Category: 88-68-6

An article Phosphomolybdic Acid (PMA)-catalyzed One-pot Synthesis of 2,3-Dihydroquinazolines WOS:000474370100005 published article about SOLVENT-FREE; CATALYST; EFFICIENT; 2,3-DIHYDRO-4(1H)-QUINAZOLINONES; QUINAZOLINONES; FACILE in [Chen, Chuanhuan; Xuejiao, A.; Li, Xia; Huang, Guoli; Liu, Bo] Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China in 2019, Cited 34. Recommanded Product: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

We have developed a new method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yields via phosphomolybdic acid (PMA)-catalyzed cyclocondensation of 2-aminobenzamides with aldehydes or ketones in N,N-dimethylformamide (DMF) at room temperature. The present method proves to be efficient in terms of short reaction time, high yield, simple workup and easy purification.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Chen, CH; Xuejiao, A; Li, X; Huang, GL; Liu, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Anthranilamide-based Short Peptides Self-Assembled Hydrogels as Antibacterial Agents WOS:000512142100008 published article about NANOFIBERS; ARCHITECTURE; TRANSITION; NANOTUBES; GELATORS; NETWORKS; DESIGN; WATER in [Aldilla, Vina R.; Chen, Renxun; Black, David StC; Thordarson, Pall; Kumar, Naresh] Sch Chem, UNSW Sydney NSW, Sydney, NSW 2052, Australia; [Martin, Adam D.] Macquarie Univ, Fac Med & Hlth Sci, Dementia Res Ctr, Sydney, NSW 2109, Australia; [Marjo, Christopher E.; Rich, Anne M.] UNSW Sydney, Mark Wainwright Analyt Ctr, Sydney, NSW 2052, Australia in 2020, Cited 79. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Name: 2-Aminobenzamide

In this study, we describe the synthesis and molecular properties of anthranilamide-based short peptides which were synthesised via ring opening of isatoic anhydride in excellent yields. These short peptides were incorporated as low molecular weight gelators (LMWG), bola amphiphile, and C-3-symmetric molecules to form hydrogels in low concentrations (0.07-0.30% (w/v)). The critical gel concentration (CGC), viscoelastic properties, secondary structure, and fibre morphology of these short peptides were influenced by the aromaticity of the capping group or by the presence of electronegative substituent (namely fluoro) and hydrophobic substituent (such as methyl) in the short peptides. In addition, the hydrogels showed antibacterial activity against S. aureus 38 and moderate toxicity against HEK cells in vitro.

About 2-Aminobenzamide, If you have any questions, you can contact Aldilla, VR; Chen, RX; Martin, AD; Marjo, CE; Rich, AM; Black, DS; Thordarson, P; Kumar, N or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Palladium Catalyzed Cross-Dehydrogenative Coupling/Annulation Reaction: A Practical and Efficient Approach to Hydroxyisoindolo[1,2-b]quinazolinone WOS:000471298500007 published article about C-H; NATURAL-PRODUCTS; ACYLATION; QUINAZOLINONES; ALDEHYDES; QUINAZOLIN-4(3H)-ONES; ANILIDES; BONDS in [Dabiri, Minoo; Lehi, Noushin Farajinia; Movahed, Siyavash Kazemi; Khavasi, Hamid Reza] Shahid Beheshti Univ, Fac Chem & Petr Sci, Dist 1,Daneshjou Blvd, Tehran 1983969411, Tehran Province, Iran in 2019, Cited 38. Safety of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The palladium-catalyzed cross-dehydrogenative coupling (CDC) followed by an intramolecular cyclization between arylquinazolinones and aldehydes has been described. This viable transformation provides a variety of novel substituted hydroxyisoindolo[1,2-b]quinazolinone compounds in moderate to good yields. Additionally, the reaction is performed with toluene in place of benzaldehyde by using an excess amount of tert-butyl hydroperoxide (TBHP) as the oxidant in good yield.

Safety of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Dabiri, M; Lehi, NF; Movahed, SK; Khavasi, HR or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Dato, FM; Neudorfl, JM; Gutschow, M; Goldfuss, B; Pietsch, M in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about ACID-AMIDE HYDROLASE; MONOGLYCERIDE LIPASE; ENDOCANNABINOID SYSTEM; ACCURATE DOCKING; MAGL; DERIVATIVES; ANALOGS; GLIDE; IDENTIFICATION; PREDICTION in [Dato, Florian M.; Pietsch, Markus] Univ Cologne, Med Fac, Ctr Pharmacol, Inst Pharmacol 2, Gleueler Str 24, D-50931 Cologne, Germany; [Dato, Florian M.; Neudoerfl, Jorg-Martin; Goldfuss, Bernd] Univ Cologne, Inst Organ Chem, Dept Chem, Greinstr 4, D-50939 Cologne, Germany; [Guetschow, Michael] Univ Bonn, Pharmaceut Inst, Pharmaceut Chem 1, Immenburg 4, D-53121 Bonn, Germany in 2020, Cited 60. Name: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The serine hydrolase monoacylglycerol lipase (MAGL) is involved in a plethora of pathological conditions, in particular pain and inflammation, various types of cancer, metabolic, neurological and cardiovascular disorders, and is therefore a promising target for drug development. Although a large number of irreversible-acting MAGL inhibitors have been discovered over the past years, there are only few compounds known so far which inhibit the enzyme in a reversible manner. Therefore, much effort is put into the development of novel chemical entities showing reversible inhibitory behavior, which is thought to cause less undesired side effects. To explore a wide range of chemical structures as MAGL binders, we have applied a virtual screening approach by docking small molecules into the crystal structure of human MAGL (hMAGL) and envisaged a library of 45 selected compounds which were then synthesized. Biochemical investigations included the determination of the inhibitory potency on hMAGL and two related hydrolases, i.e. human fatty acid amide hydrolase (hFAAH) and murine cholesterol esterase (mCEase). The most promising candidates from theses analyses, i.e. three w-quinazolinonylalkyl aryl ureas bearing alkyl spacers of three to five methylene groups, exhibited IC50 values of 20-41 mu M and reversible, detergent-insensitive behavior towards hMAGL. Among these compounds, the inhibitor 1-(3,5-bis(tri-fluoromethyl)phenyl)-3-(4-(4-oxo-3,4 dihydroquinazolin-2-yl)butyl)urea (96) was selected for further kinetic characterization, yielding a dissociation constant K-i = 15.4 mu M and a mixed-type inhibition with a pronounced competitive component (alpha = 8.94). This mode of inhibition was further supported by a docking experiment, which suggested that the inhibitor occupies the substrate binding pocket of hMAGL.

About 2-Aminobenzamide, If you have any questions, you can contact Dato, FM; Neudorfl, JM; Gutschow, M; Goldfuss, B; Pietsch, M or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Phosphomolybdic Acid (PMA)-catalyzed One-pot Synthesis of 2,3-Dihydroquinazolines WOS:000474370100005 published article about SOLVENT-FREE; CATALYST; EFFICIENT; 2,3-DIHYDRO-4(1H)-QUINAZOLINONES; QUINAZOLINONES; FACILE in [Chen, Chuanhuan; Xuejiao, A.; Li, Xia; Huang, Guoli; Liu, Bo] Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China in 2019, Cited 34. Computed Properties of C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

We have developed a new method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yields via phosphomolybdic acid (PMA)-catalyzed cyclocondensation of 2-aminobenzamides with aldehydes or ketones in N,N-dimethylformamide (DMF) at room temperature. The present method proves to be efficient in terms of short reaction time, high yield, simple workup and easy purification.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Chen, CH; Xuejiao, A; Li, X; Huang, GL; Liu, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H8N2O. In 2019 EUR J MED CHEM published article about IN-VITRO; CANCER; QUINOXALINONES; EPIGENETICS; EXPRESSION; PHYSIOLOGY; ROLES in [Cheng, Chunhui; Yun, Fan; He, Jie; Ullah, Sadeeq; Yuan, Qipeng] Beijing Univ Chem Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Biomed Mat Nat Macromol, 15 Beisanhuan East Rd, Beijing 100029, Peoples R China in 2019, Cited 43. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A series of novel 2-aminobenzamide derivatives decorated with thioquinazolinone were designed and synthesized as histone deacetylase (HDAC) inhibitors. These derivatives were evaluated for their anti-proliferative activities against several human cancer cell lines including A375, Hela, A549, HCT116 and SMMC7721. It’s significantly indicated that some inhibitors exhibited potent antiproliferative activities towards all the studied cancer cell lines. Compounds 7a, 4i, 4o, and 4p exhibited higher antiproliferative activities towards three cancer cell lines: A375, A549 and SMMC7721 compared to CS055, MS275, and C1994. Compound 4p showed more than 4000-fold the isoform selectivity for HDACI and more than 250-fold selectivity for HDAC2 compared with HDAC6. The molecular docking analysis reasonably explained the HDAC inhibitory activity and isoform selectivity. In addition, compounds 7a, 4i, 4o, and 4p showed potent inhibitory activities in migration assay and colony formation analysis, and also promoted cell apoptosis. Moreover, compounds 7a, 4i, and 4o inhibited the growth of SMMC7721 cells at S phase of the cell cycle. The immunofluorometric analysis indicated that compounds 7a, 4i, 4o, and 4p could increase the acetylation status of H3K9. Furthermore, in vivo anticancer efficacy of compound 4p was assessed in the A549 xenograft models, and 4p demonstrated potent antitumor activity (TGI = 62.5%). This study provided an effective strategy for further development of tumor-targeting therapy. (C) 2019 Elsevier Masson SAS. All rights reserved.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Cheng, CH; Yun, F; He, J; Ullah, S; Yuan, QP or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Sulfur-Promoted Synthesis of 2-Aroylquinazolin-4(3H)-ones by Oxidative Condensation of Anthranilamide and Acetophenones WOS:000475925900008 published article about ONE-POT SYNTHESIS; ELEMENTAL SULFUR; REDOX CONDENSATION; QUINAZOLINE DERIVATIVES; O-AMINOBENZAMIDES; AMINES; KETONES; ACCESS; CYCLIZATION; INHIBITORS in [Thanh Binh Nguyen; Hou, Jing-ya; Retailleau, Pascal] Univ Paris Saclay, Inst Chim Subst Nat, CNRS, UPR 2301,Univ Paris Sud, 1 Ave Terrasse, F-91198 Gif Sur Yvette, France in 2019, Cited 50. Name: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A sulfur-promoted three-component reaction of isatoic anhydride, primary aliphatic or aromatic amines, and acetophenones leading to densely substituted 3-substituted 2-aroylquinazolin-4(3H)-ones is reported. The key step involves a cascade reaction of selective oxidation of the methyl group of the acetophenones, followed by a condensation with anthranilamides. The scope of the reaction is applicable to the synthesis of tryptanthrin and various 3-unsubstituted 2-aroylquinazolin-4(3H)-ones.

About 2-Aminobenzamide, If you have any questions, you can contact Nguyen, TB; Hou, JY; Retailleau, P or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 2-Aminobenzamide. I found the field of Agriculture; Chemistry; Food Science & Technology very interesting. Saw the article Synthesis, Crystal Structure, and Agricultural Antimicrobial Evaluation of Novel Quinazoline Thioether Derivatives Incorporating the 1,2,4-Triazolo[4,3-a]pyridine Moiety published in 2019, Reprint Addresses Bao, XP (corresponding author), Guizhou Univ, Ctr Res & Dev Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Guizhou, Peoples R China.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide.

A total of 22 quinazoline thioether derivatives incorporating a 1,2,4-triazolo[4,3-a]pyridine moiety were designed, synthesized, and evaluated as antimicrobial agents in agriculture. Among these compounds, the chemical structure of compound 61 was further confirmed via single-crystal X-ray diffraction analysis. The bioassay results revealed that some of the compounds possessed noticeable in vitro antibacterial activities against the tested phytopathogenic bacteria. For example, compounds 6b and 6g had EC50 values as low as 10.0 and 24.7 mu g/mL against Xanthomonas axonopodis pv. citri (Xac), respectively, which were significantly better than that of the commercial agrobactericide bismerthiazol (56.9 mu g/mL). Particularly, compound 6b was also found to be capable of suppressing the pathogenic bacterium Xanthomonas oryzae pv. oryzae (Xoo) approximately 12-fold more potent than control bismerthiazol, in terms of their EC 50 values (7.2 versus 89.8 mu g/mL). Importantly, the most active compound 6b turned out to be one with the highest hydrophilicity and the lowest molecular weight within the series. In vivo bioassays further showed the application prospect of 6b as a promising plant bactericide for controlling Xoo. Additionally, in vitro antifungal activities of these compounds were also evaluated at the concentration of 50 mu g/mL. Overall, the present study demonstrated the potential of 1,2,4-triazolo[4,3-a]pyridine-bearing quinazoline thioether derivatives as efficient agricultural antibacterial agents for crop protection.

About 2-Aminobenzamide, If you have any questions, you can contact Fan, ZJ; Shi, J; Luo, N; Ding, MH; Bao, XP or concate me.. Application In Synthesis of 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about PALLADIUM-CATALYZED ALKYLATION; THERMAL OXIDATIVE-DEGRADATION; POLYETHYLENE-GLYCOL; STEREOSELECTIVE-SYNTHESIS; SELECTIVE ALKYLATION; ALPHA-METHYLATION; C(SP(3))-H BONDS; METHANOL; ARYLACRYLAMIDES; HETEROCYCLES, Saw an article supported by the Ministry of Science and Technology (MOST), TaiwanMinistry of Science and Technology, Taiwan; Centre for Research and Development of Kaohsiung Medical University. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Kudale, VS; Wang, JJ. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Name: 2-Aminobenzamide

The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O-2 and TsOH center dot H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.

About 2-Aminobenzamide, If you have any questions, you can contact Kudale, VS; Wang, JJ or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H8N2O. Recently I am researching about C/EBP-ALPHA; INHIBITORS; CYTOTOXICITY; CANCER, Saw an article supported by the Singapore Ministry of Health’s National Medical Research Council under its Singapore Translational Research (STaR) Investigator AwardMinistry of Health-SingaporeNational Medical Research Council, Singapore; National Research Foundation SingaporeNational Research Foundation, Singapore; Singapore Ministry of Education under its Research Centres of Excellence initiativeMinistry of Education, Singapore; Cancer Science Institute of Singapore; National Institution of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [P01 CA66996, R21CA178301, R01CA169259]; American Cancer SocietyAmerican Cancer Society [RSG-13-047]; Harvard Stem Cell Institute Blood Program [DP-0110-12-00]; CSIR-HRDGCouncil of Scientific & Industrial Research (CSIR) – India [13(8906-A)/2017-pool]; CSIR, New DelhiCouncil of Scientific & Industrial Research (CSIR) – India [CSC0301]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Radhakrishnan, S; Syed, R; Takei, H; Kobayashi, IS; Nakamura, E; Sultana, F; Kamal, A; Tenen, DG; Kobayashi, SS. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

The tumor suppressor transcription factor CCAAT enhancer-binding protein alpha (C/EBP alpha) expression is down-regulated in myeloid leukemias and enhancement of C/EBP alpha expression induces granulocytic differentiation in leukemic cells. Previously we reported that Styryl quinazolinones induce myeloid differentiation in HL-60 cells by upregulating C/EBP alpha expression. To identify more potent molecule that can induce leukemic cell differentiation we synthesized and evaluated new series of styryl quinazolinones, ethynyl styryl quinazolinones, styryl quinolinones and thienopyrimidinones. Thienopyrimidinones were found toxic and styryl quinolinones were found inactive. Ethynyl styryl quinazolinone 39 and styryl quinazolinone 5 were found active on par with the earlier reported analogues 1 and 2 suggesting that the 5-nitro furan-2-yl styryl quinazolinones find a real promise in leukemic cell differentiation. The improved potency of 5 suggested that further modifications in the 5-nitro furan-2-yl styryl quinazolinones can be at the phenyl substitution at the 3-position of the quinazolinone ring apart from the 5-position of the heteroaryl ring.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Radhakrishnan, S; Syed, R; Takei, H; Kobayashi, IS; Nakamura, E; Sultana, F; Kamal, A; Tenen, DG; Kobayashi, SS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem