Category: 99-61-6

I found the field of Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Dihydroquinoline derivative as a potential anticancer agent: synthesis, crystal structure, and molecular modeling studies published in 2021.0. Safety of 3-Nitrobenzaldehyde, Reprint Addresses Vaz, WF (corresponding author), Univ Estadual Goias, BR-75132400 Anapolis, Go, Brazil.; Vaz, WF (corresponding author), Inst Fed Educ Ciencia & Tecnol Mato Grosso, BR-78455000 Lucas Do Rio Verde, MT, Brazil.. The CAS is 99-61-6. Through research, I have a further understanding and discovery of 3-Nitrobenzaldehyde

Cancer is one of the leading causes of death worldwide and requires intense and growing research investments from the public and private sectors. This is expected to lead to the development of new medicines. A determining factor in this process is the structural understanding of molecules with potential anticancer properties. Since the major compounds used in cancer therapies fail to encompass every spectrum of this disease, there is a clear need to research new molecules for this purpose. As it follows, we have studied the class of quinolinones that seem effective for such therapy. This paper describes the structural elucidation of a novel dihydroquinoline by single-crystal X-ray diffraction and spectroscopy characterization. Topology studies were carried through Hirshfeld surfaces analysis and molecular electrostatic potential map; electronic stability was evaluated from the calculated energy of frontier molecular orbitals. Additionally, in silico studies by molecular docking indicated that this dihydroquinoline could act as an anticancer agent due to their higher binding affinity with human aldehyde dehydrogenase 1A1 (ALDH 1A1). Tests in vitro were performed for VERO (normal human skin keratinocytes), B16F10 (mouse melanoma), and MDA-MB-231 (metastatic breast adenocarcinoma), and the results certified that compound as a potential anticancer agent. [GRAPHICS] .

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Sorrentino, JP; Orsi, DL; Altman, RA in AMER CHEMICAL SOC published article about in [Sorrentino, Jacob P.] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA; [Orsi, Douglas L.] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA; [Altman, Ryan A.] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47906 USA; [Altman, Ryan A.] Purdue Univ, Dept Chem, W Lafayette, IN 47906 USA in 2021.0, Cited 35.0. Recommanded Product: 3-Nitrobenzaldehyde. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

The substitution of hydrogen atoms with fluorine in bioactive molecules can greatly impact physicochemical, pharmacokinetic, and pharmacodynamic properties. However, current synthetic methods cannot readily access many fluorinated motifs, which impedes utilization of these groups. Thus, the development of new methods to introduce fluorinated functional groups is critical for developing the next generation of biological probes and therapeutic agents. The synthesis of one such substructure, the alpha,alpha-difluoroalkylthioether, typically requires specialized conditions that necessitate early-stage installation. A late-stage and convergent approach to access alpha,alpha-difluoroalkylthioethers could involve nucleophilic addition of thiols across gem-difluorostyrenes. Unfortunately, under basic conditions, nucleophilic addition to gem-difluorostyrenes generates an anionic intermediate that can undergo facile elimination of fluoride to generate alpha-fluorovinylthioethers. To overcome this decomposition, we herein exploit an acid-based catalyst system to facilitate simultaneous nucleophilic addition and protonation of the unstable intermediate. Ultimately, the optimized mild conditions afford the desired alpha,alpha-difluoroalkylthioethers in high selectivity and moderate to excellent yields. These alpha,alpha-difluoroalkylthioethers are less nucleophilic and more oxidatively stable relative to nonfluorinated thioethers, suggesting the potential application of this unexplored functional group in biological probes and therapeutic agents.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Computed Properties of C7H5NO3. Recently I am researching about SCHIFF-BASE COMPLEX; HETEROGENEOUS CATALYST; REUSABLE CATALYST; GREEN SYNTHESIS; CHLOROPHYLL-A; EFFICIENT; REDUCTION; AMINES; POLYSALICYLALDEHYDE; NANOPARTICLES, Saw an article supported by the University of Kurdistan Research Council. Published in ELSEVIER in AMSTERDAM ,Authors: Mahmoudi, B; Rostami, A; Kazemnejadi, M; Hamah-Ameen, BA. The CAS is 99-61-6. Through research, I have a further understanding and discovery of 3-Nitrobenzaldehyde

A redox catalytic system for oxidation-reduction reactions and the domino preparation of tetrazole compounds from nitro and alcohol precursors was designed, prepared and characterized by UV-vis, GPC, TGA, XRD, EDX, XPS, VSM, FE-SEM, TEM, DLS, BET, NMR, and ICP analyses. The catalyst was prepared via several successive steps by demetalation of chlorophyll b, copolymerization with acrylated TEMPO monomers, complexation with Ni and Co metals (In two different steps), then immobilized on magnetic nanoparticles. The presence of three functional groups including TEMPO, coordinated cobalt, and coordinated nickel in the catalyst, allowed the oxidation of various types of alcohols, alkyl benzenes as well as the reduction of nitro compounds by a single catalyst. All reactions yielded up to 97 % selectivity for oxidation and reduction reactions. Next, the ability of the catalyst to successfully convert alcohol, methyl benzenes and nitro to their corresponding tetrazoles was studied.

Computed Properties of C7H5NO3. Welcome to talk about 99-61-6, If you have any questions, you can contact Mahmoudi, B; Rostami, A; Kazemnejadi, M; Hamah-Ameen, BA or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H5NO3. In 2021 RUSS J BIOORG CHEM+ published article about MAGNETICALLY SEPARABLE CATALYST; COATED NIFE2O4 NANOPARTICLES; POT MULTICOMPONENT REACTIONS; POTENTIAL ANTITUMOR AGENTS; SOLVENT-FREE SYNTHESIS; EFFICIENT SYNTHESIS; HANTZSCH REACTION; HETEROGENEOUS CATALYST; REUSABLE CATALYST; DERIVATIVES in [Fekri, Leila Zare; Zadeh, Leila Hassan] Payame Noor Univ, Dept Chem, POB 19395-3697, Tehran, Iran in 2021, Cited 38. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6.

Fe3O4@SiO2-Pr@L-proline magnetic nanoparticles were synthesized and their efficiency as nanocatalyst for the synthesis of new derivatives of bis dapsone derived dihydropyridines via one-pot three-component condensation reaction of various aromatic aldehydes, dimedone and dapsone in aqueous media was investigated. The products were characterized by H-1 NMR, C-13 NMR, FT-IR and CHNS analysis. These bis-drugs present high antibacterial activities against both gram-negative (Pseudomonas aeruginosa and Escherichia coli) and gram-positive (Micrococcus luteus and Bacillus subtilis) bacteria, which are in general more sensitive to compounds with halogen or hydroxyl functional groups.

COA of Formula: C7H5NO3. Welcome to talk about 99-61-6, If you have any questions, you can contact Fekri, LZ; Zadeh, LH or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H5NO3. Authors Ma, RN; Xiao, ZY; Zhong, W; Lu, CX; Shen, ZQ; Zhao, D; Liu, XM in WILEY published article about in [Ma, Ruonan; Xiao, Zhiyin; Zhong, Wei; Lu, Chunxin; Shen, Zhongquan; Liu, Xiaoming] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Peoples R China; [Ma, Ruonan; Zhao, Dan; Liu, Xiaoming] Nanchang Univ, Sch Chem, Nanchang 330031, Jiangxi, Peoples R China in 2021.0, Cited 35.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

Cuprous halides, best described as (CuX)(n) (X = Cl-, Br-, and I-) in their solid state, catalyse selective aerobic oxidation of alcohols with the assistance of both NMI (N-methylimidazole) and TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl), and the iodide generally demonstrates the highest activity, for example, in the oxidation of 1-octanol at ambient temperature under 24 h’ reaction. However, in the aerobic oxidation of benzylic alcohols, the chloride showed superiority to the iodide in that the aerobic oxidation was quantitatively completed within 3 h at ambient temperature whereas the iodide showed only about half the activity of the chloride analogue. By probing the system using electrochemistry, electric conductivity, and H-1 NMR titration, it was revealed that the surprising anomaly was due to the difference in the rate of forming active species, [Cu (NMI)(2)X(MeCN)], from the polymeric solid in a two-stage process. Substrates expansion of 11 benzylic alcohols indicated that CuCl/NMI/TEMPO system demonstrated quantitative conversion of benzylic alcohols into corresponding aldehydes within 3 h and showed great tolerance to the substituents on the phenyl ring of the substrates. Furthermore, electron-withdrawing substituent was beneficial to the oxidation and could offset the steric effect at orthro-substituent. Such a behaviour suggested that in the catalysis, increasing the acidity of the hydroxyl group (OH) of the substrates could ease the oxidation, which implied that the deprotonation via an internal pathway might be one of the rate-determining steps. Our results also showed that the anion halide participated actively in the catalysis by coordinating to Cu(I) in the active species.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C7H5NO3. Mousapour, M; Shirini, F in [Mousapour, Maryam; Shirini, Farhad] Univ Guilan, Dept Chem, Coll Sci, Rasht 4133519141, Iran published Piperazinium Nano Silica Sulfonate: An Efficient Catalyst for the Hantzsch Reaction in 2021.0, Cited 67.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6.

Piperazinium nano silica sulfonate (PNSS) is simply prepared by the reaction of piperazine with nano sized silica sulfuric acid. After preparation it was completely characterized using different techniques including FT-IR, XRD, TGA, FESEM, EDS and TEM analysis. In continue PNSS was efficiently used for the promotion of the synthesis of polyhydroquinolines and 1,8-dioxo-decahydroacridines through unsymmetrical and symmetrical Hantzsch condensation reaction. High yields, short reaction times, ease of preparation and reusability of the catalyst, easy work-up procedure and solvent-free conditions are among the most important advantages of this method.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Computed Properties of C7H5NO3. Authors Wu, ZH; He, ZC; Xu, YK; Wang, J; Lu, XH; Xia, QH; Zhou, D in SPRINGER published article about in [Wu, Zhonghan; He, Zhechao; Xu, Yinke; Wang, Jing; Lu, Xinhuan; Xia, Qinghua; Zhou, Dan] Hubei Univ, Minist Of Educ, Key Lab Synth & Applicat Organ Funct Mol, Wuhan 430062, Peoples R China in 2021.0, Cited 21.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

From the view of energy saving and environment protection, green catalysis has become one of the most important goals of chemists, including both the green preparation of catalyst and the highly efficient catalysis under mild reaction condition. Herein, N,N-dimethylaminopropyl-functionalized hybrid zeolite is firstly synthesized by one-step non-templating method, which is characterized by powder X-ray diffraction, Fourier-transform IR, thermogravimetric analysis, element analysis, scanning electron microscope, water contact angle measurements, inductively coupled plasma atomic emission spectrometry, and N-2 adsorption-desorption measurements. The functionalized hybrid zeolite can be directly used as base catalyst without any post modification and achieve high yields of corresponding products in the Knoevenagel condensation of benzaldehyde (or substituted benzaldehyde) with ethyl cyanoacetate at room temperature by using ethanol as solvent. By the comparison with other zeolite catalysts, the unique and excellent catalytic properties of N,N-dimethylaminopropyl-functionalized hybrid zeolite was ascribed to not only the synergic effect of basic property and hydrophobic/lipophilicity of the organic groups, but also the easier accessibility of bulky substrate molecules with highly exposed catalytic active sites over the solid catalyst. The recycling and control experiments show that it owes excellent reusable stability.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 99-61-6. I found the field of Chemistry very interesting. Saw the article Three-component synthesis of 2-acyl-2,3-dihydro-4H-thiochromeno[4,3-b]furan-4-ones and their reductive rearrangement into 4H,5H-thiochromeno[4,3-b]pyran-5-ones published in 2021.0, Reprint Addresses Osyanin, VA (corresponding author), Samara State Tech Univ, 244 Molodogvardeyskaya St, Samara 443100, Russia.. The CAS is 99-61-6. Through research, I have a further understanding and discovery of 3-Nitrobenzaldehyde.

Three-component condensation of in situ generated pyridinium acyl methylides with aromatic aldehydes and 4-hydroxythiocoumarin led to a series of 2-acyl-2,3-dihydro-4H-thiochromeno[4,3-b]furan-4-ones. The reaction proceeds diastereoselectively with the formation of trans-isomers and represents a cascade process involving the Knoevenagel condensation, carbo-Michael reaction, and intramolecular nucleophilic substitution. The subsequent redox rearrangement of 2-acyl-2,3-dihydro-4H-thiochromeno[4,3-b]furan-4-ones by the action of Zn and ZrCl4 grants access to 4H,5H-thiochromeno[4,3-b]pyran-5-ones.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis, Characterization, and Evaluation of Antibacterial Activity of New Bis-Dapsone-Derived Dihydropyridines Using Fe3O4@SiO2-Pr@L-proline WOS:000644646500026 published article about MAGNETICALLY SEPARABLE CATALYST; COATED NIFE2O4 NANOPARTICLES; POT MULTICOMPONENT REACTIONS; POTENTIAL ANTITUMOR AGENTS; SOLVENT-FREE SYNTHESIS; EFFICIENT SYNTHESIS; HANTZSCH REACTION; HETEROGENEOUS CATALYST; REUSABLE CATALYST; DERIVATIVES in [Fekri, Leila Zare; Zadeh, Leila Hassan] Payame Noor Univ, Dept Chem, POB 19395-3697, Tehran, Iran in 2021, Cited 38. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6. Product Details of 99-61-6

Fe3O4@SiO2-Pr@L-proline magnetic nanoparticles were synthesized and their efficiency as nanocatalyst for the synthesis of new derivatives of bis dapsone derived dihydropyridines via one-pot three-component condensation reaction of various aromatic aldehydes, dimedone and dapsone in aqueous media was investigated. The products were characterized by H-1 NMR, C-13 NMR, FT-IR and CHNS analysis. These bis-drugs present high antibacterial activities against both gram-negative (Pseudomonas aeruginosa and Escherichia coli) and gram-positive (Micrococcus luteus and Bacillus subtilis) bacteria, which are in general more sensitive to compounds with halogen or hydroxyl functional groups.

Product Details of 99-61-6. Welcome to talk about 99-61-6, If you have any questions, you can contact Fekri, LZ; Zadeh, LH or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

HPLC of Formula: C7H5NO3. Authors Nasirmahale, LN; Jolodar, OG; Shirini, F; Tajik, H in TAYLOR & FRANCIS LTD published article about in [Nazemi Nasirmahale, Leyla; Goli Jolodar, Omid; Shirini, Farhad; Tajik, Hassan] Univ Guilan, Dept Chem, Coll Sci, Rasht 4133519141, Iran in 2021.0, Cited 66.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

An effective method for the one-pot synthesis of dihydropyrano[3,2-c]chromene and biscoumarin derivatives have been reported using poly (4-vinylpyridine) as a cheap, efficient and recyclable catalyst. All reactions are performed in a green media during acceptable reaction times with good to high yields.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem