Category: Thiomorpholine

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Design, synthesis and biological evaluation of novel thioquinazolinone-based 2-aminobenzamide derivatives as potent histone deacetylase (HDAC) inhibitors published in 2019. Product Details of 88-68-6, Reprint Addresses Yuan, QP (corresponding author), Beijing Univ Chem Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Biomed Mat Nat Macromol, 15 Beisanhuan East Rd, Beijing 100029, Peoples R China.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A series of novel 2-aminobenzamide derivatives decorated with thioquinazolinone were designed and synthesized as histone deacetylase (HDAC) inhibitors. These derivatives were evaluated for their anti-proliferative activities against several human cancer cell lines including A375, Hela, A549, HCT116 and SMMC7721. It’s significantly indicated that some inhibitors exhibited potent antiproliferative activities towards all the studied cancer cell lines. Compounds 7a, 4i, 4o, and 4p exhibited higher antiproliferative activities towards three cancer cell lines: A375, A549 and SMMC7721 compared to CS055, MS275, and C1994. Compound 4p showed more than 4000-fold the isoform selectivity for HDACI and more than 250-fold selectivity for HDAC2 compared with HDAC6. The molecular docking analysis reasonably explained the HDAC inhibitory activity and isoform selectivity. In addition, compounds 7a, 4i, 4o, and 4p showed potent inhibitory activities in migration assay and colony formation analysis, and also promoted cell apoptosis. Moreover, compounds 7a, 4i, and 4o inhibited the growth of SMMC7721 cells at S phase of the cell cycle. The immunofluorometric analysis indicated that compounds 7a, 4i, 4o, and 4p could increase the acetylation status of H3K9. Furthermore, in vivo anticancer efficacy of compound 4p was assessed in the A549 xenograft models, and 4p demonstrated potent antitumor activity (TGI = 62.5%). This study provided an effective strategy for further development of tumor-targeting therapy. (C) 2019 Elsevier Masson SAS. All rights reserved.

Product Details of 88-68-6. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 EUR J ORG CHEM published article about DIELS-ALDER REACTIONS; CYCLOADDITION REACTION; ORGANIC SYNTHESES; ELECTRON-TRANSFER; (1-ALKYNYL)CARBENE COMPLEXES; REGIOSELECTIVE SYNTHESIS; CYCLIZATION REACTIONS; CATALYZED REACTIONS; ANTHRONE; CHROMIUM(0) in [Collado, Alba; Gomez-Gallego, Mar; Santiago, Alicia; Sierra, Miguel A.] Univ Complutense, Fac Quim, Dept Quim Organ 1, Ctr Invest Quim Avanzada ORFEO CINQA, E-28040 Madrid, Spain in 2019, Cited 75. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8. Product Details of 90-44-8

Group 6 alkynyl Fischer carbene complexes behave as electrophiles with highly reactive masked dienes such as anthrone and 3-hydroxy-2-pyrone, which also can react as bidentate nucleophiles. Both Cr-0 and W-0 alkynyl carbene complexes require tertiary amines to promote the formation of 1,4-C-addition products, but a marked dependence of the reactivity on the metal was observed. Although W-0 complexes form exclusively the 1,4-C-adducts in the presence of a catalytic amount of base, Cr-0 complexes lead to new anthrone-derived bis-carbene complexes, obtained by a sequential 1,4-C- and 1,4-O-addition process with high diastereoselectivity and only in the presence of an excess of base. DFT computational studies show that the gap between the LUMO of the complex and the HOMO of the anthrone determines the differences in reactivity and that the stability of the intermediate metal allenyls formed after the initial 1,4-addition is decisive for the outcome of the reaction.

Product Details of 90-44-8. Welcome to talk about 90-44-8, If you have any questions, you can contact Collado, A; Gomez-Gallego, M; Santiago, A; Sierra, MA or send Email.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C7H8N2O. Authors Thorve, PR; Maji, B in ROYAL SOC CHEMISTRY published article about in [Thorve, Pradip Ramdas; Maji, Biplab] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741246, India in 2021, Cited 72. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Herein, we report a bioinspired catalytic system for the one-pot cascade oxidation of a native primary amine and an in situ generated non-native secondary amine. The catalyst consists of an o-quinone cofactor phd (1,10-phenanthroline-5,6-dione) and a copper ion and operates under ambient air conditions. Quinazolin-4(3H)-ones, which are common pharmacophores present in numerous pharmaceuticals and bioactive compounds, were synthesized in high yields. A detailed kinetic and mechanistic study elucidates the role of the catalyst in the multi-step oxidative cascade reaction.

Welcome to talk about 88-68-6, If you have any questions, you can contact Thorve, PR; Maji, B or send Email.. Formula: C7H8N2O

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Thiomorpholine – Wikipedia,
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An article Metal free decarboxylative aminoxylation of carboxylic acids using a biphasic solvent system WOS:000607351800023 published article about RADICAL CYCLIZATION; ALKYL RADICALS; GENERATION; ANNULATION in [Kirschning, Andreas] Leibniz Univ Hannover, Inst Organ Chem, Schneiderberg 1B, D-30167 Hannover, Germany; Leibniz Univ Hannover, Ctr Biomol Drug Res BMWZ, Schneiderberg 1B, D-30167 Hannover, Germany in 2021.0, Cited 45.0. Computed Properties of C13H10O. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

The smooth oxidative radical decarboxylation of carboxylic acids with TEMPO and other derivatives as radical scavengers is reported. The key to success was the use of a two-phase solvent system to avoid otherwise predominant side reactions such as the oxidation of TEMPO by persulfate and enabled the selective formation of synthetically useful alkoxyamines. The method does not require transition metals and was successfully used in a new synthetic approach for the antidepressant indatraline.

Computed Properties of C13H10O. Welcome to talk about 119-61-9, If you have any questions, you can contact Schulz, G; Kirschning, A or send Email.

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Thiomorpholine – Wikipedia,
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In 2020 NAT CATAL published article about FLUORINATION; REACTIVITY; FLUORIDE; PHENOLS; ENABLES in [Tay, Nicholas E. S.; Levens, Alison; Pistritto, Vincent A.; Nicewicz, David A.] Univ N Carolina, Dept Chem, Venable Labs, Chapel Hill, NC 27515 USA; [Tay, Nicholas E. S.] Columbia Univ, Dept Chem, New York, NY 10027 USA; [Chen, Wei; Huang, Zeng; Wu, Zhanhong; Li, Zibo] Univ N Carolina, Dept Radiol, Biomed Res Imaging Ctr, Chapel Hill, NC 27515 USA; [Chen, Wei; Huang, Zeng; Wu, Zhanhong; Li, Zibo] Univ N Carolina, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA; [Levens, Alison] FMC Stine Res Ctr, Newark, DE USA in 2020, Cited 46. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2. SDS of cas: 104-21-2

Nucleophilic aromatic substitution (SNAr) is routinely used to install (19)F(-)and (18)F(-)in aromatic molecules, but is typically limited to electron-deficient arenes due to kinetic barriers associated with C-F bond formation. Here we demonstrate that a polarity-reversed photoredox-catalysed arene deoxyfluorination that operates via cation-radical-accelerated SNAr enables the fluorination of electron-rich arenes with (19)F(-)and (18)F(-)under mild conditions, and thus complements the traditional arene polarity requirements necessary for SNAr-based fluorination. The utility of our radiofluorination strategy is highlighted by short reaction times, compatibility with multiple nucleofuges and high radiofluorination yields, especially that of an important cancer positron emission tomography agent [F-18]5-fluorouracil. Taken together, our fluorination approach enables the development of fluorinated and radiofluorinated compounds that can be difficult to access by classical SNAr strategies, with the potential for use in the synthesis and discovery of positron emission tomography radiopharmaceuticals.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 99-61-6. Authors Shi, TT; Wang, SZ; Yang, Z; Wang, YL; Liu, CK; He, W; Fang, Z; Guo, K in ROYAL SOC CHEMISTRY published article about in [Shi, Ting-Ting; Wang, Shu-Zhan; Wang, Yilin; Liu, Chengkou; He, Wei; Fang, Zheng; Guo, Kai] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 211814, Peoples R China; [Shi, Ting-Ting] Bengbu Med Coll, Dept Chem, Bengbu 233030, Peoples R China; [Yang, Zhao] China Pharmaceut Univ, Sch Engn, 639 Longmian Ave, Nanjing 211198, Peoples R China; [Fang, Zheng; Guo, Kai] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Peoples R China in 2021.0, Cited 25.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

A green and efficient method for the synthesis of substituted benzimidazoles has been developed in a two-step continuous flow system. Enzymatic electrochemical cascade reactions between aromatic alcohols and o-phenylenediamines are reported. The reaction was performed under mild reaction conditions with air as the green oxidant and oxidase as the biocatalyst. Alcohol oxidation and substituted benzimidazole formation, which are usually accomplished separately, were integrated into a single operation. A scale up experiment was completed successfully in a continuous flow system which offers an industrially relevant, practical and efficient method.

Product Details of 99-61-6. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Shi, TT; Wang, SZ; Yang, Z; Wang, YL; Liu, CK; He, W; Fang, Z; Guo, K or concate me.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO; AUTOMATED RADIOSYNTHESIS; MEDIATED SYNTHESIS; RECEPTOR AGONIST; PET; BIODISTRIBUTION; CARBONYLATION; RADIOLIGAND; LIGAND, Saw an article supported by the European Union (EU) through the project Radiochemistry for Molecular Imaging [EU FP7-PEOPLE-2012-ITN-RADIOMI]; Centre National de la Recherche Scientifique (CNRS)Centre National de la Recherche Scientifique (CNRS); Institut national de la sante et de la recherche medicale (INSERM)Institut National de la Sante et de la Recherche Medicale (Inserm); University of Lyon 1. COA of Formula: C7H8N2O. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Liger, F; Cadarossanesaib, F; Iecker, T; Tourvieille, C; Le Bars, D; Billard, T. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

Labeling of heterocycles with carbon-11 is generally performed through peripheral functionalizations and more scarcely inside heterocyclic core. Such less common approach usually requires preliminary multi-step synthesis of reactive species. Herein, a cyclization reaction by direct use of cyclotron-produced [C-11]CO2 is described to obtain various heterocycles intracyclically labeled in only 10 minutes.

COA of Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Liger, F; Cadarossanesaib, F; Iecker, T; Tourvieille, C; Le Bars, D; Billard, T or send Email.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Gold(i)-NHC-catalysed synthesis of benzofuransviamigratory cyclization of 2-alkynylaryl ethers WOS:000580494600017 published article about C-N BOND; SILVER-FREE; 2,3-DISUBSTITUTED BENZOFURANS; CATALYZED CYCLIZATION; GOLD CATALYSIS; COMPLEXES; ALKYNES; CARBOALKOXYLATION; CARBOTHIOLATION; REACTIVITY in [Le, Quang; Dillon, Christopher C.; Lichtenstein, Dana A.; Pisor, Jeremy W.; Closser, Kristina D.; Muchalski, Hubert] Calif State Univ Fresno, 2555 E San Ramon Ave M-S SB70, Fresno, CA 93740 USA in 2020, Cited 46. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2. Formula: C10H12O3

Homogeneous cationic gold(i) catalysis emerged as a preferred avenue for the activation of alkenes and alkynes towards reactions with weak nucleophiles, especially in cyclization reactions. Here we report an intramolecular carboalkoxylation reaction of electron-rich benzyl ethers of 2-ethynylaryl phenols catalysed by a digold(i)-NHC complex. The reaction proceeds efficiently with low catalyst loading and the resulting 2,3-disubstituted benzofurans form in moderate to good yields. Based on the results of a cross-over experiment, spectroscopic data, and DFT calculations, we propose a mechanism that accounts for the observed chemo- and regioselectivity.

Formula: C10H12O3. About 4-Methoxybenzyl acetate, If you have any questions, you can contact Le, Q; Dillon, CC; Lichtenstein, DA; Pisor, JW; Closser, KD; Muchalski, H or concate me.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about LEAF GEL EXTRACT; IN-VITRO; OXIDATIVE STRESS; ANTIINFLAMMATORY ACTIVITY; INHIBITS PROLIFERATION; BARBADENSIS MILLER; MOLECULAR-WEIGHT; EMODIN; SKIN; ANTIOXIDANT, Saw an article supported by the Council of Scientific and Industrial Research, New Delhi, IndiaCouncil of Scientific & Industrial Research (CSIR) – India; University Grant Commission, New Delhi, IndiaUniversity Grants Commission, India. Published in ELSEVIER GMBH in MUNICH ,Authors: Kumar, R; Singh, AK; Gupta, A; Bishayee, A; Pandey, AK. The CAS is 90-44-8. Through research, I have a further understanding and discovery of Anthrone. Product Details of 90-44-8

Background: Aloe vera is commonly used in the primary health care of human beings since time immemorial. It is an herb widely used in various traditional systems of medicine worldwide. Systematic and scientific investigation on A. vera as a medicinal plant has drawn considerable attention, and many laboratories are involved in isolation, characterization and evaluation of phytoconstituents for their nutraceutical and pharmaceutical applications. Purpose: The aim of this study was to provide an overview of the phytochemical, biological and medicinal attributes of A. vera against various diseases with special emphasis on underlying mechanisms of action. Methods: PubMed, EBOSCO host, Science Direct, Scopus, and Cochrane library databases were utilized to search literature published between1977 and 2019 (fill March). Major keywords used in various combinations included: Aloe vera, phytochemistry, metabolism, pharmacological activity, prevention, treatment, health, disease, in vivo, in vitro, and clinical studies. Results: Various biological and pharmacological activities of A. vera, such as antioxidant, anti-inflammatory, immuno-modulatory, antimicrobial, antiviral, antidiabetic, hepatoprotective, anticancer, and skin-protective and wound-healing responses, have been attributed to the presence of many active compounds, including anthraquinones, anthrones, chromones, flavonoids, amino acids, lipids, carbohydrates, vitamins and minerals. Conclusion: Based on various preclinical studies, A. vera constituents have enormous potential to prevent and treat various diseases. Randomized clinical trials are needed to understand the full therapeutic potential of this unique medicinal plant.

Welcome to talk about 90-44-8, If you have any questions, you can contact Kumar, R; Singh, AK; Gupta, A; Bishayee, A; Pandey, AK or send Email.. Product Details of 90-44-8

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 J CHEM ENG DATA published article about O-AMINOBENZAMIDE; ACID; WATER; OLIGOSACCHARIDES; MIXTURE in [Wu, Kui] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China; [Li, Yajun] Guangdong Acad Sci, Guangzhou Sugarcane Ind Res Inst, Guangdong Prov Bioengn Inst, Guangzhou S10316, Guangdong, Peoples R China in 2019, Cited 24. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. SDS of cas: 88-68-6

The solubility of 2-aminobenzamide in 15 pure organic solvents, including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, n-hexanol, n-octanol, acetone, ethyl acetate, acetonitrile, tetrahydrofuran, and methyl acetate, was measured using a gravimetric method over the temperature range from 273.15 to 324.15 K under atmosphere pressure. Four thermodynamic models, that is, Apelblat equation, 2,11 equation, nonrandom two-liquid equation, and Wilson equation, were applied to correlate the measured solubility data. The correlation results were evaluated by the relative average deviation. The results indicated that the mole fraction solubility increased with the rising of temperature in all 15 solvents, and the Wilson model gave the best fitting results. The experimental data and correlation models would be useful in the purification and synthesis process of 2-aminobenzamide.

SDS of cas: 88-68-6. Welcome to talk about 88-68-6, If you have any questions, you can contact Wu, K; Li, YJ or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem