Tag: M.W=100-150

Recently I am researching about AMINATION; FUNCTIONALIZATION; INDOLINES; NITROGENATION, Saw an article supported by the National Research Foundation of Korea (NRF) – Korea government (MSIT) [2018R1C1B6005607, 2019R1A4A2001451, 2020R1A2C3005357]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Kim, S; Jeoung, D; Kim, K; Lee, SB; Lee, SH; Park, MS; Ghosh, P; Mishra, NK; Hong, S; Kim, IS. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Recommanded Product: 2-Aminobenzamide

The site-selective modifications of quinazolinones constitute a pivotal topic in drug discovery and material science. Herein, we describe the rhodium(III)-catalyzed C-H amidation of 2-aryl quinazolin-4(3H)-ones with a range of nitrene surrogates including dioxazolones, organic azides, andN-methoxyamides. Complete site-selectivity and functional group tolerance are observed. Notably, the large-scale reaction and late-stage functionalization highlight the synthetic potential of the developed protocol. Combined mechanistic investigations elucidate a plausible reaction mechanism of this process.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Kim, S; Jeoung, D; Kim, K; Lee, SB; Lee, SH; Park, MS; Ghosh, P; Mishra, NK; Hong, S; Kim, IS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 2-Aminobenzamide. In 2020 TETRAHEDRON LETT published article about NONCOVALENT INHIBITION; INDUCED HETEROARYLATION; PRIVILEGED SCAFFOLD; 20S PROTEASOME; CANCER; QUINOLINE; IDENTIFICATION; QUINAZOLINES; ALLOSTERY; TMC-95A in [Boualia, Imen; Debache, Abdelmadjid; Boulcina, Raouf] Univ Freres Mentouri Constantine, Lab Synthese Mol Interets Biol, Constantine 25000, Algeria; [Boualia, Imen; Roisnel, Thierry; Berree, Fabienne; Vidal, Joelle; Carboni, Bertrand] Univ Rennes, ISCR, CNRS, UMR 6226, F-35000 Rennes, France; [Boulcina, Raouf] Univ Mostefa Benboulaid Batna 2, Dept Sci & Tech, Fac Technol, Batna 05000, Algeria in 2020, Cited 45. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A new series of 3-(quinazol-2-yl)-quinolines was synthesized by SNAr reaction from easily prepared 4-chloro-2-(2-chloroquinolin-3-yl)quinazolines and a range of phenols and thiophenol as nucleophiles. The AlCl3-mediated CC bond formation was also successfully exploited to introduce aryl and hereroaryl substituents on one or both heterocyclic units. These procedures afford efficient syntheses of polysubstituted 3-(quinazol-2-yl)-quinolines in few steps and high yields. Some of these polysubstituted 3-(quinazol-2-yl)-quinolines inhibit the human 20S proteasome. (C) 2020 Elsevier Ltd. All rights reserved.

About 2-Aminobenzamide, If you have any questions, you can contact Boualia, I; Debache, A; Boulcina, R; Roisnel, T; Berree, F; Vidal, J; Carboni, B or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 2-Aminobenzamide. In 2019 EUR J MED CHEM published article about BIOLOGICAL EVALUATION; DERIVATIVES; PI3K/AKT/MTOR; GEFITINIB; PATHWAY; DESIGN; GROWTH in [Li, Er-dong; Lin, Qiao; Meng, Ya-qi; Zhang, Lu-ye; Song, Pan-pan; Li, Na; Xin, Jing-chao; Yang, Peng; Bao, Chong-nan; Zhang, Dan-qing; Zhang, Yang; Wang, Ji-kuan; Zhang, Qiu-rong; Liu, Hong-min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China; [Li, Er-dong; Lin, Qiao; Meng, Ya-qi; Zhang, Lu-ye; Song, Pan-pan; Li, Na; Xin, Jing-chao; Yang, Peng; Bao, Chong-nan; Zhang, Dan-qing; Zhang, Yang; Wang, Ji-kuan; Zhang, Qiu-rong; Liu, Hong-min] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 32. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A series of novel 2,4-disubstituted quinazolines were synthesized and evaluated for their anti-tumor activity against five human cancer cells (MDA-MB-231, MCF-7, PC-3, HGC-27 and MGC-803) using MIT assay. Among them, compound 9n showed the most potent cytotoxicity against breast cancer cells. Compound 9n also significantly inhibited the colony formation and migration of MDA-MB-231 and MCF-7 cells. Meanwhile, compound 9n induced cell cycle arrest at G1 phase and cell apoptosis, as well as increased accumulation of intracellular ROS. Furthermore, compound 9n exerted anti-tumor effects in vitro via decreasing the expression of anti-apoptotic protein Bcl-2 and increasing the pro-apoptotic protein Bax and p53. Mechanistically, compound 9n markedly decreased p-EGFR and p-PI3K expression, which revealed that compound 9n targeted breast cancer cells via interfering with EGFR-PI3K signaling pathway. Molecular docking suggested that compound 9n could indeed bind into the active pocket of EGFR. All the findings suggest that compound 9n might be a valuable lead compound for anti-tumor agents targeting breast cancer cells. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 2-Aminobenzamide, If you have any questions, you can contact Li, ED; Lin, Q; Meng, YQ; Zhang, LY; Song, PP; Li, N; Xin, JC; Yang, P; Bao, CN; Zhang, DQ; Zhang, Y; Wang, JK; Zhang, QR; Liu, HM or concate me.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Environmental Sciences & Ecology very interesting. Saw the article Improvement of pesticide removal in contaminated media using aqueous extracts from contaminated biopurification systems published in 2019.0. Safety of 1-Phenylurea, Reprint Addresses Romero, E (corresponding author), CSIC, EEZ, Dept Environm Protect, C Prof Albareda 1, E-18008 Granada, Spain.. The CAS is 64-10-8. Through research, I have a further understanding and discovery of 1-Phenylurea

Despite certain limitations, bioaugmentation enhances the efficiency of bioremediation systems. In this study, three aqueous extracts (APE, ACE and APE) from aged residual biomixtures in three biopurification systems (BPSs) exposed to pesticides at a pilot scale were found to improve pesticide removal. The addition of ACEs and AVEs to solutions containing the model compound diuron increased removal rates 6- and 17-fold, respectively, as compared to APEs. These extracts also increased the removal of the metabolite 3,4-dichloroaniline, while AVEs, in particular, were found to remove all pesticides within 9 days. Three metabolites less hazardous than 3,4-dichloroaniline were identified by SPME/GC/MS. AVEs, which also enhance linuron removal in liquid media, were found to increase diuron removal 6-fold in BPSs. We observed an increase in the relative abundance of taxa, such as Chloroflexi, Acidobacteria, Gemmatimonadetes, Firmicutes, Deinococcus-Thermus and especially Proteobacteria (10%), in AV biomixtures, as well as an enrichment of gamma-proteobacteria and the actinobacterial genus Dokdonella in AVEs with respect to initial noncontaminated IV biomixture. We demonstrate that extracts containing a pollutant-acclimatized microbiome could be used as part of a bioaugmentation strategy to improve the functioning of on-farm BPSs and contaminated systems. (c) 2019 Elsevier B.V. All rights reserved.

Safety of 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Romero, IA; van Dillewijn, P; Nesme, J; Sorensen, SJ; Romero, E or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 1-Phenylurea. Rogers, B; Rogers, B; Frazzoni, M; Savarino, E; Roman, S; Sifrim, D; Gyawali, CP in [Rogers, Barrett; Rogers, Benjamin; Gyawali, C. Prakash] Washington Univ, Sch Med, Div Gastroenterol, St Louis, MO 63110 USA; [Frazzoni, Marzio] Baggiovara Hosp, Dept Specialized Med, Digest Pathophysiol Unit, Modena, Italy; [Savarino, Edoardo] Univ Padua, Div Gastroenterol, Dept Surg Oncol & Gastroenterol, Padua, Italy; [Roman, Sabine] Univ Lyon, Hosp Civils Lyon, Digest Physiol, Hop E Herriot, Lyon, France; [Roman, Sabine] Lyon I Univ, Univ Lyon, Digest Physiol, Lyon, France; [Roman, Sabine] Univ Lyon, LabTAU, Inserm U1032, Lyon, France; [Sifrim, Daniel] Queen Mary Univ London, Barts & London Sch Med & Dent, London, England published Episode-level reflux characteristics: How experienced reviewers differentiate true reflux from artifact on pH-impedance studies in , Cited 21.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

Background Accurate reflux episode identification is crucial for pH-impedance interpretation. Individual reflux episode characteristics associated with inter-reviewer concordance are incompletely understood. Methods Ambulatory pH-impedance studies from 19 GERD patients (median age 52 years, 78.9% F) were analyzed by 5 reviewers. Metadata from pH-impedance studies were exported to a dedicated software tool designed to compare episode-by-episode identification between reviewers within a +/- 7.5 s window. Patient position, acidic vs. nonacidic episodes, acid clearance time (ACT), bolus clearance time (BCT), and proximal extent of reflux episodes were compared between episodes identified by all reviewers against those identified by automated analysis, and one to four reviewers, respectively. Results Automated analysis identified 1644 episodes (median 78 episodes per patient, IQR 64-108), of which 84.9% were identified by >= 3 reviewers and 57.1% by all reviewers; 339 unique episodes were added by at least 1 reviewer. Characteristics defining 5 reviewer concordance included acid reflux episodes (88.9%), upright episodes (88.4%), high proximal extent (median 17 cm, IQR 15-17 cm), and longer acid clearance times (67.0 s, IQR 29.0-146.0 s) (P < 0.001 compared to 1-4 reviewer concordance for each). In contrast, 1 reviewer-identified episodes were 69.8% acidic, 76.9% upright, and limited to the distal esophagus. Using 5-reviewer concordance, designation of GERD evidence changed from automated analysis in 16%-19% of patients. Conclusions Acidic episodes with high proximal extent in the upright position and longer acid clearance times on pH-impedance studies have the highest concordance for identification by expert reviewers. Reflux episode identification may be influenced by reviewer opinion despite availability of established criteria. Name: 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Rogers, B; Rogers, B; Frazzoni, M; Savarino, E; Roman, S; Sifrim, D; Gyawali, CP or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about PARP INHIBITORS; DNA-REPAIR; BRD4; DISCOVERY; LETHALITY; ADAPTER; TUMORS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81922064, 81874290, 81673455, 81573290, U1603123]; project of Science and Technology Department of Sichuan Province [20YYJC3921]. Published in INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES in BEIJING ,Authors: Chang, XS; Sun, DJ; Shi, DF; Wang, G; Chen, YM; Zhang, K; Tan, HD; Liu, J; Liu, B; Ouyang, L. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Computed Properties of C7H8N2O

This study was aimed to design the first dual-target small-molecule inhibitor co-targeting poly (ADP-ribose) polymerase-1 (PARP1) and bromodomain containing protein 4 (BRD4), which had important cross relation in the global network of breast cancer, reflecting the synthetic lethal effect. A series of new BRD4 and PARP1 dual-target inhibitors were discovered and synthesized by fragment-based combinatorial screening and activity assays that together led to the chemical optimization. Among these compounds, 19d was selected and exhibited micromole enzymatic potencies against BRD4 and PARP1, respectively. Compound 19d was further shown to efficiently modulate the expression of BRD4 and PARP1. Subsequently, compound 19d was found to induce breast cancer cell apoptosis and stimulate cell cycle arrest at G1 phase. Following pharmacokinetic studies, compound 19d showed its antitumor activity in breast cancer susceptibility gene 1/2 (BRCA1/2) wild-type MDA-MB-468 and MCF-7 xenograft models without apparent toxicity and loss of body weight. These results together demonstrated that a highly potent dual-targeted inhibitor was successfully synthesized and indicated that co-targeting of BRD4 and PARP1 based on the concept of synthetic lethality would be a promising therapeutic strategy for breast cancer. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Chang, XS; Sun, DJ; Shi, DF; Wang, G; Chen, YM; Zhang, K; Tan, HD; Liu, J; Liu, B; Ouyang, L or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Chemistry very interesting. Saw the article Framework Copper Catalyzed Oxidative Synthesis of Quinazolinones: A Benign Approach Using Cu-3(BTC)(2)MOF as an Efficient and Reusable Catalyst published in 2020. Recommanded Product: 88-68-6, Reprint Addresses Suresh, P (corresponding author), Madurai Kamaraj Univ, Sch Chem, Dept Nat Prod Chem, Supramol & Catalysis Lab, Madurai 625021, Tamil Nadu, India.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A benign and straightforward method to access quinazolinones have been developed using easily preparable Cu-3(BTC)(2)MOF as a sustainable solid-Lewis acid catalyst under mild condition. Cu-3(BTC)(2)MOF was prepared and characterized using various analytical tools such as PXRD, FT-IR, SEM, TGA, and ICP-OES. Synthesis of the quinazolinone is catalyzed by the presence of coordinatively unsaturated open Cu(II)sites in Cu-3(BTC)(2)MOF using renewable ethanol as a solvent with minimum copper loading (0.07 mmol) without any harsh reaction condition. A series of substituted quinazolinones were synthesized with good to excellent yields. The efficiency of the present framework copper catalysts was rationalized by comparing with other MOFs and homogeneous catalytic systems. The stability of the catalyst was demonstrated by six consecutive runs and heterogeneity test, which was also evidenced from the technical supports such as PXRD, FT-IR and SEM analyses of the recovered catalyst.

About 2-Aminobenzamide, If you have any questions, you can contact Latha, G; Devarajan, N; Suresh, P or concate me.. Recommanded Product: 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article 2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K WOS:000466828400004 published article about BIOLOGICAL EVALUATION; DERIVATIVES; PI3K/AKT/MTOR; GEFITINIB; PATHWAY; DESIGN; GROWTH in [Li, Er-dong; Lin, Qiao; Meng, Ya-qi; Zhang, Lu-ye; Song, Pan-pan; Li, Na; Xin, Jing-chao; Yang, Peng; Bao, Chong-nan; Zhang, Dan-qing; Zhang, Yang; Wang, Ji-kuan; Zhang, Qiu-rong; Liu, Hong-min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China; [Li, Er-dong; Lin, Qiao; Meng, Ya-qi; Zhang, Lu-ye; Song, Pan-pan; Li, Na; Xin, Jing-chao; Yang, Peng; Bao, Chong-nan; Zhang, Dan-qing; Zhang, Yang; Wang, Ji-kuan; Zhang, Qiu-rong; Liu, Hong-min] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 32. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Recommanded Product: 2-Aminobenzamide

A series of novel 2,4-disubstituted quinazolines were synthesized and evaluated for their anti-tumor activity against five human cancer cells (MDA-MB-231, MCF-7, PC-3, HGC-27 and MGC-803) using MIT assay. Among them, compound 9n showed the most potent cytotoxicity against breast cancer cells. Compound 9n also significantly inhibited the colony formation and migration of MDA-MB-231 and MCF-7 cells. Meanwhile, compound 9n induced cell cycle arrest at G1 phase and cell apoptosis, as well as increased accumulation of intracellular ROS. Furthermore, compound 9n exerted anti-tumor effects in vitro via decreasing the expression of anti-apoptotic protein Bcl-2 and increasing the pro-apoptotic protein Bax and p53. Mechanistically, compound 9n markedly decreased p-EGFR and p-PI3K expression, which revealed that compound 9n targeted breast cancer cells via interfering with EGFR-PI3K signaling pathway. Molecular docking suggested that compound 9n could indeed bind into the active pocket of EGFR. All the findings suggest that compound 9n might be a valuable lead compound for anti-tumor agents targeting breast cancer cells. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 2-Aminobenzamide, If you have any questions, you can contact Li, ED; Lin, Q; Meng, YQ; Zhang, LY; Song, PP; Li, N; Xin, JC; Yang, P; Bao, CN; Zhang, DQ; Zhang, Y; Wang, JK; Zhang, QR; Liu, HM or concate me.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Sarma, D; Majumdar, B; Deori, B; Jain, S; Sarma, TK in [Sarma, Daisy; Majumdar, Biju; Deori, Barsha; Jain, Siddarth; Sarma, Tridib K.] Indian Inst Technol Indore, Sch Basic Sci, Discipline Chem, Indore 453552, India published Photoinduced Enhanced Decomposition of TBHP: A Convenient and Greener Pathway for Aqueous Domino Synthesis of Quinazolinones and Quinoxalines in 2021, Cited 39. Name: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Catalyst-free photoinduced processes in aqueous medium represent significant advancement toward development of green and sustainable pathways in organic synthesis. tert-Butyl hydroperoxide (TBHP) is a widely used oxidant in organic reactions, where the decomposition of TBHP into its radicals by metal catalysts or other reagents is a key factor for efficient catalytic outcome. Herein, we report a simple and environmentally friendly visible light-promoted synthetic pathway for the synthesis of N-heterocyclic moieties, such as quinazolinones and quinoxalines, in the presence of TBHP as an oxidizing agent in aqueous medium that requires no catalysts/photocatalysts. The enhanced rate of decomposition to generate free radicals from TBHP upon visible light irradiation is the driving force for the domino reaction.

About 2-Aminobenzamide, If you have any questions, you can contact Sarma, D; Majumdar, B; Deori, B; Jain, S; Sarma, TK or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 64-10-8. Slachtova, V; Chasak, J; Brulikova, L in [Slachtova, Veronika; Chasak, Jan; Brulikova, Lucie] Palacky Univ Olomouc, Fac Sci, Dept Organ Chem, 17 Listopadu 12, Olomouc 77146, Czech Republic published Synthesis of Various 2-Aminobenzoxazoles: The Study of Cyclization and Smiles Rearrangement in 2019.0, Cited 38.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

This study reports two synthetic approaches leading to 2-aminobenzoxazoles and their N-substituted analogues. Our first synthetic strategy involves a reaction between various o-aminophenols and N-cyano-N-phenyl-p-toluenesulfonamide as a nonhazardous electrophilic cyanating agent in the presence of Lewis acid. The second synthetic approach uses the Smiles rearrangement upon activation of benzoxazole-2-thiol with chloroacetyl chloride. Both developed synthetic protocols are widely applicable, afford the desired aminobenzoxazoles in good to excellent yields, and use nontoxic and inexpensive starting material.

Product Details of 64-10-8. About 1-Phenylurea, If you have any questions, you can contact Slachtova, V; Chasak, J; Brulikova, L or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem