Heterocyclic Building Blocks-Thiomorpholine

An article An Efficient Green Protocol for Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Using SBA-16/GPTMS-TSC-Cu-I under Solvent-Free Conditions WOS:000514728300028 published article about 2-AMINOETHYL DIHYDROGEN PHOSPHATE; ONE-POT SYNTHESIS; MAGNETICALLY REUSABLE NANOCATALYST; HIGHLY ENANTIOSELECTIVE SYNTHESIS; SOLID ACID; 3-COMPONENT SYNTHESIS; HETEROGENEOUS CATALYST; RAPID SYNTHESIS; SUZUKI-MIYAURA; IONIC LIQUID in [Erfan, Mohammad Anwar; Akhlaghinia, Batool; Ghodsinia, Sara S. E.] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad 9177948974, Razavi Khorasan, Iran in 2020, Cited 87. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. COA of Formula: C7H8N2O

Herein a rapid, efficient, facile and environmentally benign synthesis of 2,3-dihydroquinazolin-4(1H)-ones using SBA-16/GPTMS-TSC-Cu-I (Cu-I anchored onto mesoporous SBA-16 functionalized by aminated 3-glycidyloxypropyltrimethoxysilane with thiosemicarbazid) is reported. The aforesaid mesostructured catalyst with a unique super-cage structure and narrow particle size distribution (3-7 nm) exhibited excellent catalytic activity in high yielding preparation of 2,3 dihydroquinazolin-4(1H)-ones from the condensation of 2-aminobenzamide and an aldehyde in solvent-free conditions. Furthermore, SBA-16/GPTMS-TSC-Cu-I as a heterogeneous catalyst was stable under reaction conditions and can be recycled at least five times without any loss of its catalytic efficiency.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Erfan, MA; Akhlaghinia, B; Ghodsinia, SSE or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about OXIDATIVE STRESS; MODEL, Saw an article supported by the . COA of Formula: C13H10O. Published in PHARMACOTHERAPY GROUP in BENIN CITY ,Authors: Saleem, MF; Khan, MA; Ahmad, I; Aslam, N; Khurshid, U. The CAS is 119-61-9. Through research, I have a further understanding and discovery of Benzophenone

Purpose: To synthesize and characterize some new gabapentin Schiff base derivatives, and to assess their antibacterial, antioxidant and antiepileptic activities. Methods: Four Schiff base derivatives of gabapentin, termed G1, G2, G3 and G4, were synthesized by condensation with benzoin, vanillin, acetophenone, and benzophenone, respectively. Their chemical identities were established by FTIR, H-1 NMR and C-13 NMR techniques. The new compounds were screened for antibacterial activity using agar well method, antioxidant activity by DPPH assay, and anticonvulsant activity against pentylenetetrazole (PTZ) induced seizures in mice. Results: All the compounds showed antibacterial activity against the test strains to variable degrees, while the parent drug did not exhibit antibacterial activity. The zones of inhibition of compound G2 against Micrococcus luteus (36.2 +/- 1.0 mm) and Serratia marcescens (28.2 +/- 1.0 mm), and of compound G4 against Stenotrophomonas maltophilia (36.8 +/- 1.0 mm) were larger compared to the standard drug, doxycycline, exhibiting zones of inhibition 28.2 +/- 1.3, 28.2 +/- 0.9 and 20.0 +/- 0.9 mm, respectively. In addition, compounds G1 and G2 possessed significantly greater (p < 0.05) radical scavenging activity (82.3 +/- 1.8 and 92.3 +/- 2.2 %, respectively) than the precursor drug, gabapentin (63.2 +/- 2.6 %). The seizure scores for compounds GI (0.7 +/- 0.06) and G2 (0.9 +/- 0.07) were comparable (p > 0.05) with gabapentin (0.8 +/- 0.06), while compounds G3 and G4 were less active (p < 0.05) than gabapentin. Conclusion: Compounds G1 and G2 exhibit good antibacterial and antioxidant activities while retaining the anticonvulsant activity of the parent drug, gabapentin, thus making them suitable candidates for further development for the treatment of neurodegenerative pathologies associated with bacterial infections. COA of Formula: C13H10O. About Benzophenone, If you have any questions, you can contact Saleem, MF; Khan, MA; Ahmad, I; Aslam, N; Khurshid, U or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of Anthrone. Authors Kaur, K; Mittal, SK; Kumar, SKA; Kumar, A; Kumar, S; Metters, JP; Banks, CE in MDPI published article about in [Kaur, Karamjeet; Mittal, Susheel K.] Thapar Inst Engn & Technol, Sch Chem & Biochem, Patiala 147001, Punjab, India; [Kumar, Ashok S. K.] VIT Univ, Sch Adv Sci, Vellore 632014, Tamil Nadu, India; [Kumar, Ashwani; Kumar, Subodh] GND Univ, Dept Chem, Amritsar 143005, Punjab, India; [Metters, Jonathan P.; Banks, Craig E.] Manchester Metropolitan Univ, Fac Sci & Engn, Sch Chem & Environm, Div Chem & Environm Sci, John Dalton Bldg,Chester St, Manchester M1 5GD, Lancs, England in 2021, Cited 33. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

Voltammetric sensor using a symmetrical derivative of anthrone3 (1,7-diamino-3,9-dibutyl benzo[1,2,3-de:4,5,6-d’e’]diquinoline-2,8(3H,9H)-dione) (SPE-A) has been developed as a probe for Hg(II) ions. Performance of the probe as screen-printed electrode modified with the receptor (SPE-A) has been compared with anthrone3 in solution phase, using 1:1 water-acetonitrile solvent system. Anthrone3 displayed an electrochemically quasi-reversible nature in voltammograms with both the systems and is presented as a novel disposable voltammetric sensor for mercury ions. Upon interaction with cations, both the electrode systems showed sensitivity towards Hg2+ ions with a lower detection limit of 0.61 mu M. The magnitude of the voltammetric current with the SPE-A exhibited three times the current obtained with a bare glassy carbon electrode (GC). Kinetic performance of the SPE-A electrode is better than the GC electrode. The morphological studies indicate reusability of the electrodes.

About Anthrone, If you have any questions, you can contact Kaur, K; Mittal, SK; Kumar, SKA; Kumar, A; Kumar, S; Metters, JP; Banks, CE or concate me.. Quality Control of Anthrone

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Development and Verification of a Precolumn Derivatization LC-MS/MS Method for the Pharmacokinetic Study of Houttuynine of Houttuynia Essential Oil WOS:000644610800001 published article about DNPH DERIVATIZATION; CORDATA THUNB.; CARBONYL-COMPOUNDS; VOLATILE OIL; IN-VIVO; IDENTIFICATION; HOUTTUYFONATE; SODIUM in [Liu, Yuanyuan; Yang, Yanfang; Wang, Bangyuan; Wang, Renyun; Pang, Jianmei; Jiang, Yu; Liu, Yuling] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China; [Liu, Yuanyuan; Yang, Yanfang; Wang, Bangyuan; Wang, Renyun; Pang, Jianmei; Jiang, Yu; Liu, Yuling] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Delivery Technol & Novel For, 1 Xiannongtan St, Beijing 100050, Peoples R China in 2021.0, Cited 31.0. Quality Control of Benzophenone. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Houttuynia essential oil (HEO) has excellent antiviral, anti-inflammatory, and other pharmacological effects, but the lack of effective analytical methods to quantify HEO in plasma has hindered its better clinical monitoring. Houttuynine (Hou) is one of the main active ingredients and quality control substances of HEO, so the pharmacokinetic study of HEO could be conducted by determining Hou blood concentration. Hou is active and not stable in plasma, which makes its blood concentration difficult to measure. In this work, a novel liquid chromatography tandem mass spectrometry (LC-MS/MS) method for Hou determination in rat blood was established that involves Hou being derivatized with 2, 4-dinitrophenylhydrazine to form a stable compound to prevent degradation. Herein, p-Tolualdehyde-2,4-dinitrophenylphenylhydrazone was selected as an internal standard substance and the LC-MS/MS method was evaluated for selectivity, precision, accuracy, calibration limit, matrix effect, recovery, and stability. Good linearity (r(2) = 0.998) was reached in the range of 2-2000 ng/mL, and the lower limit of quantification of Hou was determined to be 2 ng/mL. The mean intra-assay accuracy ranged from 77.7% to 115.6%, whereas the intra-assay precision (relative standard deviation, RSD) was below 11.42%. The matrix effect value for Hou in rat plasma was greater than 75%, and for the internal standard (IS) it was 104.56% +/- 3.62%. The extraction recovery of Hou were no less than 90%, and for the IS it was 96.50% +/- 4.68%. Our method is sensitive and reliable and has been successfully applied to the pharmacokinetic analysis of Hou in rats given HEO via gavage and injection.

Quality Control of Benzophenone. About Benzophenone, If you have any questions, you can contact Liu, YY; Yang, YF; Wang, BY; Wang, RY; Pang, JM; Jiang, Y; Liu, YL or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 119-61-9. Authors Liu, RZ; Mabury, SA in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Liu, Runzeng; Mabury, Scott A.] Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada in 2021.0, Cited 67.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Although synthetic antioxidants (AOs) and photoinitiators (PIs) are known to be used in printing inks, there are little data on residual concentrations in printing paper products. In the present study, twenty-five PIs, ten AOs, and six transformation products were analyzed in two types of printing paper products, magazines and paperboard food packaging materials, both of which are unavoidable everyday products in our life. Nine AOs and six transformation products can be detected in food packaging materials with total concentrations (geometric mean, GM) of 1.16 x 10(4) ng/dm2. Twenty-two PIs were detected in food packaging materials with total concentrations (GM) of 1.76 x 10(4) ng/dm2. These chemicals were also detected in magazines, albeit at low concentrations (GM of AOs: 466 ng/dm(2), GM of PIs: 1.17 x 10(3) ng/dm(2)). Magazine front covers were found to have much higher concentrations of the target compounds than magazine inside pages. Tris(2,4-di-tert-butylphenyl) phosphate (AO168O), 2,6-di-tert-butyl-4-methylphenol (BHT), bisphenol A (BPA), and benzophenone (BP) were among the predominant chemicals in those printing paper products. Preliminary calculations suggest that dermal exposure to AOs (GM: 6.25 ng/day) and PIs (GM: 17.0 ng/day) via contact with printing paper products is a minor exposure pathway compared to food intake/dust ingestion and is exceedingly unlikely to cause adverse health effects.

Product Details of 119-61-9. About Benzophenone, If you have any questions, you can contact Liu, RZ; Mabury, SA or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about PROPARGYLIC ALCOHOLS; ORGANIC-DYES, Saw an article supported by the CSIR-New DelhiCouncil of Scientific & Industrial Research (CSIR) – India. Computed Properties of C7H8N2O. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Athira, M; Shanmugam, P. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A boron trifluoride catalysed reaction of coplanar 9-(phenyl-ethynyl)-9 H-fluoren-9-ols with various 2-aminobenzamides affords a number of highly functionalized, conjugated (Z)-2-((2-(9 H-fluoren-9-ylidene)-1-phenylethylidene)amino) benzamides in excellent yield. The reaction in the presence of N-bromosuccinimide affords (E)-5-bromo-2-((2-bromo-2-(9 H-fluoren-9-ylidene)-1-phenylethylidene)amino)benz-amides in very good yields. The scope of the reaction is demonstrated by selecting N-aryl substituted 2-aminobenzamides and aminosulfonamides as reaction partners. The structures of representative compounds were established by single-crystal XRD analysis. Based on the structure of the products, a plausible mechanism via formation of allene carbocation intermediates is proposed.

About 2-Aminobenzamide, If you have any questions, you can contact Athira, M; Shanmugam, P or concate me.. Computed Properties of C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Smyrnov, V; Muriel, B; Waser, J in AMER CHEMICAL SOC published article about VINYL AZIDES; CATALYZED CYCLOPROPENATION; 3+2 ANNULATION; TRIALKYLBORANES; DERIVATIVES; CHEMISTRY; ACCESS; STRAIN in [Smyrnov, Vladyslav; Muriel, Bastian; Waser, Jerome] Ecole Polytech Fed Lausanne, Lab Catalysis & Organ Synth, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland in 2021.0, Cited 48.0. Safety of Benzophenone. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

We report the synthesis of quinolines using cyclopropenes and an azidobenziodazolone (ABZ) hypervalent iodine reagent as an azide radical source under visible-light irradiation. Multisubstituted quinoline products were obtained in 34-81% yield. The reaction was most efficient for 3-trifluoromethylcyclopropenes, affording valuable 4-trifluoromethylquinolines. The transformation probably proceeds through the cyclization of an iminyl radical formed by the addition of the azide radical on the cyclopropene double bond, followed by ring-opening and fragmentation.

About Benzophenone, If you have any questions, you can contact Smyrnov, V; Muriel, B; Waser, J or concate me.. Safety of Benzophenone

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 EUR J MED CHEM published article about DEPENDENT KINASE INHIBITOR; MICROTUBULE POLYMERIZATION; CDK4-SPECIFIC INHIBITORS; BIOLOGICAL EVALUATION; SELECTIVE INHIBITORS; CRYSTAL-STRUCTURE; NONPLANAR ANALOG; CYCLIN D1-CDK4; IN-VITRO; PROTEIN in [Sonawane, Vinay; Chaudhuri, Bhabatosh] De Montfort Univ, Leicester Sch Pharm, Leicester LE1 9BH, Leics, England; [Siddique, Mohd Usman Mohd; Sinha, Barij Nayan; Jayaprakash, Venkatesan] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Bihar, India; [Jadav, Surender Singh] Indian Inst Chem Technol, CSIR, Hyderabad 500007, Telangana, India in 2019, Cited 79. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Category: thiomorpholine

Inhibition of cyclin dependent kinase 4 (Cdk4) prevents cancer cells from entering the early G(0)/G(1) phase of the cell division cycle whereas inhibiting tubulin polymerization blocks cancer cells’ ability to undergo mitosis (M) late in the cell cycle. We had reported earlier that two non-planar and relatively non-toxic fascaplysin derivatives, an indole and a tryptoline, inhibit Cdk4 with IC50 values of 6.2 and 10 mu M, respectively. Serendipitously, we had also found that they inhibited tubulin polymerization. The molecules were efficacious in mouse tumor models. We have now identified Cink4T in a 59-compound quinazolinone library, designed on the basis of ligand-based virtual screening, as a compound that inhibits Cdk4 and tubulin. Its IC50 value for Cdk4 inhibition is 0.47 mu M and >50 mu M for inhibition of Cdk1, Cdk2, Cdk6, Cdk9. Cink4T inhibits tubulin polymerization with an IC50 of 0.6 mu M. Molecular modelling studies on Cink4T with Cdk4 and tubulin crystal structures lend support to these observations. Cancer cell cycle analyses confirm that Cink4T blocks cells at both G(0)/G(1) and M phases as it should if it were to inhibit both Cdk4 and tubulin polymerization. Our results show, for the very first time, that virtual screening can be used to design novel inhibitors that can potently block two crucial phases of the cell division cycle. (C) 2019 Elsevier Masson SAS. All rights reserved.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Sonawane, V; Siddique, MUM; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Bouhrim, M; Ouassou, H; Loukili, E; Ramdani, M; Mekhfi, H; Ziyyat, A; Legssyer, A; Aziz, M; Bnouham, M in WOLTERS KLUWER MEDKNOW PUBLICATIONS published article about ANTIOXIDANT; EXTRACT; GLUCOSE; METABOLISM in [Bouhrim, Mohamed; Ouassou, Hayat; Loukili, El Hassania; Ramdani, Mohammed; Mekhfi, Hassane; Ziyyat, Abderrahim; Legssyer, Abdelkhaleq; Aziz, Mohammed; Bnouham, Mohamed] Univ Mohamed First, Fac Sci, Oujda, Morocco in 2019, Cited 39. Name: Anthrone. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

Objective: To assess the antidiabetic effect of Opuntia dillenii seed oil on rats with diabetes mellitus. Methods: A rat diabetes model was established by intraperitoneal injection of rats with 50 mg/kg streptozotocin. Thirty albino Wistar rats were divided into five groups: the diabetic control group and normal control group were treated only with distilled water, two diabetic groups received 1 and 2 mL/kg of oil per day, respectively, for 30 days and one diabetic group received 2 mg/kg of glibenclamide. In addition, blood glucose was determined weekly. Body weight, average daily food, water intake and urinary volume of each animal were determined before and after the treatment period. After the treatment period, hepatic glycogen was determined using the anthrone reagent, and glycosuria, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and uric acid were estimated using common clinical diagnostic kits. Results: Oral intake of the oil at 1 and 2 mL/kg for the diabetic animals significantly diminished blood glucose, glycosuria, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and uric acid, accompanied by a noticeable elevation in the amount of hepatic glycogen in comparison with the diabetic control group. Similarly, Opuntia dillenii seed oil significantly increased the food intake and decreased the urinary volume per day in treated rats of the same groups in comparison with the period before the treatment intervention and attenuated body weight loss in the diabetic rats. Moreover, this effect of the oil was dose dependent. On the other hand, the oil did not affect their need for water. Conclusions: The results show that Opuntia dillenii seed oil has a very important antidiabetic effect on streptozotocin-induced diabetic rats. Hence, we suggest it as a preventive control of diabetes mellitus.

Name: Anthrone. About Anthrone, If you have any questions, you can contact Bouhrim, M; Ouassou, H; Loukili, E; Ramdani, M; Mekhfi, H; Ziyyat, A; Legssyer, A; Aziz, M; Bnouham, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about ONE-POT SYNTHESIS; NATURAL-PRODUCTS; MULTICOMPONENT REACTIONS; NITROGEN-HETEROCYCLES; CASCADE REACTIONS; ISOCYANIDE; CYCLIZATION; DERIVATIVES; ANNULATION; ACCESS, Saw an article supported by the National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21871044, 21472017]; Natural Sciences Foundation of Jilin Province [20190201073JC]. Category: thiomorpholine. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Meng, XH; Wu, DN; Zhang, YJ; Zhao, YL. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A PPTS (pyridinium p-toluenesulfonate)-catalyzed bicyclization reaction of 2-isocyanobenzaldehydes as 1,5-dielectrophiles with various amines has been developed. The reaction not only provides a simple and efficient strategy for the assembly of structurally diverse fused quinazoline derivatives from readily available substrates under metal-free and mild conditions in a single step with only water and hydrogen as the by-products, but also opens the way to the application of o-formyl arylisocyanides in the synthesis of nitrogen-containing heterocycles.

About 2-Aminobenzamide, If you have any questions, you can contact Meng, XH; Wu, DN; Zhang, YJ; Zhao, YL or concate me.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem