Heterocyclic Building Blocks-Thiomorpholine

New research progress on 90-11-9 in 2021. Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 90-11-9, Name is 1-Bromonaphthalene, molecular formurla is C10H7Br. In a document, author is Battula, Kumara Swamy, introducing its new discovery. Reference of 90-11-9.

A series of new thirteen N-(3-Methoxyphenyl)thiomorpholine-2-carboxamide 1, 1-dioxide derived 1, 4-disubtituted 1, 2, 3-triazole hybrids (7a-7m) were synthesized by Cu (I) catalyzed cycloaddition reaction and well characterized by (HNMR)-H-1, (CNMR)-C-13, FTIR, mass spectral and elemental analysis data. All the hybrid compounds were subjected to invitro anticancer activity against three human cancer cell lines MCF-7, Hela and A-549 and 2-hydroxy phenyl, 2-methoxy phenyl and 3-methoxy phenyl substituted (7f, 7g and 7h) derivatives were found to possess potential antiproliferative activity.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 86-55-5 in 2021. Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 86-55-5, Name is 1-Naphthoic acid, molecular formurla is C11H8O2. In a document, author is Yurttas, Leyla, introducing its new discovery. Formula: https://www.ambeed.com/products/86-55-5.html.

Background: In this study, 2-(substituted-sulfanyl)-N, N-dicyclohexylacetamide derivatives (2a-2g) and 2-(dicyclohexylamino)-2-oxoethyl-1-substituted carbodithioate derivatives (2h-2m) were synthesized and screened for their antimicrobial activity. Methods: Newly synthesized compounds were screened against two gram negative bacteria (S. typhimurium and E. coli), three gram positive bacteria (S. aureus, B. cereus and L. monocytogenes), four Candida species, four Aspergillus spp. and three Penicillium spp. Among them (2a-2m), compounds 2i (2-(dicyclohexylamino)-2-oxoethyl-thiomorpholine-4-carbodithioate) and 2k (2( dicyclohexylamino)-2-oxoethyl-4-(4-methoxyphenyl) piperazine-1-carbodithioate) were detected to have higher inhibitory effect than other compounds. Results and Conclusion: Minumum inhibitor concentrations (MICs) of the compounds were determined between the range of 97.5-390 mu g/mL. Additionally, parameters determined that some physicochemical and toxic properties were predicted using computational methods.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

You could be based in a university, combining chemical research with teaching; or in a public-sector research center, helping to ensure national healthcare provision keeps pace with new discoveries. In an article, author is Zelenkova, N. F., once mentioned the application of 529-35-1, Name is 5,6,7,8-Tetrahydro-1-naphthol, molecular formula is C10H12O, molecular weight is 148.2017, MDL number is MFCD00001734, category is thiomorpholine. Now introduce a scientific discovery about this category, Synthetic Route of 529-35-1.

A combination of thin-layer chromatography (TLC) with high-performance liquid chromatography (HPLC) was shown to be efficient in determining the intermediate products of the utilization of thiomorpholine with ligninolytic basidiomycete fungus Bjerkandera adusta VKM F-3477. The chromatographic mobility of the products of microbiological degradation of thiomorpholine was studied on Sorbfil PTSKh-P-V plates in the systems of chloroform-methanol-25% aqueous ammonia (80: 20: 2) for determining cyclic amines and isopropanol-25% aqueous ammonia (70: 30) for determining thio acids. The optimum conditions were selected for the separation of thiomorpholine and the formed metabolites by ion-exchange chromatography and reversed-phase chromatography.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. In an article, author is Lanoix, J. -P., once mentioned the application of 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formula is C9H12ClNO3S, molecular weight is 249.7145, MDL number is MFCD00216817, category is thiomorpholine. Now introduce a scientific discovery about this category, Related Products of 125464-42-8.

In the context of increasing drug resistance among Mycobacterium tuberculosis (Mtb) strains, new, potent and well tolerated drugs are urgently needed. Bedaquiline has obtained accelerated approval, but additional novel agents are needed to enable effective combination chemotherapy of extensively drug-resistant tuberculosis (TB). Linezolid, the first and only marketed oxazolidinone antibiotic, has shown certain activity against Mtb. However, serious safety concerns related to long-term administration have limited its utility for TB treatment. Sutezolid (formerly PNU-100480) is a thiomorpholine analogue of linezolid with greater potency in several experimental TB models and the potential for a superior safety profile. This article reviews available preclinical and clinical data regarding the pharmacokinetics, safety and efficacy of sutezolid and presents the case for its further development for the treatment of TB.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. In an article, author is Cindric, Marina, once mentioned the application of 72235-52-0, Name is (2,4-Difluorophenyl)methanamine, molecular formula is C7H7F2N, molecular weight is 143.134, MDL number is MFCD00010142, category is thiomorpholine. Now introduce a scientific discovery about this category, Electric Literature of 72235-52-0.

Eight mononuclear [Ni(sal 4-Phtsc)center dot D] thiosemicarbazonato complexes [sal4-Phtsc = salicylaldehyde 4-phenylthiosemicarbazonato ligand; D = imidazole (1), methylimidazole (2), pyridine (3), 4-aminopyridine (4), 4-methylpyridine (6), morpholine (7), thiomorpholine (8), 2-aminophenol (9)] and one dinuclear {[Ni(sal 4-Phtsc)](2)center dot D} center dot 2DMSO [D = 4,4′-bipyridine (5)] complex have been prepared by adding the corresponding Lewis base to the methanol suspension of the parent complex [Ni(sal 4-Phtsc)(H(2)sal4-Phtsc)]center dot CH3OH. The exchange of the neutral salicylaldehyde 4-phenylthiosemicarbazone (H(2)sal4-Phtsc) ligand in the parent complex for the appropriate Lewis base has been confirmed by IR spectroscopy and powder X-ray diffraction (PXRD) in the solid state. The single-crystal X-ray diffraction of seven complexes 1 and 3-8 confirmed the formation of the complexes with the Ni-II ion, coordinated through O,N,S-donor atoms from the dibasic salicylaldehyde 4-phenylthiosemicarbazonato ligand and endocyclic N-donor atom from the neutral ligand D in the form of a distorted square-planar coordination. NMR spectroscopy in DMF or DMSO and quantum mechanical calculations have been performed in order to explain and compare the stability of the complexes in solution, depending on the polarity of solvents in the context of donor properties and the nucleophilicity of the heterocyclic Lewis base. The single-crystal X-ray data enables a comparison with calculated standard Gibbs energies of binding in the context of crystal packing forces, leading to a general conclusion that the stability of the mononuclear complexes results in the formation of more stable hydrogen-bonded cyclic dimers as a crystal packing pattern.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. In an article, author is Gokmen, Zeliha, once mentioned the application of 120-46-7, Name is 1,3-Diphenylpropane-1,3-dione, molecular formula is C15H12O2, molecular weight is 224.26, MDL number is MFCD00003085, category is thiomorpholine. Now introduce a scientific discovery about this category, Category: thiomorpholine.

S,S- and S,S,S-substituted nitrodienes 3a, 3b, and 4a were synthesized by reactions of 1,1,2,4,4-pentachloro-3-nitro-1,3-butadiene with some thiols 4-chlorobenzylmercaptan and 2-chlorobenzylmercaptan in ethanol in the presence of sodium hydroxide. Thiomorpholine ring substituted nitrodienes 6c and 6d and were obtained from the reactions of the mono(thio)substituted nitrodienes with thiomorpholine in dichloromethane. The single crystal X-ray structure of 4-(1-thiomorpholinyl)-4-(butylsulfanyl)-1,1,2-trichloro-3-nitro-1,3-butadiene (6c) is reported. In this present paper, the structures of new compounds were characterized by using nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and Fourier transform infrared (FTIR) spectroscopy spectroscopic data.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 21145-77-7 in 2021. Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. 21145-77-7, Name is 1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone, molecular formurla is C18H26O. In a document, author is Vargas-Pineday, Gabriela, introducing its new discovery. Synthetic Route of 21145-77-7.

Thirteen new stannacyclododecane dithiocarbamate complexes have been prepared by reacting 12-chloro-12-n-butyl-1,11-dioxa-4,8-dithia-12-stannacyclododecane (1) and 12-chloro-12-n-butyl-1,4,8,11-tetrathia-12-stannacyclododecane (2) with pyrrolidine-, morpholine-, thiomorpholine-, piperidine-, piperazinebis-, and 3-pyrroline-carbodithioates, respectively, as well as with diethyl-dithiocarbamate. All complexes were characterized by elemental analyses, IR, EI-MS, and NMR (H-1, C-13, and Sn-119) studies. The spectroscopic data suggest the replacement of the chlorides by the corresponding dithiocarbamates with monodentate coordination, leading to six-coordinate tin atoms in all the cases.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves., HPLC of Formula: https://www.ambeed.com/products/95-83-0.html, 95-83-0, Name is 4-Chlorobenzene-1,2-diamine, molecular formula is C6H7ClN2, belongs to thiomorpholine compound. In a document, author is Padmavathi, V, introduce the new discover.

The mass spectra of 2-methoxycarbonyl-3,5-di(4-methylphenyl)-1,4-thiomorpholine-1,1-dioxide (1), 2-(4-chlorobenzoyl)-3-(4-chlorophenyl)-5-(4-methylphenyl)-1,4-thiomorfpholine-1,1-dioxide (2) and 2-benzoyl-3,5-diphenyl-6-methoxycarbonyl-1,4-thiomorpholine-1,1-dioxides (3) have been studied with the aid of Eledctron Impact (EI), High Resolution (HR) and Total Ion Chromatogram (TLC) technique. Cleavage alpha to the heteroqatoms appears to be the predominant process in the disintegration of 1, 2 and 3. The important fragmented ions are characterized by HR and TLC.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 88-05-1 in 2021. Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 88-05-1, Name is 2,4,6-Trimethylaniline, molecular formurla is C9H13N. In a document, author is Olma, A., introducing its new discovery. Application of 88-05-1.

The cyclization of -Boc-alpha-alkylserines to corresponding beta-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced -Boc-alpha-alkyl-beta-(-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protein amino acids.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Product Details of 99-61-6, 99-61-6, Name is 3-Nitrobenzaldehyde, molecular formula is C7H5NO3, belongs to thiomorpholine compound. In a document, author is Mezil, Lynda, introduce the new discover.

Background: Targeted therapies, associated with standard chemotherapies, have improved breast cancer care. However, primary and acquired resistances are frequently observed and the development of new concepts is needed. High-throughput approaches to identify new active and safe molecules with or without an a priori” are currently developed. Also, repositioning already-approved drugs in cancer therapy is of growing interest. The thiomorpholine hydroxamate compound TMI-1 has been previously designed to inhibit metalloproteinase activity for the treatment of rheumatoid arthritis. We present here the repositioning of TMI-1 drug in breast cancer. Methodology/Principal Findings: We tested the effect of TMI-1 on luminal, basal and ERBB2-overexpressing breast tumor cell lines and on MMTV-ERBB2/neu tumor evolution. We measured the effects on i) cell survival, ii) cell cycle, iii) extrinsic and intrinsic apoptotic pathways, iv) association with doxorubicin, docetaxel and lapatinib, v) cancer stem cells compartment. In contrast with conventional cytotoxic drugs, TMI-1 was highly selective for tumor cells and cancer stem cells at submicromolar range. All non-malignant cells tested were resistant even at high concentration. TMI-1 was active on triple negative (TN) and ERBB2-overexpressing breast tumor cell lines, and was also highly efficient on human and murine primary” ERBB2-overexpressing cells. Treatment of transgenic MMTV-ERBB2/neu mice with 100 mg/kg/day TMI-1 alone induced tumor apoptosis, inhibiting mammary gland tumor occurrence and development. No adverse effects were noticed during the treatment. This compound had a strong synergistic effect in association with docetaxel, doxorubicin and lapatinib. We showed that TMI-1 mediates its selective effects by caspase-dependent apoptosis. TMI-1 was efficient in 34/40 tumor cell lines of various origins (ED50: 0.6 mu M to 12.5 mu M). Conclusions/Significance: This is the first demonstration of the tumor selective cytotoxic action of a thiomorpholin hydroxamate compound. TMI-1 is a novel repositionable drug not only for the treatment of adverse prognosis breast cancers but also for other neoplasms.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 99-61-6, you can contact me at any time and look forward to more communication. Product Details of 99-61-6.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem