Category: 88-68-6

In 2021 ACTA PHARMACOL SIN B published article about MULTICENTER PHASE-II; BREQUINAR SODIUM; IMMUNOSUPPRESSIVE DRUG; PLASMODIUM-FALCIPARUM; PYRIMIDINE SYNTHESIS; DHODH; VIDOFLUDIMUS; LEFLUNOMIDE; DISCOVERY; BLOCKADE in [Zeng, Fanxun; Yang, Guantian; Zhang, Letian; Xu, Xiaoyong] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China; [Li, Shiliang; Luo, Yating; Qi, Tiantian; Liang, Yingfan; Yang, Tingyuan; Wang, Rui; Zhu, Lili; Li, Honglin] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China in 2021, Cited 62. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. HPLC of Formula: C7H8N2O

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents were designed and synthesized. 2-Acrylamidobenzoic acid analog 11 was identified as the lead compound for structure-activity relationship (SAR) studies. The replacement of the phenyl group with naphthyl moieties improved inhibitory activity significantly to double-digit nanomolar range. Further structure optimization revealed that an acrylamide with small hydrophobic groups (Me, Cl or Br) at the 2-position was preferred. Moreover, adding a fluoro atom at the 5-position of the benzoic acid enhanced the potency. The optimization efforts led to potent compounds 42 and 53.55 with IC50 values of 41, 44, 32, and 42 nmol/L, respectively. The most potent compound 54 also displayed favorable pharmacokinetic (PK) profiles and encouraging in vivo anti-arthritic effects in a dose-dependent manner. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

About 2-Aminobenzamide, If you have any questions, you can contact Zeng, FX; Li, SL; Yang, GT; Luo, YT; Qi, TT; Liang, YF; Yang, TY; Zhang, LT; Wang, R; Zhu, LL; Li, HL; Xu, XY or concate me.. HPLC of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 2-Aminobenzamide. In 2020 J MOL LIQ published article about HIGHLY EFFICIENT SYNTHESIS; ACID; DERIVATIVES; SOLVENTS; ALPHA in [Azizi, Najmedin; Edrisi, Mahtab] Chem & Chem Engn Res Ctr Iran, Dept Green Chem, POB 14335-186, Tehran, Iran in 2020, Cited 47. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Supported ionic liquids (SILs) have attracted rising interest and the subject of active research in the last decades due to the diversified range of applications and yet reports on ILs is still rapidly increasing. This work reports a choline sulfate ionic liquid supported on fascinating and highly stable porous graphitic carbon nitride (g-C3N4) nanosheets as an inexpensive and an environmentally friendly reusable ionic catalyst in organic synthesis typically requiring a harmful organic solvent and highly toxic adds. g-C3N4@SO3 Ch was prepared by mixing sulfonic add functionalized graphitic carbon nitride nanosheets (g-C3N4@SO3H) with choline hydroxide or via a novel approach. The introduction of a choline sulfate could significantly enlarge specific surface areas with rich reaction sites and suppressed the recombination of sheets. This work provides a new way to improve the chemical property of g-C3N4 along with the recyclability of the ionic liquid. g-C3N4@SO3 Ch (IL/g-C3N4) offers an effective, reusable, inexpensive, environmentally friendly and low-cost catalyst for the synthesis of 3,4-dihydropyrimidin-2 (IH)-ones, 2,3-dihydroquinazolin-4 (IH)-ones and bisindolylmethanes in good to excellent yields. The prepared catalyst synthesized compounds were well characterized by different techniques such as FT-IR, XRD, SEM, EDX and TGA. (C) 2018 Elsevier B.V. All rights reserved.

Application In Synthesis of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Azizi, N; Edrisi, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Praseodymium(iii) anchored on CoFe2O4 MNPs: an efficient heterogeneous magnetic nanocatalyst for one-pot, multi-component domino synthesis of polyhydroquinoline and 2,3-dihydroquinazolin-4(1H)-one derivatives WOS:000516578300034 published article about GREEN; NANOPARTICLES; CATALYST; OXIDATION; COMPLEX; ACID; DEGRADATION; SULFIDES; SURFACE; MCM-41 in [Tamoradi, Taiebeh] Islamic Azad Univ, Dept Chem, Izeh, Iran; [Mousavi, Seyedeh Masoumeh] Univ Tehran, Dept Environm Planning, Tehran, Iran; [Mohammadi, Masoud] Ilam Univ, Fac Sci, Dept Chem, Ilam, Iran in 2020, Cited 46. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Quality Control of 2-Aminobenzamide

In the present study, a facile technique to immobilize praseodymium(iii) complex on the surface of magnetic nanoparticles by using available materials is reported. The prepared samples were characterized by chemical and physical methods such as FTIR, SEM, XRD and EDX and were tested in the synthesis of polyhydroquinoline and 2,3-dihydroquinazolin-4(1H)-one derivatives. It was observed that the yields of the reactions in the presence of the prepared nanocatalyst were good to excellent. More importantly, the use of a recoverable and novel magnetic nanocatalyst in these reactions is the outstanding feature of this protocol.

About 2-Aminobenzamide, If you have any questions, you can contact Tamoradi, T; Mousavi, SM; Mohammadi, M or concate me.. Quality Control of 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Facile access toN-formyl imide as anN-formylating agent for the direct synthesis ofN-formamides, benzimidazoles and quinazolinones WOS:000553219600023 published article about ACID-CATALYZED TRANSAMIDATION; N-SUBSTITUTED FORMAMIDES; CARBON-DIOXIDE; EFFICIENT SYNTHESIS; AMINES; DERIVATIVES; CARBOXAMIDES; METHANOL; OXIDATION; CO2 in [Huang, Hsin-Yi; Lin, Xiu-Yi; Yen, Shih-Yao; Liang, Chien-Fu] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan in 2020, Cited 91. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Safety of 2-Aminobenzamide

N-Formamide synthesis usingN-formyl imide with primary and secondary amines with catalytic amounts ofp-toluenesulfonic acid monohydrate (TsOH center dot H2O) is described. This reaction is performed in water without the use of surfactants. Moreover,N-formyl imide is efficiently synthesized using acylamidines with TsOH center dot H2O in water. In addition,N-formyl imide was successfully used as a carbonyl source in the synthesis of benzimidazole and quinazolinone derivatives. Notable features ofN-formylation of amines by usingN-formyl imide include operational simplicity, oxidant- and metal-free conditions, structurally diverse products, and easy applicability to gram-scale operation.

Safety of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Huang, HY; Lin, XY; Yen, SY; Liang, CF or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Jakobsson, JE; Lu, SY; Telu, S; Pike, VW in WILEY-V C H VERLAG GMBH published article about MEDIATED SYNTHESIS; MONOXIDE; C-11; RECEPTOR in [Jakobsson, Jimmy E.; Lu, Shuiyu; Telu, Sanjay; Pike, Victor W.] NIMH, Mol Imaging Branch, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA in 2020, Cited 35. Computed Properties of C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Herein, the synthesis and use of [C-11]carbonyl difluoride for labeling heterocycles with [C-11]carbonyl groups in high molar activity is described. A very mild single-pass gas-phase conversion of [C-11]carbon monoxide into [C-11]carbonyl difluoride over silver(II) fluoride provides easy access to this new synthon in robust quantitative yield for labeling a broad range of cyclic substrates, for example, imidazolidin-2-ones, thiazolidin-2-ones, and oxazolidin-2-ones. Labeling reactions may utilize close-to-stoichiometric precursor quantities and short reaction times at room temperature in a wide range of solvents while also showing high water tolerability. The overall radiosynthesis protocol is both simple and reproducible. The required apparatus can be constructed from widely available parts and is therefore well suited to be automated for PET radiotracer production. We foresee that this straightforward method will gain wide acceptance for PET radiotracer syntheses across the radiochemistry community.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Jakobsson, JE; Lu, SY; Telu, S; Pike, VW or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Dandia, A; Bansal, S; Sharma, R; Mahawar, DK; Rathore, KS; Meena, ML; Parewa, V in ELSEVIER SCIENCE SA published article about ARYL ALKYL ETHERS; PHOTOCATALYTIC DEGRADATION; ANTITUMOR BENZOTHIAZOLES; SELECTIVE DEPROTECTION; HETEROGENEOUS CATALYST; HYDROGEN-PRODUCTION; GREEN SYNTHESIS; QUANTUM DOTS; ORGANIC-DYES; IONIC LIQUID in [Dandia, Anshu; Bansal, Sarika; Sharma, Ruchi; Mahawar, Dinesh Kumar; Meena, Mohan Lal; Parewa, Vijay] Univ Rajasthan, Dept Chem, Ctr Adv Studies, Jaipur, Rajasthan, India; [Rathore, Kuldeep S.] Arya Coll Engn & IT, Dept Phys, Jaipur, Rajasthan, India; [Meena, Mohan Lal] Natl Taiwan Univ, Dept Chem Engn, Taipei, Taiwan in 2020, Cited 91. Recommanded Product: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

ZnS and Cu:ZnS nanoparticles were prepared by aqueous chemical method and characterized by several analytical tools. Nanoparticles have an average size of about similar to 18 nm and possess highly open mesopores, moderate surface area, and uniform morphology. UV-vis spectra designate that doping of Cu shifted the optical response of the ZnS nanoparticles in to a visible region. These Cu:ZnS nanoparticles were employed as a photocatalyst for chemoselective synthesis of 2-substituted azoles by the reaction of benzyl bromides and 1,2-Diaminobenzene or 2-Mercaptoaniline in visible light. Analogous experiments confirmed that the reaction were proceeds through one pot C-N arylation/ CSp(3)- H oxidation/ cyclization/dehydration sequence. The enhanced catalytic activity by doping could be attributed to the presence of trapping level generated by copper doping which augments the relaxation time of electron and holes so that they are easily available for the reaction. The method was also applicable for the synthesis of quinazolin-4(3H)-ones.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Dandia, A; Bansal, S; Sharma, R; Mahawar, DK; Rathore, KS; Meena, ML; Parewa, V or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article ompg-C3N4/SO3H: an efficient and recyclable organocatalyst for the facile synthesis of 2,3-dihydroquinazolin-4(1H)-ones WOS:000486518900019 published article about ACIDIC IONIC LIQUID; CARBON NITRIDE; MESOPOROUS CARBON; MULTICOMPONENT SYNTHESIS; SULFATED ZIRCONIA; HIGHLY EFFICIENT; CATALYST; G-C3N4; DERIVATIVES; GREEN in [Ghafuri, Hossein; Goodarzi, Nahal; Rashidizadeh, Afsaneh; Fard, Mohammad Ali Douzandegi] Iran Univ Sci & Technol, Dept Chem, Catalysts & Organ Synth Res Lab, Tehran 1684613114, Iran in 2019, Cited 48. Safety of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

In the present work, sulfonated highly ordered mesoporous graphitic carbon nitride (ompg-C3N4/SO3H) was synthesized successfully and employed as an efficient and reusable heterogeneous solid acid catalyst for the rapid and one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones via the condensation of anthranilamide with aldehydes or ketones in good to excellent yields. The organocatalyst was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, energy-dispersive X-ray spectrometer, Brunauer-Emmett-Teller surface area, and thermal gravimetric and differential thermal analysis. The substantial advantages of this procedure involve short reaction times, high catalytic activity, easy workup, high purity of the products, and easy recovery and reusability of the catalyst.

Safety of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Ghafuri, H; Goodarzi, N; Rashidizadeh, A; Fard, MAD or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis and antitumor activities of novel bis-quinazolin-4(3H)-ones WOS:000505757300001 published article about BREAST-CANCER; DERIVATIVES; QUINAZOLINONES; 2-AMINOBENZAMIDES in [Rahmannejadi, Nasrin] Islamic Azad Univ, Dept Chem Sci, Tehran, Iran; [Rahmannejadi, Nasrin] Islamic Azad Univ, Res Branch, Tehran, Iran; [Yavari, Issa] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran; [Khabnadideh, Soghra] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran in 2020, Cited 28. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Category: thiomorpholine

With the aim of obtaining new antitumor agents, a series of bis-quinazolin-4(3H)-ones (3a-3 f) were designed and synthesized. These products contain 4-oxo-1,2,3,4-tetrahydro-quinazoline and 3H-quinazolin-4-one moieties linked together via a propyl chain. Cytotoxic activities of 3a-3 f were evaluated against lung adenocarcinoma (A549), breast carcinoma (MCF-7) and ovarian cancer (SKOV3) cell lines using MTT method. Cisplatin was used as a positive control. Among the tested compounds 3a, 3b, and 3e showed the best cytotoxic activities against all cancerous cell lines with IC50 values even less than cisplatin. Compounds 3d and 3f also showed desirable cytotoxic activities especially against A549 and MCF-7.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Rahmannejadi, N; Yavari, I; Khabnadideh, S or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Site-Selective C-H Amidation of 2-Aryl Quinazolinones Using Nitrene Surrogates WOS:000573134100001 published article about AMINATION; FUNCTIONALIZATION; INDOLINES; NITROGENATION in [Kim, Saegun; Jeoung, Daeun; Kim, Kunyoung; Lee, Suk Hun; Park, Min Seo; Ghosh, Prithwish; Mishra, Neeraj Kumar; Kim, In Su] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; [Lee, Seok Beom; Hong, Suckchang] Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea in 2020, Cited 47. Product Details of 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The site-selective modifications of quinazolinones constitute a pivotal topic in drug discovery and material science. Herein, we describe the rhodium(III)-catalyzed C-H amidation of 2-aryl quinazolin-4(3H)-ones with a range of nitrene surrogates including dioxazolones, organic azides, andN-methoxyamides. Complete site-selectivity and functional group tolerance are observed. Notably, the large-scale reaction and late-stage functionalization highlight the synthetic potential of the developed protocol. Combined mechanistic investigations elucidate a plausible reaction mechanism of this process.

About 2-Aminobenzamide, If you have any questions, you can contact Kim, S; Jeoung, D; Kim, K; Lee, SB; Lee, SH; Park, MS; Ghosh, P; Mishra, NK; Hong, S; Kim, IS or concate me.. Product Details of 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of 2-Aminobenzamide. In 2019 BIOORG MED CHEM LETT published article about C/EBP-ALPHA; INHIBITORS; CYTOTOXICITY; CANCER in [Radhakrishnan, Sridhar; Tenen, Daniel G.] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore; [Syed, Riyaz; Sultana, Farheen; Kamal, Ahmed] Indian Inst Chem Technol, CSIR, Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India; [Syed, Riyaz] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad 500085, India; [Takei, Hisashi; Kobayashi, Ikei S.; Nakamura, Eugene; Kobayashi, Susumu S.] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA; [Takei, Hisashi; Kobayashi, Ikei S.; Nakamura, Eugene; Kobayashi, Susumu S.] Harvard Med Sch, Boston, MA 02215 USA; [Takei, Hisashi] Gunma Univ, Grad Sch Med, Dept Med & Clin Sci, Maebashi, Gunma 3718511, Japan; [Kamal, Ahmed] Janda Harndard, SPER, New Delhi 110062, India; [Tenen, Daniel G.] Harvard Med Sch, Harvard Stem Cell Inst, Boston, MA 02215 USA; [Kobayashi, Susumu S.] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Div Translat Genom, Kashiwa, Chiba 2778577, Japan; [Sultana, Farheen] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA in 2019, Cited 21. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The tumor suppressor transcription factor CCAAT enhancer-binding protein alpha (C/EBP alpha) expression is down-regulated in myeloid leukemias and enhancement of C/EBP alpha expression induces granulocytic differentiation in leukemic cells. Previously we reported that Styryl quinazolinones induce myeloid differentiation in HL-60 cells by upregulating C/EBP alpha expression. To identify more potent molecule that can induce leukemic cell differentiation we synthesized and evaluated new series of styryl quinazolinones, ethynyl styryl quinazolinones, styryl quinolinones and thienopyrimidinones. Thienopyrimidinones were found toxic and styryl quinolinones were found inactive. Ethynyl styryl quinazolinone 39 and styryl quinazolinone 5 were found active on par with the earlier reported analogues 1 and 2 suggesting that the 5-nitro furan-2-yl styryl quinazolinones find a real promise in leukemic cell differentiation. The improved potency of 5 suggested that further modifications in the 5-nitro furan-2-yl styryl quinazolinones can be at the phenyl substitution at the 3-position of the quinazolinone ring apart from the 5-position of the heteroaryl ring.

Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Radhakrishnan, S; Syed, R; Takei, H; Kobayashi, IS; Nakamura, E; Sultana, F; Kamal, A; Tenen, DG; Kobayashi, SS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem