Category: 88-68-6

An article Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27 WOS:000460642800021 published article about COMPLETE GENOME SEQUENCE; NATURAL-PRODUCTS; ANTIBIOTIC PRODUCTION; SECONDARY METABOLISM; MASS-SPECTROMETRY; MOLECULAR NETWORKING; PATHOGENS; PLATFORM; STRESS; LINKS in [Machushynets, Nataliia V.; Wu, Changsheng; Elsayed, Somayah S.; van Wezel, Gilles P.] Leiden Univ, Inst Biol, Mol Biotechnol, Sylviusweg 72, NL-2333 BE Leiden, Netherlands; [Wu, Changsheng] Shandong Univ, Inst Microbial Technol, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China; [Hankemeier, Thomas] Leiden Univ, LACDR, Einsteinweg 55, NL-2333 CC Leiden, Netherlands in 2019, Cited 57. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Quality Control of 2-Aminobenzamide

Actinobacteria are a major source of novel bioactive natural products. A challenge in the screening of these microorganisms lies in finding the favorable growth conditions for secondary metabolite production and dereplication of known molecules. Here, we report that Streptomyces sp. MBT27 produces 4-quinazolinone alkaloids in response to elevated levels of glycerol, whereby quinazolinones A (1) and B (2) form a new sub-class of this interesting family of natural products. Global Natural Product Social molecular networking (GNPS) resulted in a quinazolinone-related network that included anthranilic acid (3), anthranilamide (4), 4(3H)-quinazolinone (5), and 2,2-dimethyl-1,2-dihydroquinazolin-4(3H)-one (6). Actinomycins D (7) and X2 (8) were also identified in the extracts of Streptomyces sp. MBT27. The induction of quinazolinone production by glycerol combined with biosynthetic insights provide evidence that glycerol is integrated into the chemical scaffold. The unprecedented 1,4-dioxepane ring, that is spiro-fused into the quinazolinone backbone, is most likely formed by intermolecular etherification of two units of glycerol. Our work underlines the importance of varying the growth conditions for the discovery of novel natural products and for understanding their biosynthesis.

Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Machushynets, NV; Wu, CS; Elsayed, SS; Hankemeier, T; van Wezel, GP or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Facile access toN-formyl imide as anN-formylating agent for the direct synthesis ofN-formamides, benzimidazoles and quinazolinones WOS:000553219600023 published article about ACID-CATALYZED TRANSAMIDATION; N-SUBSTITUTED FORMAMIDES; CARBON-DIOXIDE; EFFICIENT SYNTHESIS; AMINES; DERIVATIVES; CARBOXAMIDES; METHANOL; OXIDATION; CO2 in [Huang, Hsin-Yi; Lin, Xiu-Yi; Yen, Shih-Yao; Liang, Chien-Fu] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan in 2020, Cited 91. Computed Properties of C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

N-Formamide synthesis usingN-formyl imide with primary and secondary amines with catalytic amounts ofp-toluenesulfonic acid monohydrate (TsOH center dot H2O) is described. This reaction is performed in water without the use of surfactants. Moreover,N-formyl imide is efficiently synthesized using acylamidines with TsOH center dot H2O in water. In addition,N-formyl imide was successfully used as a carbonyl source in the synthesis of benzimidazole and quinazolinone derivatives. Notable features ofN-formylation of amines by usingN-formyl imide include operational simplicity, oxidant- and metal-free conditions, structurally diverse products, and easy applicability to gram-scale operation.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Huang, HY; Lin, XY; Yen, SY; Liang, CF or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Guo, YB; Gao, ZH; Li, JC; Bi, XJ; Shi, EX; Xiao, JH in ROYAL SOC CHEMISTRY published article about in [Guo, Yongbiao; Gao, Zhenhua; Li, Junchen; Bi, Xiaojing; Shi, Enxue; Xiao, Junhua] State Key Lab NBC Protect Civilian, Beijing, Peoples R China in 2021, Cited 30. SDS of cas: 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Herein, we report on the highly efficient and practical synthesis of 2,3-dihydroquinazolinones directly from diverse aldehydes with excellent yields and enantioselectivity. Particularly, this protocol affords better enantiocontrol for aliphatic aldehydes (up to 99% yield, 97% ee), which always gave unsatisfactory results in the previous studies. Moreover, this catalytic system shows wide tolerance to different functional groups such as alkenyl, nitro and halogens. Most importantly, its practicability is well elucidated via the gram-scale synthesis of different types of products at 0.1 mol% catalyst loading and the simplified work-up procedure. To better understand the reaction pathway and origin of the enantioselectivity, DFT calculations were also performed.

SDS of cas: 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Guo, YB; Gao, ZH; Li, JC; Bi, XJ; Shi, EX; Xiao, JH or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Lehmann, DM; Camp, AA in [Lehmann, David M.] US EPA, Ctr Publ Hlth & Environm Assessment CPHEA, Hlth & Environm Effects Assessment Div, Integrated Hlth Assessment Branch, Durham, NC 27709 USA; [Camp, Allison A.] Oak Ridge Associated Univ, Oak Ridge, TN USA published A systematic scoping review of the methodological approaches and effects of pesticide exposure on solitary bees in 2021, Cited 108. Safety of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Background Pollination services provided by solitary bees, the largest group of bees worldwide, are critical to the vitality of ecosystems and agricultural systems alike. Disconcertingly, bee populations are in decline, and while no single causative factor has been identified, pesticides are believed to play a role in downward population trends. The effects of pesticides on solitary bee species have not been previously systematically cataloged and reviewed. Objectives This systematic scoping review examines available evidence for effects of pesticide exposure on solitary bees to identify data gaps and priority research needs. Methods A systematic literature search strategy was developed to identify and document reports on solitary bee pesticide exposure-effects investigations. Literature was subsequently screened for relevance using a Population, Exposures, Comparators, and Outcomes (PECO) statement and organized into a systematic evidence map. Investigations were organized by effect category (lethal effects on immatures, lethal effects on adults, sublethal effects on immatures, and sublethal effects on adults), species, pesticide class, and publication year. Results A comprehensive literature search of Web of Science and ProQuest Agricultural & Environmental Science supplemented by targeted internet searching and reference mining yielded 176 reports and publications for title and abstract screening and 65 that met PECO criteria (22 included lethal and 43 included sublethal effects endpoints). Relevant design details (pesticide, test compound configuration, study type, species, sex, exposure duration) were extracted into literature inventory tables to reveal the extent endpoints have been investigated and areas in need of additional research. Conclusions Evidence mapping revealed diversity in the pesticides and endpoints studied across the database. However, dilution across bee species, lack of complementary laboratory work and paucity of replicated investigations complicate efforts to interpret and apply available data to support pesticide risk assessment.

Safety of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Lehmann, DM; Camp, AA or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Linear and cyclic oligomers in PET, glycol-modified PET and Tritan (TM) used for food contact materials WOS:000590108700001 published article about POLYETHYLENE TEREPHTHALATE PET; IDENTIFICATION; MIGRATION; POLY(ETHYLENE-TEREPHTHALATE); QUANTIFICATION; POLYMERIZATION; POLYESTERS; MONOMERS in [Brenz, Fabrian; Linke, Susanne; Simat, Thomas J.] Tech Univ Dresden, Dept Chem & Food Chem, Chair Food Sci & Food Contact Mat, Dresden, Germany in 2021, Cited 39. Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Polyesters are commonly used as food contact materials. During manufacture of polyesters different low molecular mass oligomers (<1000 Da) are formed in the polymer melt. These so-called non-intentionally added substances (NIAS) are potential migrants into foods. In this work, different polyester samples made of polyethylene terephthalate (PET), glycol-modified PET (PETG) and Tritan (TM) were investigated on their qualitative and quantitative oligomer composition. The analysis of acetonitrile extracts by HPLC-DAD/ESI-MS revealed the presence of about 100 linear (different combinations of hydroxyl-, carboxyl-, methyl ester end groups) and cyclic oligomers depending on the main and co-monomers. The identified oligomers were quantified in different extracts and after reprecipitation by HPLC-DAD using bis-hydroxyethylene terephthalate (BHET) as external standard. The amount of oligomers isolated by reprecipitation ranged between 0.80 and 3.4% in the respective polyester. Cyclic oligomers generally made up 90% or more of the isolated oligomers. Compared to the exhaustive extracts the leaching of oligomers into 20% ethanol (1 h, 60 degrees C) resulted in a considerable change of the oligomer distribution with a predominant detection of linear oligomers. This suggests linear oligomers to be relevant for migration into aqueous foods despite the dominant amount of extractable cyclic oligomers in polyesters. Analysis of the extractable oligomers of a PET preform and a PETG container and their corresponding raw material pellets revealed that the injection moulding process did not significantly change the amount of cyclic oligomers but did increase the amount of low molecular mass linear oligomers about twofold. About 2-Aminobenzamide, If you have any questions, you can contact Brenz, F; Linke, S; Simat, TJ or concate me.. Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 2-Aminobenzamide. Authors Huang, TL; Wang, T; Shi, YS; Chen, J; Guo, XY; Lai, RZ; Liu, XX; Wu, ZP; Peng, DX; Wang, LY; Li, H; Hai, L; Wu, Y in AMER CHEMICAL SOC published article about in [Huang, Tianle; Wang, Ting; Shi, Yuesen; Chen, Jian; Guo, Xiaoyu; Lai, Ruizhi; Liu, Xuexin; Wu, Zhouping; Peng, Dongxue; Wang, Longyu; Li, Hao; Hai, Li; Wu, Yong] Sichuan Univ, Sichuan Engn Lab Plant Sourced Drug & Sichuan Res, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst,Educ, Chengdu 610041, Peoples R China; [Huang, Tianle; Wang, Ting; Shi, Yuesen; Chen, Jian; Guo, Xiaoyu; Lai, Ruizhi; Liu, Xuexin; Wu, Zhouping; Peng, Dongxue; Wang, Longyu; Li, Hao; Hai, Li; Wu, Yong] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China in 2021, Cited 30. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Inspired by the diversity created by nature, organic chemists have been using a divergent strategy to improve the synthetic efficiency of diverse molecules. Transition-metal-catalyzed C-H functionalization has become one of the most straightforward, powerful, and atom-economical methods to construct complex scaffolds. However, C-H activation initiated divergent transformation to prepare diverse molecules is still limited. To address this challenge, we herein developed Rh(III)-catalyzed C-H olefination/annulation reaction cascades to divergently construct diverse polyheterocycles by tuning manipulations of directing groups (DGs). Up to 9 distinct scaffolds were creatively synthesized under simple conditions with good functional group tolerance, chemo-, and regioselectivity. Such a versatile strategy and its extension may encourage researchers to discover more promising manipulations of DGs for transition-metal-catalyzed C-H bond activation, making diverse available targets and materials that would have been previously out of range.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Huang, TL; Wang, T; Shi, YS; Chen, J; Guo, XY; Lai, RZ; Liu, XX; Wu, ZP; Peng, DX; Wang, LY; Li, H; Hai, L; Wu, Y or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Evaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S) donors for lowering blood pressure WOS:000475378400035 published article about FLUORESCENT-PROBE; IN-VITRO; ORGANOPHOSPHORUS COMPOUNDS; PHARMACOLOGICAL EVALUATION; PHOSPHORUS PENTASULFIDE; REAGENT COMBINATION; EFFICIENT SYNTHESIS; ELEMENTAL SULFUR; KINDLER REACTION; RATIONAL DESIGN in [Zaorska, Ewelina; Hutsch, Tomasz; Gawrys-Kopczynska, Marta; Ufnal, Marcin] Med Univ Warsaw, Lab Ctr Preclin Res, Dept Expt Physiol & Pathophysiol, Pawinskiego 3c, PL-02106 Warsaw, Poland; [Ostaszewski, Ryszard; Koszelewski, Dominik] Polish Acad Sci, Inst Organ Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland in 2019, Cited 156. Application In Synthesis of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Hydrogen sulfide (H2S) is a biologically important gaseous molecule that exhibits promising protective effects against a variety of pathological processes. For example, it was recognized as a blood pressure lowering agent. Aligned with the need for easily modifiable platforms for the H2S supply, we report here the preparation and the H2S release kinetics from a series of structurally diversified thioamides, thiolactams and thioureas. Three different thionation methods based on the usage of a phosphorus pentasulfide and Lawesson reagent were applied to prepare the target thioamides and thiolactams. Furthermore, obtained H2S donors were evaluated both in in vivo and in vitro studies. The kinetic parameters of the liberating H2S was determined and compared with NaHS and GYY4137 using two different detection technics i.e.; fluorescence labeling 7-azido-4-methyl-2H-chromen-2-one and 5,5′-dithiobis (2-nitrobenzoic acid), sulfhydryl probe, also known as the Ellman’s reagent. We have proved that the amount of releasing H2S from these compounds is controllable through structural modifications. Finally, the present study shows a hypotensive response to an intravenous administration of the developed donors in the anesthetized rats.

Application In Synthesis of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Zaorska, E; Hutsch, T; Gawrys-Kopczynska, M; Ostaszewski, R; Ufnal, M; Koszelewski, D or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Oxidative ring-opening of isatins for the synthesis of 2-aminobenzamides and 2-aminobenzoates WOS:000460715200006 published article about C-H AMINATION; ONE-POT SYNTHESIS; BOND; INHIBITORS; DISCOVERY; DESIGN; ARENES; QUINAZOLIN-4(3H)-ONES; QUINAZOLINONES; CONDENSATION in [Wang, Yu-Wei; Zheng, Lei; Jia, Feng-Cheng; Chen, Yun-Feng] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Hubei, Peoples R China; [Wu, An-Xin] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China in 2019, Cited 58. Computed Properties of C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

An efficient and practical isatin-based oxidative domino protocol has been developed for the facile synthesis of 2-aminobenzamides and 2-aminobenzoates. The robust nature of this reaction system is reflected by accessible starting materials, room temperature and high-yield gram-scale synthesis. (C) 2019 Elsevier Ltd. All rights reserved.

About 2-Aminobenzamide, If you have any questions, you can contact Wang, YW; Zheng, L; Jia, FC; Chen, YF; Wu, AX or concate me.. Computed Properties of C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 88-68-6. In 2020 CHEM PHARM BULL published article about CELL LUNG-CANCER; ACTIVATED PROTEIN-KINASE; EGFR INHIBITORS; RESISTANT; MUTATIONS; AZD9291; POTENT; DISCOVERY; AFATINIB; TKI in [Zhang, Mingguang; Wang, Yunyun; Li, Mingxin; Wang, Shifa] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Peoples R China; [Zhang, Mingguang; Wang, Jia; Liu, Zhaogang; Shi, Jingmiao; Zhu, Yongqiang] Jiangsu Chia Tai Fenghai Pharmaceut Co Ltd, 9 Weidi Rd, Nanjing 210046, Peoples R China; [Zhu, Yongqiang] Nanjing Normal Univ, Coll Life Sci, Nanjing 210046, Peoples R China in 2020, Cited 31. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Inhibition of the epidermal growth factor receptor (EGFR) has been proved to be one of the most promising strategies for the treatment of non-small cell lung cancers. A series of 2-aryl-4-amino substituted quinazoline derivatives were designed and synthesized with the purpose to overcome L858R/T790M/C797S (CTL) triple mutant drug resistance and the biological activity for inhibition of CTL kinases and EGFR wild type (WT) were evaluated. Three compounds (20, 24 and 27) showed excellent inhibitory activities against EGFR kinases triple mutant CTL (IC50 < 1 mu M) and high selectivity (IC50: WT/CTL >10000). Cell line evaluation showed that the most potent compound 27 was significantly potent against H1975-EGFR L858R/T790M (IC50 = 3.3 mu M) and H1975-EGFR L858R/T790M/C797S (IC50 = 1.2 mu M). Compound 27 also exhibited good microsomes stabilities in human, rat and mouse liver species, but low bioavailability. This work would be very useful for discovering new quinazoline derivatives as tyrosine kinase inhibitors targeting triple mutant L858R/T790M/C797S.

Product Details of 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Zhang, MG; Wang, YY; Wang, J; Liu, ZG; Shi, JM; Li, MX; Zhu, YQ; Wang, SF or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021 J CHROMATOGR A published article about SILICA; RETENTION; BEHAVIOR in [Moravcova, Dana; Cmelik, Richard; Krenkova, Jana] Czech Acad Sci, Inst Analyt Chem, Veveri 97, Brno 60200, Czech Republic in 2021, Cited 25. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Application In Synthesis of 2-Aminobenzamide

The advantages of using mixtures of organic solvents for the separation of labeled oligosaccharides on the amide stationary phase under hydrophilic interaction liquid chromatography conditions are presented. The effect of the type of buffer as well as solvent or their mixtures on retention of uracil, saccharide labeling reagents (2-aminobenzoic acid, 2-aminobenzamide, ethyl 4-aminobenzoate, procainamide), and corresponding labeled saccharides were evaluated. The successful isocratic separation of labeled isomeric trisaccharides (maltotriose, panose, and isomaltotriose) was achieved in the mobile phase consisting of a 90% (v/v) mixture of organic solvents (methanol/acetonitrile 60:40) and 10% (v/v) 30 mM ammonium formate, pH 3.3. Changing the volume ratio between methanol/acetonitrile from 60:40 to 50:50 (v/v) allowed to obtain the separation of di-, tri-, and tetrasaccharides labeled by ethyl 4-aminobenzoate in less than 10.5 min. (c) 2021 Elsevier B.V. All rights reserved.

Application In Synthesis of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Moravcova, D; Cmelik, R; Krenkova, J or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem