Category: 88-68-6

An article Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy WOS:000610494400011 published article about PARP INHIBITORS; DNA-REPAIR; BRD4; DISCOVERY; LETHALITY; ADAPTER; TUMORS in [Chang, Xiaosa; Sun, Dejuan; Shi, Danfeng; Wang, Guan; Chen, Yanmei; Zhang, Kai; Tan, Huidan; Liu, Jie; Liu, Bo; Ouyang, Liang] Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China in 2021, Cited 72. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Name: 2-Aminobenzamide

This study was aimed to design the first dual-target small-molecule inhibitor co-targeting poly (ADP-ribose) polymerase-1 (PARP1) and bromodomain containing protein 4 (BRD4), which had important cross relation in the global network of breast cancer, reflecting the synthetic lethal effect. A series of new BRD4 and PARP1 dual-target inhibitors were discovered and synthesized by fragment-based combinatorial screening and activity assays that together led to the chemical optimization. Among these compounds, 19d was selected and exhibited micromole enzymatic potencies against BRD4 and PARP1, respectively. Compound 19d was further shown to efficiently modulate the expression of BRD4 and PARP1. Subsequently, compound 19d was found to induce breast cancer cell apoptosis and stimulate cell cycle arrest at G1 phase. Following pharmacokinetic studies, compound 19d showed its antitumor activity in breast cancer susceptibility gene 1/2 (BRCA1/2) wild-type MDA-MB-468 and MCF-7 xenograft models without apparent toxicity and loss of body weight. These results together demonstrated that a highly potent dual-targeted inhibitor was successfully synthesized and indicated that co-targeting of BRD4 and PARP1 based on the concept of synthetic lethality would be a promising therapeutic strategy for breast cancer. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

About 2-Aminobenzamide, If you have any questions, you can contact Chang, XS; Sun, DJ; Shi, DF; Wang, G; Chen, YM; Zhang, K; Tan, HD; Liu, J; Liu, B; Ouyang, L or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article A facile synthesis of (Z)-1, 6-disubstituted-7H-benzo[b][1,5]diazonin-7-one derivatives via arylation-allylation-RCM pathway of anthranilamide and isatoic anhydride WOS:000491626500009 published article about RING-CLOSING METATHESIS; NITROGEN-HETEROCYCLES; OLEFIN METATHESIS; SEPTANOSIDES; PEPTIDES; LACTAMS; ANALOGS; BETA in [Novanna, Motakatla; Kannadasan, Sathananthan] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India; [Shanmugam, Ponnusamy] CSIR, Organ & Bioorgan Chem Div, Cent Leather Res Inst, Chennai 600020, Tamil Nadu, India in 2019, Cited 46. Name: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A facile and efficient method has been developed for the synthesis of (2)-6-allyl-1-phenyl-1,2,5,6tetrahydro-7H-benzo[b][1,5]-diazonin-7-one and (Z)-1,6-diphenyl-1,2,5,6-tetrahydro-7H-benzo[b][1,5]-diazonin-7-one from anthranilamide via N-arylation/N-allylation and from isatoic anhydride via ring opening/N-arylation/N-allylation followed by ring closing metathesis using Grubbs-II catalyst as a key step. Grubbs-II catalyst was found to be superior over Grubbs-I catalyst in terms of reaction time and yield of the product, and the routes developed were suitable to synthesize benzo fused nine membered nitrogen heterocycles. The requirement of diallylated substrates with protected amine and amide nitrogen is suitable for RCM has been established for the synthesis of diazoninone derivatives. (C) 2019 Elsevier Ltd. All rights reserved.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Novanna, M; Kannadasan, S; Shanmugam, P or concate me.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 2-Aminobenzamide. Authors Yang, L; Hou, HQ; Li, L; Wang, J; Zhou, SY; Wu, M; Ke, F in ROYAL SOC CHEMISTRY published article about in [Yang, Li; Li, Lan; Ke, Fang] Yibin Univ, Coll Chem & Chem Engn, Yibin, Sichuan, Peoples R China; [Hou, Huiqing; Wang, Jin; Zhou, Sunying; Wu, Mei; Ke, Fang] Fujian Med Univ, Fuzhou, Fujian, Peoples R China in 2021, Cited 64. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

An efficient and practical electrochemically catalyzed transition metal-free process for the synthesis of substituted quinazolinones from simple and readily available o-aminobenzonitriles and aldehydes in water has been accomplished. I-2/base and water play an unprecedented and vital role in the reaction. By electrochemically catalysed hydrolysis of o-aminobenzonitriles, the synthesis of quinazolinones with benzaldehyde was first proposed. The synthetic utility of this method was demonstrated by gram-scale operation, as well as the preparation of bioactive N-(2,5-dichlorophenyl)-6-(2,2,2-trifluoroethoxy) pteridin-4-amine, which enables straightforward, practical and environmentally benign quinazolinone formation.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Yang, L; Hou, HQ; Li, L; Wang, J; Zhou, SY; Wu, M; Ke, F or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about PHARMACOLOGICAL CHAPERONES; DESIGN; AZASUGARS; ENZYMES, Saw an article supported by the National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21772031, 21778013]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Sun, JJ; Kang, YQ; Gao, LG; Lu, X; Ju, HH; Li, XL; Chen, H. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. COA of Formula: C7H8N2O

A series of novel tricyclic quinazolinone-iminosugars 1 (a-c) were synthesized from the benzyl protected sugars through three steps. Firstly, the benzyl protected sugar (aldehyde) 5 reacted with o-aminobenzamide by the iodine-induced oxidative condensation to afford the corresponding aldo-quizanolinone 6. Secondly, through the intramolecular cyclization of the unprotected OH and the amide NH in 6, the tricyclic compounds 7 and 8 were constructed by the key Mitsunobu reaction. Finally, removal of the benzyl group gave the target tricyclic quinazolinone-iminosugars 1. The protocol was effective for the preparation of the tricyclic iminosugars in satisfactory yield. Interestingly, an unusual C-2 epimerization was observed with D-mannose and D-ribose compounds under the conditions of the Mitsunobu reaction that generated the products having the trans configuration at the C-2 and C-3 positions. Unfortunately, such tricyclic quinazolinone-iminosugars showed no inhibitory effects on the tested five glycosidases.

About 2-Aminobenzamide, If you have any questions, you can contact Sun, JJ; Kang, YQ; Gao, LG; Lu, X; Ju, HH; Li, XL; Chen, H or concate me.. COA of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Qualitative and quantitative characterization of sialylated N-glycans using three fluorophores, two columns, and two instrumentations WOS:000462102400006 published article about HYDROPHILIC-INTERACTION CHROMATOGRAPHY; LIQUID-CHROMATOGRAPHY; ALPHA(1)-ACID GLYCOPROTEIN; MASS-SPECTROMETRY; GLYCOSYLATION; OLIGOSACCHARIDES; IDENTIFICATION; PROCAINAMIDE; FUCOSYLATION; SEPARATION in [Kim, Wooseok; Kim, Jihye; You, Seungkwan; Do, Jonghye; Jang, Yeonjoo; Kim, Donghwi; Lee, Junmyoung; Ha, Jongkwan; Kim, Ha Hyung] Chung Ang Univ, Coll Pharm, Biotherapeut & Glyc Lab, 84 Heukseok Ro, Seoul 06944, South Korea in 2019, Cited 31. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Recommanded Product: 2-Aminobenzamide

Sialylation can influence the stability, half-life, and immunogenicity of glycoproteins, but sialylated N-glycans are known to be difficult to analyze. Human alpha1-acid glycoprotein (AGP) is reported to have glycans that consist of sialylated N-glycans. The N-glycan profiling of AGP is qualitatively and quantitatively investigated here by UPLC and LC-ESI-MS/MS. Three fluorescent tags (AB, AA, and ProA) and two separation columns (HILIC and AEX-HILIC) were adopted to confirm and compare each analytical characteristic. The results of AA were comparable to those of the well-established AB. The qualification of ProA was notable due to its superior fluorescence intensity and ionization efficiency, and ProA showed smaller quantitative or larger-sized fragments in LC-ESI-MS/MS compared to AB and AA. However, the MS quantification of ProA was distorted because the increased sialylation level decreased the LC-ESI-MS/MS ionization efficiency. HILIC had better peak separability, AEX-HILIC had an advantage in UPLC sialylation profiling, and each isomeric glycan could be Identified by both columns in LC-ESI-MS/MS. In conclusion, ProA is favored for UPLC and LC-ESI-MS/MS detection but not reliable for MS quantification. This study firstly demonstrates the qualification and quantification of sialylated N-glycans by comparing the conunonly used analytical conditions with different fluorescent tags, columns, and instruments.

About 2-Aminobenzamide, If you have any questions, you can contact Kim, W; Kim, J; You, S; Do, J; Jang, Y; Kim, D; Lee, J; Ha, J; Kim, HH or concate me.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Substrate Profiling of the Cobalt Nitrile Hydratase from Rhodococcus rhodochrous ATCC BAA 870 published in 2020. Recommanded Product: 88-68-6, Reprint Addresses Bode, ML; Brady, D (corresponding author), Univ Witwatersrand, Sch Chem, Mol Sci Inst, ZA-2050 Johannesburg, South Africa.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ranging in size from small (90 Da) to large (325 Da) were evaluated. Larger compounds included those with a bi-aryl axis, prepared by the Suzuki coupling reaction, Morita-Baylis-Hillman adducts, heteroatom-linked diarylpyridines prepared by Buchwald-Hartwig cross-coupling reactions and imidazo[1,2-a]pyridines prepared by the Groebke-Blackburn-Bienayme multicomponent reaction. The enzyme active site was moderately accommodating, accepting almost all of the small aromatic nitriles, the diarylpyridines and most of the bi-aryl compounds and Morita-Baylis-Hillman products but not the Groebke-Blackburn-Bienayme products. Nitrile conversion was influenced by steric hindrance around the cyano group, the presence of electron donating groups (e.g., methoxy) on the aromatic ring, and the overall size of the compound.

Recommanded Product: 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Mashweu, AR; Chhiba-Govindjee, VP; Bode, ML; Brady, D or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article An expeditious synthesis of 2,3-dihydroquinozoline-4(1H)-ones using graphene-supported sulfonic acid WOS:000501404400001 published article about ONE-POT SYNTHESIS; IONIC-LIQUID; HIGHLY EFFICIENT; ENANTIOSELECTIVE SYNTHESIS; QUINAZOLINONE DERIVATIVES; HETEROGENEOUS CATALYSIS; OXIDE NANOSHEETS; GREEN; ADSORPTION; WATER in [Gajare, Shivanand; Jagadale, Megha; Naikwade, Altafhusen; Bansode, Prakash; Patil, Pradnya; Rashinkar, Gajanan] Shivaji Univ, Dept Chem, Kolhapur 416004, Maharashtra, India in 2020, Cited 86. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Category: thiomorpholine

Graphene-supported sulfonic acid (Gr@SO3H) has been prepared by covalent grafting of (3-mercaptopropyl)trimethoxysilane in the matrix of graphene followed by treatment with sulfuric acid and hydrogen peroxide. Gr@SO3H has been successfully characterized by Fourier transform infrared (FT-IR) spectroscopy, Fourier transform Raman (FT-Raman) spectroscopy, CP-MAS C-13 NMR spectroscopy, thermogravimetric analysis (TGA), energy dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) analysis, and X-ray diffractometer (XRD) analysis. Gr@SO3H served as a robust heterogeneous catalyst for the synthesis of bioactive 2,3-dihydroquinazolin-4(1H)-ones from anthranilamide and aryl aldehydes in ethanol. Recyclability experiments were executed successfully for six consecutive runs.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Gajare, S; Jagadale, M; Naikwade, A; Bansode, P; Patil, P; Rashinkar, G or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 88-68-6. Authors Laconsay, CJ; Seguin, TJ; Wheeler, SE in AMER CHEMICAL SOC published article about in [Laconsay, Croix J.; Seguin, Trevor J.; Wheeler, Steven E.] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA; [Wheeler, Steven E.] Univ Georgia, Dept Chem, Athens, GA 30602 USA in 2020, Cited 55. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Chiral phosphoric acids have received considerable attention because of their excellent performance in many asymmetric catalytic reactions. However, the full breadth of means by which the stereoselectivity of these catalysts can be tuned has not been fully elucidated. Herein, the origin of enantioselectivity in a catalytic asymmetric synthesis of 2,3-dihydroquinazolinones using SPINOL-derived chiral phosphoric acids (ACS Catal. 2013, 3, 2244) is explored using density functional theory computations. We show that the enantioselectivity of this reaction is determined during the intramolecular amine addition step of an organocascade sequence and is modulated by differential noncovalent interactions of the substrate with the aryl groups of the catalyst as well as CH center dot center dot center dot O and NH center dot center dot center dot O interactions with the phosphate core of the catalyst. Most notably, we demonstrate that the strength of these latter interactions is modulated by their position within the electrostatic environment created by the catalyst. This provides clear evidence of the ability to precisely control the selectivity of an organocatalyzed reaction through the tuning of electrostatic interactions.

About 2-Aminobenzamide, If you have any questions, you can contact Laconsay, CJ; Seguin, TJ; Wheeler, SE or concate me.. Product Details of 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Sun, JJ; Kang, YQ; Gao, LG; Lu, X; Ju, HH; Li, XL; Chen, H in ELSEVIER SCI LTD published article about PHARMACOLOGICAL CHAPERONES; DESIGN; AZASUGARS; ENZYMES in [Sun, Jiajing; Kang, Yaqing; Gao, Ligang; Lu, Xin; Ju, Huanhuan; Li, Xiaoliu; Chen, Hua] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China in 2019, Cited 37. COA of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A series of novel tricyclic quinazolinone-iminosugars 1 (a-c) were synthesized from the benzyl protected sugars through three steps. Firstly, the benzyl protected sugar (aldehyde) 5 reacted with o-aminobenzamide by the iodine-induced oxidative condensation to afford the corresponding aldo-quizanolinone 6. Secondly, through the intramolecular cyclization of the unprotected OH and the amide NH in 6, the tricyclic compounds 7 and 8 were constructed by the key Mitsunobu reaction. Finally, removal of the benzyl group gave the target tricyclic quinazolinone-iminosugars 1. The protocol was effective for the preparation of the tricyclic iminosugars in satisfactory yield. Interestingly, an unusual C-2 epimerization was observed with D-mannose and D-ribose compounds under the conditions of the Mitsunobu reaction that generated the products having the trans configuration at the C-2 and C-3 positions. Unfortunately, such tricyclic quinazolinone-iminosugars showed no inhibitory effects on the tested five glycosidases.

About 2-Aminobenzamide, If you have any questions, you can contact Sun, JJ; Kang, YQ; Gao, LG; Lu, X; Ju, HH; Li, XL; Chen, H or concate me.. COA of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

SDS of cas: 88-68-6. Authors Guo, YB; Gao, ZH; Li, JC; Bi, XJ; Shi, EX; Xiao, JH in ROYAL SOC CHEMISTRY published article about in [Guo, Yongbiao; Gao, Zhenhua; Li, Junchen; Bi, Xiaojing; Shi, Enxue; Xiao, Junhua] State Key Lab NBC Protect Civilian, Beijing, Peoples R China in 2021, Cited 30. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Herein, we report on the highly efficient and practical synthesis of 2,3-dihydroquinazolinones directly from diverse aldehydes with excellent yields and enantioselectivity. Particularly, this protocol affords better enantiocontrol for aliphatic aldehydes (up to 99% yield, 97% ee), which always gave unsatisfactory results in the previous studies. Moreover, this catalytic system shows wide tolerance to different functional groups such as alkenyl, nitro and halogens. Most importantly, its practicability is well elucidated via the gram-scale synthesis of different types of products at 0.1 mol% catalyst loading and the simplified work-up procedure. To better understand the reaction pathway and origin of the enantioselectivity, DFT calculations were also performed.

SDS of cas: 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Guo, YB; Gao, ZH; Li, JC; Bi, XJ; Shi, EX; Xiao, JH or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem