Heterocyclic Building Blocks-Thiomorpholine

Authors Xie, ZB; Li, HX; Liu, LS; Lan, J; Hu, ZY; Le, ZG in SCIENCE PRESS published article about ONE-POT SYNTHESIS; ENZYME; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES; EFFICIENT; NANOCATALYST; PROMISCUITY; ACYLASE; MILD in [Xie, Zongbo; Li, Hongxia; Liu, Liansheng; Lan, Jin; Hu, Zhiyu; Le, Zhanggao] East China Univ Technol, Dept Appl Chem, Nanchang 330013, Jiangxi, Peoples R China in 2019, Cited 41. Product Details of 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Alkaline protease-catalyzed synthesis of quinazolinone derivatives was developed between beta-keotester and o-aminobenzamide. Because ethanol is one kind of eco-friendly solvents, this method can reduce the impact of solvents on the environment. Alkaline protease as a biocatalyst has many advantages, e.g. high catalytic activity, environmentally friendly, wide variety of sources and simple operation. In addition, a variety of quinazolinone derivatives was obtained with good to excellent yields just using 2000 U alkaline protease as catalyst.

Product Details of 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Xie, ZB; Li, HX; Liu, LS; Lan, J; Hu, ZY; Le, ZG or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C14H10O. In 2021 ORG LETT published article about REACTIVITY in [Ueno, Keisuke; Nishii, Yuji; Miura, Masahiro] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan in 2021, Cited 46. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

Herein, we disclose a unique directing effect of 9-substituted triptycenes in electrophilic substitution to achieve the regioselective functionalization of the triptycene core. The Hirshfeld population analysis was adopted to predict the selectivity in electrophilic substitution. TMS and t-Bu groups were found to considerably accelerate the reaction at C2 positions to produce C3symmetric isomers. Correlation between distortion and charge distribution within benzene rings was systematically examined.

Formula: C14H10O. About Anthrone, If you have any questions, you can contact Ueno, K; Nishii, Y; Miura, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article HFIP-mediated 2-aza-Cope rearrangement: metal-free synthesis of alpha-substituted homoallylamines at ambient temperature WOS:000640673100001 published article about FLUORINATED ALCOHOLS in [Gadde, Karthik; Maes, Bert U. W.; Abbaspour Tehrani, Kourosch] Univ Antwerp, Dept Chem, Groenenborgerlaan 171, B-2020 Antwerp, Belgium in 2021.0, Cited 80.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6. Application In Synthesis of 3-Nitrobenzaldehyde

An efficient metal-free strategy for the synthesis of alpha-substituted homoallylamine derivatives has been developed via a 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP)-promoted 2-aza-Cope rearrangement of aldimines, generated in situ by condensation of aldehydes with easily accessible 1,1-diphenylhomoallylamines. This reaction provides rapid access to alpha-substituted homoallylamines with excellent functional group tolerance and yields. The reaction takes place at room temperature and no chromatographic purification is required for product isolation. The synthetic utility of the current method is further demonstrated by the transformation of the obtained benzophenone ketimines into N-unprotected homoallylamines, an alpha-amino alcohol and an alpha-amino amide.

Application In Synthesis of 3-Nitrobenzaldehyde. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Gadde, K; Maes, BUW; Tehrani, KA or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about LIMITED ENGLISH PROFICIENCY; PATIENT ACTIVATION MEASURE; EMERGENCY-DEPARTMENT USE; HEALTH-CARE SERVICES; CHILDREN; PARENTS; DISPARITIES; OUTCOMES; CONTINUITY; INSURANCE, Saw an article supported by the Gordon and Betty Moore FoundationGordon and Betty Moore Foundation. Published in AMER ACAD PEDIATRICS in ELK GROVE VILLAGE ,Authors: DeCamp, LR; Godage, SK; Araujo, DV; Cortez, JD; Wu, LX; Psoter, KJ; Quintanilla, K; Rodri’guez, TR; Polk, S. The CAS is 104-21-2. Through research, I have a further understanding and discovery of 4-Methoxybenzyl acetate. Computed Properties of C10H12O3

BACKGROUND AND OBJECTIVES: Latino children in immigrant families experience health care disparities. Text messaging interventions for this population may address disparities. The objective of this study was to evaluate the impact of a Spanish-language text messaging intervention on infant emergency department use and well care and vaccine adherence. METHODS: The Salud al Dia intervention, an educational video and interactive text messages throughout the child’s first year of life, was evaluated via randomized controlled trial conducted in an urban, academic pediatric primary care practice from February 2016 to December 2017. Inclusion criteria were publicly insured singleton infant < 2 months of age; parent age > 18, with Spanish as the preferred health care language; and at least 1 household cellular phone. Primary outcomes were abstracted from the electronic medical record at age 15 months. Intention-to-treat analyses were used. RESULTS: A total of 157 parent-child dyads were randomly assigned to Salud al Dia (n = 79) or control groups (n = 78). Among all participants, mean parent age was 29.3 years (SD: 6.2 years), mean years in the United States was 7.3 (SD: 5.3 years), and 87% of parents had limited or marginal health literacy. The incidence rate ratio for emergency department use for the control versus intervention group was 1.48 (95% confidence interval: 1.04-2.12). A greater proportion of intervention infants received 2 flu vaccine doses compared with controls (81% vs 67%; P = .04). CONCLUSIONS: This Spanish-language text messaging intervention reduced emergency department use and increased flu vaccine receipt among a population at high risk for health care disparities. Tailored text message interventions are a promising method for addressing disparities.

Computed Properties of C10H12O3. About 4-Methoxybenzyl acetate, If you have any questions, you can contact DeCamp, LR; Godage, SK; Araujo, DV; Cortez, JD; Wu, LX; Psoter, KJ; Quintanilla, K; Rodri’guez, TR; Polk, S or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of Benzophenone. Recently I am researching about NICKEL PHOSPHIDE; HYDROGEN EVOLUTION; PRIMARY AMINES; DOPED CARBON; CHEMOSELECTIVE HYDROGENATION; SELECTIVE HYDROGENATION; MOLECULAR-HYDROGEN; GENERAL-SYNTHESIS; NANOPARTICLES; EFFICIENT, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [26105003, 17H03457, 18H01790, 20H02523, 20H05879]; Cooperative Research Program of Institute for Catalysis, Hokkaido University [19A1002, 20B1027]; Nanotechnology Platform Program at Hokkaido University, Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [A-20-HK-0011]; Nanotechnology Open Facilities in Osaka University, Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [A-20-OS-0025]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Sheng, M; Fujita, S; Yamaguchi, S; Yamasaki, J; Nakajima, K; Yamazoe, S; Mizugaki, T; Mitsudome, T. The CAS is 119-61-9. Through research, I have a further understanding and discovery of Benzophenone

The development of metal phosphide catalysts for organic synthesis is still in its early stages. Herein, we report the successful synthesis of single-crystal cobalt phosphide nanorods (Co2P NRs) containing coordinatively unsaturated Co-Co active sites, which serve as a new class of air-stable, highly active, and reusable heterogeneous catalysts for the reductive amination of carbonyl compounds. The Co2P NR catalyst showed high activity for the transformation of a broad range of carbonyl compounds to their corresponding primary amines using an aqueous ammonia solution or ammonium acetate as a green amination reagent at 1 bar of H-2 pressure; these conditions are far milder than previously reported. The air stability and high activity of the Co2P NRs is noteworthy, as conventional Co catalysts are air-sensitive (pyrophorous) and show no activity for this transformation under mild conditions. P-alloying is therefore of considerable importance for nanoengineering air-stable and highly active non-noble-metal catalysts for organic synthesis.

About Benzophenone, If you have any questions, you can contact Sheng, M; Fujita, S; Yamaguchi, S; Yamasaki, J; Nakajima, K; Yamazoe, S; Mizugaki, T; Mitsudome, T or concate me.. Application In Synthesis of Benzophenone

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article T3P mediated intramolecular rearrangement of o-aminobenzamide to o-ureidobenzonitrile using isothiocyanates WOS:000616581600001 published article about PRIMARY AMIDES; UREA; DISCOVERY; DERIVATIVES; INHIBITORS; AMINES; TRANSFORMATION; EFFICIENT; KINASE; MAP in [Shamanth, Sadashivamurthy; Sagar, Kunigal S.; Narayana, Yatheesh; Rangappa, Kanchugarakoppal S.; Kempegowda, Mantelingu] Univ Mysore, DOS Chem, Manasagangotri, Mysuru 570006, Karnataka, India; [Nagarakere, Sandhya C.] St Philomenas Coll, PG Dept Studies Chem, Mysuru, India; [Nagarakere, Sandhya C.] St Philomenas Coll, Res Ctr, Mysuru, India; [Mamatha, Mahesha] SRSMN Govt First Grade Coll, Barkur, India in 2021, Cited 38. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Name: 2-Aminobenzamide

Current work describes the environmentally benign approach for the synthesis of o-ureidobenzonitriles, from o-aminobenzamides and isothiocyanates using T3P. Here, the conversion of thiourea to urea and amide to nitrile take place simultaneously via unprecedented intramolecular rearrangement. This protocol is operationally facile and offers wide variety of o-ureidobenzonitriles at room temperature in good to excellent yields.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Shamanth, S; Nagarakere, SC; Sagar, KS; Narayana, Y; Mamatha, M; Rangappa, KS; Kempegowda, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 99-61-6. Recently I am researching about PYRAZOLE DERIVATIVES; HETEROGENEOUS CATALYST; SILICA NANOPARTICLES; EFFICIENT CATALYST; CONTROLLED-RELEASE; ONE-POT; GREEN; NANOCATALYST; COMPOSITE; ACID, Saw an article supported by the University of Kashan. Published in WILEY in HOBOKEN ,Authors: Mirheidari, M; Safaei-Ghomi, J. The CAS is 99-61-6. Through research, I have a further understanding and discovery of 3-Nitrobenzaldehyde

A core-shell structured magnetic metal-mesoporous microsphere materials NiFe2O4@SiO2@Al-MS in which magnetic particles of NiFe2O4 are core and ordered mesoporous silica are shell, incorporated with aluminum to modify acid-catalyzed reactions. The catalyst was synthesized by Pluronic P123 as a first surfactant and a small quantity of cetrimonium bromide as a template for assistant in acidic medium to create a porous layer. The structural characterization of the catalyst was assessed by Fourier transform infrared (FT-IR), scanning electron microscopy (SEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), vibrating-sample magnetometer (VSM), and Brunauer-Emmett-Teller (BET) analyses. The catalyst demonstrated considerable magnetic properties, a unique mesoporous structure with great surface area (370.36 m(2) g(-1)), high-value recovery, and reusability. The catalyst performance was evaluated for the synthesis of indenopyrazolones via the condensation of ninhydrin, phenylhydrazine, and various aldehydes. The mild conditions for the synthesis, easy workup, and short reaction time are the considerable benefits of the reaction in the presence of Nife(2)O(4)@SiO2@Al-MS as a catalyst.

About 3-Nitrobenzaldehyde, If you have any questions, you can contact Mirheidari, M; Safaei-Ghomi, J or concate me.. Product Details of 99-61-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Domino Processes of Arynes Reacting with Three Classes of Nucleophiles for Organic Syntheses WOS:000604339500001 published article about CARBONYL-COMPOUNDS; ASYMMETRIC-SYNTHESIS; EPOXIDATION; MILD; BENZYNE; 1,2-DIHYDROQUINOLINES; DERIVATIVES; ALDEHYDES; EPOXIDES; ACCESS in [Hwu, Jih Ru; Panja, Avijit; Gupta, Nitesh K.; Tan, Kui-Thong; Lin, Chun-Cheng; Hwang, Kuo-Chu; Huang, Wen-Chieh; Tsay, Shwu-Chen] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan; [Hwu, Jih Ru; Panja, Avijit; Gupta, Nitesh K.; Tan, Kui-Thong; Lin, Chun-Cheng; Hwang, Kuo-Chu; Huang, Wen-Chieh; Tsay, Shwu-Chen] Natl Tsing Hua Univ, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu 30013, Taiwan; [Hu, Yu-Chen] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan; [Hsu, Ming-Hua] Natl Changhua Univ Educ, Dept Chem, Changhua 50007, Changhua, Taiwan in 2021.0, Cited 60.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6. COA of Formula: C7H5NO3

Synthetic application of arynes is broadened by their reactions with neutral N-, S-, and O-containing nucleophiles to produce three types of compounds. Accordingly, 1,2-dihydroquinolines are synthesized from Schiff bases, alkynes, and arynes through a Diels-Alder reaction. Epoxides are prepared from thioethers and arynes along with aldehydes or ketones through a Johnson-Corey-Chaykovsky reaction. Phenolic ethers are produced from allyl ethers and arynes through a Claisen-type rearrangement. These target molecules, including natural products gamma-asarone, asaricin, and a cholesteryl phenolic ether, are formed through reactions initiated by arynes. These new reactions share a prevailing feature of domino processes, which are carried out in a single flask and afford the desired products in good to high yields.

About 3-Nitrobenzaldehyde, If you have any questions, you can contact Hwu, JR; Panja, A; Gupta, NK; Hu, YC; Tan, KT; Lin, CC; Hwang, KC; Hsu, MH; Huang, WC; Tsay, SC or concate me.. COA of Formula: C7H5NO3

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 88-68-6. Cheng, CH; Yun, F; He, J; Ullah, S; Yuan, QP in [Cheng, Chunhui; Yun, Fan; He, Jie; Ullah, Sadeeq; Yuan, Qipeng] Beijing Univ Chem Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Biomed Mat Nat Macromol, 15 Beisanhuan East Rd, Beijing 100029, Peoples R China published Design, synthesis and biological evaluation of novel thioquinazolinone-based 2-aminobenzamide derivatives as potent histone deacetylase (HDAC) inhibitors in 2019, Cited 43. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A series of novel 2-aminobenzamide derivatives decorated with thioquinazolinone were designed and synthesized as histone deacetylase (HDAC) inhibitors. These derivatives were evaluated for their anti-proliferative activities against several human cancer cell lines including A375, Hela, A549, HCT116 and SMMC7721. It’s significantly indicated that some inhibitors exhibited potent antiproliferative activities towards all the studied cancer cell lines. Compounds 7a, 4i, 4o, and 4p exhibited higher antiproliferative activities towards three cancer cell lines: A375, A549 and SMMC7721 compared to CS055, MS275, and C1994. Compound 4p showed more than 4000-fold the isoform selectivity for HDACI and more than 250-fold selectivity for HDAC2 compared with HDAC6. The molecular docking analysis reasonably explained the HDAC inhibitory activity and isoform selectivity. In addition, compounds 7a, 4i, 4o, and 4p showed potent inhibitory activities in migration assay and colony formation analysis, and also promoted cell apoptosis. Moreover, compounds 7a, 4i, and 4o inhibited the growth of SMMC7721 cells at S phase of the cell cycle. The immunofluorometric analysis indicated that compounds 7a, 4i, 4o, and 4p could increase the acetylation status of H3K9. Furthermore, in vivo anticancer efficacy of compound 4p was assessed in the A549 xenograft models, and 4p demonstrated potent antitumor activity (TGI = 62.5%). This study provided an effective strategy for further development of tumor-targeting therapy. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 2-Aminobenzamide, If you have any questions, you can contact Cheng, CH; Yun, F; He, J; Ullah, S; Yuan, QP or concate me.. Product Details of 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. Zarini, D; Sangion, A; Ferri, E; Caruso, E; Zucchi, S; Orro, A; Papa, E in [Sangion, Alessandro] Univ Toronto Scarborough, Dept Phys & Environm Sci, Toronto, ON M1C 1A4, Canada; [Sangion, Alessandro; Papa, Ester] Univ Insubria, Dept Theoret & Appl Sci, QSAR Res Unit Environm Chem & Ecotoxicol, I-21100 Varese, Italy; [Zarini, Daniele; Ferri, Emanuele; Zucchi, Sara] Trusticert SRL, I-20126 Milan, Italy; [Caruso, Enrico] Univ Insubria, Dept Biotechnol & Life Sci DBSV, I-21100 Varese, Italy; [Orro, Alessandro] CNR, Inst Biomed Technol, I-20133 Segrate, Italy published Are In Silico Approaches Applicable As a First Step for the Prediction of e-Liquid Toxicity in e-Cigarettes? in 2020, Cited 55. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2.

Recent studies have raised concerns about e-cigarette liquid inhalation toxicity by reporting the presence of chemicals with European Union CLP toxicity classification. In this scenario, the regulatory context is still developing and is not yet up to date with vaping current reality. Due to the paucity of toxicological studies, robust data regarding which components in e-liquids exhibit potential toxicities, are still inconsistent. In this study we applied computational methods for estimating the toxicity of poorly studied chemicals as a useful tool for predicting the acute toxicity of chemicals contained in e-liquids. The purpose of this study was 3-fold: (a) to provide a lower tier assessment of the potential health concerns associated with e-liquid ingredients, (b) to prioritize e-liquid ingredients by calculating the e-tox index, and (c) to estimate acute toxicity of e-liquid mixtures. QSAR models were generated using QSARINS software to fill the acute toxicity data gap of 264 e-liquid ingredients. As a second step, the potential acute toxicity of e-liquids mixtures was evaluated. Our preliminary data suggest that a computational approach may serve as a roadmap to enable regulatory bodies to better regulate e-liquid composition and to contribute to consumer health protection.

Category: thiomorpholine. About 4-Methoxybenzyl acetate, If you have any questions, you can contact Zarini, D; Sangion, A; Ferri, E; Caruso, E; Zucchi, S; Orro, A; Papa, E or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem