Tag: M.W=100-150

An article Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27 WOS:000460642800021 published article about COMPLETE GENOME SEQUENCE; NATURAL-PRODUCTS; ANTIBIOTIC PRODUCTION; SECONDARY METABOLISM; MASS-SPECTROMETRY; MOLECULAR NETWORKING; PATHOGENS; PLATFORM; STRESS; LINKS in [Machushynets, Nataliia V.; Wu, Changsheng; Elsayed, Somayah S.; van Wezel, Gilles P.] Leiden Univ, Inst Biol, Mol Biotechnol, Sylviusweg 72, NL-2333 BE Leiden, Netherlands; [Wu, Changsheng] Shandong Univ, Inst Microbial Technol, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China; [Hankemeier, Thomas] Leiden Univ, LACDR, Einsteinweg 55, NL-2333 CC Leiden, Netherlands in 2019, Cited 57. Recommanded Product: 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Actinobacteria are a major source of novel bioactive natural products. A challenge in the screening of these microorganisms lies in finding the favorable growth conditions for secondary metabolite production and dereplication of known molecules. Here, we report that Streptomyces sp. MBT27 produces 4-quinazolinone alkaloids in response to elevated levels of glycerol, whereby quinazolinones A (1) and B (2) form a new sub-class of this interesting family of natural products. Global Natural Product Social molecular networking (GNPS) resulted in a quinazolinone-related network that included anthranilic acid (3), anthranilamide (4), 4(3H)-quinazolinone (5), and 2,2-dimethyl-1,2-dihydroquinazolin-4(3H)-one (6). Actinomycins D (7) and X2 (8) were also identified in the extracts of Streptomyces sp. MBT27. The induction of quinazolinone production by glycerol combined with biosynthetic insights provide evidence that glycerol is integrated into the chemical scaffold. The unprecedented 1,4-dioxepane ring, that is spiro-fused into the quinazolinone backbone, is most likely formed by intermolecular etherification of two units of glycerol. Our work underlines the importance of varying the growth conditions for the discovery of novel natural products and for understanding their biosynthesis.

Recommanded Product: 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Machushynets, NV; Wu, CS; Elsayed, SS; Hankemeier, T; van Wezel, GP or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about SILICA; RETENTION; BEHAVIOR, Saw an article supported by the Grant Agency of the Czech RepublicGrant Agency of the Czech Republic [18-00062S]; [RVO: 68081715]. Published in ELSEVIER in AMSTERDAM ,Authors: Moravcova, D; Cmelik, R; Krenkova, J. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Computed Properties of C7H8N2O

The advantages of using mixtures of organic solvents for the separation of labeled oligosaccharides on the amide stationary phase under hydrophilic interaction liquid chromatography conditions are presented. The effect of the type of buffer as well as solvent or their mixtures on retention of uracil, saccharide labeling reagents (2-aminobenzoic acid, 2-aminobenzamide, ethyl 4-aminobenzoate, procainamide), and corresponding labeled saccharides were evaluated. The successful isocratic separation of labeled isomeric trisaccharides (maltotriose, panose, and isomaltotriose) was achieved in the mobile phase consisting of a 90% (v/v) mixture of organic solvents (methanol/acetonitrile 60:40) and 10% (v/v) 30 mM ammonium formate, pH 3.3. Changing the volume ratio between methanol/acetonitrile from 60:40 to 50:50 (v/v) allowed to obtain the separation of di-, tri-, and tetrasaccharides labeled by ethyl 4-aminobenzoate in less than 10.5 min. (c) 2021 Elsevier B.V. All rights reserved.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Moravcova, D; Cmelik, R; Krenkova, J or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Chemistry; Crystallography very interesting. Saw the article The first example of the stereoselective synthesis and crystal structure of a spirobicycloquinazolinone based on (-)-fenchone and anthranilamide published in 2019. Computed Properties of C7H8N2O, Reprint Addresses Chernyshov, VV (corresponding author), NN Vorozhtsov Novosibirsk Inst Organ Chem SB RAS, 9 Acad Lavrentiev Ave, Novosibirsk 630090, Russia.; Chernyshov, VV (corresponding author), Novosibirsk State Univ, Pirogova St 2, Novosibirsk 630090, Russia.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

The possibility of a single-stage solvent-free stereoselective synthesis of a spirocyclic compound from the natural bicyclic monoterpenoid (-)-fenchone and anthranilamide has been shown for the first time. The molecular and crystal structure of (1R,2S,4S)-1,3,3-trimethyl-10H-spiro[bicyclo[2.2.1]heptane-2,2′-quinazolin]-4′(3’H)-one, C17H22N2O, was established by X-ray diffraction though the chirality was assumed via the known reactant connectivity and H-1 and C-13 NMR spectroscopy. It has shown that in the molecule, for steric reasons, there is an elongation of the Me2C-C(N)N bond to 1.603 (5) A degrees. The formation of dimers via N-H center dot center dot center dot O C hydrogen bonds with an interaction energy of 93.30 kJ mol(-1) and through cavities (33.7% of the unit-cell volume) was established in the packing of the molecules. There are no pi-stacking interactions in the structure.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Chernyshov, VV; Gatilov, YV; Yarovaya, OI; Koskin, IP; Yarovoy, SS; Brylev, KA; Salakhutdinov, NF or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Shiota, M; Endo, S; Fujimoto, N; Tsukahara, S; Ushijima, M; Kashiwagi, E; Takeuchi, A; Inokuchi, J; Uchiumi, T; Eto, M in ELSEVIER SCIENCE INC published article about METASTATIC PROSTATE-CANCER; NADIR TESTOSTERONE; PREDICTS PROGNOSIS; HORMONE; PROGRESSION; IMPACT; MEN; STEROIDOGENESIS; INHIBITION; EXPRESSION in [Shiota, Masaki; Tsukahara, Shigehiro; Ushijima, Miho; Kashiwagi, Eiji; Takeuchi, Ario; Inokuchi, Junichi; Eto, Masatoshi] Kyushu Univ, Grad Sch Med Sci, Dept Urol, Fukuoka, Japan; [Endo, Satoshi] Gifu Pharmaceut Univ, Dept Biopharmaceut Sci, Lab Biochem, Gifu, Japan; [Fujimoto, Naohiro] Univ Occupat & Environm Hlth, Sch Med, Dept Urol, Kitakyushu, Fukuoka, Japan; [Tsukahara, Shigehiro; Uchiumi, Takeshi] Kyushu Univ, Grad Sch Med Sci, Dept Clin Chem & Lab Med, Fukuoka, Japan in 2020.0, Cited 36.0. HPLC of Formula: C7H8N2O. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

Objective: Androgen metabolism is a key component in therapeutic resistance to androgen deprivation therapy (ADT). This study aimed to reveal the significance of genetic polymorphisms in genes involved in androgen metabolism, including CYP17A1, AKR1C3, and HSD17B, on serum testosterone levels during ADT, as well as the prognosis of men undergoing ADT for metastatic prostate cancer (CaP). Materials and methods: This study included 104 Japanese patients with metastatic CaP, for whom serum testosterone data during ADT were available for 80 patients. The association of CYP17A1 (rs743572), AKR1C3 (rs12529), HSD17B1 (rs605059), HSD17B3 (rs2066479), and HSD17B4 (rs7737181) with serum testosterone levels during ADT and prognosis (progression-free survival and overall survival) was examined. Enzymatic activity in AKR1C3 H5Q was examined using recombinant protein. Results: Homozygous wild-type (GG allele; median [interquartile range], 12.0 ng/ml [8.0-19.0 ng/ml]) AKR1C3 rs12529 was associated with higher serum testosterone levels during ADT compared with variant-type (GC/CC alleles; median [interquartile range], 9.0 ng/ml [6.4-10.8 ng/ml]). Consistently, variant-type (GC/CC alleles) AKR1C3 rs12529 showed significantly lower risk of progression (hazard ratio [95% confidence interval], 0.47 [0.24-0.96], P = 0.039) compared with homozygous wild-type (GG allele) on multivariate analysis. Meanwhile, other genetic variations were associated with neither serum testosterone during ADT nor prognosis. Enzyme activity of wild-type AKR1C3 was comparable to the H5Q mutant. Conclusions: Taken together, this study demonstrated that AKR1C3 polymorphism, which was associated with serum testosterone levels during ADT, may be a prognostic factor of the progression to castration-resistant prostate cancer in Japanese men with metastatic CaP. (C) 2020 Elsevier Inc. All rights reserved.

HPLC of Formula: C7H8N2O. About 1-Phenylurea, If you have any questions, you can contact Shiota, M; Endo, S; Fujimoto, N; Tsukahara, S; Ushijima, M; Kashiwagi, E; Takeuchi, A; Inokuchi, J; Uchiumi, T; Eto, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. In 2019 LETT ORG CHEM published article about SOLVENT-FREE; CATALYST; EFFICIENT; 2,3-DIHYDRO-4(1H)-QUINAZOLINONES; QUINAZOLINONES; FACILE in [Chen, Chuanhuan; Xuejiao, A.; Li, Xia; Huang, Guoli; Liu, Bo] Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China in 2019, Cited 34. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

We have developed a new method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yields via phosphomolybdic acid (PMA)-catalyzed cyclocondensation of 2-aminobenzamides with aldehydes or ketones in N,N-dimethylformamide (DMF) at room temperature. The present method proves to be efficient in terms of short reaction time, high yield, simple workup and easy purification.

About 2-Aminobenzamide, If you have any questions, you can contact Chen, CH; Xuejiao, A; Li, X; Huang, GL; Liu, B or concate me.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 2-Aminobenzamide. Authors Vaidya, GN; Nagpure, M; Kumar, D in AMER CHEMICAL SOC published article about in [Vaidya, Gargi Nikhil; Nagpure, Mithilesh; Kumar, Dinesh] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Gandhinagar 382355, Gujarat, India in 2021, Cited 72. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A borrowing carbonate-enabled allylic cross-amination reactions employing allylic alcohol were discovered via merging acyl/allyl C-O bonds activation under nickel catalysis. The key component of this protocol is the ability of nickel [Ni(II)-Ni(0)] to execute a relay process via the nucleophilic trapping of the generated acyl Ni complex, resulting from the acyl C-O bond cleavage of dialkyl carbonates, followed by selective allylic C-O bond activations (allylic C-O vs alkyl C-O vs acyl C-O) to yield pi-allyINi-complexes. The finding truly represents Ni-catalyzed green allylic amination reactions under additive(s)-free conditions with excellent chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) with a wide range of fundamentally challenging N-heterocycles and allylic alcohols. The reaction is scalable, does not require harmful reaction media and a globe box, and is successfully applied to the scale-up synthesis of pharmaceuticals (cinnarizine, flunarizine, and naftifine) with promising yields.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Vaidya, GN; Nagpure, M; Kumar, D or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Electrochemical Synthesis of Quinazolinones by the Metal-Free and Acceptor-Free Dehydrogenation of 2-Aminobenzamides WOS:000560729500001 published article about ONE-POT SYNTHESIS; OXIDATIVE SYNTHESIS; DERIVATIVES; ALCOHOLS; QUINAZOLIN-4(3H)-ONES; AMINES; ELECTROSYNTHESIS; SULFONYLATION; AMINATION; ANTITUMOR in [Yao, Yan; Meng, Xiu-Jin; Teng, Qing-Hu] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China; [Teng, Qing-Hu] Guilin Univ Technol, Coll Chem & Bioengn, Guangxi Key Lab Electrochem & Magnetochem Funct M, Guilin 541004, Peoples R China; [Chen, Yan-Yan] Guilin Med Univ, Pharm Sch, Guilin 541004, Peoples R China in 2020, Cited 47. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Quality Control of 2-Aminobenzamide

An efficient approach has been developed for the construction of quinazolin-4(3H)-ones by the selective anodic dehydrogenative oxidation/cyclization of benzylic chlorides and 2-aminobenzamides. The method features acceptor-free and metal-free dehydrogenation of amines to imines; a subsequent intermolecular addition provides the products in moderate to good yields.

Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Yao, Y; Meng, XJ; Teng, QH; Chen, YY or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Quinazoline-4(3H)-one derivatives as novel and potent inhibitors of soluble epoxide hydrolase: Design, synthesis and biological evaluation published in 2020. Computed Properties of C7H8N2O, Reprint Addresses Tabatabai, SA (corresponding author), Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut Chem, Tehran, Iran.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

Inhibition of soluble epoxide hydrolase (sEH) is considered as a promising target to reduce blood pressure, improve insulin sensitivity, and decrease inflammation. In this study, a series of some novel quinazoline-4(3H)one derivatives (3a-t) with varying steric and electronic properties was designed, synthesized and evaluated as sEH Inhibitors. Most of the synthesized compounds had similar inhibitory activity to the commercial reference inhibitor, 12-(3-adamantan-1-ylureido)dodecanoic acid, and amongst them, 4-chloro-N-(4-(4-oxo-3,4-dihydroquinazoline-2-yl)phenyl)benzamide (3g) was identified as the most active sEH inhibitor (IC50 = 0.5 nM), about 2-fold more potent compared to the reference inhibitor. The results of molecular modeling followed by biological studies indicate that a quinazolinone ring serves as a suitable scaffold to develop novel small molecule candidates to inhibit sEH and the nature of substituent on the amide moiety has a moderate effect on the activity.

About 2-Aminobenzamide, If you have any questions, you can contact Hejazi, L; Rezaee, E; Tabatabai, SA or concate me.. Computed Properties of C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Neurosciences & Neurology very interesting. Saw the article Exploring Cerebrospinal Fluid IgG N-Glycosylation as Potential Biomarker for Amyotrophic Lateral Sclerosis published in 2019. COA of Formula: C7H8N2O, Reprint Addresses Costa, J (corresponding author), Univ Nova Lisboa, Lab Glycobiol, Inst Tecnol Quim & Biol Antonio Xavier, Ave Republ, P-2780157 Oeiras, Portugal.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which the existing candidate biomarkers (neurofilaments) have low specificity. Changes in blood IgG N-glycosylation have been observed in several diseases, including ALS, whereas cerebrospinal fluid (CSF) IgG has been less studied. Here, we characterized N-glycans of CSF IgG from ALS patients in comparison with a control group of other neurological diseases. Cerebrospinal fluid was collected from patients with ALS (n=26) and other neurological diseases (n=10). N-Glycans were released from CSF purified IgG with peptide N-glycosidase F, labeled with 2-aminobenzamide and analyzed by NP-HPLC chromatography in combination with exoglycosidase digestion and MALDI-TOF mass spectrometry. The N-glycosylation profile of ALS CSF IgG consisted of diantennary N-glycans predominantly with proximal fucose and some bisecting GlcNAc; agalacto-, mono-, and digalactosylated as well as alpha 2,6-sialylated structures were detected. Differences between ALS and control patients were observed; most relevant was the increase in ALS CSF IgG of the level of galactosylated structures defined here as Gal-index (median 46.87 and 40.50% for ALS and controls, respectively; p=0.006). The predictive value of the Gal-index (AUC=0.792, p=0.007) considering ROC analysis had potential utility as a diagnostic test for ALS and was comparable to that of phosphoneurofilament heavy chain (AUC=0.777, p=0.011), which was used as benchmark marker for our group of patients. The results provide the basis to further explore the potential of IgG N-glycan galactosylation as biomarker for ALS by using larger cohorts of patients and controls.

About 2-Aminobenzamide, If you have any questions, you can contact Costa, J; Streich, L; Pinto, S; Pronto-Laborinho, A; Nimtz, M; Conradt, HS; de Carvalho, M or concate me.. COA of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 88-68-6. Recently I am researching about RESIDUE LOSS; N-GLYCANS; ROLES, Saw an article supported by the Basque GovernmentBasque Government; EU CommissionEuropean CommissionEuropean Commission Joint Research Centre [749996]; Netherlands Organization for Scientific Research (NWO)Netherlands Organization for Scientific Research (NWO) [718.015.003, 731.016.402]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Torano, JS; Gagarinov, IA; Vos, GM; Broszeit, F; Srivastava, AD; Palmer, M; Langridge, JI; Aizpurua-Olaizola, O; Somovilla, VJ; Boons, GJ. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

The fucosylation of glycans leads to diverse structures and is associated with many biological and disease processes. The exact determination of fucoside positions by tandem mass spectrometry (MS/MS) is complicated because rearrangements in the gas phase lead to erroneous structural assignments. Here, we demonstrate that the combined use of ion-mobility MS and well-defined synthetic glycan standards can prevent misinterpretation of MS/MS spectra and incorrect structural assignments of fucosylated glycans. We show that fucosyl residues do not migrate to hydroxyl groups but to acetamido moieties of N-acetylneuraminic acid as well as N-acetylglucosamine residues and nucleophilic sites of an anomeric tag, yielding specific isomeric fragment ions. This mechanistic insight enables the characterization of unique IMS arrival-time distributions of the isomers which can be used to accurately determine fucosyl positions in glycans.

About 2-Aminobenzamide, If you have any questions, you can contact Torano, JS; Gagarinov, IA; Vos, GM; Broszeit, F; Srivastava, AD; Palmer, M; Langridge, JI; Aizpurua-Olaizola, O; Somovilla, VJ; Boons, GJ or concate me.. Recommanded Product: 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem