Tag: M.W=100-150

An article Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the Selectivity Pocket, Substrate-Binding Site, and NAD(+)-Binding Site WOS:000473251200008 published article about HISTONE DEACETYLASE SIRT6; GLUCOSE-HOMEOSTASIS; TUMOR-SUPPRESSOR; PROTEIN; CANCER; PROMOTES; PGC-1-ALPHA; ACTIVATION; CHROMAN-4-ONE; ACETYLATION in [Mellini, Paolo; Itoh, Yukihiro; Elboray, Elghareeb E.; Li, Ying; Suzuki, Miki; Takahashi, Yukari; Tojo, Toshifumi; Kurohara, Takashi; Miyake, Yuka; Kitao, Yuki; Kotoku, Masayuki; Iida, Tetsuya; Suzuki, Takayoshi] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Sakyo Ku, 1-5 Shimogamohangi Cho, Kyoto 6060823, Japan; [Elboray, Elghareeb E.] South Valley Univ, Fac Sci, Chem Dept, Qena 83523, Egypt; [Tsumoto, Hiroki; Miura, Yuri] Tokyo Metropolitan Inst Gerontol, Res Team Mech Aging, Itabashi Ku, 35-2 Sakae Cho, Tokyo 1730015, Japan; [Suzuki, Takayoshi] Japan Sci & Technol Agcy JST, CREST, 4-1-8 Honcho Kawaguchi, Saitama 3320012, Japan in 2019, Cited 90. Quality Control of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The NAD(+)-dependent deacetylase SIRT2 represents an attractive target for drug development. Here, we designed and synthesized drug-like SIRT2-selective inhibitors based on an analysis of the putative binding modes of recently reported SIRT2-selective inhibitors and evaluated their SIRT2-inhibitory activity. This led us to develop a more drug-like diketopiperazine structure as a hydrogen bond (H-bond) hunter to target the substrate-binding site of SIRT2. Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the selectivity pocket of SIRT2, exhibited potent SIRT2-selective inhibition. Inhibition of SIRT2 by 53 was mediated by the formation of a 53-ADP-ribose conjugate, suggesting that 53 is a mechanism-based inhibitor targeting the selectivity pocket, substrate-binding site, and NAD(+)-binding site. Furthermore, 53 showed potent antiproliferative activity toward breast cancer cells and promoted neurite outgrowth of Neuro-2a cells. These findings should pave the way for the discovery of novel therapeutic agents for cancer and neurological disorders.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. In 2020 FRONT CHEM published article about DEPENDENT RNA-POLYMERASE; SOLUBILITY MEASUREMENT; BVDV INFECTION; PESTIVIRUS; AGENTS; REPLICATION; DISCOVERY; ACCURACY; DISEASE; TARGETS in [Fernandez, Gabriela A.; Fidalgo, Daniela M.; Adler, Natalia S.; Battini, Leandro; Bollini, Mariela] Ctr Invest Bionanociencias CIBION, Lab Quim Med, Consejo Nacl Invest Cient Tecn CONICET, Buenos Aires, DF, Argentina; [Castro, Eliana F.] Ctr Invest Ciencias Vet & Agro, Inst Virol & Innovac Tecnol, Inst Nacl Tecnol Agropecuaria, Consejo Nacl Invest Cient & Tecn CONICET, Buenos Aires, DF, Argentina; [Castro, Eliana F.; Espana de Marco, Maria J.] Univ Buenos Aires, Fac Farm & Bioquim, Dept Microbiol Inmunol Biotecnol & Genet, Buenos Aires, DF, Argentina; [Rosas, Rocio A.; Fabiani, Matias; Cavallaro, Lucia V.] Univ Buenos Aires, Inst Invest Bacteriol & Virol Mol IBaViM, Dept Microbiol Inmunol Biotecnol & Genet, Catedra Virol,Fac Farm & Bioquim, Buenos Aires, DF, Argentina; [Rosas, Rocio A.; Fabiani, Matias] Consejo Nacl Invest Cient & Tecn CONICET, Buenos Aires, DF, Argentina; [Bruno, Ana M.] Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Organ, Buenos Aires, DF, Argentina in 2020, Cited 54. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Bovine viral diarrhea virus (BVDV) belongs to the Pestivirus genus (Flaviviridae). In spite of the availability of vaccines, the virus is still causing substantial financial losses to the livestock industry. In this context, the use of antiviral agents could be an alternative strategy to control and reduce viral infections. The viral RNA-dependent RNA polymerase (RdRp) is essential for the replication of the viral genome and constitutes an attractive target for the identification of antiviral compounds. In a previous work, we have identified potential molecules that dock into an allosteric binding pocket of BVDV RdRp via a structure-based virtual screening approach. One of them, N-(2-morpholinoethyl)-2-phenylquinazolin-4-amine [1, 50% effective concentration (EC50) = 9.7 +/- 0.5 mu M], was selected to perform different chemical modifications. Among 24 derivatives synthesized, eight of them showed considerable antiviral activity. Molecular modeling of the most active compounds showed that they bind to a pocket located in the fingers and thumb domains in BVDV RdRp, which is different from that identified for other non-nucleoside inhibitors (NNIs) such as thiosemicarbazone (TSC). We selected compound 2-[4-(2-phenylquinazolin-4-yl)piperazin-1-yl]ethanol (1.9; EC50 = 1.7 +/- 0.4 mu M) for further analysis. Compound 1.9 was found to inhibit the in vitro replication of TSC-resistant BVDV variants, which carry the N264D mutation in the RdRp. In addition, 1.9 presented adequate solubility in different media and a high-stability profile in murine and bovine plasma.

Category: thiomorpholine. Welcome to talk about 88-68-6, If you have any questions, you can contact Fernandez, GA; Castro, EF; Rosas, RA; Fidalgo, DM; Adler, NS; Battini, L; de Marco, MEJ; Fabiani, M; Bruno, AM; Bollini, M; Cavallaro, LV or send Email.

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Thiomorpholine – Wikipedia,
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An article Solvent-Free, Mechanochemically Scalable Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Using Bronsted Acid Catalyst WOS:000480370500099 published article about QUINAZOLINONE; MECHANOSYNTHESIS; CHEMISTRY; GREEN; COMPLEXES; HYDROXIDE; EFFICIENT; PROTOCOL; BENIGN; UREAS in [Yashwantrao, Gauravi; Jejurkar, Valmik P.; Kshatriya, Rajpratap; Saha, Satyajit] Inst Chem Technol, Dept Dyestuff Technol, Mumbai 400019, Maharashtra, India in 2019, Cited 76. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Product Details of 88-68-6

Although the synthesis of novel N-heterocyclic molecules is extremely demanding as well as challenging, the involvement of toxic solvents often triggers environmental safety concerns, resulting in process-engineering challenges. Herein, we have demonstrated a rapid, environmentally benign and energy efficient scalable method for the synthesis of 2,3-dihydroquinazolin-4(1H)-one by grinding in a mortar pestle as well as mechanochemically via ball milling using p-TSA catalyst. The ability to accomplish the reaction in the absence of solvent via grinding or milling with p-TSA catalyst, with an immediate reduction in the cost and operational procedures, features the significant advantages of this protocol. The scalability and significance of the operational parameters during mechanochemical milling in the tubular ball mill were also demonstrated. Excellent yield in short duration, large substrate scope, product scalability, and easy recoverability are the prime features of this mechanochemical solvent-free protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-one. The study also demonstrated the significant role of ball diameter to improve the efficiency of the milling operation in this mechanochemical synthesis.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of 2-Aminobenzamide. Moslin, R; Zhang, YL; Wrobleski, ST; Lin, SQ; Mertzman, M; Spergel, S; Tokarski, JS; Strnad, J; Gillooly, K; McIntyre, KW; Zupa-Fernandez, A; Cheng, LH; Sun, HD; Chaudhry, C; Huang, C; D’Arienzo, C; Heimrich, E; Yang, XX; Muckelbauer, JK; Chang, C; Tredup, J; Mulligan, D; Xie, DL; Aranibar, N; Chiney, M; Burke, JR; Lombardo, L; Carter, PH; Weinstein, DS in [Moslin, Ryan; Zhang, Yanlei; Wrobleski, Stephen T.; Lin, Shuqun; Mertzman, Michael; Spergel, Steven; Lombardo, Louis; Carter, Percy H.; Weinstein, David S.] Bristol Myers Squibb Res & Dev, Immunosci Discovery Chem, POB 4000, Princeton, NJ 08543 USA; [Strnad, Joann; Gillooly, Kathleen; McIntyre, Kim W.; Zupa-Fernandez, Adriana; Cheng, Lihong; Heimrich, Elizabeth; Yang, Xiaoxia; Burke, James R.] Bristol Myers Squibb Res & Dev, Immunosci Discovery Biol, POB 4000, Princeton, NJ 08543 USA; [Tokarski, John S.; Muckelbauer, Jodi K.; Chang, ChiehYing; Tredup, Jeffrey; Mulligan, Dawn; Xie, Dianlin] Bristol Myers Squibb Res & Dev, Mol Struct & Design, Mol Discovery Technol, POB 4000, Princeton, NJ 08543 USA; [Sun, Huadong; Huang, Christine; D’Arienzo, Celia; Aranibar, Nelly; Chiney, Manoj] Bristol Myers Squibb Res & Dev, Lead Discovery & Optimizat, POB 4000, Princeton, NJ 08543 USA; [Chaudhry, Charu] Bristol Myers Squibb Res & Dev, Metab & Pharmacokinet Dept, Pharmaceut Candidate Optimizat, POB 4000, Princeton, NJ 08543 USA; [Weinstein, David S.] Vividion Therapeut Inc, Chem, 5820 Nancy Ridge Dr, San Diego, CA 92121 USA published Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2) in 2019, Cited 53. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

As a member of the Janus OAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide 4, identified by a SPA-based high-throughput screen targeting the TYK2 pseudokinase domain, potently inhibits IL-23 and IFN alpha signaling in cellular assays. The described work details the optimization of this poorly selective hit (4) to potent and selective molecules such as 47 and 48. The discoveries described herein were critical to the eventual identification of the clinical TYK2 JH2 inhibitor (see following report in this issue). Compound 48 provided robust inhibition in a mouse IL-12-induced IFN gamma pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model. These results demonstrate the ability of TYK2 JH2 domain binders to provide a highly selective alternative to conventional TYK2 orthosteric inhibitors.

Welcome to talk about 88-68-6, If you have any questions, you can contact Moslin, R; Zhang, YL; Wrobleski, ST; Lin, SQ; Mertzman, M; Spergel, S; Tokarski, JS; Strnad, J; Gillooly, K; McIntyre, KW; Zupa-Fernandez, A; Cheng, LH; Sun, HD; Chaudhry, C; Huang, C; D’Arienzo, C; Heimrich, E; Yang, XX; Muckelbauer, JK; Chang, C; Tredup, J; Mulligan, D; Xie, DL; Aranibar, N; Chiney, M; Burke, JR; Lombardo, L; Carter, PH; Weinstein, DS or send Email.. Safety of 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article 2-Styryl-4-aminoquinazoline derivatives as potent DNA-cleavage, p53-activation and in vivo effective anticancer agents WOS:000509616800015 published article about MUTANT P53; CANCER-CELLS; CP-31398; RESEARCHES; GROWTH; IDENTIFICATION; INHIBITORS; BINDING; PROTEIN; TARGET in [Wei, Xin-Wei; Yuan, Jing-Mei; Chen, Nan-Ying; Li, Xiao-Juan; Pan, Cheng-Xue; Mo, Dong-Liang; Su, Gui-Fa] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China; [Huang, Wan-Yun] Guilin Med Univ, Dept Pharmacol, Guilin 541004, Peoples R China in 2020, Cited 39. Safety of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Forty-eight analogues of CP-31398, an antitumor agent modulated the mutant p53 gene were synthesized and their cytotoxicities against four cancer cell lines with different p-53 status including bladder cell 724 (w-p53), gastric cell MGC-803 (m-p53), prostate cell DU145 (m-p53), prostate cell PC-3 (null-p53), lung cell A549 (w-p53) and normal liver cell line HL-7702 (w-p53) were examined. (E)-2-(4-Nitrostyryl)-4-(3-dimethylaminopropyl)-aminoquinazoline (10ah) was identified as the most potent compound in anti-proliferation against MGC-803 cells, with IC50 lowed to 1.73 mu M, far potency than that of CP-31398. Molecular mechanism study revealed that 10ah and CP-31398 differ greatly in mechanism to exert their antitumor properties. 10ah could intercalate into DNA and resulted in significant DNA double-strand break 10ah-treatment in MGC-803 cells increased the expression of p53, phosphorylated p53 (p-p53), CDK4, p21 to cause cell cycle arrest at G2/M phase, significantly up-regulated the levels of pro-apoptosis proteins Bak, Bax, Bim while down-regulated the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1, fluctuated the intracellular reactive oxygen species (ROS), Ca2+ and mitochondria! membrane potential, activated Caspase-9 and Caspase-3 to induce apoptosis. 10ah also displayed potent anticancer efficiency against MGC-803 xenograft tumors models, with tumor growth inhibition (TGI) up to 61.8% at 20 mg/kg without obvious toxicity. (C) 2019 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 88-68-6, If you have any questions, you can contact Wei, XW; Yuan, JM; Huang, WY; Chen, NY; Li, XJ; Pan, CX; Mo, DL; Su, GF or send Email.. Safety of 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Lehmann, DM; Camp, AA in [Lehmann, David M.] US EPA, Ctr Publ Hlth & Environm Assessment CPHEA, Hlth & Environm Effects Assessment Div, Integrated Hlth Assessment Branch, Durham, NC 27709 USA; [Camp, Allison A.] Oak Ridge Associated Univ, Oak Ridge, TN USA published A systematic scoping review of the methodological approaches and effects of pesticide exposure on solitary bees in 2021, Cited 108. Quality Control of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Background Pollination services provided by solitary bees, the largest group of bees worldwide, are critical to the vitality of ecosystems and agricultural systems alike. Disconcertingly, bee populations are in decline, and while no single causative factor has been identified, pesticides are believed to play a role in downward population trends. The effects of pesticides on solitary bee species have not been previously systematically cataloged and reviewed. Objectives This systematic scoping review examines available evidence for effects of pesticide exposure on solitary bees to identify data gaps and priority research needs. Methods A systematic literature search strategy was developed to identify and document reports on solitary bee pesticide exposure-effects investigations. Literature was subsequently screened for relevance using a Population, Exposures, Comparators, and Outcomes (PECO) statement and organized into a systematic evidence map. Investigations were organized by effect category (lethal effects on immatures, lethal effects on adults, sublethal effects on immatures, and sublethal effects on adults), species, pesticide class, and publication year. Results A comprehensive literature search of Web of Science and ProQuest Agricultural & Environmental Science supplemented by targeted internet searching and reference mining yielded 176 reports and publications for title and abstract screening and 65 that met PECO criteria (22 included lethal and 43 included sublethal effects endpoints). Relevant design details (pesticide, test compound configuration, study type, species, sex, exposure duration) were extracted into literature inventory tables to reveal the extent endpoints have been investigated and areas in need of additional research. Conclusions Evidence mapping revealed diversity in the pesticides and endpoints studied across the database. However, dilution across bee species, lack of complementary laboratory work and paucity of replicated investigations complicate efforts to interpret and apply available data to support pesticide risk assessment.

Quality Control of 2-Aminobenzamide. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 2-Aminobenzamide. Recently I am researching about 1,2,3-BENZOTRIAZIN-4-ONE DERIVATIVES; NEMATOCIDAL ACTIVITIES; INDOLES; 1-ALKYNES; RV1885C; 2-HETEROARYL; DOCKING; PROTEIN; 2-ARYL, Saw an article supported by the DST, IndiaDepartment of Science & Technology (India) [IF160590]; DBT, New Delhi, IndiaDepartment of Biotechnology (DBT) India [BT/PR12817/COE/34/23/2015]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria. A series of 3-indolylmethyl substituted pyrazolo-triazinone derivatives were designed and docked into CM in silico as potential inhibitors. These compounds were efficiently synthesized using the Pd/Cu-catalyzed coupling-cyclization in a single pot involving the construction of indole ring. The methodology was later extended to the preparation of corresponding benzo analogs of pyrazolotriazinones i.e. 3-indolylmethyl substituted benzotriazinone derivatives. Several of these novel compounds showed significant inhibition of CM when tested in vitro at 30 mu M. The SAR (Structure-Activity-Relationship) studies suggested that benzotriazinone moiety was more favorable over the pyrazolotriazinone ring. The two best active compounds showed IC50 similar to 0.4-0.9 mu M (better than the reference/known compounds used) and no toxicity till 30 mu M in vitro.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article N-donor 2-(Sulfonamido)benzamide ligands, their palladium(II) coordination species and C-C coupling catalysis efficiencies WOS:000487932000035 published article about SUZUKI-MIYAURA REACTION; PRE-CATALYSTS; COMPLEXES; ARYL; CHLORIDES; NANOPARTICLES; IMIDAZOLE; NICKEL; SERIES in [Oloyede, Hammed Olawale; Woods, Joseph Anthony Orighomisan] Univ Ibadan, Dept Chem, Inorgan Chem Unit, Ibadan, Nigeria; [Oloyede, Hammed Olawale; Goerls, Helmar; Plass, Winfried; Eseola, Abiodun Omokehinde] Friedrich Schiller Univ Jena, Inst Anorgan & Analyt Chem, Humboldtstr 8, D-07743 Jena, Germany; [Eseola, Abiodun Omokehinde] Redeemers Univ Ede, Dept Chem Sci, Mat Chem Grp, Ede, Osun State, Nigeria in 2019, Cited 51. SDS of cas: 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A series of synthetically accessible ligands based on new 2-(R-sulfonamido)benzamide have been prepared (R = methyl for H3M; R = 4-toly for H3T and T2CN; R = 2,4,6-triisopropylphenyl for H(3)iP and HiPCN). The R-substituents were selected to vary in sizes. Allowing ligand H(3)iP and palladium acetate to stand in solvent leads to self-assembly of the well-defined solvent- and stoichiometry-controlled tetranuclear or hexanuclear coordination macromolecules Pd-4(iP)(2) and (PdHiP)(6), which were analysed by X-ray crystallography. It was observed that palladium active species for Suzuki coupling catalysis could be stabilized by these simple and synthetically assessable N-donor ligands as revealed by turnover frequencies reaching 5500h(-1). Electronic features of these N-donors appear to be more important than the steric properties. (C) 2019 Elsevier B.V. All rights reserved.

SDS of cas: 88-68-6. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Keivanloo, A; Bakherad, M; Mokhtarei, L in [Keivanloo, Ali; Bakherad, Mohammad; Mokhtarei, Lotfollah] Shahrood Univ Technol, Fac Chem, Shahrood 3619995161, Iran published Sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate an efficient ligand for click reaction in water: Synthesis of 1,2,3-triazole pharmacophore linked-quinazolinone scaffold in 2020, Cited 42. SDS of cas: 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Water soluble sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate ligand was used successfully for the preparation of 1,2,3-triazoles pharmacophore linked-quinazolinone scaffold. The reaction of ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate and related amide compounds with propargyl bromide afforded ethyl 4-oxo-3-(prop-2-yn-1-yl)-3,4-dihydroquinazoline-2-carboxylate and its amide derivatives. The reaction of propargylated compounds with azides catalyzed by copper (II) salt, in the presence of Sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate as a ligand in water produced novel 1,2,3-triazole pharmacophore linked-quinazolinone-4-one scaffold with high-to-excellent yields. The ligand assisted in the click reaction and reduced loading of copper salt to 2 mol%. Simplicity, short reaction times, use of water as green solvent, and low catalyst loading are the main advantages of this procedure.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2020.0 EUR J ORG CHEM published article about CALCIUM-CHANNEL BLOCKERS; HETEROCYCLIC CARBENE; KINETIC RESOLUTION; STEREOSELECTIVE-SYNTHESIS; COOPERATIVE CATALYSIS; ASYMMETRIC-SYNTHESIS; REDOX AMIDATIONS; ACID-ESTERS; ALDEHYDES; POTENT in [Brandolese, Arianna; Ragno, Daniele; Leonardi, Costanza; Bortolini, Olga; De Risi, Carmela; Massi, Alessandro] Univ Ferrara, Dept Chem & Pharmaceut Sci, Via L Borsari 46, I-44121 Ferrara, Italy; [Di Carmine, Graziano] Univ Manchester, Sch Chem Engn & Analyt Sci, Sackville St, Manchester M13 9PL, Lancs, England in 2020.0, Cited 92.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. SDS of cas: 64-10-8

The oxidative N-acylation reaction of 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) with enals and N-heterocyclic carbene (NHC) catalysts is described. The reaction proceeds in the presence of quinone oxidant without additional acyl transfer agents and in the asymmetric variant produces pharmaceutically relevant N3-acylated products with good-to-moderate enantioselectivity.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem