Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors WOS:000503114700006 published article about FAILURE; POTENT; PATHOPHYSIOLOGY; PAROXETINE; PREVENTS; GRKS in [Rowlands, Rachel A.; Waldschmidt, Helen V.; Larsen, Scott D.; White, Andrew D.] Univ Michigan, Vahlteich Med Chem Core, Coll Pharm, 428 Church St, Ann Arbor, MI 48109 USA; [Cato, M. Claire; Bouley, Renee A.] Univ Michigan, Life Sci Inst, Dept Pharmacol, 210 Washtenaw Ave, Ann Arbor, MI 48109 USA; [Cato, M. Claire; Bouley, Renee A.] Univ Michigan, Dept Biol Chem, 210 Washtenaw Ave, Ann Arbor, MI 48109 USA; [Chen, Qiuyan; Avramova, Larisa; Tesmer, John J. G.] Purdue Univ, Dept Biol Sci, 915 W State St, W Lafayette, IN 47907 USA; [Chen, Qiuyan; Avramova, Larisa; Tesmer, John J. G.] Purdue Univ, Dept Med Chem, 915 W State St, W Lafayette, IN 47907 USA; [Chen, Qiuyan; Avramova, Larisa; Tesmer, John J. G.] Purdue Univ, Dept Mol Pharmacol, 915 W State St, W Lafayette, IN 47907 USA in 2019, Cited 38. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Computed Properties of C7H8N2O

The ability of G protein-coupled receptor (GPCR) kinases (GRKs) to regulate desensitization of GPCRs has made GRK2 and GRK5 attractive targets for treating heart failure and other diseases such as cancer. Although advances have been made toward developing inhibitors that are selective for GRK2, there have been far fewer reports of GRK5 selective compounds. Herein, we describe the development of GRK5 subfamily selective inhibitors, 5 and 16d that covalently interact with a nonconserved cysteine (Cys474) unique to this subfamily. Compounds 5 and 16d feature a highly amenable pyrrolopyrimidine scaffold that affords high nanomolar to low micromolar activity that can be easily modified with Michael acceptors with various reactivities and geometries. Our work thereby establishes a new pathway toward further development of subfamily selective GRK inhibitors and establishes Cys474 as a new and useful covalent handle in GRK5 drug discovery.

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Thiomorpholine – Wikipedia,
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Name: 2-Aminobenzamide. Recently I am researching about SOLUBLE FLUORESCENT-PROBE; ON CHEMOSENSOR; SENSOR; WATER; IONS; HOCL; PH, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21676124, 21878131]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Li, YY; Liu, L; Tang, Y; Wang, Y; Han, J; Ni, L. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

In this study, a new fluorescence probe HMAQ based on quinazoline and diaminomaleonitrile was constructed for sensing ClO- and Al3+. A fluorescence blue-shift with 102 nm together with a color change from golden-yellow to colorless was found by hypochlorite-induced hydrolysis of -CH = N- group to release the initial fluorophore. Besides, Al3+ could cause a 72-nm blue-shifted emission spectra and a color change from golden-yellow to brown. As expected, HMAQ exhibited a satisfactory selectivity and sensitivity to ClO-/Al3+ with a quick response. Most notably, the reversibility of the [HMAQ+Al3+] complex could be used to detect ClO- and Al3+ simultaneously without mutual interferences. The detection limits of HMAQ for ClO- and Al3+ were turned out to be 102 nM and 1.56 nM, respectively. The high-performance results of real-time detections demonstrated the enormous potential of HMAQ in real-water samples and living cells. (C) 2020 Published by Elsevier B.V.

Name: 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Li, YY; Liu, L; Tang, Y; Wang, Y; Han, J; Ni, L or send Email.

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Thiomorpholine – Wikipedia,
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Application In Synthesis of 1-Phenylurea. In 2020.0 J CHROMATOGR A published article about LIQUID-CHROMATOGRAPHY; CLASSIFICATION; PURIFICATION; SELECTIVITY; RETENTION; SYSTEM; SFC in [Jiang, Dasen; Ke, Yanxiong; Cai, Jianfeng; Zhang, Huanhuan; Fu, Qing; Jin, Yu; Liang, Xinmiao] East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China; [Liang, Xinmiao] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Key Lab Nat Med, Dalian 116023, Liaoning, Peoples R China in 2020.0, Cited 29.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

In recent years, supercritical fluid chromatography (SFC) has become a powerful tool in modern analytical chemistry, and the diversity of stationary phases in SFC promotes phenyl-type phases to confront with a significant resurgence of interest. In this paper, a series of phenyl-type stationary phases with different substituted benzenes involving N-propylbenzamide (PB), 4-fluoro-N-propylbenzamide (PB-F), and 4-ethyl-N-propylbenzamide (PB-ET) were synthesized. Retention mechanism of these phases in SFC was investigated using a linear solvation energy relationship (LSER) model. The phenyl-type stationary phases with all positive parameters can provide all types of interaction, typically involving hydrogen bonding, dipole-dipole and dispersive interactions. The different benzene’s substituents of the stationary phases mainly affected their hydrogen bonding and dipole-dipole interactions, which could be reflected by the angle between the solvation vectors to some extent. The k-k plot showed that the selectivity difference of phenyl-type stationary phases was closely related to the type of solute. Thus, based on twenty-five natural phenolic compounds, two systems with high orthogonality (63.49%) were constructed using three columns, namely phenyl column (PHE) x PB-F and PB x PB-F. Finally, after investigating the influence of chromatographic conditions, ten flavonoids could be separated by using PB, PB-F and PHE columns in SFC. (C) 2019 Published by Elsevier B.V.

Application In Synthesis of 1-Phenylurea. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

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Thiomorpholine – Wikipedia,
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Recently I am researching about PHARMACOLOGICAL CHAPERONES; DESIGN; AZASUGARS; ENZYMES, Saw an article supported by the National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21772031, 21778013]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Sun, JJ; Kang, YQ; Gao, LG; Lu, X; Ju, HH; Li, XL; Chen, H. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. SDS of cas: 88-68-6

A series of novel tricyclic quinazolinone-iminosugars 1 (a-c) were synthesized from the benzyl protected sugars through three steps. Firstly, the benzyl protected sugar (aldehyde) 5 reacted with o-aminobenzamide by the iodine-induced oxidative condensation to afford the corresponding aldo-quizanolinone 6. Secondly, through the intramolecular cyclization of the unprotected OH and the amide NH in 6, the tricyclic compounds 7 and 8 were constructed by the key Mitsunobu reaction. Finally, removal of the benzyl group gave the target tricyclic quinazolinone-iminosugars 1. The protocol was effective for the preparation of the tricyclic iminosugars in satisfactory yield. Interestingly, an unusual C-2 epimerization was observed with D-mannose and D-ribose compounds under the conditions of the Mitsunobu reaction that generated the products having the trans configuration at the C-2 and C-3 positions. Unfortunately, such tricyclic quinazolinone-iminosugars showed no inhibitory effects on the tested five glycosidases.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 88-68-6. I found the field of Chemistry very interesting. Saw the article Design and synthesis of novel sulphamide tethered quinazolinone hybrids as potential antitumor agents published in 2019, Reprint Addresses Nagarapu, L (corresponding author), CSIR Indian Inst Chem Technol, Fluoro Agrochem Div 2, Hyderabad 500007, India.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide.

In an attempt to develop potential and selective antitumor agents, a series of novel sulphamide tethered quinazolinone hybrids were efficiently synthesized and evaluated for antitumor activity against four cancer cell lines such as HeLa (cervical), MDA-MB-231 (breast), PANC-1 (pancreatic), and A549 (lung) in vitro. All the compounds (5a-j, 6a-g) exhibited significant anti-proliferative activity with GI(50) values ranging from 0.045 to 6.94 mu M, while compound 10c showed potent activity against all the cell lines (He La, MDA-MB-231, PANC-1 and A549) with GI(50) values ranging from 0.09 to 0.21 mu M. We have explored the binding mode and key active site interactions in HDAC8 and EHMT2 proteins. The docking results are complementary to the experimental results. (C) 2019 Elsevier B.V. All rights reserved.

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Thiomorpholine – Wikipedia,
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I found the field of Chemistry; Science & Technology – Other Topics; Engineering very interesting. Saw the article Solvent-Free, Mechanochemically Scalable Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Using Bronsted Acid Catalyst published in 2019. Recommanded Product: 88-68-6, Reprint Addresses Saha, S (corresponding author), Inst Chem Technol, Dept Dyestuff Technol, Mumbai 400019, Maharashtra, India.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

Although the synthesis of novel N-heterocyclic molecules is extremely demanding as well as challenging, the involvement of toxic solvents often triggers environmental safety concerns, resulting in process-engineering challenges. Herein, we have demonstrated a rapid, environmentally benign and energy efficient scalable method for the synthesis of 2,3-dihydroquinazolin-4(1H)-one by grinding in a mortar pestle as well as mechanochemically via ball milling using p-TSA catalyst. The ability to accomplish the reaction in the absence of solvent via grinding or milling with p-TSA catalyst, with an immediate reduction in the cost and operational procedures, features the significant advantages of this protocol. The scalability and significance of the operational parameters during mechanochemical milling in the tubular ball mill were also demonstrated. Excellent yield in short duration, large substrate scope, product scalability, and easy recoverability are the prime features of this mechanochemical solvent-free protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-one. The study also demonstrated the significant role of ball diameter to improve the efficiency of the milling operation in this mechanochemical synthesis.

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Thiomorpholine – Wikipedia,
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Product Details of 88-68-6. Authors Peng, J; Hu, LD; Chen, MW; Deng, ZH; Peng, YY in GEORG THIEME VERLAG KG published article about in [Peng, Yiyuan] Jiangxi Normal Univ, Minist Educ, Key Lab Small Funct Organ Mol, Nanchang 330022, Jiangxi, Peoples R China; Jiangxi Normal Univ, Key Lab Green Chem, Nanchang 330022, Jiangxi, Peoples R China in 2021, Cited 41. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A highly selective difluoromethylation of quinazolines has been achieved by using commercially available ethyl bromodifluoroacetate as difluorocarbene precursor, providing the corresponding difluoromethyl substituted quinazoline derivatives with up to 83% yield.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem