Tag: M.W=100-150

Matsushita, T; Sekizawa, A; Jacobs, LK in [Matsushita, Tomomi] Johns Hopkins Bloomberg Sch Publ Hlth, 615 North Wolfe St, Baltimore, MD 21205 USA; [Matsushita, Tomomi; Sekizawa, Akihiko] Showa Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan; [Jacobs, Lisa K.] Dept Surg, Tokyo, Japan; Johns Hopkins Univ, Sch Med, Baltimore, MD USA published Racial Disparities in Response to a US Food and Drug Administration Safety Communication Regarding the Use of Power Morcellation for the Treatment of Uterine Leiomyoma in 2020.0, Cited 25.0. Name: 1-Phenylurea. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

Study Objective: To investigate whether the rate of increase in the performance of abdominal myomectomy over a laparoscopic approach after the US Food and Drug Administration (FDA) safety communication regarding morcellator use for myomectomy differs among races. Design: Retrospective cohort study. Setting: The American College of Surgeons National Surgical Quality Improvement data. Patients: Patients aged 18 to 55 years who underwent either laparoscopic or abdominal myomectomy, excluding malignant cases, emergency cases, operations performed by nongynecologic specialists, and cases in which myomectomy was performed during cesarean section. Interventions: None. Measurements and Main Results: The odds ratios of abdominal myomectomy over laparoscopic myomectomy before and after the release of the FDA communication were calculated in 3 race categories: white, African American, and other races. In a logistic regression analysis adjusted for possible confounders, including all races, the odds ratio of abdominal myomectomy before and after the FDA communication was 1.30 (95% confidence interval [CI], 1.20-1.41; p <. 001). In a logistic regression analysis with a product term of FDA communication exposure and race as a possible effect modifier, the African American population showed a significantly greater change in the odds of abdominal myomectomy over laparoscopic myomectomy in comparison with the white population (1.22; 95% CI, 1.02-1.47; p =.03). In contrast, other races showed no significant change (.83; 95% CI,.64-1.08; p =.17). Conclusion: After the FDA communication, the odds ratio of abdominal myomectomy was disproportionately increased in the African American population. (C) 2019 Published by Elsevier Inc. on behalf of AAGL. Name: 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Matsushita, T; Sekizawa, A; Jacobs, LK or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Selective Toll-like receptor 7 agonists with novel chromeno[3,4-d] imidazol-4(1H)-one and 2-(trifluoromethyl)quinoline/quinazoline-4-amine scaffolds published in 2019. SDS of cas: 88-68-6, Reprint Addresses Sova, M (corresponding author), Univ Ljubljana, Fac Pharm, Askerceva 7, SI-1000 Ljubljana, Slovenia.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

Toll-like receptors (TLRs) are promising targets for treatment of viral infections, autoimmune diseases, and cancers. Here, two new series of selective small-molecule TLR7 agonists with novel scaffolds and good selectivity over TLR8 are described, some with potencies in the low micromolar range. 8-Hydroxy-1-isobutylchromeno[3,4-d]imidazol-4(1H)-one (26) from the first series was designed and synthesized on the basis of previously described TLR7 antagonist 2, and is shown to be a selective TLR7 agonist (EC50, 1.8 mu M). The second series was based on 2-(trifluoromethyl)quinolin-4-amine and 2-(trifluoromethyl) quinazolin-4-amine scaffolds, which were defined according to our in-house ligand-based virtual screening protocol. Further synthesis of a focused library of analogs, biological evaluation, and docking studies provided systematic exploration of the structure-activity relationships, which indicate that a secondary or tertiary amine with smaller flexible alkyl substituents up to three carbon atoms in length, or bulkier rigid aliphatic rings is required at position 4 on 2-(trifluoromethyl)quinoline/quinazoline scaffold for potent TLR7 agonist activity. The influence of selected TLR7 agonists on cytokine production is also reported showing that N-cyclopropyl-2-(trifluoromethyl)quinazolin-4-amine (46) is able to induce increased levels of IL-6 and IL-8. These data demonstrate successful in-silico definition of novel TLR7 versus TLR8-selective compounds as promising chemical probes for further development of potent small-molecule immunomodulators. (C) 2019 Elsevier Masson SAS. All rights reserved.

SDS of cas: 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Dolsak, A; Svajger, U; Lesnik, S; Konc, J; Gobec, S; Sova, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Preferential catabolism of the (S)-enantiomer of the herbicide napropamide mediated by the enantioselective amidohydrolase SnaH and the dioxygenase Snpd in Sphingobium sp. strain B2 WOS:000496407200001 published article about EFFICIENT GENERATION; AM1-BCC MODEL; PROTEIN; DEGRADATION; ENANTIOMERS in [Huang, Junwei; Chen, Dian; Jiang, Jiandong] Nanjing Agr Univ, Dept Microbiol, Coll Life Sci, Key Lab Microbiol Agr Environm,Minist Agr, Nanjing 210095, Jiangsu, Peoples R China; [Chen, Dian] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China in 2020.0, Cited 37.0. Recommanded Product: 1-Phenylurea. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

The (R)- and (S)-enantiomers of the chiral herbicide napropamide (NAP) show different biological activities and ecotoxicities. These two enantiomers behave differently in the environment due to enantioselective catabolism by microorganisms. However, the molecular mechanisms underlying this enantioselective catabolism remain largely unknown. In this study, the genes (snaH and snpd) involved in the catabolism of NAP were cloned from Sphingobium sp. B2, which was capable of catabolizing both NAP enantiomers. Compared with (R)-NAP, (S)-NAP was much more rapidly transformed by the amidase SnaH, which initially cleaved the amide bonds of (S)/(R)-NAP to form (S)/(R)-2-(1-naphthalenyloxy)-propanoic acid [(S)/(R)-NP] and diethylamine. The alpha-ketoglutarate-dependent dioxygenase Snpd, showing strict stereoselectivity for (S)-NP, further transformed (S)-NP to 1-naphthol and pyruvate. Molecular docking and site-directed mutagenesis analyses revealed that when the (S)-enantiomers of NAP and NP occupied the active sites, the distance between the ligand molecule and the coordination atom was shorter than that when the (R)-enantiomers occupied the active sites, which facilitated formation of the transition state complex. This study enhances our understanding of the preferential catabolism of the (S)-enantiomer of NAP on the molecular level.

Recommanded Product: 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Huang, JW; Chen, D; Jiang, JD or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Heidari, L; Shiri, L in [Heidari, Leili; Shiri, Lotfi] Ilam Univ, Fac Basic Sci, Dept Chem, POB 69315-516, Ilam, Iran published CoFe2O4@SiO2-CPTES-Guanidine-Cu(II): A novel and reusable nanocatalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones and polyhydroquinolines and oxidation of sulfides in 2019, Cited 42. Name: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

CoFe2O4@SiO2-CPTES-Guanidine-Cu(II) magnetic nanoparticles were synthesized and used as a new, inexpensive and efficient heterogeneous catalyst for the synthesis of polyhydroquinolines and 2,3-dihydroquinazoline-4(1H)-ones and for the oxidation of sulfides. The structure of this nanocatalyst was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, vibrating sample magnetometry, thermogravimetric analysis, X-ray diffraction and inductively coupled plasma optical emission spectrometry. Simple preparation, high catalytic activity, simple operation, high yields, use of green solvents, easy magnetic separation and reusability of the catalyst are some of the advantages of this protocol.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Heidari, L; Shiri, L or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Xi, HC; Zhang, ZP; Zhang, WW; Li, MQ; Lian, C; Luo, QF; Tian, H; Zhu, WH in AMER CHEMICAL SOC published article about SCHIFF-BASE; DIARYLETHENE; DESIGN; PHOTOCHROMISM; EQUILIBRIUM; PHOTOCYCLIZATION; DEACTIVATION; TAUTOMERISM; NANOSYSTEMS; MOLECULES in [Zhu, Wei-Hong] East China Univ Sci & Technol, Key Lab Adv Mat, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China; [Zhu, Wei-Hong] East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Inst Fine Chem,Shanghai Key L, Shanghai 200237, Peoples R China in 2019, Cited 64. COA of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The fast light-responsive dithienylethenes (DTEs) are one of the most attractive photochromic families because of their excellent thermal irreversibility and fatigue resistance. However, the all-visible-light-activated DTE system still remains challenging because most of them require the harmful high-energy ultraviolet light to trigger their photocyclization reaction. Here, we have for the first time borrowed a specific intramolecular proton transfer (IPT) process and rationally designed a series of all-visible-light-driven DTEs. Incorporating the IPT-functional group to DTE unit gives rise to an extra absorption band with a distinct red shift, which enables the photocyclization of DTEs under stimuli of visible light at 450 nm, as well as ensuring the desirable photoswitching efficiency. The isomerization from OH form to NH form induced by IPT can decrease the energy gap for excitation and photocyclization, thereby affording the all-visible-light-triggered photochromic performance, which can not only work well in a polar solvent system but also show its effectiveness in polymeric gel systems. In this regard, we can provide a general and reliable platform to construct all-visible-light-driven DTEs with excellent reversible photoswitching and broad applicability, especially with avoiding the use of harmful ultraviolet light to induce their photocyclization.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Xi, HC; Zhang, ZP; Zhang, WW; Li, MQ; Lian, C; Luo, QF; Tian, H; Zhu, WH or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Heriyanto; Pahlevani, F; Sahajwalla, V in ELSEVIER SCI LTD published article about in [Heriyanto; Pahlevani, Farshid; Sahajwalla, Veena] UNSW, Sch Mat Sci & Engn, Ctr Sustainable Mat Res & Technol SMaRT, Sydney, NSW 2052, Australia in 2019.0, Cited 24.0. HPLC of Formula: C7H8N2O. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

This study reports an innovative pathway for successfully synthesizing composite panels using various waste input. For this purpose, seven types of powder from waste or widely available filler i.e. Quartz off-cut, sand, waste seashell, dolomite, limestone aggregates, concrete waste and limestone dust were used. The study aims to assess the effectiveness and mechanical properties of the various waste powder in the production of powder-resin composites. The panels were then compared with the novel polymeric glass composite (PGC) in the previous study (Heriyanto et al., 2018). Following the same procedure in PGC, the filler was individually grounded to 64-108 mu m and chemically treated with amino silane coupling agent (CA). The powder filler (untreated or treated) is then mixed with the resin binder with a ratio of 80/20 respectively, followed by hot pressing the mixture at the pressure of 550 bar at 65 degrees C for 1 h. The final composite slab is then further cut for mechanical testing. It was found in the study that when CA was not added, surface roughness of the powder particles affected the flexural strength of the final panel significantly. High surface roughness particles such as in Quartz, sand and seashell adhere effectively with the resin binder which led to higher strength. On the contrary, other factors like smooth particle morphology in glass, dolomite and limestone as well as porous structure in concrete and clump of very fine powder in limestone dust degrade the strength of the final panels. With CA addition, adhesion between resin and powder filler were improved significantly. Flexural strength after the CA treatment was found to be much affected by particle characteristics. Silica-based panels i.e. quartz, sand and glass which consist of high strength and hardness of silica particles perform better compared to that of calcium carbonate-based panels. Compression strength, toughness, stiffness, scratch resistance, density and water absorption were also reported in this study. The properties of all the treated panels are found to be comparable, or if not, much better than natural stones. These new approaches of using waste filler in powder – resin based composites can be a new alternative to produce green materials that deliver economic and environmental benefits. (C) 2019 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H8N2O. About 1-Phenylurea, If you have any questions, you can contact Heriyanto; Pahlevani, F; Sahajwalla, V or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Chemistry very interesting. Saw the article Graphene Oxide: A Metal- Free Carbocatalyst for the Synthesis of Diverse Amides under Solvent- Free Conditions published in 2019.0. COA of Formula: C7H8N2O, Reprint Addresses Shankarling, GS (corresponding author), Inst Chem Technol, Dept Dyestuff Technol, NP Marg, Mumbai 400019, Maharashtra, India.. The CAS is 64-10-8. Through research, I have a further understanding and discovery of 1-Phenylurea

An environmentally friendly, inexpensive, carbocatalyst, graphene oxide (GO) promoted efficient, metal-free transamidation of various carboxamides with aliphatic, cyclic, and aromatic amines is demonstrated. The protocol is equally applicable to phthalimide, urea, and thioamide determining its adaptability. The oxygenated functionalities such as carbonyl (C=O), epoxy (O), carboxyl (COOH) and hydroxyl (OH), present on graphene oxide surface impart acidic properties to the catalyst. The graphene oxide being heterogeneous in nature, work efficiently under solvent-free reaction conditions providing desired products in good to excellent yields. The one-pot synthesis of 2,3-Dihydro-5H-benzo[b]-1,4-thiazepin-4-one moiety by GO catalyzed Aza Michael addition followed by intramolecular transamidation is also described. A plausible reaction mechanistic pathway involving H-bonding is discussed. The graphene oxide can be recycled and reused up to five cycles without much loss in catalytic activity.

COA of Formula: C7H8N2O. About 1-Phenylurea, If you have any questions, you can contact Patel, KP; Gayakwad, EM; Patil, VV; Shankarling, GS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 2-Aminobenzamide. Recently I am researching about ALPHA-ARYLATION; CATALYZED SYNTHESIS; DERIVATIVES; TRYPTANTHRIN; QUINAZOLINE; CYCLIZATION; COMPLEXES; KETONES; ACCESS; ARYL, Saw an article supported by the CSIRCouncil of Scientific & Industrial Research (CSIR) – India; DST, New DelhiDepartment of Science & Technology (India). Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Reddy, PG; Indukuri, DR; Alla, M. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A one pot sequential addition protocol for synthesis of polycyclic quinazolines with beta-amino acid motifs has been achieved starting from anthranilamide. Initialin situformation of 2-(2-bromophenyl)quinazolin-4(3H)-one followed by addition of alkyl cyanoacetates catalyzed by copper (I) salts gives the target compound in good to excellent yields. The expedient and facile cascade protocol involves nucleophilic alpha-arylation, intramolecular cycloamidation of nitriles followed by 1,3-hydrogen shift allowing direct access to 6-amino-8-oxo-8H-isoquinolino[1,2-b]quinazoline-5-carboxylates.

Application In Synthesis of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Reddy, PG; Indukuri, DR; Alla, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 64-10-8. Authors Abdourahime, H; Anastassiadou, M; Brancato, A; Brocca, D; Cabrera, LC; De Lentdecker, C; Ferreira, L; Greco, L; Jarrah, S; Kardassi, D; Leuschner, R; Lostia, A; Lythgo, C; Medina, P; Miron, I; Molnar, T; Nave, S; Pedersen, R; Raczyk, M; Reich, H; Ruocco, S; Sacchi, A; Santos, M; Stanek, A; Sturma, J; Tarazona, J; Theobald, A; Vagenende, B; Verani, A; Villamar-Bouza, L in EUROPEAN FOOD SAFETY AUTHORITY-EFSA published article about in in 2019.0, Cited 16.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

According to Article 12 of Regulation (EC) No396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance fluometuron. To assess the occurrence of fluometuron residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Commission Regulation (EC) No33/2008 as well as the European authorisations reported by Member States (including the supporting residues data). Based on the assessment of the available data, an MRL proposal was derived and a consumer risk assessment was carried out. All information required by the regulatory framework was present and a risk to consumers was not identified. In addition, EFSA identified some data gaps which are not expected to impact on the validity of the MRL derived but which might have an impact on national authorisations.

Product Details of 64-10-8. About 1-Phenylurea, If you have any questions, you can contact Abdourahime, H; Anastassiadou, M; Brancato, A; Brocca, D; Cabrera, LC; De Lentdecker, C; Ferreira, L; Greco, L; Jarrah, S; Kardassi, D; Leuschner, R; Lostia, A; Lythgo, C; Medina, P; Miron, I; Molnar, T; Nave, S; Pedersen, R; Raczyk, M; Reich, H; Ruocco, S; Sacchi, A; Santos, M; Stanek, A; Sturma, J; Tarazona, J; Theobald, A; Vagenende, B; Verani, A; Villamar-Bouza, L or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2) WOS:000492801800005 published article about MONOCLONAL-ANTIBODY; POTENT; ACTIVATION; MODERATE; SIGNAL; ROLES; OPTIMIZATION; USTEKINUMAB; MOLECULES; DISCOVERY in [Moslin, Ryan; Zhang, Yanlei; Wrobleski, Stephen T.; Lin, Shuqun; Mertzman, Michael; Spergel, Steven; Lombardo, Louis; Carter, Percy H.; Weinstein, David S.] Bristol Myers Squibb Res & Dev, Immunosci Discovery Chem, POB 4000, Princeton, NJ 08543 USA; [Strnad, Joann; Gillooly, Kathleen; McIntyre, Kim W.; Zupa-Fernandez, Adriana; Cheng, Lihong; Heimrich, Elizabeth; Yang, Xiaoxia; Burke, James R.] Bristol Myers Squibb Res & Dev, Immunosci Discovery Biol, POB 4000, Princeton, NJ 08543 USA; [Tokarski, John S.; Muckelbauer, Jodi K.; Chang, ChiehYing; Tredup, Jeffrey; Mulligan, Dawn; Xie, Dianlin] Bristol Myers Squibb Res & Dev, Mol Struct & Design, Mol Discovery Technol, POB 4000, Princeton, NJ 08543 USA; [Sun, Huadong; Huang, Christine; D’Arienzo, Celia; Aranibar, Nelly; Chiney, Manoj] Bristol Myers Squibb Res & Dev, Lead Discovery & Optimizat, POB 4000, Princeton, NJ 08543 USA; [Chaudhry, Charu] Bristol Myers Squibb Res & Dev, Metab & Pharmacokinet Dept, Pharmaceut Candidate Optimizat, POB 4000, Princeton, NJ 08543 USA; [Weinstein, David S.] Vividion Therapeut Inc, Chem, 5820 Nancy Ridge Dr, San Diego, CA 92121 USA in 2019, Cited 53. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Application In Synthesis of 2-Aminobenzamide

As a member of the Janus OAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide 4, identified by a SPA-based high-throughput screen targeting the TYK2 pseudokinase domain, potently inhibits IL-23 and IFN alpha signaling in cellular assays. The described work details the optimization of this poorly selective hit (4) to potent and selective molecules such as 47 and 48. The discoveries described herein were critical to the eventual identification of the clinical TYK2 JH2 inhibitor (see following report in this issue). Compound 48 provided robust inhibition in a mouse IL-12-induced IFN gamma pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model. These results demonstrate the ability of TYK2 JH2 domain binders to provide a highly selective alternative to conventional TYK2 orthosteric inhibitors.

About 2-Aminobenzamide, If you have any questions, you can contact Moslin, R; Zhang, YL; Wrobleski, ST; Lin, SQ; Mertzman, M; Spergel, S; Tokarski, JS; Strnad, J; Gillooly, K; McIntyre, KW; Zupa-Fernandez, A; Cheng, LH; Sun, HD; Chaudhry, C; Huang, C; D’Arienzo, C; Heimrich, E; Yang, XX; Muckelbauer, JK; Chang, C; Tredup, J; Mulligan, D; Xie, DL; Aranibar, N; Chiney, M; Burke, JR; Lombardo, L; Carter, PH; Weinstein, DS or concate me.. Application In Synthesis of 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem