Category: 88-68-6

Name: 2-Aminobenzamide. Bohlen, ML; Jeon, HP; Kim, YJ; Sung, B in [Bohlen, Marie-Leonie; Jeon, Hyun Pyo; Kim, Young Jun; Sung, Baeckkyoung] KIST Europe Forschungsgesell MbH, Saarbrucken, Germany published In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox in 2019, Cited 39. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Computational analyses of toxicological processes enables high-throughput screening of chemical substances and prediction of their endpoints in biological systems. In particular, quantitative structure-activity relationship (QSAR) models have been increasingly applied to assess the environmental effects of a plethora of toxic materials. In recent years, some more highlighted types of toxicants are endocrine disruptors (EDs, which are chemicals that can interfere with any hormone-related metabolism). Because EDs may significantly affect animal development and reproduction, rapidly predicting the adverse effects of EDs using in silico techniques is required. This study presents an in silico method to generate prediction data on the effects of representative EDs in aquatic vertebrates, particularly fish species. The protocol describes an example utilizing the automated workflow of the QSAR Toolbox software developed by the Organization for Economic Co-operation and Development (OECD) to enable acute ecotoxicity predictions of EDs. As a result, the following are determined: (1) calculation of the numerical correlations between the concentration for 50% of lethality (LC50) and octanol-water partition coefficient (K-ow), (2) output performances in which the LC50 values determined in experiments are compared to those generated by computations, and (3) the dependence of estrogen receptor binding affinity on the relationship between K-ow and LC50.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Bohlen, ML; Jeon, HP; Kim, YJ; Sung, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article T3P mediated intramolecular rearrangement of o-aminobenzamide to o-ureidobenzonitrile using isothiocyanates WOS:000616581600001 published article about PRIMARY AMIDES; UREA; DISCOVERY; DERIVATIVES; INHIBITORS; AMINES; TRANSFORMATION; EFFICIENT; KINASE; MAP in [Shamanth, Sadashivamurthy; Sagar, Kunigal S.; Narayana, Yatheesh; Rangappa, Kanchugarakoppal S.; Kempegowda, Mantelingu] Univ Mysore, DOS Chem, Manasagangotri, Mysuru 570006, Karnataka, India; [Nagarakere, Sandhya C.] St Philomenas Coll, PG Dept Studies Chem, Mysuru, India; [Nagarakere, Sandhya C.] St Philomenas Coll, Res Ctr, Mysuru, India; [Mamatha, Mahesha] SRSMN Govt First Grade Coll, Barkur, India in 2021, Cited 38. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Name: 2-Aminobenzamide

Current work describes the environmentally benign approach for the synthesis of o-ureidobenzonitriles, from o-aminobenzamides and isothiocyanates using T3P. Here, the conversion of thiourea to urea and amide to nitrile take place simultaneously via unprecedented intramolecular rearrangement. This protocol is operationally facile and offers wide variety of o-ureidobenzonitriles at room temperature in good to excellent yields.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Shamanth, S; Nagarakere, SC; Sagar, KS; Narayana, Y; Mamatha, M; Rangappa, KS; Kempegowda, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Xie, ZB; Li, HX; Liu, LS; Lan, J; Hu, ZY; Le, ZG in SCIENCE PRESS published article about ONE-POT SYNTHESIS; ENZYME; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES; EFFICIENT; NANOCATALYST; PROMISCUITY; ACYLASE; MILD in [Xie, Zongbo; Li, Hongxia; Liu, Liansheng; Lan, Jin; Hu, Zhiyu; Le, Zhanggao] East China Univ Technol, Dept Appl Chem, Nanchang 330013, Jiangxi, Peoples R China in 2019, Cited 41. Product Details of 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Alkaline protease-catalyzed synthesis of quinazolinone derivatives was developed between beta-keotester and o-aminobenzamide. Because ethanol is one kind of eco-friendly solvents, this method can reduce the impact of solvents on the environment. Alkaline protease as a biocatalyst has many advantages, e.g. high catalytic activity, environmentally friendly, wide variety of sources and simple operation. In addition, a variety of quinazolinone derivatives was obtained with good to excellent yields just using 2000 U alkaline protease as catalyst.

Product Details of 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Xie, ZB; Li, HX; Liu, LS; Lan, J; Hu, ZY; Le, ZG or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Copper-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1 H )-ones from 2-Nitrobenzonitriles and Carbonyl Compounds Mediated by Diboronic Acid in Methanol-Water WOS:000509900900013 published article about AROMATIC O-AMINONITRILE; GREEN SYNTHESIS; COMBINATORIAL SYNTHESIS; COORDINATION POLYMER; FACILE SYNTHESIS; AQUEOUS-MEDIA; QUINAZOLINONES; DERIVATIVES; ALDEHYDES; EFFICIENT in [Liu, Qixing; Sui, Yuebo; Zhang, Yin; Zhang, Kaili; Chen, Yongsheng; Zhou, Haifeng] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Res Ctr Green Pharmaceut Technol & Proc, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China in 2020, Cited 50. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Quality Control of 2-Aminobenzamide

A copper-catalyzed one-pot synthesis of 2,3-dihydroquinazolin-4(1 H )-ones with diboronic acid as a reductant in an aqueous medium is described. Various 2,3-dihydroquinazolin-4(1 H )-ones were prepared with good functional-group tolerance in good yields under mild conditions from readily available 2-nitrobenzonitriles and various carbonyl compounds.

About 2-Aminobenzamide, If you have any questions, you can contact Liu, QX; Sui, YB; Zhang, Y; Zhang, KL; Chen, YS; Zhou, HF or concate me.. Quality Control of 2-Aminobenzamide

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Microwave-Assisted Green Synthesis of 2,3-Dihydroquinazolinones under Base- and Catalyst-Free conditions WOS:000656866400005 published article about ONE-POT SYNTHESIS; HIGHLY ENANTIOSELECTIVE SYNTHESIS; INTRAMOLECULAR AMIDATION; FACILE SYNTHESIS; EFFICIENT; QUINAZOLINONES; MILD; NANOPARTICLES; DERIVATIVES; WATER in [Kerdphon, Sutthichat; Channei, Duangdao] Naresuan Univ, Dept Chem, Fac Sci, Phitsanulok 65000, Thailand; [Jongcharoenkamol, Jira] Naresuan Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem & Pharmacognosy, Phitsanulok 65000, Thailand; [Chatwichien, Jaruwan] Chulabhorn Royal Acad, Chulabhorn Grad Inst, Program Chem Sci, Bangkok 10210, Thailand; [Singh, Thishana] Univ Kwazulu Natal, Sch Chem & Phys, Private Bag X54001, ZA-4000 Durban, South Africa; [Choommongkol, Vachira] Maejo Univ, Dept Chem, Fac Sci, Chiang Mai 50290, Thailand; [Rithchumpon, Puracheth; Meepowpan, Puttinan] Chiang Mai Univ, Dept Chem, Fac Sci, Chiang Mai 50200, Thailand; [Rithchumpon, Puracheth; Meepowpan, Puttinan] Chiang Mai Univ, Grad Sch, Chiang Mai 50200, Thailand; [Meepowpan, Puttinan] Chiang Mai Univ, Ctr Excellence Mat Sci & Technol, Chiang Mai 50200, Thailand in 2021, Cited 47. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Recommanded Product: 2-Aminobenzamide

A facile and green one-pot synthesis of 2,3-dihydroquinazolinones, using microwave irradiation, has been developed. Dihydroquinazolinones were synthesized from 2-aminobenzamide derivatives and various aldehydes in aqueous solution under base and catalyst free reaction conditions. The desired products, from aliphatic and aromatic aldehydes substrates, were obtained in 5 minutes with up to 99 % isolated yields.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Kerdphon, S; Jongcharoenkamol, J; Chatwichien, J; Singh, T; Channei, D; Choommongkol, V; Rithchumpon, P; Meepowpan, P or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H8N2O. Athira, M; Shanmugam, P in [Athira, Mohanakumaran; Shanmugam, Ponnusamy] CSIR Cent Leath Res Inst CLRI, Organ & Bioorgan Chem Div, Chennai 600020, Tamil Nadu, India published Synthesis of Functionalized 9-Substituted Fluorene Derivatives via Boron Trifluoride Catalysed Reaction of Coplanar 9-(Phenylethynyl)-9H-fluoren-9-ols, Aryl Aminoamides and N-Bromosuccinimide in 2021, Cited 32. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A boron trifluoride catalysed reaction of coplanar 9-(phenyl-ethynyl)-9 H-fluoren-9-ols with various 2-aminobenzamides affords a number of highly functionalized, conjugated (Z)-2-((2-(9 H-fluoren-9-ylidene)-1-phenylethylidene)amino) benzamides in excellent yield. The reaction in the presence of N-bromosuccinimide affords (E)-5-bromo-2-((2-bromo-2-(9 H-fluoren-9-ylidene)-1-phenylethylidene)amino)benz-amides in very good yields. The scope of the reaction is demonstrated by selecting N-aryl substituted 2-aminobenzamides and aminosulfonamides as reaction partners. The structures of representative compounds were established by single-crystal XRD analysis. Based on the structure of the products, a plausible mechanism via formation of allene carbocation intermediates is proposed.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Athira, M; Shanmugam, P or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 2-Aminobenzamide. In 2019 ORG LETT published article about OXIDATIVE SYNTHESIS; O-AMINOBENZAMIDES; QUINAZOLIN-4(3H)-ONES; DOXAZOSIN; ALCOHOLS in [Arachchige, Pandula T. Kirinde; Yi, Chae S.] Marquette Univ, Dept Chem, Milwaukee, WI 53201 USA in 2019, Cited 45. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines led to the efficient formation of quinazolinone products. The catalytic coupling method provides an efficient synthesis of quinazoline and quinazolinone derivatives without using any reactive reagents or forming any toxic byproducts.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Arachchige, PTK; Yi, CS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synergistic catalysis on Fe-N-x sites and Fe nanoparticles for efficient synthesis of quinolines and quinazolinones via oxidative coupling of amines and aldehydes WOS:000497283300004 published article about SELECTIVE AEROBIC OXIDATION; OXYGEN REDUCTION; COBALT NANOPARTICLES; NITROGEN-HETEROCYCLES; NONPRECIOUS METAL; CASCADE SYNTHESIS; GENERAL-SYNTHESIS; CARBON NANOTUBES; ACTIVE-SITES; C CATALYST in [Ma, Zhiming; Song, Tao; Yang, Yong] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China; [Ma, Zhiming] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Yuan, Youzhu] Xiamen Univ, State Key Lab Phys Chem Solid Surface, Natl Engn Lab Green Chem Prod Alcohols Ethers Est, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China in 2019, Cited 68. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Quality Control of 2-Aminobenzamide

In this paper, we developed a reusable heterogeneous non-precious iron nanocomposite comprising metallic Fe-Fe3C nanoparticles and Fe-N-x sites on N-doped porous carbon, which allows for highly efficient synthesis of quinolines and quinazolinones via oxidative coupling of amines and aldehydes using H2O2 as the oxidant in aqueous solution under mild conditions. A set of quinazolines and quinazolinones were synthesized in high yields with a broad substrate scope and good tolerance of functional groups. Characterization and control experiments disclose that a synergistic effect between the metallic Fe nanoparticles and built-in Fe-N-x sites is primarily responsible for the outstanding catalytic performance. Furthermore, the iron nanocomposite could be readily recovered for successive use without appreciable loss in catalytic activity and selectivity. This work provides an expedient and sustainable method to access pharmaceutically relevant N-heterocycles.

About 2-Aminobenzamide, If you have any questions, you can contact Ma, ZM; Song, T; Yuan, YZ; Yang, Y or concate me.. Quality Control of 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis of 3-indolylmethyl substituted (pyrazolo/benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM) WOS:000487812000051 published article about 1,2,3-BENZOTRIAZIN-4-ONE DERIVATIVES; NEMATOCIDAL ACTIVITIES; INDOLES; 1-ALKYNES; RV1885C; 2-HETEROARYL; DOCKING; PROTEIN; 2-ARYL in [Reddy, Gangireddy Sujeevan; Snehalatha, Ampalam Venkata; Edwin, Rebecca Kristina; Hossain, Kazi Amirul; Misra, Parimal; Pal, Manojit] Dr Reddys Inst Life Sci, Univ Hyderabad Campus, Hyderabad 500046, India; [Reddy, Gangireddy Sujeevan; Giliyaru, Varadaraj Bhat; Hariharapura, Raghu Chandrashekhar; Shenoy, G. Gautham] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India in 2019, Cited 38. Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria. A series of 3-indolylmethyl substituted pyrazolo-triazinone derivatives were designed and docked into CM in silico as potential inhibitors. These compounds were efficiently synthesized using the Pd/Cu-catalyzed coupling-cyclization in a single pot involving the construction of indole ring. The methodology was later extended to the preparation of corresponding benzo analogs of pyrazolotriazinones i.e. 3-indolylmethyl substituted benzotriazinone derivatives. Several of these novel compounds showed significant inhibition of CM when tested in vitro at 30 mu M. The SAR (Structure-Activity-Relationship) studies suggested that benzotriazinone moiety was more favorable over the pyrazolotriazinone ring. The two best active compounds showed IC50 similar to 0.4-0.9 mu M (better than the reference/known compounds used) and no toxicity till 30 mu M in vitro.

Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 88-68-6. Cheng, CH; Yun, F; He, J; Ullah, S; Yuan, QP in [Cheng, Chunhui; Yun, Fan; He, Jie; Ullah, Sadeeq; Yuan, Qipeng] Beijing Univ Chem Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Biomed Mat Nat Macromol, 15 Beisanhuan East Rd, Beijing 100029, Peoples R China published Design, synthesis and biological evaluation of novel thioquinazolinone-based 2-aminobenzamide derivatives as potent histone deacetylase (HDAC) inhibitors in 2019, Cited 43. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A series of novel 2-aminobenzamide derivatives decorated with thioquinazolinone were designed and synthesized as histone deacetylase (HDAC) inhibitors. These derivatives were evaluated for their anti-proliferative activities against several human cancer cell lines including A375, Hela, A549, HCT116 and SMMC7721. It’s significantly indicated that some inhibitors exhibited potent antiproliferative activities towards all the studied cancer cell lines. Compounds 7a, 4i, 4o, and 4p exhibited higher antiproliferative activities towards three cancer cell lines: A375, A549 and SMMC7721 compared to CS055, MS275, and C1994. Compound 4p showed more than 4000-fold the isoform selectivity for HDACI and more than 250-fold selectivity for HDAC2 compared with HDAC6. The molecular docking analysis reasonably explained the HDAC inhibitory activity and isoform selectivity. In addition, compounds 7a, 4i, 4o, and 4p showed potent inhibitory activities in migration assay and colony formation analysis, and also promoted cell apoptosis. Moreover, compounds 7a, 4i, and 4o inhibited the growth of SMMC7721 cells at S phase of the cell cycle. The immunofluorometric analysis indicated that compounds 7a, 4i, 4o, and 4p could increase the acetylation status of H3K9. Furthermore, in vivo anticancer efficacy of compound 4p was assessed in the A549 xenograft models, and 4p demonstrated potent antitumor activity (TGI = 62.5%). This study provided an effective strategy for further development of tumor-targeting therapy. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 2-Aminobenzamide, If you have any questions, you can contact Cheng, CH; Yun, F; He, J; Ullah, S; Yuan, QP or concate me.. Product Details of 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem