Heterocyclic Building Blocks-Thiomorpholine

Application In Synthesis of Anthrone. Che, YM; Zhang, Z; Zhu, D; Hao, J; Hou, LX; Liu, X in [Che Yongmei; Zhang Zhen; Zhu Dan; Hao Jie; Hou Lixia; Liu Xin] Qingdao Agr Univ, Key Lab Plant Biotechnol Univ Shandong Prov, Coll Life Sci, Qingdao 266109, Shandong, Peoples R China published VvWRKY13 from Vitis vinifera negatively modulates salinity tolerance in 2019, Cited 38. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

WRKY transcription factors participate in the salt stress responses of various plant species, but the underlying functional mechanisms are not well understood, particularly in grape. In this study, the role of VvWRKY13 in the salt stress response was characterized and the underlying physiological and molecular mechanisms were explored. The results show that VvWRKY13 expression was induced by salt stress, and the VvWRKY13 transcript level in the salt stress-sensitive cultivar was significantly higher than that in the resistant cultivars. Overexpression of VvWRKY13 in Arabidopsis significantly inhibited the growth of transgenic plants under salt stress, indicating that VvWRKY13 has a negative effect on the salt stress response. The photosynthetic rate, contents of proline and soluble sugars, activities of superoxide dismutase (SOD) and catalase (CAT), as well as transcriptional levels of proline and soluble sugar metabolic genes, such as P5CS1, SS1, SS2 and G6PDH, as well as SOD and CAT encoding genes CAT1, CAT2, and Cu/Zn-SOD, all decreased under salt stress, whereas hydrogen peroxide and oxygen-free radical contents increased in transgenic Arabidopsis plants compared with those of wild-type plants. VvWRKY13 suppressed upregulation of SnRK2.3, ABF1, ABF2, ABF3, RD29B, RD29A, and RAB18 induced by salt stress, but showed no significant effect on the transcript levels of SnRK2.2, SnRK2.6, or RD22, indicating that VvWRKY13 affects salt stress tolerance via a specific abscisic acid signaling pathway. Key message VvWRKY13, isolated from grapevine, negatively regulate salt stress tolerance by depressing photosynthetic capacity, inhibiting salt-induced accumulation of osmolytes andup-regulation in antioxidant activity as well as expression of related genes. VvWRKY13 may affects salt stress tolerance by specific ABA signalling.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of 4-Methoxybenzyl acetate. In 2021 EJNMMI RES published article about PREOPERATIVE LYMPHOSCINTIGRAPHY in [Chahid, Youssef; Verberne, Hein J.; Booij, Jan] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands; [Chahid, Youssef; Qiu, Xinbo] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Clin Pharm, Amsterdam, Netherlands; [van de Garde, Ewoudt M. W.] St Antonius Hosp, Dept Clin Pharm, Utrecht, Netherlands; [van de Garde, Ewoudt M. W.] Univ Utrecht, Dept Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands in 2021, Cited 17. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2.

Background Accurate sentinel lymph node (SLN) staging is essential for both prognosis and treatment in patients with breast cancer. However, the preoperative lymphoscintigraphy may fail to visualize the SLN in some patients. The purpose of this retrospective study was to identify risk factors associated with SLN nonvisualization on lymphoscintigraphy. For this single-center retrospective study, all data of lymphoscintigraphy of SLN procedures from March 2011 to April 2021 were collected and reviewed from the Amsterdam UMC database. Results A total of 1886 SLN procedures were included in this study. The SLN nonvisualization rate was 25.1% on lymphoscintigraphy at 4 h post-injection. The SLN nonvisualization rate decreased to 9.4% after reinjection. Multivariable analysis showed that age >= 70 years (P < 0.001; OR: 2.27; 95% CI: 1.46-3.53), BMI >= 30 kg/m(2) (P = 0.031; OR: 1.48; 95% CI: 1.04-2.12) and nonpalpable tumors (P = 0.004; OR: 1.54; 95% CI: 1.15-2.07) were independent predictors of SLN nonvisualization. Tumor location, brand of radiopharmaceutical, injected dose and volume, experience of preparer and administrator were not associated with SLN nonvisualization. None of the patient, tumor or tracer characteristics were associated with SLN nonvisualization after radiotracer reinjection. Conclusions This study shows that risk factors for SLN nonvisualization in breast cancer patients during preoperative lymphoscintigraphy are age >= 70 years, BMI >= 30 kg/m(2) and nonpalpable tumors. Our results support the notion that SLN lymphoscintigraphy is a very robust technique that does not depend on the experience of the preparer or administrator of the radiotracer.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of Anthrone. Glinski, M; Markowska, A; Wronska, L; Jerzak, A; Tarkowska, M in [Glinski, Marek; Markowska, Anna; Wronska, Laura; Jerzak, Anna; Tarkowska, Magdalena] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland published Highly Selective Vapor and Liquid Phase Transfer Hydrogenation of Diaryl and Polycyclic Ketones with Secondary Alcohols in the Presence of Magnesium Oxide as Catalyst in 2021, Cited 47. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

MgO has been shown to catalyze an almost quantitative hydrogen transfer from 2-octanol as the hydrogen donor to benzophenone to form benzhydrol, a useful intermediate product in the pharmaceutical industry. The hydrogen transfer from a series of alcohols to the carbonyl group of benzophenone, its ten derivatives, four polycyclic ketones, and 2-naphthyl phenyl ketone was carried out in liquid (LP) or vapor phase (VP). The dependence of reactivity on the structure of the hydrogen donor, reaction temperature, donor-acceptor ratio, amount of catalyst, and the type and position of substituents has been established. For both reaction modes, optimal conditions for selective synthesis of the alcohols were determined and side reactions were investigated. The results indicate that the reactivity of the ketone is suppressed by the presence of a methyl substituent in the ortho position to a much greater extent in LP mode. A scale-up was demonstrated in the liquid phase mode.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of 2-Aminobenzamide. In 2021 SYNTHETIC COMMUN published article about PRIMARY AMIDES; UREA; DISCOVERY; DERIVATIVES; INHIBITORS; AMINES; TRANSFORMATION; EFFICIENT; KINASE; MAP in [Shamanth, Sadashivamurthy; Sagar, Kunigal S.; Narayana, Yatheesh; Rangappa, Kanchugarakoppal S.; Kempegowda, Mantelingu] Univ Mysore, DOS Chem, Manasagangotri, Mysuru 570006, Karnataka, India; [Nagarakere, Sandhya C.] St Philomenas Coll, PG Dept Studies Chem, Mysuru, India; [Nagarakere, Sandhya C.] St Philomenas Coll, Res Ctr, Mysuru, India; [Mamatha, Mahesha] SRSMN Govt First Grade Coll, Barkur, India in 2021, Cited 38. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Current work describes the environmentally benign approach for the synthesis of o-ureidobenzonitriles, from o-aminobenzamides and isothiocyanates using T3P. Here, the conversion of thiourea to urea and amide to nitrile take place simultaneously via unprecedented intramolecular rearrangement. This protocol is operationally facile and offers wide variety of o-ureidobenzonitriles at room temperature in good to excellent yields.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about GOLD(I)-CATALYZED CASCADE; METATHESIS REACTION; TANDEM REACTION; CYCLIZATION; EFFICIENT; ALKYNES; HYDROCARBOXYLATION; COMPLEXES; ACCESS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21472024, 21242008]. Recommanded Product: 88-68-6. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zheng, YY; Liu, JM; Lei, XS. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A simple, efficient, and mild method for the preparation of aryl-fused heterocycles has been developed using alpha,omega-alkynoic acids and arylethylamines. In the present method, one of Grubbs’ ruthenium carbenes is able to catalyze the formation of exocyclic enol lactones from alpha,omega-alkynoic acids, which subsequently undergo aminolysis and N-acyl iminium ion formation/cyclization with arylethylamines in the presence of TFA, affording one kind of drug-privileged scaffold. Demonstrated with high functional group tolerance, this new cascade reaction endows the Grubbs’ ruthenium carbene with a new synthetic utility beyond routine olefin metathesis.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Synthesis, crystal structure and antimicrobial activity of 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives against phytopathogens published in 2019. HPLC of Formula: C7H8N2O, Reprint Addresses Bao, XP (corresponding author), Guizhou Univ, Ctr Res & Dev Fine Chem, Minist Educ,Key Lab Green Pesticide & Agr Bioengn, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Guizhou, Peoples R China.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A total of eighteen 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives were designed and synthesized, via hybrid pharmacophore approach. Among these compounds, chemical structure of compound 4a was unambiguously confirmed by means of single-crystal X-ray diffraction analysis. All the compounds were evaluated in vitro for their inhibition activity against several important phytopathogenic bacteria and fungi in agriculture. The obtained results indicated that several compounds demonstrated potent antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo). For example, compounds 4c, 4g and 4q had EC50 values of 35.0, 36.5 and 32.4 mu g/mL toward this bacterium, respectively, around 1.5 times more active than commercial bactericide bismerthiazol (EC50 = 89.8 mu g/mL). Additionally, compounds 4j and 4p were found to display comparable antifungal activity against Gloeosporium fructigenum at 50 mu g/mL, to commercial fungicide hymexazol. Finally, the relationships between antibacterial activities and molecular structures of this class of compounds were discussed in detail. [GRAPHICS] .

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 2-Aminobenzamide. In 2020 ORG BIOMOL CHEM published article about DIORGANYL DISELENIDES SYNTHESIS; C-H ACTIVATION; ELECTROPHILIC CYCLIZATION; IRON(III) CHLORIDE; BETA-PHENYLETHYLAMINES; CATALYZED ANNULATION; TANDEM CYCLIZATION; BOND FORMATION; DERIVATIVES; 2-ALKYNYLBENZALDEHYDES in [Sonawane, Amol D.; Sonawane, Rohini A.; Win, Khin Myat Noe; Ninomiya, Masayuki; Koketsu, Mamoru] Gifu Univ, Dept Chem & Biomol Sci, Fac Engn, Gifu 5011193, Japan in 2020, Cited 58. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

An efficient, metal free and environment friendly synthesis of isoquinoline-fused benzimidazole has been developed via in situ air oxidation. Also, syntheses of isoquinoline-fused quinazolinone heteroacenes were successfully achieved. The synthesized isoquinoline-fused benzimidazole and isoquinoline-fused quinazolinone derivatives showed lambda(max), F-max and phi(f) values in the ranges 356-394 nm, 403-444 nm and 0.063-0.471, respectively, in CHCl3.

Name: 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Sonawane, AD; Sonawane, RA; Win, KMN; Ninomiya, M; Koketsu, M or send Email.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 SYNTHESIS-STUTTGART published article about ISOCYANIDE INSERTION REACTION; BAYLIS-HILLMAN ADDUCTS; CARBOXYLIC-ACIDS; STEREOSELECTIVE-SYNTHESIS; ONE-POT; COUPLING REACTION; ESTERIFICATION; EFFICIENT; ACCESS; ALDEHYDES in [Cui, Yongmei; Jia, Xueshun; Li, Jian] Shanghai Univ, Dept Chem, Ctr Supramol Chem & Catalysis, Coll Sci, 99 Shangda Rd, Shanghai 200444, Peoples R China; Shanghai Univ, Inst Sustainable Energy, 99 Shangda Rd, Shanghai 200444, Peoples R China in 2019, Cited 73. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2. Computed Properties of C10H12O3

A novel oxidative esterification of 1-arylprop-2-en-1-ols with toluene derivatives catalyzed by tetrabutylammonium iodide (TBAI) is reported. The optimization of the reaction conditions illustrates that each of experiment parameters including the catalyst, solvent, and oxidant is significant for present oxidative functionalization. This metal-free protocol has a broad substrate scope including the halogen groups for further functionalization and enriches the reactivity profile of allyl alcohol and toluene derivatives. In addition, this protocol represents a new transformation of allyl alcohol involving C-C bond cleavage and C-O bond forming.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis, molecular packing and anti-cholinesterase activity of some new C-2 N-substituted anthranilamide derivatives WOS:000489324100006 published article about 2-AMINOBENZAMIDE DERIVATIVES; BIOLOGICAL EVALUATION; CRYSTAL-STRUCTURES; QUINAZOLINONES; INHIBITORS; EFFICIENT; DESIGN in [Sarfraz, Muhammad; Sultana, Nargis; Tariq, Muhammad Ilyas] Univ Sargodha, Dept Chem, Sargodha 40100, Pakistan; [Parvez, Masood] Univ Calgary, Dept Chem, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada in 2019, Cited 30. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Application In Synthesis of 2-Aminobenzamide

Synthesis of C-2 N-substituted anthranilamide derivatives was carried out in a straight forward manner, utilizing 2-aminobenzamide and benzyl chloride as starting materials. Their crystal structures have been established by single crystal X-ray crystallographic method. In the molecules of 2-benzylamino-benzamide (3a), intramolecular hydrogen bonding b/w O atom and proton of -NH and classical intermolecular hydrogen bonding of the type N-H center dot center dot center dot O forming eight membered rings in R-4(2)(8) pattern. In both molecules of 2-(dibenzylamino)benzamide (3b), unlike the molecule in 3a, each H atoms is pointed towards N atom causing intramolecular hydrogen bonding interactions, resulting in S(6) motifs. However, it is interesting to note that both molecules in 3b are lying about inversion centres and form dimers in R-4(2)(8) motifs; the two dimers are linked via non-classical intermolecular hydrogen bonds C-H center dot center dot center dot O resulting in clusters of four molecules in the structure. In vitro assay results revealed that molecule 3b with IC50 values of 3.8 +/- 0.08 mu M (AChE) and 17.6 +/- 1.10 mu M (BChE) possessed better cholinesterase (AChE and BChE) inhibition potential as compared to standard drug galantamine. Preliminary in silico studies showed that more biological active derivatives were also having good pharmacokinetic profile with no AMES toxicity and carcinogenicity.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 RSC ADV published article about DENSITY-FUNCTIONAL THERMOCHEMISTRY; CORROSION INHIBITION PROPERTIES; MILD-STEEL; ABSOLUTE ELECTRONEGATIVITY; CARBON-STEEL; QUINOLINE DERIVATIVES; ELECTRONIC-STRUCTURE; QUANTUM-CHEMISTRY; HARDNESS; ADSORPTION in [Dagdag, Omar; El Harfi, Ahmed] Ibn Tofail Univ, LAPPE, Dept Chem, Fac Sci, BP 133, Kenitra 14000, Morocco; [Cherkaoui, Omar] Higher Sch Text & Clothing Ind, Lab REMTEX, BP 7731, Casablanca, Morocco; [Safi, Zaki] AlAzhar Univ Gaza, Dept Chem, Fac Sci, POB 1277, Gaza, Palestine; [Wazzan, Nuha] King Abdulaziz Univ, Dept Chem, Fac Sci, POB 42805, Jeddah 21589, Saudi Arabia; [Guo, Lei] Tongren Univ, Sch Mat & Chem Engn, Tongren 554300, Peoples R China; [Akpan, E. D.; Verma, Chandrabhan; Ebenso, E. E.] North West Univ, Dept Chem, Fac Nat & Agr Sci, Sch Chem & Phys Sci, Private Bag X2046, ZA-2735 Mmabatho, South Africa; [Akpan, E. D.; Verma, Chandrabhan; Ebenso, E. E.] North West Univ, Mat Sci Innovat & Modelling MaSIM Res Focus Area, Fac Nat & Agr Sci, Private Bag X2046, ZA-2735 Mmabatho, South Africa; [Jalgham, Ramzi T. T.] Bani Walid Univ, Fac Engn, Dept Oil & Gas, Bani Walid, Libya in 2019, Cited 67. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Formula: C7H8N2O

A new epoxy monomer, namely, tetraglycidyl-1,2-aminobenzamide (ER), was synthesized by condensation of the amines with epichlorohydrin in a basic medium. The obtained epoxy monomer was characterized by FT-IR and H-1 NMR spectroscopy. Rheological properties of this monomer were determined using an advanced rheometer. Subsequently, the synthesized ER monomer was investigated as corrosion inhibitor for carbon steel in 1 M HCl solution. The adsorption properties of ER were analyzed by electrochemical, surface investigation and theoretical computational studies using DFT and molecular dynamics (MD). Results showed a high dependence of the viscosity of ER on temperature and concentration, and also, that ER has better inhibition performance. A good agreement between the results derived from computational (MD and DFT) and experimental methods was observed. The thermodynamic parameters, along with the kinetic parameters, showed that the adsorption of ER molecules onto carbon steel surface obeyed the Langmuir isotherm model, and the adsorption at metal-electrolyte interfaces involved both chemical and physical adsorption, but predominantly chemisorption mechanism.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem