Category: 88-68-6

Category: thiomorpholine. In 2019 GREEN CHEM published article about C-H BOND; CARBON-MONOXIDE SOURCE; CATALYZED SYNTHESIS; DIMETHYL-SULFOXIDE; ALPHA-METHYLATION; FACILE SYNTHESIS; GREEN CHEMISTRY; TERTIARY-AMINES; SITU GENERATION; BUILDING-BLOCK in [Senadi, Gopal Chandru; Kudale, Vishal Suresh; Wang, Jeh-Jeng] Kaohsiung Med Univ, Dept Med & Appl Chem, 100,Shiquan 1st Rd, Kaohsiung 807, Taiwan; [Wang, Jeh-Jeng] Kaohsiung Med Univ Hosp, Dept Med Res, 100,Tzyou 1st Rd, Kaohsiung 807, Taiwan; [Senadi, Gopal Chandru] SRM Inst Sci & Technol, Dept Chem, Chennai 603203, Tamil Nadu, India in 2019, Cited 132. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Alcohols and ethers were identified as sustainable methine sources for synthesizing quinazolinone and benzimidazole derivatives using a combination of TsOHH2O/O-2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C-2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone (2e), 2f (a common precursor of rutaecarpine and (+/-) evodiamine), and dimedazole (6d). Notable features of this method include its low toxicity, use of commercial feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Senadi, GC; Kudale, VS; Wang, JJ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H8N2O. Authors Yang, L; Hou, HQ; Li, L; Wang, J; Zhou, SY; Wu, M; Ke, F in ROYAL SOC CHEMISTRY published article about in [Yang, Li; Li, Lan; Ke, Fang] Yibin Univ, Coll Chem & Chem Engn, Yibin, Sichuan, Peoples R China; [Hou, Huiqing; Wang, Jin; Zhou, Sunying; Wu, Mei; Ke, Fang] Fujian Med Univ, Fuzhou, Fujian, Peoples R China in 2021, Cited 64. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

An efficient and practical electrochemically catalyzed transition metal-free process for the synthesis of substituted quinazolinones from simple and readily available o-aminobenzonitriles and aldehydes in water has been accomplished. I-2/base and water play an unprecedented and vital role in the reaction. By electrochemically catalysed hydrolysis of o-aminobenzonitriles, the synthesis of quinazolinones with benzaldehyde was first proposed. The synthetic utility of this method was demonstrated by gram-scale operation, as well as the preparation of bioactive N-(2,5-dichlorophenyl)-6-(2,2,2-trifluoroethoxy) pteridin-4-amine, which enables straightforward, practical and environmentally benign quinazolinone formation.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Yang, L; Hou, HQ; Li, L; Wang, J; Zhou, SY; Wu, M; Ke, F or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Iridium(III)-Catalyzed Alkynylation of 2-(Hetero)arylquinazolin-4-one Scaffolds via C-H Bond Activation WOS:000460491600052 published article about CROSS-COUPLING REACTION; TERMINAL ALKYNES; ETHYNYL BENZIODOXOLONES; CATALYZED ALKYNYLATION; SONOGASHIRA REACTIONS; ARENES; QUINAZOLINONE; AMIDATION; ACETYLENE; AMINATION in [Rohokale, Rajendra S.; Kalshetti, Rupali G.; Ramana, Chepuri V.] CSIR Natl Chem Lab, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Kalshetti, Rupali G.; Ramana, Chepuri V.] Acad Sci & Innovat Res, New Delhi 110025, India in 2019, Cited 80. Application In Synthesis of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The directed C-H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as -F, -Cl, -Br, -CF3, -OMe, -NO2, and alkyl, etc.

Application In Synthesis of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Rohokale, RS; Kalshetti, RG; Ramana, CV or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about MONOCLONAL-ANTIBODY; POTENT; ACTIVATION; MODERATE; SIGNAL; ROLES; OPTIMIZATION; USTEKINUMAB; MOLECULES; DISCOVERY, Saw an article supported by the Bristol-Myers Squibb CompanyBristol-Myers Squibb. COA of Formula: C7H8N2O. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Moslin, R; Zhang, YL; Wrobleski, ST; Lin, SQ; Mertzman, M; Spergel, S; Tokarski, JS; Strnad, J; Gillooly, K; McIntyre, KW; Zupa-Fernandez, A; Cheng, LH; Sun, HD; Chaudhry, C; Huang, C; D’Arienzo, C; Heimrich, E; Yang, XX; Muckelbauer, JK; Chang, C; Tredup, J; Mulligan, D; Xie, DL; Aranibar, N; Chiney, M; Burke, JR; Lombardo, L; Carter, PH; Weinstein, DS. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

As a member of the Janus OAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide 4, identified by a SPA-based high-throughput screen targeting the TYK2 pseudokinase domain, potently inhibits IL-23 and IFN alpha signaling in cellular assays. The described work details the optimization of this poorly selective hit (4) to potent and selective molecules such as 47 and 48. The discoveries described herein were critical to the eventual identification of the clinical TYK2 JH2 inhibitor (see following report in this issue). Compound 48 provided robust inhibition in a mouse IL-12-induced IFN gamma pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model. These results demonstrate the ability of TYK2 JH2 domain binders to provide a highly selective alternative to conventional TYK2 orthosteric inhibitors.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Moslin, R; Zhang, YL; Wrobleski, ST; Lin, SQ; Mertzman, M; Spergel, S; Tokarski, JS; Strnad, J; Gillooly, K; McIntyre, KW; Zupa-Fernandez, A; Cheng, LH; Sun, HD; Chaudhry, C; Huang, C; D’Arienzo, C; Heimrich, E; Yang, XX; Muckelbauer, JK; Chang, C; Tredup, J; Mulligan, D; Xie, DL; Aranibar, N; Chiney, M; Burke, JR; Lombardo, L; Carter, PH; Weinstein, DS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Iridium(III)-Catalyzed Alkynylation of 2-(Hetero)arylquinazolin-4-one Scaffolds via C-H Bond Activation WOS:000460491600052 published article about CROSS-COUPLING REACTION; TERMINAL ALKYNES; ETHYNYL BENZIODOXOLONES; CATALYZED ALKYNYLATION; SONOGASHIRA REACTIONS; ARENES; QUINAZOLINONE; AMIDATION; ACETYLENE; AMINATION in [Rohokale, Rajendra S.; Kalshetti, Rupali G.; Ramana, Chepuri V.] CSIR Natl Chem Lab, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Kalshetti, Rupali G.; Ramana, Chepuri V.] Acad Sci & Innovat Res, New Delhi 110025, India in 2019, Cited 80. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Name: 2-Aminobenzamide

The directed C-H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as -F, -Cl, -Br, -CF3, -OMe, -NO2, and alkyl, etc.

About 2-Aminobenzamide, If you have any questions, you can contact Rohokale, RS; Kalshetti, RG; Ramana, CV or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Arynes and Their Precursors from Arylboronic Acids via Catalytic C-H Silylation WOS:000467319600089 published article about BENZYNE; INSERTION; GENERATION; PHENOLS in [Devaraj, Karthik; Ingner, Fredric J. L.; Sollert, Carina; Pilarski, Lukasz T.] Uppsala Univ, Dept Chem BMC, Box 576, S-75123 Uppsala, Sweden; [Gates, Paul J.] Univ Bristol, Sch Chem, Cantocks Close, Bristol BS8 1TS, Avon, England; [Orthaber, Andreas] Uppsala Univ, Dept Chem, Angstrom Labs, Box 523, S-75120 Uppsala, Sweden in 2019, Cited 90. COA of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A new, operationally simple approach is presented to access arynes and their fluoride-activated precursors based on Ru-catalyzed C-H silylation of arylboronates. Chromatographic purification may be deferred until after aryne capture, rendering the arylboronates de facto precursors. Access to various new arynes and their derivatives is demonstrated, including, for the first time, those based on a 2,3-carbazolyne and 2,3-fluorenyne core, which pave the way for novel derivatizations of motifs relevant to materials chemistry.

About 2-Aminobenzamide, If you have any questions, you can contact Devaraj, K; Ingner, FJL; Sollert, C; Gates, PJ; Orthaber, A; Pilarski, LT or concate me.. COA of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H8N2O. Authors Peng, J; Hu, LD; Chen, MW; Deng, ZH; Peng, YY in GEORG THIEME VERLAG KG published article about in [Peng, Yiyuan] Jiangxi Normal Univ, Minist Educ, Key Lab Small Funct Organ Mol, Nanchang 330022, Jiangxi, Peoples R China; Jiangxi Normal Univ, Key Lab Green Chem, Nanchang 330022, Jiangxi, Peoples R China in 2021, Cited 41. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A highly selective difluoromethylation of quinazolines has been achieved by using commercially available ethyl bromodifluoroacetate as difluorocarbene precursor, providing the corresponding difluoromethyl substituted quinazoline derivatives with up to 83% yield.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Peng, J; Hu, LD; Chen, MW; Deng, ZH; Peng, YY or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 BIOORG CHEM published article about ACID-BINDING PROTEIN; LINEAR-REGRESSION; CELL-GROWTH; QSAR; EXPRESSION; PLS; DISCOVERY; PROSTATE; DESIGN; POTENT in [Floresta, Giuseppe; Spampinato, Ambra; Zagni, Chiara; Rescifina, Antonio] Univ Catania, Dept Drug Sci, Vle A Doria 6, I-95125 Catania, Italy; [Floresta, Giuseppe] Univ Catania, Dept Chem Sci, Vle A Doria, I-95125 Catania, Italy; [Floresta, Giuseppe; Cilibrizzi, Agostino] Kings Coll London, Inst Pharmaceut Sci, Stamford St, London SE1 9NH, England; [Cilibrizzi, Agostino; Abbate, Vincenzo] Kings Coll London, Sch Populat Hlth & Environm Sci, Kings Forens, Franklin Wilkins Bldg,150 Stamford St, London SE1 9NH, England in 2019, Cited 68. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Category: thiomorpholine

Following on the recent publication of pharmacologically relevant effects, small molecule inhibitors of adipocyte fatty-acid binding protein 4 (FABP4) have attracted high interest. FABP4 is mainly expressed in macrophages and adipose tissue, where it regulates fatty acid storage and lipolysis, being also an important mediator of inflammation. In this regard, FABP4 recently demonstrated an interesting molecular target for the treatment of type 2 diabetes, other metabolic diseases and some type of cancers. In the past years, hundreds of effective FABP4 inhibitors have been synthesized. In this paper, a quantitative structure-activity relationship (QSAR) model has been produced, in order to predict the bioactivity of FABP4 inhibitors. The methodology has been combined with a scaffold-hopping approach, allowing to identify three new molecules that act as effective inhibitors of this protein. These molecules, synthesized and tested for their FABP4 inhibitor activity, showed IC(50 )values between 3.70 and 5.59 mu M, with a high level of agreement with the predicted values.

About 2-Aminobenzamide, If you have any questions, you can contact Floresta, G; Cilibrizzi, A; Abbate, V; Spampinato, A; Zagni, C; Rescifina, A or concate me.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Computed Properties of C7H8N2O. Kerdphon, S; Jongcharoenkamol, J; Chatwichien, J; Singh, T; Channei, D; Choommongkol, V; Rithchumpon, P; Meepowpan, P in [Kerdphon, Sutthichat; Channei, Duangdao] Naresuan Univ, Dept Chem, Fac Sci, Phitsanulok 65000, Thailand; [Jongcharoenkamol, Jira] Naresuan Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem & Pharmacognosy, Phitsanulok 65000, Thailand; [Chatwichien, Jaruwan] Chulabhorn Royal Acad, Chulabhorn Grad Inst, Program Chem Sci, Bangkok 10210, Thailand; [Singh, Thishana] Univ Kwazulu Natal, Sch Chem & Phys, Private Bag X54001, ZA-4000 Durban, South Africa; [Choommongkol, Vachira] Maejo Univ, Dept Chem, Fac Sci, Chiang Mai 50290, Thailand; [Rithchumpon, Puracheth; Meepowpan, Puttinan] Chiang Mai Univ, Dept Chem, Fac Sci, Chiang Mai 50200, Thailand; [Rithchumpon, Puracheth; Meepowpan, Puttinan] Chiang Mai Univ, Grad Sch, Chiang Mai 50200, Thailand; [Meepowpan, Puttinan] Chiang Mai Univ, Ctr Excellence Mat Sci & Technol, Chiang Mai 50200, Thailand published Microwave-Assisted Green Synthesis of 2,3-Dihydroquinazolinones under Base- and Catalyst-Free conditions in 2021, Cited 47. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A facile and green one-pot synthesis of 2,3-dihydroquinazolinones, using microwave irradiation, has been developed. Dihydroquinazolinones were synthesized from 2-aminobenzamide derivatives and various aldehydes in aqueous solution under base and catalyst free reaction conditions. The desired products, from aliphatic and aromatic aldehydes substrates, were obtained in 5 minutes with up to 99 % isolated yields.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Kerdphon, S; Jongcharoenkamol, J; Chatwichien, J; Singh, T; Channei, D; Choommongkol, V; Rithchumpon, P; Meepowpan, P or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: synthesis of primary amides WOS:000507289600012 published article about SOLVENT-FREE CONDITIONS; RHINOVIRUS 3C PROTEASE; STRUCTURE-BASED DESIGN; ONE-POT SYNTHESIS; HETEROGENEOUS CATALYST; TITANIUM SUPEROXIDE; CARBOXYLIC-ACIDS; PRIMARY AMINES; ALCOHOLS; AMMONIA in [Kamble, Rohit B.; Mane, Kishor D.; Rupanawar, Bapurao D.; Sudalai, A.; Suryavanshi, Gurunath] CSIR, Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India; [Kamble, Rohit B.; Mane, Kishor D.; Rupanawar, Bapurao D.; Sudalai, A.; Suryavanshi, Gurunath] Acad Sci & Innovat Res, Ghaziabad 201002, UP, India; [Korekar, Pranjal] MES Abasaheb Garware Coll, Dept Chem, Pune 411004, Maharashtra, India in 2020, Cited 55. COA of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Kamble, RB; Mane, KD; Rupanawar, BD; Korekar, P; Sudalai, A; Suryavanshi, G or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem