Tag: M.W=100-150

I found the field of Chemistry very interesting. Saw the article 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-Mediated Tandem Oxidative Annulation for Preparing 2,2-Disubstituted 2,3-Dihydroquinazolin-4(1H)-ones published in 2021. Recommanded Product: 2-Aminobenzamide, Reprint Addresses Cheng, DP (corresponding author), Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China.; Xu, XL (corresponding author), Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

An efficient tandem oxidative annulation for the synthesis of 2,2-disubstituted 2,3-dihydroquinazolin-4(1H)-ones via DDQ-mediated dual cross-dehydrogenative-coupling (CDC) reactions is described. This transformation proceeds from easily available o-aminobenzamides and 1,3-diarylpropenes under mild conditions, and the corresponding products are obtained in moderate to excellent yields.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Cheng, DP; Yan, XH; Pu, YQ; Shen, J; Xu, XL; Yan, JZ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Jabbour, SA; Frias, JP; Ahmed, A; Hardy, E; Choi, J; Sjostrom, CD; Guja, C in AMER DIABETES ASSOC published article about TYPE-2 DIABETES-MELLITUS; ADD-ON THERAPY; SGLT2 INHIBITORS; TOLERABILITY; METFORMIN in [Jabbour, Serge A.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA; [Frias, Juan P.] Natl Res Inst, Los Angeles, CA USA; [Ahmed, Azazuddin] Apex Med Res, Chicago, IL USA; [Hardy, Elise] AstraZeneca, Gaithersburg, MD USA; [Choi, Jasmine] Statum Res, Irvine, CA USA; [Sjostrom, C. David] AstraZeneca, Gothenburg, Sweden; [Guja, Cristian] Carol Davila Univ Med & Pharm, Bucharest, Romania in 2020.0, Cited 17.0. Safety of 1-Phenylurea. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

OBJECTIVE In patients with type 2 diabetes uncontrolled with metformin, exenatide once weekly (QW) plus dapagliflozin produced greater reductions in glycemic parameters (glycated hemoglobin [HbA(1c)], fasting plasma glucose [FPG], and 2-h postprandial glucose [2-h PPG]), weight, and systolic blood pressure (SBP) than exenatide QW or dapagliflozin alone after 28 weeks of treatment in DURATION-8. Following a 24-week extension period, improvements were sustained at 52 weeks. In this study, we investigated efficacy and safety at 104 weeks after randomization. RESEARCH DESIGN AND METHODS DURATION-8 was a 104-week, multicenter, double-blind, randomized, active-controlled, phase 3 trial. In total, 695 adults (aged >= 18 years) with type 2 diabetes and inadequate glycemic control (HbA(1c)8.0-12.0% [64-108 mmol/mol]) despite stable metformin monotherapy (>= 1,500 mg/day) were randomly assigned (1:1:1) to receive exenatide 2 mg QW plus once-daily dapagliflozin 10 mg, exenatide QW plus placebo, or dapagliflozin plus placebo. All 104-week evaluations were exploratory. RESULTS At week 104, 431 (62.0%) patients completed treatment. The adjusted least squares mean change (SE) from baseline to week 104 in HbA(1c)was greater with exenatide QW plus dapagliflozin (-1.70% [0.11]) versus exenatide QW plus placebo (-1.29% [0.12];P= 0.007) and dapagliflozin plus placebo (-1.06% [0.12];P< 0.001). Clinically relevant changes in FPG, 2-h PPG, weight, and SBP were also observed with exenatide QW plus dapagliflozin. There were no unexpected safety findings, and exenatide QW plus dapagliflozin was well tolerated, with no episodes of major hypoglycemia. CONCLUSIONS In this exploratory analysis, among those individuals who completed the trial without rescue therapy, there was clinically relevant efficacy over 2 years with exenatide QW plus dapagliflozin, with no unexpected safety findings. Safety of 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Jabbour, SA; Frias, JP; Ahmed, A; Hardy, E; Choi, J; Sjostrom, CD; Guja, C or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 2-Aminobenzamide. In 2020 INORG CHEM COMMUN published article about ORGANIC-REACTIONS; ORGANOMETALLIC CATALYSIS; TETRAZOLATO COMPLEXES; SELECTIVE HYDRATION; AQUEOUS-SOLUTION; LIGANDS; AMIDES; WATER; HYDROLYSIS; CHEMISTRY in [Vyas, Komal M.; Mandal, Poulami; Singh, Rinky; Mobin, Shaikh M.; Mukhopadhyay, Suman] Indian Inst Technol Indore, Sch Basic Sci, Discipline Chem, Khandwa Rd, Indore 453552, India; [Vyas, Komal M.] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India; [Mandal, Poulami] Helmholtz Zensrum Dresden Rossendorf, Dept Resource Ecol, D-01328 Dresden, Germany in 2020, Cited 86. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Three new arene-ruthenium(II) complexes were prepared by treating [{RuCl(mu-Cl)(eta(6)-arene)}(2)] (eta(6)-arene = p-cymene) dimer with tri(2-furyl)phosphine (PFu(3)) and 1,3,5-triaza-7-phosphaadamantane (PTA), respectively to obtain [RuCl2(eta(6)-arene)PFu(3)] [Ru] -1, (RuCl(eta(6)-arene)(PFu(3))(PTA)]BF4 [Ru] -2 and HtuCl(eta(6)-arene)(PFu(3))(2)]BF4 [Ru] -3. All the complexes were structurally identified using analytical and spectroscopic methods including single-crystal X-ray studies. The effectiveness of resulting complexes as potential homogeneous catalysts for selective hydration of different nitriles into corresponding amides in aqueous medium and air atmosphere was explored. There was a remarkable difference in catalytic activity of the catalysts depending on the nature and number of phosphorus-donor ligands and sites available for catalysis. Experimental studies performed using structural analogues of efficient catalyst concluded a structural-activity relationship for the higher catalytic activity of [Ru] -1, being able to convert huge variety of aromatic, heteroaromatic and aliphatic nitriles. The use of eco-friendly water as a solvent, open atmosphere and avoidance of any organic solvent during the catalytic reactions prove the reported process to be truly green and sustainable.

About 2-Aminobenzamide, If you have any questions, you can contact Vyas, KM; Mandal, P; Singh, R; Mobin, SM; Mukhopadhyay, S or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of 2-Aminobenzamide. Authors Akyuz, G in WILEY published article about in [Akyuz, Gulay] Recep Tayyip Erdogan Univ, Art & Sci Fac, Dept Chem, Rize, Turkey in 2021, Cited 18. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

In this study, novel quinazolinones were designed, synthesized, characterized by FT-IR, H-1-NMR, C-13-NMR spectral data, and LC-MS. New compounds inhibitory activities on urease were assessed. All of the compounds exhibited potent urease inhibitory activities. Especially in the synthesized compounds, 2-benzyl-3-({5-[(4-nitrophenyl)amino]-1,3,4-thiadiazol2-yl}methyl)quinazolin-4(3H)-one has the best inhibitory effect against Jack bean urease with IC50 = 3.30 +/- 0.09 mu g/mL. And also, N-(4-nitrophenyl)-2-[(4-oxoquinazolin-3(4H)-yl)acetyl] hydrazinecarbothioamide, N-(4-fluorophenyl)-2-[(4-oxoquinazolin-3(4H)-yl)acetyl] hydrazinecarbothioamide, and 2-benzyl-3-({5-[(4-fluorophenyl)amino]-1,3,4-thiadiazol-2yl} methyl)quinazolin-4(3H)-one have best activities among the synthesized compounds.

Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Akyuz, G or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article omega-Quinazolinonylalkyl aryl ureas as reversible inhibitors of monoacylglycerol lipase WOS:000505596300011 published article about ACID-AMIDE HYDROLASE; MONOGLYCERIDE LIPASE; ENDOCANNABINOID SYSTEM; ACCURATE DOCKING; MAGL; DERIVATIVES; ANALOGS; GLIDE; IDENTIFICATION; PREDICTION in [Dato, Florian M.; Pietsch, Markus] Univ Cologne, Med Fac, Ctr Pharmacol, Inst Pharmacol 2, Gleueler Str 24, D-50931 Cologne, Germany; [Dato, Florian M.; Neudoerfl, Jorg-Martin; Goldfuss, Bernd] Univ Cologne, Inst Organ Chem, Dept Chem, Greinstr 4, D-50939 Cologne, Germany; [Guetschow, Michael] Univ Bonn, Pharmaceut Inst, Pharmaceut Chem 1, Immenburg 4, D-53121 Bonn, Germany in 2020, Cited 60. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Recommanded Product: 2-Aminobenzamide

The serine hydrolase monoacylglycerol lipase (MAGL) is involved in a plethora of pathological conditions, in particular pain and inflammation, various types of cancer, metabolic, neurological and cardiovascular disorders, and is therefore a promising target for drug development. Although a large number of irreversible-acting MAGL inhibitors have been discovered over the past years, there are only few compounds known so far which inhibit the enzyme in a reversible manner. Therefore, much effort is put into the development of novel chemical entities showing reversible inhibitory behavior, which is thought to cause less undesired side effects. To explore a wide range of chemical structures as MAGL binders, we have applied a virtual screening approach by docking small molecules into the crystal structure of human MAGL (hMAGL) and envisaged a library of 45 selected compounds which were then synthesized. Biochemical investigations included the determination of the inhibitory potency on hMAGL and two related hydrolases, i.e. human fatty acid amide hydrolase (hFAAH) and murine cholesterol esterase (mCEase). The most promising candidates from theses analyses, i.e. three w-quinazolinonylalkyl aryl ureas bearing alkyl spacers of three to five methylene groups, exhibited IC50 values of 20-41 mu M and reversible, detergent-insensitive behavior towards hMAGL. Among these compounds, the inhibitor 1-(3,5-bis(tri-fluoromethyl)phenyl)-3-(4-(4-oxo-3,4 dihydroquinazolin-2-yl)butyl)urea (96) was selected for further kinetic characterization, yielding a dissociation constant K-i = 15.4 mu M and a mixed-type inhibition with a pronounced competitive component (alpha = 8.94). This mode of inhibition was further supported by a docking experiment, which suggested that the inhibitor occupies the substrate binding pocket of hMAGL.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Dato, FM; Neudorfl, JM; Gutschow, M; Goldfuss, B; Pietsch, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Chemistry very interesting. Saw the article Design and synthesis of new benzopyrimidinone derivatives: alpha-amylase inhibitory activity, molecular docking and DFT studies published in 2021. Recommanded Product: 2-Aminobenzamide, Reprint Addresses Ben Jannet, H; Romdhane, A (corresponding author), Univ Monastir, Fac Sci Monastir, Chem Dept,Team Med Chem & Nat Prod LR11ES39, Lab Heterocycl Chem Nat Prod & React, Ave Environm, Monastir 5019, Tunisia.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

New benzopyrimidinone derivatives have been synthesized by reaction of 2-aminobenzamide with different acyl chlorides in good yield and their structures were confirmed by H-1 NMR, C-13 NMR and mass spectrometry. The newly synthesized compounds were studied theoretically by Density Functional Theory (DFT) method with 6-311++G(d, p) basis set, structural and some spectroscopic parameters were determined. The synthesized compounds were assessed for their in vitro alpha-amylase inhibitory activity. The structure-activity relationship (SAR) was discussed with the help of molecular docking analysis. (C) 2021 ElsevierB.V. Allrightsreserved.

About 2-Aminobenzamide, If you have any questions, you can contact Chortani, S; Horchani, M; Znati, M; Issaoui, N; Ben Jannet, H; Romdhane, A or concate me.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Chemistry very interesting. Saw the article Aerobic oxidative synthesis of quinazolinones and benzothiazoles in the presence of laccase/DDQ as a bioinspired cooperative catalytic system under mild conditions published in 2020. COA of Formula: C7H8N2O, Reprint Addresses Rostami, A (corresponding author), Univ Kurdistan, Fac Sci, Dept Chem, Sanandaj 6617715175, Iran.; Rostami, A (corresponding author), Univ Saskatchewan, Dept Chem & Biol Engn, 57 Campus Dr, Saskatoon, SK S7N 5A9, Canada.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

The current study applied laccase/DDQ as a bioinspired cooperative catalytic system for the synthesis of quinazolinones (80-95% yield) and benzothiazoles (65-98% yield) using air or O-2 as ideal oxidants in aqueous media at ambient temperature. The aerobic oxidative cyclization reactions occur in two steps: (i) chemical cyclization; (ii) chemoenzymatic oxidation. These methods are more environment-friendly, efficient, simple and practical than other reported methods due to the use of O-2 as an oxidant, laccase as an eco-friendly biocatalyst, aqueous media as the solvent and free from any toxic transition metal and halide catalysts. Therefore, these methods can be applied in pharmaceutical and other sensitive synthetic procedures.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Ghorashi, N; Shokri, Z; Moradi, R; Abdelrasoul, A; Rostami, A or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2020.0 MOLECULES published article about PERSONAL CARE PRODUCTS; WATERS LABORATORY MEASURES; DISSOLVED ORGANIC-MATTER; CLOFIBRIC ACID; SURFACE WATERS; RATE CONSTANTS; PHENYLUREA HERBICIDES; DRINKING WATERS; RISK-ASSESSMENT; WASTE-WATER in [Carena, Luca; Vione, Davide] Univ Torino, Dipartimento Chim, Via Pietro Giuria 5, I-10125 Turin, Italy in 2020.0, Cited 78.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Quality Control of 1-Phenylurea

The abiotic photochemical reactions that take place naturally in sunlit surface waters can degrade many contaminants that pose concern to water bodies for their potentially toxic and long-term effects. This works aims at assessing the ability of European rivers to photoproduce reactive transient intermediates, such as HO center dot radicals and the excited triplet states of chromophoric dissolved organic matter ((CDOM)-C-3*), involved in pollutant degradation. A photochemical mapping of the steady-state concentrations of these transients was carried out by means of a suitable modeling tool, in the latitude belt between 40 and 50 degrees N. Such a map allowed for the prediction of the photochemical lifetimes of the phenylurea herbicide isoproturon (mostly undergoing photodegradation upon reaction with HO center dot and especially (CDOM)-C-3*) across different European countries. For some rivers, a more extensive dataset was available spanning the years 1990-2002, which allowed for the computation of the steady-state concentration of the carbonate radicals (CO3 center dot-). With these data, it was possible to assess the time trends of the photochemical half-lives of further contaminants (atrazine, ibuprofen, carbamazepine, and clofibric acid). The calculated lifetimes were in the range of days to weeks, which might or might not allow for efficient depollution depending on the river-water flow velocity.

About 1-Phenylurea, If you have any questions, you can contact Carena, L; Vione, D or concate me.. Quality Control of 1-Phenylurea

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 2-Aminobenzamide. In 2020 TETRAHEDRON LETT published article about NONCOVALENT INHIBITION; INDUCED HETEROARYLATION; PRIVILEGED SCAFFOLD; 20S PROTEASOME; CANCER; QUINOLINE; IDENTIFICATION; QUINAZOLINES; ALLOSTERY; TMC-95A in [Boualia, Imen; Debache, Abdelmadjid; Boulcina, Raouf] Univ Freres Mentouri Constantine, Lab Synthese Mol Interets Biol, Constantine 25000, Algeria; [Boualia, Imen; Roisnel, Thierry; Berree, Fabienne; Vidal, Joelle; Carboni, Bertrand] Univ Rennes, ISCR, CNRS, UMR 6226, F-35000 Rennes, France; [Boulcina, Raouf] Univ Mostefa Benboulaid Batna 2, Dept Sci & Tech, Fac Technol, Batna 05000, Algeria in 2020, Cited 45. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A new series of 3-(quinazol-2-yl)-quinolines was synthesized by SNAr reaction from easily prepared 4-chloro-2-(2-chloroquinolin-3-yl)quinazolines and a range of phenols and thiophenol as nucleophiles. The AlCl3-mediated CC bond formation was also successfully exploited to introduce aryl and hereroaryl substituents on one or both heterocyclic units. These procedures afford efficient syntheses of polysubstituted 3-(quinazol-2-yl)-quinolines in few steps and high yields. Some of these polysubstituted 3-(quinazol-2-yl)-quinolines inhibit the human 20S proteasome. (C) 2020 Elsevier Ltd. All rights reserved.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Boualia, I; Debache, A; Boulcina, R; Roisnel, T; Berree, F; Vidal, J; Carboni, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of 2-Aminobenzamide. Authors Wang, ZH; Wang, H; Wang, H; Li, L; Zhou, MD in AMER CHEMICAL SOC published article about in [Wang, Zhao-Hui; Wang, He; Wang, Hua; Li, Lei; Zhou, Ming-Dong] Liaoning Shihua Univ, Sch Chem & Mat Sci, Fushun 113001, Peoples R China in 2021, Cited 63. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

In this work, ruthenium(II)-catalyzed C-C/C-N annulation of 2-arylquinazolinones with vinylene carbonate is reported to synthesize fused quinazolinones. This catalytic system tolerates a wide range of substrates with excellent functional-group compatibility. In this transformation, the vinylene carbonate acts as an ethynol surrogate without any external oxidant involved. Furthermore, preliminary mechanistic studies were conducted, and a plausible catalytic cycle was also proposed.

Safety of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Wang, ZH; Wang, H; Wang, H; Li, L; Zhou, MD or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem