Heterocyclic Building Blocks-Thiomorpholine

Computed Properties of C4H6N4O2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Methyl-4-nitro-1H-imidazol-5-amine, is researched, Molecular C4H6N4O2, CAS is 4531-54-8, about Development and validation of stability – indicating RP-HPLC chromatographic method by forced degradation studies for azathioprine by related substances. Author is Hiralben, S. Mehta; Shinghvi, Indrajeet; Raj, Hasumati A..

Simple, rapid and reproducible stability-indicating methods were established for quant. determination of azathioprine using a, phenomenex 250 mm × 4.9 mm C18, 5 μm, inertsil and UV detection at 240 nm. The isocratic elution was used to quantify the analyte and the mobile phase was acetate buffer: acetonitrile: methanol (30: 35: 35) was pumped at 1.0 mL/min. The method was linear between 10-300 μg/mL, statistically validated for its linearity, precision and accuracy. In this study, degradation behavior of azathioprine was studied by subjecting the drug to various ICH stress conditions. The intra and inter day variation was found to be less than 1% showing high precision of the assay method. It was found that the excipients in the com. tablet did not interfere with the method. Developed method can routinely use for the estimation of azathioprine related compounds from the dosage form and also for stability sample.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Imidazole series. XX. Aminonitroimidazoles and diaminoimidazoles, published in 1965, which mentions a compound: 4531-54-8, Name is 1-Methyl-4-nitro-1H-imidazol-5-amine, Molecular C4H6N4O2, Application of 4531-54-8.

cf. preceding abstract The aminonitroimidazoles I-XII were prepared by heating the corresponding nitrochloroimidazoles with a 8-15% alc. NH3 solution at 120-50° for 5-10 hrs. The products I, VII, and XII were obtained in the presence of CuSO4 catalyst (formula, R, m.p., and % yield 131-1.5°, 15-20; VII, iso-Bu, 108-10°, 15; VIII, H, 222.5-23°, 30.5; IX, Me, 198-9°, 39.5; X, Et, 160-1°, 58; XI, Pr, 130-1°, 32; XII, iso-Bu, 129-30°, 21.5. The hydrogenation of II in Ac2O in the presence of Raney Ni gave 1-ethyl-2-methyl-4,5-diaminoimidazole diacetate at 30-45° and initial H pressure of 10 atm. and tetraacetate at 50-80° and 100 atm.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Optical rotations of configurationally related azides》. Authors are Levene, P. A.; Rothen, Alexandre; Kuna, Martin.The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Safety of 1-Iodo-2-methylbutane. Through the article, more information about this compound (cas:616-14-8) is conveyed.

Substances of the type MeCH[(CH2)n1X][(CH2)n2R], where n1 or n2 = 0 or an integer, X = a functional group and R = a normal alkyl, Ph or C6Hn group, can be classified into 2 categories, viz., those, typified by X = CHO, in which the configuration of the 1st members having n1 = 0 can be correlated by classical methods to those having n1 > 0, and those, typified by X = halogen, in which such correlation cannot be accomplished by classical methods. For the purpose of solving the latter problem the azides were chosen over the halides, inasmuch as they can be converted into the corresponding amines. The amines, while belonging to the 2nd category, can be correlated among themselves by a sufficiently reliable though nonclassical argument which will be reported later. The secondary azides were prepared by the action of NaN3 on the iodides and the amines by reduction of the azides with PtO2. The rotatory phenomena observed in the series of azides and halides were compared with those in the series of aldehydes and were found to be dissimilar in both series. Hence a comparison of these phenomena cannot be used for the correlation of the members of the series of halides and azides having n1 = 0 with those having n1 > 0. The following compounds were prepared: l-2-iodobutane, b. 111-18°, [M]D25 -24.1°, from the alc. and anhydrous HI in a bomb tube at room temperature for 2 days; d-2-azidobutane, b500 85°, d425 0.8619, nD25 1.4122, [M]D25 15.9°; d-2-aminobutane, [M]D25, 0.66° (in H2O), (HCl salt, [M]5875.625 -0.44° (in H2O)); l-2-iodoöctane, b1 52°, nD25 1.4863, d425 1.3158, [M]D25 -80.0°; d-2-azidoöctane, b9 68°, nD25 1.4332, d425 0.8555, [M]D25 43.4°, 42.5° (in heptane (I)); d-2-aminoöctane, b9 48°, nD25 1.4220, [M]D25 5.41°, (HCl salt, [M]D25 -6.44° (in H2O)); d-1-iodo-2-methylbutane, b. 145-6°, nD25 1.4950, [M]D25 8.28°, maximum [M]D25 11.1°; d-1-azido-2-methylbutane, b138 72°, nD25 1.4240, d425 0.8770, [M]D25 8.61°, maximum [M]D25 11.6°; l-1-amino-2-methylbutane, b12 40-5°, [M]5875.625 -0.21° (in H2O); l-1-azido-2-methylhexane, b15 59-60°, [α]D25 -0.30°; d-1-iodo-2-methylnonane, b4 86°, d425 1.254, [M]D25 2.54°; l-1-azido-2-methylnonane, b10 98-102°, d425 0.8658, nD25 1.4430, [M]D25 -0.74°; l-1-iodo-3-methylpentane, b12 54°, d425 1.3934, nD25 1.4866, [M]D25 -16.1°, maximum [M]D25 -43.9°; l-1-azido-3-methylpentane, b. 145-8°, nD25 1.4300, [M]D25 -9.63°, maximum [M]5875.625 -26.3° (in I); d-1-iodo-4-methylhexane, b13 74-5°, b103 124-6°, nD25 1.4852, d425 1.3579, [M]D25 8.20°, maximum [M]D25 26.2°; d-1-azido-4-methylhexane, b418 157°, d425 0.8636, nD25 1.4323, [M]5875.625 5.41°, maximum [M]5875.625 17.3° (in I.). All values for [M] are for the homogenous substance unless otherwise stated.

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Formula: C5H11I. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Preparation of (S)-2-methylbutyl and (S)-sec-butyl ketones from optically active 2-methyl-1-butanol by the dithiane method. Author is Seebach, D.; Steinmueller, D..

Optically active aldehydes and ketones EtMeCHCRO (where R = H, Me, Ph, Me3Si, C5H11, or 1-cyclohexenyl) were prepared by treating EtMeCHCHO, obtained from EtMeCHCH2OH, with CH2(CH2SH)2 to give 2-(1-methylpropyl)-1,3-dithiane, which was then alkylated and hydrolyzed. The loss of optical activity was <20% for the reaction sequence. If you want to learn more about this compound(1-Iodo-2-methylbutane)Formula: C5H11I, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(616-14-8).

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Formation of 4(5)-aminoglyoxalines. I》. Authors are Balaban, Isidore E..The article about the compound:1-Methyl-4-nitro-1H-imidazol-5-aminecas:4531-54-8,SMILESS:NC1=C([N+]([O-])=O)N=CN1C).Category: thiomorpholine. Through the article, more information about this compound (cas:4531-54-8) is conveyed.

The only evidence at present that 4(5)-aminoglyoxalines are true aromatic amines is the formation, after diazotization, of colored soln with aqueous β-C10H7ONa. Reduction of 4(5)-nitro-2-methyl- and 4(5)-nitroglyoxalines with Fe and H2O, FeSO4 and NaOH, Na2S or activated Al gave no basic material. Et glyoxaline-4(5)-carboxylate and N2H4.H2O, heated on the H2O bath for 30 min., give nearly quant. glyoxaline-4(5)-carboxyhydrazide, crystallizing with 1H2O, m. 213°, reduces NH4OH-AgNO3 slowly but not Fehling solution; picrate, yellow, m. 223° (decomposition), crystallizes from 85 parts boiling H2O. With HNO3 there results glyoxaline-4(5)-carboxyazide (I), decomposes explosively at 137°; heating with H2O does not give the urea; the green solution gives an amorphous picrate, chars 230°. Boiling I with absolute EtOH for 4 hrs. gives 42.2% of 4(5)-carbethoxyaminoglyoxaline, m. 180°; picrate, golden, decomposes 210°, crystallizes from 60 parts boiling H2O; nitrate (II), decomposes 143°. I and MeOH give 50% of the corresponding carbomethoxy derivative, m. 175°; picrate, decomposes 243°. Neither derivative could be hydrolyzed by acid or alkali. II and concentrated H2SO4 give 58% of 5(4)-nitro-4(5)-carbethoxyaminoglyoxaline, m. 234° (decomposition); this could not be converted by 10% Na2CO3 into the corresponding amine. 5-Chloro-4-nitro-1-methylglyoxaline and EtOH-NH3, heated 4 hrs. at 140°, give 63.7% of the 5-NH2 derivative, yellow, m. 303° (decomposition), crystallizes from 170 parts boiling H2O; it does not form an Ac derivative, a benzylidene derivative or a picrate; after treatment with HNO2, alk. C10H7ONa gives a greenish blue color and alk. m-C6H4(OH)2 a violet color. With 16% HCl, HNO2 is liberated and α-methylamino-α-hydroxyacetamide, pale brown, m. 140°, is formed.

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Related Products of 616-14-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Synthetic methods and reactions. 63. Pyridinium poly(hydrogen fluoride) (30% pyridine-70% hydrogen fluoride): a convenient reagent for organic fluorination reactions. Author is Olah, George A.; Welch, John T.; Vankar, Yashwant D.; Nojima, Mosatomo; Kerekes, Istvan; Olah, Judith A..

Pyridinium polyhydrogen fluoride (30% pyridine-70% HF) reagent, a stabilized, less-volatile form of HF, is a convenient and effective fluorinating agent. Fluorination, halofluorination, nitrofluorination, and hydrofluorination of olefins were achieved using the reagent. The in situ diazotization and subsequent fluorinative dediazonization of α-amino acids, aminoarenes, and carbamates yielded α-fluorocarboxylic acids, aryl fluorides, and fluoroformates, resp. Geminal dihalides and α-halo ketones were treated with HgO in pyridinium polyhydrogen fluoride to form geminal difluorides and α-fluoro ketones. Solutions of alkali halides in pyridinium polyhydrogen fluoride were also effective halogenating agents for aminoarenes, via in situ diazotization and subsequent nucleophilic dediazonization by the corresponding halides, as well as for alcs., via SN2 displacement reactions. Diazo ketones and diazoalkanes also reacted smoothly with halide ions in pyridinium polyhydrogen fluoride solution to give the corresponding geminally halofluorinated compounds Proper precautions must be observed in using pyridinium polyhydrogen fluoride.

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SDS of cas: 198544-60-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (R)-(9H-Fluoren-9-yl)methyl (1-chloro-4-methyl-1-oxopentan-2-yl)carbamate, is researched, Molecular C21H22ClNO3, CAS is 198544-60-4, about Total Solid Phase Syntheses of the Quinazoline Alkaloids: Verrucines A and B and Anacine. Author is Wang, Haishan; Sim, Mui Mui.

The first total syntheses of verrucines A and B and anacine (revised structure) were accomplished on Sasrin resin. This work confirmed the structure of verrucine A and unambiguously showed verrucine B to be a derivative of D-phenylalanine and L-glutamine. The study also proved that anacine and its epimer are quinazoline alkaloids, not benzodiazepines as originally proposed. 1-Hydroxyverrucine B, derived from air oxidization of verrucine B, was also isolated and characterized.

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Suzuki, Takahisa published the article 《Identification of the aggregation pheromone of flour beetles Tribolium castaneum and T. confusum (Coleoptera: Tenebrionidae)》. Keywords: pheromone aggregation Tribolium methyldecanalysis; beetle aggregation pheromone methyldecanalysis.They researched the compound: 1-Iodo-2-methylbutane( cas:616-14-8 ).Computed Properties of C5H11I. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:616-14-8) here.

The aggregation pheromone produced by the male red flour beetle, T. castaneum, and confused flour beetle, T. confusum, was identified as 4,8-dimethyldecan-1-al by gas-liquid chromatog., gas chromatog.-mass spectrometry, 1H NMR spectra, and synthesis of the compound The synthetic pheromone was less attractive compared with the natural pheromone, because the synthetic sample was composed of 4 optical isomers.

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Related Products of 616-14-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about On labelling with generator nuclides. Author is Otto, R.; Hecht, P..

Short-lived radioisotopes separated from radionuclide generators are widely used. Possibilities of labeling with the daughter nuclides of the com. available Mo/Tc-, Sn/In-, and Te/I-generators and of the self-made Ba/La-generator in industrial tracer experiments are presented. The transfer of the daughter nuclides from the generator eluates into organic phases and the labeling of oil-phases and solid particles are investigated. The developed simple, quick and efficient methods are suitable for routine application under industrial conditions. Some examples of industrial applications of the generator nuclides are given, too.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Chromatography called Gas chromatography of alkyl halides on a silicone oil capillary column, Author is Hepburn, D. R.; Hudson, H. R., which mentions a compound: 616-14-8, SMILESS is CCC(CI)C, Molecular C5H11I, HPLC of Formula: 616-14-8.

RX (R = C3H7, C4H9, and C5H11; X = Cl-, Br-, and I-) isomers were separated and identified by gas chromatog. on a capillary column containing silicone fluid MS 550 at 20° with N carrier gas and a flame ionization detector. The straight-chain secondary hexyl, heptyl, and octyl halide isomers were similarly separated at 20-80°. The technique was used to analyze quant. 27 com. available secondary alkyl halides for their isomeric composition

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