Tag: M.W=100-150

Fan, ZJ; Shi, J; Luo, N; Bao, XP in [Fan, Zhijiang; Shi, Jun; Luo, Na; Bao, Xiaoping] Guizhou Univ, Ctr Res & Dev Fine Chem, Minist Educ,Key Lab Green Pesticide & Agr Bioengn, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Guizhou, Peoples R China published Synthesis, crystal structure and antimicrobial activity of 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives against phytopathogens in 2019, Cited 29. Recommanded Product: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A total of eighteen 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives were designed and synthesized, via hybrid pharmacophore approach. Among these compounds, chemical structure of compound 4a was unambiguously confirmed by means of single-crystal X-ray diffraction analysis. All the compounds were evaluated in vitro for their inhibition activity against several important phytopathogenic bacteria and fungi in agriculture. The obtained results indicated that several compounds demonstrated potent antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo). For example, compounds 4c, 4g and 4q had EC50 values of 35.0, 36.5 and 32.4 mu g/mL toward this bacterium, respectively, around 1.5 times more active than commercial bactericide bismerthiazol (EC50 = 89.8 mu g/mL). Additionally, compounds 4j and 4p were found to display comparable antifungal activity against Gloeosporium fructigenum at 50 mu g/mL, to commercial fungicide hymexazol. Finally, the relationships between antibacterial activities and molecular structures of this class of compounds were discussed in detail. [GRAPHICS] .

About 2-Aminobenzamide, If you have any questions, you can contact Fan, ZJ; Shi, J; Luo, N; Bao, XP or concate me.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Dabiri, M; Lehi, NF; Movahed, SK; Khavasi, HR in WILEY-V C H VERLAG GMBH published article about C-H; NATURAL-PRODUCTS; ACYLATION; QUINAZOLINONES; ALDEHYDES; QUINAZOLIN-4(3H)-ONES; ANILIDES; BONDS in [Dabiri, Minoo; Lehi, Noushin Farajinia; Movahed, Siyavash Kazemi; Khavasi, Hamid Reza] Shahid Beheshti Univ, Fac Chem & Petr Sci, Dist 1,Daneshjou Blvd, Tehran 1983969411, Tehran Province, Iran in 2019, Cited 38. Safety of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The palladium-catalyzed cross-dehydrogenative coupling (CDC) followed by an intramolecular cyclization between arylquinazolinones and aldehydes has been described. This viable transformation provides a variety of novel substituted hydroxyisoindolo[1,2-b]quinazolinone compounds in moderate to good yields. Additionally, the reaction is performed with toluene in place of benzaldehyde by using an excess amount of tert-butyl hydroperoxide (TBHP) as the oxidant in good yield.

Safety of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Dabiri, M; Lehi, NF; Movahed, SK; Khavasi, HR or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Cheng, DP; Yan, XH; Pu, YQ; Shen, J; Xu, XL; Yan, JZ in WILEY-V C H VERLAG GMBH published article about CATALYZED SYNTHESIS; METAL-FREE; DERIVATIVES; QUINAZOLINONES; CYCLIZATION; ALDEHYDES; 2,3-DIHYDRO-4(1H)-QUINAZOLINONES; INHIBITORS; EFFICIENT; CHLORIDE in [Cheng, Dongping; Yan, Xianhang; Pu, Yueqi; Shen, Jing; Yan, Jizhong] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China; [Xu, Xiaoliang] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China in 2021, Cited 56. Category: thiomorpholine. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

An efficient tandem oxidative annulation for the synthesis of 2,2-disubstituted 2,3-dihydroquinazolin-4(1H)-ones via DDQ-mediated dual cross-dehydrogenative-coupling (CDC) reactions is described. This transformation proceeds from easily available o-aminobenzamides and 1,3-diarylpropenes under mild conditions, and the corresponding products are obtained in moderate to excellent yields.

About 2-Aminobenzamide, If you have any questions, you can contact Cheng, DP; Yan, XH; Pu, YQ; Shen, J; Xu, XL; Yan, JZ or concate me.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Kudale, VS; Wang, JJ in ROYAL SOC CHEMISTRY published article about PALLADIUM-CATALYZED ALKYLATION; THERMAL OXIDATIVE-DEGRADATION; POLYETHYLENE-GLYCOL; STEREOSELECTIVE-SYNTHESIS; SELECTIVE ALKYLATION; ALPHA-METHYLATION; C(SP(3))-H BONDS; METHANOL; ARYLACRYLAMIDES; HETEROCYCLES in [Kudale, Vishal Suresh; Wang, Jeh-Jeng] Kaohsiung Med Univ, Dept Med & Appl Chem, 100,Shiquan 1st Rd, Kaohsiung 807, Taiwan; [Wang, Jeh-Jeng] Kaohsiung Med Univ Hosp, Dept Med Res, 100 Tzyou 1st Rd, Kaohsiung 807, Taiwan in 2020, Cited 59. Category: thiomorpholine. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O-2 and TsOH center dot H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Kudale, VS; Wang, JJ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Synthesis, crystal structure and antimicrobial activity of 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives against phytopathogens published in 2019. Application In Synthesis of 2-Aminobenzamide, Reprint Addresses Bao, XP (corresponding author), Guizhou Univ, Ctr Res & Dev Fine Chem, Minist Educ,Key Lab Green Pesticide & Agr Bioengn, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Guizhou, Peoples R China.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A total of eighteen 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives were designed and synthesized, via hybrid pharmacophore approach. Among these compounds, chemical structure of compound 4a was unambiguously confirmed by means of single-crystal X-ray diffraction analysis. All the compounds were evaluated in vitro for their inhibition activity against several important phytopathogenic bacteria and fungi in agriculture. The obtained results indicated that several compounds demonstrated potent antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo). For example, compounds 4c, 4g and 4q had EC50 values of 35.0, 36.5 and 32.4 mu g/mL toward this bacterium, respectively, around 1.5 times more active than commercial bactericide bismerthiazol (EC50 = 89.8 mu g/mL). Additionally, compounds 4j and 4p were found to display comparable antifungal activity against Gloeosporium fructigenum at 50 mu g/mL, to commercial fungicide hymexazol. Finally, the relationships between antibacterial activities and molecular structures of this class of compounds were discussed in detail. [GRAPHICS] .

Application In Synthesis of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Fan, ZJ; Shi, J; Luo, N; Bao, XP or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

HPLC of Formula: C7H8N2O. I found the field of Neurosciences & Neurology very interesting. Saw the article Exploring Cerebrospinal Fluid IgG N-Glycosylation as Potential Biomarker for Amyotrophic Lateral Sclerosis published in 2019, Reprint Addresses Costa, J (corresponding author), Univ Nova Lisboa, Lab Glycobiol, Inst Tecnol Quim & Biol Antonio Xavier, Ave Republ, P-2780157 Oeiras, Portugal.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide.

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which the existing candidate biomarkers (neurofilaments) have low specificity. Changes in blood IgG N-glycosylation have been observed in several diseases, including ALS, whereas cerebrospinal fluid (CSF) IgG has been less studied. Here, we characterized N-glycans of CSF IgG from ALS patients in comparison with a control group of other neurological diseases. Cerebrospinal fluid was collected from patients with ALS (n=26) and other neurological diseases (n=10). N-Glycans were released from CSF purified IgG with peptide N-glycosidase F, labeled with 2-aminobenzamide and analyzed by NP-HPLC chromatography in combination with exoglycosidase digestion and MALDI-TOF mass spectrometry. The N-glycosylation profile of ALS CSF IgG consisted of diantennary N-glycans predominantly with proximal fucose and some bisecting GlcNAc; agalacto-, mono-, and digalactosylated as well as alpha 2,6-sialylated structures were detected. Differences between ALS and control patients were observed; most relevant was the increase in ALS CSF IgG of the level of galactosylated structures defined here as Gal-index (median 46.87 and 40.50% for ALS and controls, respectively; p=0.006). The predictive value of the Gal-index (AUC=0.792, p=0.007) considering ROC analysis had potential utility as a diagnostic test for ALS and was comparable to that of phosphoneurofilament heavy chain (AUC=0.777, p=0.011), which was used as benchmark marker for our group of patients. The results provide the basis to further explore the potential of IgG N-glycan galactosylation as biomarker for ALS by using larger cohorts of patients and controls.

HPLC of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Costa, J; Streich, L; Pinto, S; Pronto-Laborinho, A; Nimtz, M; Conradt, HS; de Carvalho, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about PHARMACOLOGICAL CHAPERONES; DESIGN; AZASUGARS; ENZYMES, Saw an article supported by the National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21772031, 21778013]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Sun, JJ; Kang, YQ; Gao, LG; Lu, X; Ju, HH; Li, XL; Chen, H. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Quality Control of 2-Aminobenzamide

A series of novel tricyclic quinazolinone-iminosugars 1 (a-c) were synthesized from the benzyl protected sugars through three steps. Firstly, the benzyl protected sugar (aldehyde) 5 reacted with o-aminobenzamide by the iodine-induced oxidative condensation to afford the corresponding aldo-quizanolinone 6. Secondly, through the intramolecular cyclization of the unprotected OH and the amide NH in 6, the tricyclic compounds 7 and 8 were constructed by the key Mitsunobu reaction. Finally, removal of the benzyl group gave the target tricyclic quinazolinone-iminosugars 1. The protocol was effective for the preparation of the tricyclic iminosugars in satisfactory yield. Interestingly, an unusual C-2 epimerization was observed with D-mannose and D-ribose compounds under the conditions of the Mitsunobu reaction that generated the products having the trans configuration at the C-2 and C-3 positions. Unfortunately, such tricyclic quinazolinone-iminosugars showed no inhibitory effects on the tested five glycosidases.

Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Sun, JJ; Kang, YQ; Gao, LG; Lu, X; Ju, HH; Li, XL; Chen, H or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. Authors Wang, CC; Qu, YL; Liu, XH; Ma, ZW; Yang, B; Liu, ZJ; Chen, XP; Chen, YJ in AMER CHEMICAL SOC published article about in [Wang, Chuan-Chuan; Ma, Zhi-Wei; Liu, Zhi-Jing; Chen, Xiao-Pei] Henan Univ Anim Husb & Econ, Fac Sci, Zhengzhou 450044, Henan, Peoples R China; [Wang, Chuan-Chuan; Yang, Bo] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Henan, Peoples R China; [Qu, Ya-Li; Liu, Xue-Hua] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China; [Chen, Ya-Jing] Zhengzhou Univ, Minist Educ China, Sch Pharmaceut Sci, Key Lab Adv Drug Preparat Technol, Zhengzhou 450001, Henan, Peoples R China; [Chen, Ya-Jing] Zhengzhou Univ, Coinnovat Ctr Henan Prov New Drug R&D & Preclin S, Zhengzhou 450001, Henan, Peoples R China in 2021.0, Cited 57.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

The convenient preparation of N2-unprotected five-membered cyclic guanidines was achieved through a cascade [3 + 2] cycloaddition between organo-cyanamides and alpha-haloamides under mild conditions in good to excellent yields (up to 99%). The corresponding cyclic guanidines could be easily transformed into hydantoins via hydrolysis.

Category: thiomorpholine. About 1-Phenylurea, If you have any questions, you can contact Wang, CC; Qu, YL; Liu, XH; Ma, ZW; Yang, B; Liu, ZJ; Chen, XP; Chen, YJ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis of Novel Tetra-Substituted Pyrazole Derivatives from 2,3-Furandione WOS:000488560500006 published article about BIOLOGICAL EVALUATION; 1,3,5-TRISUBSTITUTED PYRAZOLES; ANTIMICROBIAL ACTIVITY; ONE-POT; DESIGN; FUNCTIONALIZATION; ACID in [Genc, Hasan; Tozlu, Israfil] Van Yuzuncu Yil Univ, Fac Educ, Dept Sci, TR-65080 Van, Turkey; [Tasdemir, Volkan] Van Yuzuncu Yil Univ, Sci Res & Applicat Ctr, TR-65080 Van, Turkey; [Ogun, Erdal] Van Yuzuncu Yil Univ, Biol Dept, Sci Fac, TR-65080 Van, Turkey in 2019.0, Cited 42.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Application In Synthesis of 1-Phenylurea

Synthesis of pyrazole-3-carboxylic acid was progressed via two different protocols, one of which is solid state. Pyrazole-3-carboxylic acid was converted into different derivatives such as ester, urea, amide and nitrile. The amide compound was converted to nitrile using SOCl2 and DMF. Solid state heating of carboxylic acid gave decarboxylated product. Cyclization of tetra-substituted pyrazole with hydrazines resulted in pyrazolopyridazinones. The antimicrobial activities of the synthesized pyrazole derivatives against Bacillus cereus, Escherichia coli, Micrococcus luteus, Staphylococcus aureus, and Saccharomyces cerevisiae were evaluated. One of the pyrazole derivatives which possess nitro group showed antimicrobial activity in only B. cereus, a Gram-positive bacteria, with an MIC of 128 mu g/mL.

Application In Synthesis of 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Genc, H; Tasdemir, V; Tozlu, I; Ogun, E or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of 2-Aminobenzamide. In 2019 CHINESE CHEM LETT published article about BIOLOGICAL-ACTIVITIES; MANNICH-BASES; DESIGN; ANTIFUNGAL; FLUORINE; PRODUCT; ANALOGS in [Chen, Xiulei; Jia, Haowu; Li, Zhong; Xu, Xiaoyong] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China; [Li, Zhong; Xu, Xiaoyong] Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai 200237, Peoples R China in 2019, Cited 24. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

To explore new skeleton with nematicidal activity, a series of novel 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker were synthesized and varied fragments were also introduced to increase structure diversity of the new skeleton. Their inhibitory activities in vivo were evaluated against Meloidogyne incognita. The newly prepared compounds A6, A8, A21, A28 and A38 exhibited more than 50% inhibition at the concentration of 20 mg/L. Especially compound A6 displayed 71.4% inhibition against Meloidogyne incognita at the concentration of 20 mg/L. The nematicidal activities varied significantly depending on the types and positions of the substituents, which provided guidance for further structure modification. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Safety of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Chen, XL; Jia, HW; Li, Z; Xu, XY or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem