Heterocyclic Building Blocks-Thiomorpholine

Recently I am researching about ACQUIRED-RESISTANCE; CAPRI-GOIM; PLUS CETUXIMAB; INHIBITOR; MUTATIONS, Saw an article supported by the AIRCFondazione AIRC per la ricerca sul cancro; AIRC grant (Associazione Italiana per la Ricerca sul cancro)Fondazione AIRC per la ricerca sul cancro [MFAG-2015-ID:7778, IG-2013-ID:14800]. Published in AMER ASSOC CANCER RESEARCH in PHILADELPHIA ,Authors: Martini, G; Cardone, C; Vitiello, PP; Belli, V; Napolitano, S; Troiani, T; Ciardiello, D; Della Corte, CM; Morgillo, F; Matrone, N; Sforza, V; Papaccio, G; Desiderio, V; Paul, MC; Moreno-Viedma, V; Normanno, N; Rachiglio, AM; Tirino, V; Maiello, E; Latiano, TP; Rizzi, D; Signoriello, G; Sibilia, M; Ciardiello, F; Martinelli, E. The CAS is 64-10-8. Through research, I have a further understanding and discovery of 1-Phenylurea. Category: thiomorpholine

The EPHA2 tyrosine kinase receptor is implicated in tumor progression and targeted therapies resistance. We evaluated EPHA2 as a potential resistance marker to the antiepidermal growth factor receptor (EGFR) monoclonal antibody cetuximab in colorectal cancer. We studied activation of EPHA2 in a panel of human colorectal cancer cell lines sensitive or resistant to anti-EGFR drugs. The in vitro and in vivo effects of ALW-II-41-27 (an EPHA2 inhibitor) and/or cetuximab treatment were tested. Fonnalin-fixed paraffin-embedded tumor specimens from 82 RAS wild-type (WV) metastatic colorectal cancer patients treated with FOLFIRI + cetuximab as first-line therapy in the CAPRI-COIM trial were assessed for EPHA2 expression by immunohistochemistry and correlated with treatment efficacy. EPHA2 was differentially activated in colorectal cancer cell lines. Combined treatment with ALW-II-41-27 plus cetuximab reverted primary and acquired resistance to cetuximab, causing cell growth inhibition, inducing apoptosis and cell-cycle G1-G2 arrest. In tumor xenograft models, upon progression to cetuximab, ALW-II-41-27 addition significantly inhibited tumor growth. EPHA2 protein expression was detected in 55 of 82 tumor samples, frequently expressed in less-differentiated and left-sided tumors. High levels of EPHA2 significantly correlated with worse progression-free survival [8.6 months; confidence interval (CI) 95%, 6.4-10.8; vs. 12.3 months; CI 95%, 10.4-14,2; P = 0.03] and with increased progression rate (29% vs. 9%, P = 0.02). A specific EPHA2 inhibitor reverts in vitro and in vivo primary and acquired resistance to anti-ECFR therapy. EPHA2 levels are significantly associated with worse outcome in patients treated with FOLFIRI + cetuximab. These results highlight EPHA2 as a potential therapeutic target in metastatic colorectal cancer.

About 1-Phenylurea, If you have any questions, you can contact Martini, G; Cardone, C; Vitiello, PP; Belli, V; Napolitano, S; Troiani, T; Ciardiello, D; Della Corte, CM; Morgillo, F; Matrone, N; Sforza, V; Papaccio, G; Desiderio, V; Paul, MC; Moreno-Viedma, V; Normanno, N; Rachiglio, AM; Tirino, V; Maiello, E; Latiano, TP; Rizzi, D; Signoriello, G; Sibilia, M; Ciardiello, F; Martinelli, E or concate me.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 104-21-2. Authors Tang, ZY; Chen, XY; Zhang, WR; Sun, XF; Hou, QZ; Li, YJ; Feng, X; Chen, YR; Lv, J; Ji, L; Ding, GY; Li, D in FRONTIERS MEDIA SA published article about in [Tang, Zhaoyang; Chen, Xueyu; Zhang, Wenran; Hou, Qingzhi; Li, Yuejin; Feng, Xia; Chen, Yanru; Lv, Jian; Ji, Long; Ding, Guoyong; Li, Dong] Shandong First Med Univ & Shandong Acad Med Sci, Sch Publ Hlth, Dept Epidemiol, Tai An, Shandong, Peoples R China; [Sun, Xiangfu] Taian Traff Hosp, Tai An, Shandong, Peoples R China; [Li, Dong] Shandong First Med Univ, Affiliated Hosp 2, Tai An, Shandong, Peoples R China in 2021, Cited 48. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2

Background: Dementia, as a global public health problem, is becoming increasingly serious. As a precursor of dementia, mild cognitive impairment (MCI) plays an important role in the diagnosis and prevention of dementia. Recent studies have found a correlation between gamma-glutamyl transferase (GGT) levels and cognitive function in men. The relationship between GGT levels and cognitive function in women remains unclear because GGT activity and expression differ between the sexes. Method: We recruited a total of 2,943 Chinese women from Jidong and Taian in 2019. We grouped the participants according to GGT levels, diagnosed MCI using the Montreal Cognitive Assessment (MOCA) scale, and modeled the study outcomes using logistic regression to explore the relationship between GGT level and MCI. We also analyzed the interaction of obesity, sleep duration, and hyperuricemia with GGT in the development of MCI. Results: The prevalence of MCI increased with increasing GGT level, from the lowest quartile to the highest quartile of GGT: 8.4% (66/786), 14.2% (119/840), 17.6% (108/613), and 21.4% (151/704), respectively. At the same time, as GGT levels increased, so did the risk of MCI. In the fully adjusted model, compared with those for participants in the lowest GGT quartiles, the odds ratios (ORs), and 95% confidence intervals (CIs) for MCI for participants in the second, third, and fourth GGT quartiles were 1.49 (1.04-2.12), 1.53(1.06-2.21), and 1.88 (1.33-2.65), respectively. The risk of developing MCI was further increased in people with high GGT levels who were obese (OR = 1.96, 95% CI: 1.39-2.76, P < 0.001), slept less (OR = 1.91, 95% CI: 1.35-2.71, P < 0.001), had high levels of uric acid (OR = 1.55, 95% CI: 1.03-2.32, P < 0.001), or after menopause (OR = 2.92, 95% CI: 2.07-4.12, P < 0.001). Conclusion: We found that MCI is more common in women with elevated GGT levels, so GGT could be a potential diagnostic marker for MCI. Meanwhile, our findings indicated that women with high GGT levels had an increased risk of MCI when they were obese, sleep deprived, had high serum uric acid (SUA) levels or underwent menopause. About 4-Methoxybenzyl acetate, If you have any questions, you can contact Tang, ZY; Chen, XY; Zhang, WR; Sun, XF; Hou, QZ; Li, YJ; Feng, X; Chen, YR; Lv, J; Ji, L; Ding, GY; Li, D or concate me.. Recommanded Product: 104-21-2

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 99-61-6. Authors Custodio, JMF; D’Oliveira, GDC; Gotardo, F; Cocca, LHZ; de Boni, L; Perez, CN; Napolitano, HB; Osorio, FAP; Valverde, C in ROYAL SOC CHEMISTRY published article about in [Custodio, Jean M. F.; D’Oliveira, Giulio D. C.; Perez, Caridad N.] Univ Fed Goias, Inst Quim, BR-74690970 Goiania, Go, Brazil; [Gotardo, Fernando; Cocca, Leandro H. Z.; de Boni, Leonardo] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13566590 Sao Paulo, SP, Brazil; [Napolitano, Hamilton B.; Valverde, Clodoaldo] Univ Estadual Goias, Campus Ciencias Exatas & Tecnol, BR-75132903 Anapolis, Go, Brazil; [Osorio, Francisco A. P.] Pontificia Univ Catolica Goias, BR-13566590 Goiania, Go, Brazil; [Osorio, Francisco A. P.] Univ Fed Goias, Inst Fis, BR-74690900 Goiania, Go, Brazil; [Valverde, Clodoaldo] Univ Paulista, BR-74845090 Goiania, Go, Brazil in 2021.0, Cited 42.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

In this study, a combined experimental and theoretical study of the nonlinear optical properties (NLO) of two chalcone derivatives, (E)-3-(2-methoxyphenyl)-1-(2-(phenylsulfonylamine)phenyl)prop-2-en-1-one (MPSP) and (E)-3-(3-nitrophenyl)-1-(2-(phenylsulfonylamine)phenyl)prop-2-en-1-one (NPSP), in DMSO is reported. The single crystal structures of the compounds, which differ only by the type and position of one substituent, were grown using the slow evaporation technique, and the main structural differences are discussed. The two-photon absorption and first-order hyperpolarizability measurements were performed via the Z-scan technique and hyper-Rayleigh scattering experiment in DMSO. The theoretical calculations were performed using the Density Functional Theory (DFT) at the CAM-B3LYP/6-311++G(d,p) level, and the sum-over-states (SOS) approach in both static and dynamic cases. Besides the electron conjugation achieved by the aromatic rings, olefins, and carbonyl groups, both compounds have a nearly flat chalcone backbone, which is believed to contribute to the nonlinear optical properties. MPSP and NPSP have different positions, even though they have roughly the same conformation and form C-HMIDLINE HORIZONTAL ELLIPSISO interactions. For several studied frequencies, the HRS first hyperpolarizability values for MPSP are greater than those for NPSP, indicating that in most cases the NLO properties of MPSP are better. The comparison among the theoretical and experimental HRS first hyperpolarizability results showed a good agreement. In addition, the two-dimensional second order nonlinear optical spectra obtained from the sum-over-states model indicate good second-order NLO responses of the two chalcone derivatives under external fields. Our findings are important not only to show the potential nonlinear optical application of the two new compounds but also to gain an insight into how different chemical compositions might affect the crystal structures and physico-chemical properties.

About 3-Nitrobenzaldehyde, If you have any questions, you can contact Custodio, JMF; D’Oliveira, GDC; Gotardo, F; Cocca, LHZ; de Boni, L; Perez, CN; Napolitano, HB; Osorio, FAP; Valverde, C or concate me.. Product Details of 99-61-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Modulation of endocrine nuclear receptor activities by polyaromatic compounds present in fractionated extracts of diesel exhaust particles WOS:000468191200059 published article about ARYL-HYDROCARBON RECEPTOR; POLYCYCLIC AROMATIC-HYDROCARBONS; ESTROGEN-RECEPTOR; CELL-LINE; IN-VITRO; PARTICULATE MATTER; EPITHELIAL-CELLS; DNA-DAMAGE; ACTIVATION; EXPOSURE in [Pencikova, Katerina; Ciganek, Miroslav; Neca, Jiri; Machala, Miroslav] Vet Res Inst, Dept Chem & Toxicol, Hudcova 70, Brno 62100, Czech Republic; [Illes, Peter; Dvorak, Zdenek] Palacky Univ, Fac Sci, Dept Cell Biol & Genet, Slechtitelu 27, Olomouc 78371, Czech Republic; [Vondracek, Jan] Czech Acad Sci, Inst Biophys, Dept Cytokinet, Kralovopolska 135, Brno 61265, Czech Republic in 2019, Cited 65. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8. Recommanded Product: 90-44-8

Organic pollutants associated with diesel exhaust particles (DEP), such as polycyclic aromatic hydrocarbons (PAHs) and their derivatives, may negatively impact human health. However, a comprehensive overview of their effects on endocrine nuclear receptor activities is still missing. Here, we evaluated the effects of extracts and chromatographic fractions (fractionated according to increasing polarity) of two standard reference materials derived from distinct types of diesel engines (SRM 2975, SRM 1650b), on activation of androgen receptor (AR), estrogen receptor alpha (ER alpha), peroxisome proliferator-activated receptor gamma (PPAR gamma), glucocorticoid receptor (GR) and thyroid receptor alpha (TR alpha), using human cell-based reporter gene assays. Neither DEP standard modulated AR or GR activities. Crude extracts and fractions of SRM 1650b and SRM 2975 suppressed ER alpha-mediated activity in the ER-CALUX (TM) assay; however, this effect could be partly linked to their cytotoxicity in this cell line. We observed that only SRM 2975 extract and its fractions were partial PPAR gamma inducers, while SRM 1650b extract was not active towards this receptor. Importantly, we found that both extracts and polar fractions of SRM activated TR alpha and significantly potentiated the activity of endogenous TR alpha ligand, triiodothyronine. Based on a detailed chemical analysis of both extracts and their polar fractions, we identified several oxygenated PAH derivatives, that were present at relatively high levels in the analyzed DEP standards, including 3-nitrobenzanthrone (3-NBA), anthracene-9,10-dione, phenanthrene-9,10-dione. 9H-fluoren-9-one or benzo[a] anthracene-7,12-dione, to activate TR alpha activity. Nevertheless, these compounds provided only a minor contribution to the overall TR alpha activity identified in polar fractions. This suggests that yet unidentified polar polyaromatic compounds associated with DEP may, apart from their known impact on the aryl hydrocarbon receptor or steroid signaling, deregulate activities of additional nuclear receptors, in particular of TR alpha. This illustrates the need to better characterize endocrine disrupting activities of DEP. (C) 2019 Elsevier B.V. All rights reserved.

Recommanded Product: 90-44-8. About Anthrone, If you have any questions, you can contact Pencikova, K; Ciganek, M; Neca, J; Illes, P; Dvorak, Z; Vondracek, J; Machala, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Design and synthesis of cinchona-based chiral hyperbranched polymers and their application in asymmetric reactions WOS:000537423800004 published article about ENANTIOSELECTIVE MICHAEL ADDITION; DENDRIMERS; CATALYSTS; CHEMISTRY; MACROMOLECULES; DERIVATIVES; MICELLES; TOPOLOGY; CORE; ARYL in [Chhanda, Sadia Afrin; Itsuno, Shinichi] Toyohashi Univ Technol, Appl Chem & Life Sci, Toyohashi, Aichi 4418580, Japan in 2020, Cited 36. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8. Formula: C14H10O

Cinchona-based chiral hyperbranched polymers (HBPs) were designed and successfully synthesized via the Mizoroki-Heck (MH) coupling reaction. AB(2) and A(2)B-type chiral monomers were prepared from cinchona squaramide derivatives, where A (vinyl) reacted only with B (iodophenyl) under MH reaction conditions. The chiral HBPs obtained by the MH polymerization contained cinchona squaramide moieties and demonstrated excellent diastereoselectivity and enantioselectivity in asymmetric Michael addition reactions of methyl 2-oxocyclopentanecarboxylate and trans-beta-nitrostyrene. These newly designed HBPs were structurally robust and could be reused for further reaction without losing their catalytic activity. (C) 2020 Elsevier Ltd. All rights reserved.

Formula: C14H10O. About Anthrone, If you have any questions, you can contact Chhanda, SA; Itsuno, S or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; SYMPTOMS; PTSD; PEOPLE; CHECKLIST; BEHAVIOR; OBESITY; GENDER; IMPACT, Saw an article supported by the Fundamental Research Funds for the Central University in China [31920150018]. Application In Synthesis of 4-Methoxybenzyl acetate. Published in LIPPINCOTT WILLIAMS & WILKINS in PHILADELPHIA ,Authors: Ma, LH; Zhang, T; Ma, HB; Wang, H; Jiao, CH; Jiang, XL. The CAS is 104-21-2. Through research, I have a further understanding and discovery of 4-Methoxybenzyl acetate

This study included 1456 men and 1411 women who were trauma-exposed and underwent routine health examinations in a community epidemiological investigation. The participants completed the posttraumatic stress disorder (PTSD) Check List-Civilian Version (PCL-C) for PTSD and medical examinations to detect metabolic syndrome. Adjustments for age, marriage, exercise, education, cigarette smoking, cancer, stroke, angina, and thyroid disease were performed. The relationship between PTSD and metabolic syndrome and each of its components was analyzed by multiple logistic regression. In women, PTSD was associated with metabolic syndrome (OR = 1.53, 95% CI = 1.01-1.95, P = .047) and the high-density lipoprotein cholesterol component (OR = 1.98, 95% CI = 1.04-2.12, P = .002). In men, PTSD was related to the hypertension component of metabolic syndrome (OR = 0.54, 95% CI = 0.31-0.92, P = .023). There was also a relationship between PTSD severity and metabolism (OR = 1.141, 95% CI = 1.002-1.280, P = 0.037) in women, and PTSD was inversely associated with the hypertension component (OR = 0.54, 95% CI = 0.31-0.92, P = .023) in men. PTSD was related to metabolic syndrome only in women. We plan to further research the mechanism of sex differences and dyslipidemia.

About 4-Methoxybenzyl acetate, If you have any questions, you can contact Ma, LH; Zhang, T; Ma, HB; Wang, H; Jiao, CH; Jiang, XL or concate me.. Application In Synthesis of 4-Methoxybenzyl acetate

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 88-68-6. Authors Nguyen, TTT; Nguyen, L; Ngo, QA; Koleski, M; Nguyen, TB in ROYAL SOC CHEMISTRY published article about in [Nguyen, Thi Thu Tram] Can Tho Univ Med & Pharm, Dept Chem, Fac Sci, Can Tho, Vietnam; [Nguyen, Le Anh; Ngo, Quoc Anh] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet, Hanoi, Vietnam; [Nguyen, Le Anh; Ngo, Quoc Anh] Grad Univ Sci & Technol, Vietnam Acad Sci & Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam; [Koleski, Marina; Nguyen, Thanh Binh] Univ Paris Saclay, Univ Paris Sud, CNRS UPR 2301, Inst Chim Subst Nat, 1 Av Terrasse, F-91198 Gif Sur Yvette, France in 2021, Cited 57. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Thioamides could be conveniently synthesized in good to excellent yields via DMSO-promoted oxidative coupling of methylhetarenes with amines in the presence of a near stoichiometric amount of sulfur (1.25 equiv.). Both aliphatic and aromatic amines were found to be competent substrates. When anilines o-substituted by cyclizable groups such as OH, NH2, NHPh, SH and CONH2 were used as amine substrates, the corresponding hybrid bis-aza-heterocycles were formed in high yields even with a sulfur loading as low as 0.5 equiv.

About 2-Aminobenzamide, If you have any questions, you can contact Nguyen, TTT; Nguyen, L; Ngo, QA; Koleski, M; Nguyen, TB or concate me.. Product Details of 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2020.0 J CHROMATOGR A published article about SOLID-PHASE EXTRACTION; COVALENT ORGANIC FRAMEWORKS; PERFORMANCE LIQUID-CHROMATOGRAPHY; WATER; ADSORBENT; MICROEXTRACTION; NANOPARTICLES; POLYMER; CARBON; FOOD in [Wang, Qianqian; Wang, Xiaolan; Wang, Junmin; Liu, Weihua; Hao, Lin; Wang, Chun; Wu, Qiuhua; Wang, Zhi] Hebei Agr Univ, Coll Sci, Baoding 071001, Hebei, Peoples R China; [Zhou, Junhong] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China in 2020.0, Cited 35.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Name: 1-Phenylurea

Exploring new material as adsorbent for the efficient enrichment of pollutants is always of great significance in analytical chemistry. In this work, a magnetic azobenzene framework (labeled as MAzo) was constructed as a magnetic solid phase extraction (MSPE) adsorbent by a simple and environmentally benign strategy. The MAzo exhibited the attractive features of strong magnetism, outstanding adsorption performance, as well as good reusability. Combining MAzo-based MSPE with high performance liquid phase chromatography, a simple and effective method was developed for simultaneous determination of four phenylurea herbicides in pear juice and apple juice samples. Under optimized experimental conditions, the method offered low limits of detection of 0.05-0.15 ng mL(-1), high recoveries of 86.7-109.2% with RSD less than 7%. Density functional theory calculation indicated that the good adsorption performance of MAzo for PUHs can be ascribed to the strong H-bonding forces and weak pi-pi interactions. The facile, green, low-cost synthesis method together with the excellent adsorption performance endows the MAzo great application prospect in sample preparation. (c) 2020 Elsevier B.V. All rights reserved.

About 1-Phenylurea, If you have any questions, you can contact Wang, QQ; Wang, XL; Wang, JM; Liu, WH; Hao, L; Zhou, JH; Wang, C; Wu, QH; Wang, Z or concate me.. Name: 1-Phenylurea

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about FT-ICR MS; HYDROCARBONS PAHS; MOLECULAR CHARACTERIZATION; AIRBORNE PARTICLES; OXYGENATED-PAHS; IDENTIFICATION; EMISSIONS; PM2.5; QUANTIFICATION; CONTAMINANTS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91843301, 21976187]; State Key Project of Research and Development Plan [2019YFC1805605, 2018YFC1801601]. Formula: C14H10O. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Xu, C; Gao, LR; Zheng, MH; Qiao, L; Wang, KR; Huang, D; Wang, S. The CAS is 90-44-8. Through research, I have a further understanding and discovery of Anthrone

Polycyclic aromatic hydrocarbons (PAHs) are mutagenic and carcinogenic. 16 PAHs as priority pollutants listed by the US Environmental Protection Agency were usually monitored. Therefore, multiple potentially toxic polycyclic aromatic compounds (PACs) are not monitored. In this study, atmospheric particulate matter samples from Beijing were analyzed using atmospheric pressure photoionization (APPI) Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry and comprehensive two-dimensional gas chromatography-time-of-flight (GC x GC-TOF) mass spectrometry. The FT-ICR data detected high molecular weight PAHs, alkylated PAHs (APAHs) and heteroatom PAHs. The GC x GC-TOF data tentatively identified 386 PACs in five categories of identification confidence. Twenty-one spectra in the unknown class were manually resolved. Eighty-two PACs with high identification confidence were proposed for further research. The identities of five PAHs and five APAHs that are currently not regulated were confirmed using available standards and quantified in some samples. Some of these PACs, such as dibenzo[a,e]pyrene (C22H14) and 1-methylpyrene (C17H12), should be of concern because of their contamination levels and the high toxicities of themselves and/or their derivatives. This study highlights the possibility of expanding the traditional lists of PAHs to improve pollution control and risk assessment accuracy.

Formula: C14H10O. About Anthrone, If you have any questions, you can contact Xu, C; Gao, LR; Zheng, MH; Qiao, L; Wang, KR; Huang, D; Wang, S or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. Authors Bowser, BH; Wang, S; Kouznetsova, TB; Beech, HK; Olsen, BD; Rubinstein, M; Craig, SL in AMER CHEMICAL SOC published article about in [Bowser, Brandon H.; Wang, Shu; Kouznetsova, Tatiana B.; Beech, Haley K.; Olsen, Bradley D.; Rubinstein, Michael; Craig, Stephen L.] Duke Univ, NSF Ctr Chem Molecularly Optimized Networks, Durham, NC 27708 USA; [Bowser, Brandon H.; Wang, Shu; Kouznetsova, Tatiana B.; Rubinstein, Michael; Craig, Stephen L.] Duke Univ, Dept Chem, Durham, NC 27708 USA; [Beech, Haley K.; Olsen, Bradley D.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA; [Rubinstein, Michael] Duke Univ, Dept Phys, Durham, NC 27708 USA; [Rubinstein, Michael] Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27708 USA; [Rubinstein, Michael] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA; [Rubinstein, Michael] Hokkaido Univ, World Premier Inst Chem React Design & Discovery, Sapporo, Hokkaido, Japan in 2021.0, Cited 50.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Mechanochemical reactions that lead to an increase in polymer contour length have the potential to serve as covalent synthetic mimics of the mechanical unfolding of noncovalent stored length domains in structural proteins. Here we report the force-dependent kinetics of stored length release in a family of covalent domain polymers based on cis-1,2-substituted cyclobutane mechanophores. The stored length is determined by the size (n) of a fused ring in an [n.2.0] bicyclic architecture, and it can be made sufficiently large (>3 nm per event) that individual unravelling events are resolved in both constant-velocity and constant-force single-molecule force spectroscopy (SMFS) experiments. Replacing a methylene in the pulling attachment with a phenyl group drops the force necessary to achieve rate constants of 1 s(-1) from ca. 1970 pN (dialkyl handles) to 630 pN (diaryl handles), and the substituent effect is attributed to a combination of electronic stabilization and mechanical leverage effects. In contrast, the kinetics are negligibly perturbed by changes in the amount of stored length. The independent control of unravelling force and extension holds promise as a probe of molecular behavior in polymer networks and for optimizing the behaviors of materials made from covalent domain polymers.

Category: thiomorpholine. About Benzophenone, If you have any questions, you can contact Bowser, BH; Wang, S; Kouznetsova, TB; Beech, HK; Olsen, BD; Rubinstein, M; Craig, SL or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem