Heterocyclic Building Blocks-Thiomorpholine

Name: 2-Aminobenzamide. Bohlen, ML; Jeon, HP; Kim, YJ; Sung, B in [Bohlen, Marie-Leonie; Jeon, Hyun Pyo; Kim, Young Jun; Sung, Baeckkyoung] KIST Europe Forschungsgesell MbH, Saarbrucken, Germany published In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox in 2019, Cited 39. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Computational analyses of toxicological processes enables high-throughput screening of chemical substances and prediction of their endpoints in biological systems. In particular, quantitative structure-activity relationship (QSAR) models have been increasingly applied to assess the environmental effects of a plethora of toxic materials. In recent years, some more highlighted types of toxicants are endocrine disruptors (EDs, which are chemicals that can interfere with any hormone-related metabolism). Because EDs may significantly affect animal development and reproduction, rapidly predicting the adverse effects of EDs using in silico techniques is required. This study presents an in silico method to generate prediction data on the effects of representative EDs in aquatic vertebrates, particularly fish species. The protocol describes an example utilizing the automated workflow of the QSAR Toolbox software developed by the Organization for Economic Co-operation and Development (OECD) to enable acute ecotoxicity predictions of EDs. As a result, the following are determined: (1) calculation of the numerical correlations between the concentration for 50% of lethality (LC50) and octanol-water partition coefficient (K-ow), (2) output performances in which the LC50 values determined in experiments are compared to those generated by computations, and (3) the dependence of estrogen receptor binding affinity on the relationship between K-ow and LC50.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Bohlen, ML; Jeon, HP; Kim, YJ; Sung, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of 2-Aminobenzamide. In 2019 BIOORG MED CHEM LETT published article about C/EBP-ALPHA; INHIBITORS; CYTOTOXICITY; CANCER in [Radhakrishnan, Sridhar; Tenen, Daniel G.] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore; [Syed, Riyaz; Sultana, Farheen; Kamal, Ahmed] Indian Inst Chem Technol, CSIR, Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India; [Syed, Riyaz] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad 500085, India; [Takei, Hisashi; Kobayashi, Ikei S.; Nakamura, Eugene; Kobayashi, Susumu S.] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA; [Takei, Hisashi; Kobayashi, Ikei S.; Nakamura, Eugene; Kobayashi, Susumu S.] Harvard Med Sch, Boston, MA 02215 USA; [Takei, Hisashi] Gunma Univ, Grad Sch Med, Dept Med & Clin Sci, Maebashi, Gunma 3718511, Japan; [Kamal, Ahmed] Janda Harndard, SPER, New Delhi 110062, India; [Tenen, Daniel G.] Harvard Med Sch, Harvard Stem Cell Inst, Boston, MA 02215 USA; [Kobayashi, Susumu S.] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Div Translat Genom, Kashiwa, Chiba 2778577, Japan; [Sultana, Farheen] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA in 2019, Cited 21. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The tumor suppressor transcription factor CCAAT enhancer-binding protein alpha (C/EBP alpha) expression is down-regulated in myeloid leukemias and enhancement of C/EBP alpha expression induces granulocytic differentiation in leukemic cells. Previously we reported that Styryl quinazolinones induce myeloid differentiation in HL-60 cells by upregulating C/EBP alpha expression. To identify more potent molecule that can induce leukemic cell differentiation we synthesized and evaluated new series of styryl quinazolinones, ethynyl styryl quinazolinones, styryl quinolinones and thienopyrimidinones. Thienopyrimidinones were found toxic and styryl quinolinones were found inactive. Ethynyl styryl quinazolinone 39 and styryl quinazolinone 5 were found active on par with the earlier reported analogues 1 and 2 suggesting that the 5-nitro furan-2-yl styryl quinazolinones find a real promise in leukemic cell differentiation. The improved potency of 5 suggested that further modifications in the 5-nitro furan-2-yl styryl quinazolinones can be at the phenyl substitution at the 3-position of the quinazolinone ring apart from the 5-position of the heteroaryl ring.

Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Radhakrishnan, S; Syed, R; Takei, H; Kobayashi, IS; Nakamura, E; Sultana, F; Kamal, A; Tenen, DG; Kobayashi, SS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Site-Selective C-H Amidation of 2-Aryl Quinazolinones Using Nitrene Surrogates WOS:000573134100001 published article about AMINATION; FUNCTIONALIZATION; INDOLINES; NITROGENATION in [Kim, Saegun; Jeoung, Daeun; Kim, Kunyoung; Lee, Suk Hun; Park, Min Seo; Ghosh, Prithwish; Mishra, Neeraj Kumar; Kim, In Su] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; [Lee, Seok Beom; Hong, Suckchang] Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea in 2020, Cited 47. Product Details of 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The site-selective modifications of quinazolinones constitute a pivotal topic in drug discovery and material science. Herein, we describe the rhodium(III)-catalyzed C-H amidation of 2-aryl quinazolin-4(3H)-ones with a range of nitrene surrogates including dioxazolones, organic azides, andN-methoxyamides. Complete site-selectivity and functional group tolerance are observed. Notably, the large-scale reaction and late-stage functionalization highlight the synthetic potential of the developed protocol. Combined mechanistic investigations elucidate a plausible reaction mechanism of this process.

About 2-Aminobenzamide, If you have any questions, you can contact Kim, S; Jeoung, D; Kim, K; Lee, SB; Lee, SH; Park, MS; Ghosh, P; Mishra, NK; Hong, S; Kim, IS or concate me.. Product Details of 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021.0 TALANTA published article about PHASE MICROEXTRACTION; ANALYTICAL-CHEMISTRY; CHROMATOGRAPHY; CONTAMINANTS; AUTOMATION; FILTERS in [Will, Camila; Huelsmann, Ricardo Dagnoni; Mafra, Gabriela; Carasek, Eduardo] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil; [Carasek, Eduardo] Univ Fed Ciencias Saude Porto Alegre, Dept Farmacociencias, BR-90050170 Porto Alegre, RS, Brazil; [Anderson, Jared L.] Iowa State Univ, Dept Chem, Ames, IA 50011 USA in 2021.0, Cited 38.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Quality Control of Benzophenone

In this work, a novel and high-throughput parallel-dispersive droplet extraction (Pa-DDE) based on in situ formation of the hydrophobic MILs ([Co(C4IM)(4)(+2)]2[NTf2-], [Ni(C4IM)(4)(+2)]2[NTf2-] and [Ni(BeIM)(4)(+2)]2[NTf2]) is demonstrated, for the first time, for the determination of benzophenone, metolachlor, triclocarban, pendimethalin, 4-methylbenzylidene camphor, and 2-ethylhexyl-4-methoxycinnamate from aqueous environmental samples. This experimental setup is comprised of a 96-well plate system containing a set of magnetic pins which were used to collect the MIL droplet after in situ formation. This consolidated system enabled simultaneous extraction of up to 96 samples and MIL production in one step. Using this apparatus, sample preparation times of 0.78 min per sample was achieved. The experimental conditions were carefully optimized using uni and multivariate approaches. The optimal conditions were comprised of sample volume of 1.25 mL, 4 mg of [Co (C4IM)(4)(+2)]2[Cl] and 40 mu L of LiNTf2 for the in situ formation, and dilution in 20 mu L of acetonitrile. The analytical parameters of merit were successfully determined with LODs ranging from 7.5 to 25 mu g L-1 and coefficients of determination higher than 0.989. Intraday and interday precision ranged from 6.4 to 20.6% (n = 3) and 11.6-22.9% (n = 9), respectively, with analyte relative recovery ranging between 53.9 and 129.1%.

Quality Control of Benzophenone. About Benzophenone, If you have any questions, you can contact Will, C; Huelsmann, RD; Mafra, G; Merib, J; Anderson, JL; Carasek, E or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Olyaei, A; Aghajanzadeh, A; Feizy, E; Sadeghpour, M in WILEY-V C H VERLAG GMBH published article about DOMINO REACTIONS; 4-COMPONENT SYNTHESIS; NATURAL-PRODUCTS; EFFICIENT; CATALYST; PHENAZINES; BENZOPHENAZINES; DABCO; BENZO in [Olyaei, Abolfazl; Aghajanzadeh, Atiye; Feizy, Elaheh] Payame Noor Univ PNU, Dept Chem, POB 19395-4697, Tehran, Iran; [Sadeghpour, Mahdieh] Islamic Azad Univ, Dept Chem, Takestan Branch, Takestan, Iran in 2021, Cited 35. Category: thiomorpholine. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

A simple and efficient synthesis of novel 6,6 ‘-(arylmethylene)bis(benzo[a]phenazin-5-ol) derivatives has been developed via a sequential one-pot, two-step, pseudo-five-component tandem reaction starting from 2-hydroxynaphthalene-1,4-dione, o-phenylenediamine, and aromatic aldehydes in the presence of 2-aminopyridine as co-catalyst and p-TsOH as catalyst at 90 degrees C under solvent-free conditions. This sequential green process offers several advantages, such as operational simplicity, high yield, low cost, easy handling, clean reactions, absence of any tedious work-up, and purification of products by non-chromatographic methods.

About 3-Nitrobenzaldehyde, If you have any questions, you can contact Olyaei, A; Aghajanzadeh, A; Feizy, E; Sadeghpour, M or concate me.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2020 POLYCYCL AROMAT COMP published article about MEALYBUG HOMOPTERA-PSEUDOCOCCIDAE; 2-ARYLALKYL-SUBSTITUTED ANTHRACENONES; 12-LIPOXYGENASE ENZYMES; ANTHRONE; INHIBITORS; TAUTOMERISM; DERIVATIVES; ANTITUMOR in [Dardeer, Hemat M.; Elboray, Elghareeb E.] South Valley Univ, Dept Chem, Fac Sci, Qena, Egypt; [Mohamed, Ghada S.] South Valley Univ, Plant Protect Dept, Fac Agr, Qena, Egypt in 2020, Cited 55. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8. Computed Properties of C14H10O

Anthrone tautomerized predominantly, under the reaction conditions, into anthrol and involved in the azo coupling reaction with aryl diazonium chloride to give the corresponding azo dye. UV-Vis experiments have supported the tautomerization of anthrone and the presence of the azo dye products in the hydrazone form. Aryl amines with broad biological applications have been involved to increase the utility of the obtained products. Preliminary antibacterial activity resulted in compounds7a,dwhich showed the lowest MIC values of 0.2 and 0.1 x 10(-3) mu g/mL againstEnterococcus feacalisandEscherichia coli, respectively. Furthermore, the insecticidal activity of the nominated compounds7a,bagainst the adults of vine mealybug,Planococcusficus(Signoret), showed LC(50)values of 152.22 and 216.12 mg/mL, respectively.

Computed Properties of C14H10O. About Anthrone, If you have any questions, you can contact Dardeer, HM; Elboray, EE; Mohamed, GS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C7H8N2O. In 2020.0 EUR J ORG CHEM published article about CALCIUM-CHANNEL BLOCKERS; HETEROCYCLIC CARBENE; KINETIC RESOLUTION; STEREOSELECTIVE-SYNTHESIS; COOPERATIVE CATALYSIS; ASYMMETRIC-SYNTHESIS; REDOX AMIDATIONS; ACID-ESTERS; ALDEHYDES; POTENT in [Brandolese, Arianna; Ragno, Daniele; Leonardi, Costanza; Bortolini, Olga; De Risi, Carmela; Massi, Alessandro] Univ Ferrara, Dept Chem & Pharmaceut Sci, Via L Borsari 46, I-44121 Ferrara, Italy; [Di Carmine, Graziano] Univ Manchester, Sch Chem Engn & Analyt Sci, Sackville St, Manchester M13 9PL, Lancs, England in 2020.0, Cited 92.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

The oxidative N-acylation reaction of 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) with enals and N-heterocyclic carbene (NHC) catalysts is described. The reaction proceeds in the presence of quinone oxidant without additional acyl transfer agents and in the asymmetric variant produces pharmaceutically relevant N3-acylated products with good-to-moderate enantioselectivity.

About 1-Phenylurea, If you have any questions, you can contact Brandolese, A; Ragno, D; Leonardi, C; Di Carmine, G; Bortolini, O; De Risi, C; Massi, A or concate me.. Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Sun, ZZ; Jiang, YB; Zeng, L; Huang, LM in [Sun, Zongzhao] Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150001, Heilongjiang, Peoples R China; [Sun, Zongzhao; Jiang, Yabin; Zeng, Lei; Huang, Limin] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China published Intramolecular Charge Transfer and Extended Conjugate Effects in Donor–Acceptor-Type Mesoporous Carbon Nitride for Photocatalytic Hydrogen Evolution in 2019.0, Cited 80.0. Application In Synthesis of 1-Phenylurea. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

Inspired by donor-acceptor (D-A) polymers in organic solar cell and the extended conjugation effect, a conceptual design of D–A-type mesoporous carbon nitride with benzene or thiophene as a -spacer is proposed as an efficient photocatalyst for hydrogen evolution. The photocatalyst was successfully synthesized by a one-pot thermopolymerization based on nucleophilic substitution and a Schiff-base chemical reaction. On the molecular level, the insertion of an in-plane benzene as a -spacer by forming covalent bonds C=N (acceptor) and C-N (donor) interrupts the continuity of tri-s-triazine units and maintains the intrinsic – conjugated electronic system. Synchronously, the enlarged electron delocalization and the intramolecular charge transfer induced by polarization provide force-directed migration of electrons, leading to boosted optical absorption capability and enhanced photogenerated carrier separation. With the synergistic effects of the mesoporous structure and excellent optical and electronic properties, a fivefold increase in the H-2 evolution rate compared with that of pristine g-C3N4 was achieved with robust performance. In addition, other simple aromatic heterocyclic compounds (e.g., pyridine, thiophene and furan)-based D–A structures with a higher hydrogen evolution rate (up to sevenfold increase) were also explored to broaden the application for the design of novel photocatalysts.

Application In Synthesis of 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Sun, ZZ; Jiang, YB; Zeng, L; Huang, LM or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis and antitumor activities of novel bis-quinazolin-4(3H)-ones WOS:000505757300001 published article about BREAST-CANCER; DERIVATIVES; QUINAZOLINONES; 2-AMINOBENZAMIDES in [Rahmannejadi, Nasrin] Islamic Azad Univ, Dept Chem Sci, Tehran, Iran; [Rahmannejadi, Nasrin] Islamic Azad Univ, Res Branch, Tehran, Iran; [Yavari, Issa] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran; [Khabnadideh, Soghra] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran in 2020, Cited 28. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Category: thiomorpholine

With the aim of obtaining new antitumor agents, a series of bis-quinazolin-4(3H)-ones (3a-3 f) were designed and synthesized. These products contain 4-oxo-1,2,3,4-tetrahydro-quinazoline and 3H-quinazolin-4-one moieties linked together via a propyl chain. Cytotoxic activities of 3a-3 f were evaluated against lung adenocarcinoma (A549), breast carcinoma (MCF-7) and ovarian cancer (SKOV3) cell lines using MTT method. Cisplatin was used as a positive control. Among the tested compounds 3a, 3b, and 3e showed the best cytotoxic activities against all cancerous cell lines with IC50 values even less than cisplatin. Compounds 3d and 3f also showed desirable cytotoxic activities especially against A549 and MCF-7.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Rahmannejadi, N; Yavari, I; Khabnadideh, S or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021.0 RSC ADV published article about AGGREGATION-INDUCED EMISSION; OPTICAL WAVE-GUIDE; RATIONAL DESIGN; SINGLE-CRYSTAL; TEMPERATURE; TETRAPHENYLETHYLENE; PHOTOLUMINESCENCE; FLUORESCENCE; CARBAZOLE; HYDROGEL in [Xu, Zixuan; Chen, Xiaofen; Yang, Ying] Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China; [Su, Linhan] 940th Hosp Joint Logist Support Force Chinese PLA, Lanzhou 730050, Gansu, Peoples R China in 2021.0, Cited 34.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Name: Benzophenone

A novel ionic liquid [TPE-Dim-DMe] (Br)(2) was successfully synthesiszed. With the change of temperature, quadruple transformations of structure were observed in the [TPE-Dim-DMe] (Br)(2) crystal, and it simultaneously displayed mechanochromic phenomena. In addition, its excellent solubility in water makes it a novel bioimaging agent.

Name: Benzophenone. About Benzophenone, If you have any questions, you can contact Xu, ZX; Su, LN; Chen, XF; Yang, Y or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem