Category: 88-68-6

I found the field of Chemistry very interesting. Saw the article ompg-C3N4/SO3H: an efficient and recyclable organocatalyst for the facile synthesis of 2,3-dihydroquinazolin-4(1H)-ones published in 2019. Application In Synthesis of 2-Aminobenzamide, Reprint Addresses Ghafuri, H (corresponding author), Iran Univ Sci & Technol, Dept Chem, Catalysts & Organ Synth Res Lab, Tehran 1684613114, Iran.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

In the present work, sulfonated highly ordered mesoporous graphitic carbon nitride (ompg-C3N4/SO3H) was synthesized successfully and employed as an efficient and reusable heterogeneous solid acid catalyst for the rapid and one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones via the condensation of anthranilamide with aldehydes or ketones in good to excellent yields. The organocatalyst was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, energy-dispersive X-ray spectrometer, Brunauer-Emmett-Teller surface area, and thermal gravimetric and differential thermal analysis. The substantial advantages of this procedure involve short reaction times, high catalytic activity, easy workup, high purity of the products, and easy recovery and reusability of the catalyst.

Application In Synthesis of 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Ghafuri, H; Goodarzi, N; Rashidizadeh, A; Fard, MAD or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about METAL-ORGANIC FRAMEWORKS; ONE-POT SYNTHESIS; TERMINAL ALKYNES; TANDEM SYNTHESIS; 2-AMINOBENZAMIDES; COMPOSITE; AMINATION; CHEMISTRY; ACIDS, Saw an article supported by the UGCUniversity Grants Commission, India; Science and Engineering Research Board (SERB), New Delhi, India [SR/FT/CS-53/2011]; University Grants Commission, New Delhi, India (UGC)University Grants Commission, India [42-291/2013(SR)]; Council for Scientific and Industrial Research, New Delhi, India (CSIR) [02(0191)14/EMR-II]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Latha, G; Devarajan, N; Suresh, P. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Name: 2-Aminobenzamide

A benign and straightforward method to access quinazolinones have been developed using easily preparable Cu-3(BTC)(2)MOF as a sustainable solid-Lewis acid catalyst under mild condition. Cu-3(BTC)(2)MOF was prepared and characterized using various analytical tools such as PXRD, FT-IR, SEM, TGA, and ICP-OES. Synthesis of the quinazolinone is catalyzed by the presence of coordinatively unsaturated open Cu(II)sites in Cu-3(BTC)(2)MOF using renewable ethanol as a solvent with minimum copper loading (0.07 mmol) without any harsh reaction condition. A series of substituted quinazolinones were synthesized with good to excellent yields. The efficiency of the present framework copper catalysts was rationalized by comparing with other MOFs and homogeneous catalytic systems. The stability of the catalyst was demonstrated by six consecutive runs and heterogeneity test, which was also evidenced from the technical supports such as PXRD, FT-IR and SEM analyses of the recovered catalyst.

Name: 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Latha, G; Devarajan, N; Suresh, P or send Email.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 2-Aminobenzamide. Mondal, MA; Mondal, S; Khan, AA in [Mondal, Mohabul A.; Mondal, Sudipta; Khan, Abdul A.] Jadavpur Univ, Dept Chem, Kolkata 700032, W Bengal, India published A mechanistic insight into the acid catalyzed, one-pot synthesis of isoindole-fused quinazolin 4-ones in 2020, Cited 11. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

One-pot synthesis of isoindole fused quinazolin 4-ones via intramolecular 1,3 hydride transfer in the presence of acid catalyst has been described. Substrate scope and mechanistic insights were investigated. Substituents on the amide side have a negligible influence on the key step and therefore the method have wide scope for accessing various bicyclic core structure.

Recommanded Product: 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Mondal, MA; Mondal, S; Khan, AA or send Email.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Kalogirou, AS; Kourtellaris, A; Koutentis, PA in WILEY-V C H VERLAG GMBH published article about ANTIFUNGAL ACTIVITY; MOLECULAR DOCKING; DERIVATIVES; CHEMISTRY; 3,4,4,5-TETRACHLORO-4H-1,2,6-THIADIAZINE; CYCLOPENTATHIADIAZINES; TETRACYANOETHYLENE; SUBSTITUTION; ACCESS; SPIRO in [Kalogirou, Andreas S.] European Univ Cyprus, Dept Life Sci, 6 Diogenis Str,POB 22006, CY-1516 Nicosia, Cyprus; [Kalogirou, Andreas S.; Kourtellaris, Andreas; Koutentis, Panayiotis A.] Univ Cyprus, Dept Chem, POB 20537, CY-1678 Nicosia, Cyprus in 2019, Cited 47. COA of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A three-step synthesis of 3 ‘,5 ‘-dichloro-1H-spiro(quinazo-line-2,4 ‘-[1,2,6]thiadiazin)-4(3H)-ones starting from 3,4,4,5-tetra-chloro-4H-1,2,6-thiadiazine is presented. The latter reacts with 2-aminobenzonitriles to give 2-[(3,5-dichloro-4H-1,2,6-thiadiazin-4-ylid-ene)amino]benzonitriles, which affords, after hydration, the respective benzamides. Upon heating at reflux in EtOH or HFIP, the benzamides intramolecularly cyclize onto the thiadiazine C4 position to give 3 ‘,5 ‘-dichloro-1H-spiro(quinazoline-2,4 ‘-[1,2,6]thiadiazin)-4(3H)-ones. Single crystal X-ray crystallography supports the structure of two analogues. The chloride displacement of these new spiroquinazolinones was demonstrated by Stille coupling, and by reaction with methoxide to afford both the mono and bis-methoxy derivatives.

Welcome to talk about 88-68-6, If you have any questions, you can contact Kalogirou, AS; Kourtellaris, A; Koutentis, PA or send Email.. COA of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Sustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions WOS:000461723200006 published article about C-H BOND; CARBON-MONOXIDE SOURCE; CATALYZED SYNTHESIS; DIMETHYL-SULFOXIDE; ALPHA-METHYLATION; FACILE SYNTHESIS; GREEN CHEMISTRY; TERTIARY-AMINES; SITU GENERATION; BUILDING-BLOCK in [Senadi, Gopal Chandru; Kudale, Vishal Suresh; Wang, Jeh-Jeng] Kaohsiung Med Univ, Dept Med & Appl Chem, 100,Shiquan 1st Rd, Kaohsiung 807, Taiwan; [Wang, Jeh-Jeng] Kaohsiung Med Univ Hosp, Dept Med Res, 100,Tzyou 1st Rd, Kaohsiung 807, Taiwan; [Senadi, Gopal Chandru] SRM Inst Sci & Technol, Dept Chem, Chennai 603203, Tamil Nadu, India in 2019, Cited 132. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Product Details of 88-68-6

Alcohols and ethers were identified as sustainable methine sources for synthesizing quinazolinone and benzimidazole derivatives using a combination of TsOHH2O/O-2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C-2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone (2e), 2f (a common precursor of rutaecarpine and (+/-) evodiamine), and dimedazole (6d). Notable features of this method include its low toxicity, use of commercial feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials.

Product Details of 88-68-6. Welcome to talk about 88-68-6, If you have any questions, you can contact Senadi, GC; Kudale, VS; Wang, JJ or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Moravcova, D; Cmelik, R; Krenkova, J in ELSEVIER published article about SILICA; RETENTION; BEHAVIOR in [Moravcova, Dana; Cmelik, Richard; Krenkova, Jana] Czech Acad Sci, Inst Analyt Chem, Veveri 97, Brno 60200, Czech Republic in 2021, Cited 25. Category: thiomorpholine. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The advantages of using mixtures of organic solvents for the separation of labeled oligosaccharides on the amide stationary phase under hydrophilic interaction liquid chromatography conditions are presented. The effect of the type of buffer as well as solvent or their mixtures on retention of uracil, saccharide labeling reagents (2-aminobenzoic acid, 2-aminobenzamide, ethyl 4-aminobenzoate, procainamide), and corresponding labeled saccharides were evaluated. The successful isocratic separation of labeled isomeric trisaccharides (maltotriose, panose, and isomaltotriose) was achieved in the mobile phase consisting of a 90% (v/v) mixture of organic solvents (methanol/acetonitrile 60:40) and 10% (v/v) 30 mM ammonium formate, pH 3.3. Changing the volume ratio between methanol/acetonitrile from 60:40 to 50:50 (v/v) allowed to obtain the separation of di-, tri-, and tetrasaccharides labeled by ethyl 4-aminobenzoate in less than 10.5 min. (c) 2021 Elsevier B.V. All rights reserved.

About 2-Aminobenzamide, If you have any questions, you can contact Moravcova, D; Cmelik, R; Krenkova, J or concate me.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C7H8N2O. In 2021 ACTA PHARMACOL SIN B published article about PARP INHIBITORS; DNA-REPAIR; BRD4; DISCOVERY; LETHALITY; ADAPTER; TUMORS in [Chang, Xiaosa; Sun, Dejuan; Shi, Danfeng; Wang, Guan; Chen, Yanmei; Zhang, Kai; Tan, Huidan; Liu, Jie; Liu, Bo; Ouyang, Liang] Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China in 2021, Cited 72. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

This study was aimed to design the first dual-target small-molecule inhibitor co-targeting poly (ADP-ribose) polymerase-1 (PARP1) and bromodomain containing protein 4 (BRD4), which had important cross relation in the global network of breast cancer, reflecting the synthetic lethal effect. A series of new BRD4 and PARP1 dual-target inhibitors were discovered and synthesized by fragment-based combinatorial screening and activity assays that together led to the chemical optimization. Among these compounds, 19d was selected and exhibited micromole enzymatic potencies against BRD4 and PARP1, respectively. Compound 19d was further shown to efficiently modulate the expression of BRD4 and PARP1. Subsequently, compound 19d was found to induce breast cancer cell apoptosis and stimulate cell cycle arrest at G1 phase. Following pharmacokinetic studies, compound 19d showed its antitumor activity in breast cancer susceptibility gene 1/2 (BRCA1/2) wild-type MDA-MB-468 and MCF-7 xenograft models without apparent toxicity and loss of body weight. These results together demonstrated that a highly potent dual-targeted inhibitor was successfully synthesized and indicated that co-targeting of BRD4 and PARP1 based on the concept of synthetic lethality would be a promising therapeutic strategy for breast cancer. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

Welcome to talk about 88-68-6, If you have any questions, you can contact Chang, XS; Sun, DJ; Shi, DF; Wang, G; Chen, YM; Zhang, K; Tan, HD; Liu, J; Liu, B; Ouyang, L or send Email.. Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C7H8N2O. Nguyen, TB; Hou, JY; Retailleau, P in [Thanh Binh Nguyen; Hou, Jing-ya; Retailleau, Pascal] Univ Paris Saclay, Inst Chim Subst Nat, CNRS, UPR 2301,Univ Paris Sud, 1 Ave Terrasse, F-91198 Gif Sur Yvette, France published Sulfur-Promoted Synthesis of 2-Aroylquinazolin-4(3H)-ones by Oxidative Condensation of Anthranilamide and Acetophenones in 2019, Cited 50. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A sulfur-promoted three-component reaction of isatoic anhydride, primary aliphatic or aromatic amines, and acetophenones leading to densely substituted 3-substituted 2-aroylquinazolin-4(3H)-ones is reported. The key step involves a cascade reaction of selective oxidation of the methyl group of the acetophenones, followed by a condensation with anthranilamides. The scope of the reaction is applicable to the synthesis of tryptanthrin and various 3-unsubstituted 2-aroylquinazolin-4(3H)-ones.

About 2-Aminobenzamide, If you have any questions, you can contact Nguyen, TB; Hou, JY; Retailleau, P or concate me.. Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Palladium-catalyzed synthesis of novel trifluoromethylated quinazolinone, N-arylquinazoline and N-benzylquinazoline derivatives WOS:000646579300022 published article about ONE-POT SYNTHESIS; CHLORIDES; DOCKING; ACIDS in [Sajadi, Mahdieh Sadat; Kazemi, Elham; Darehkordi, Ali] Vali E Asr Univ Rafsanja, Fac Sci, Dept Chem, Rafsanjan 77176, Iran in 2021, Cited 49. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. HPLC of Formula: C7H8N2O

A simple and palladium-catalyzed procedure for synthesis of a novel series of potentially biologically active trifluoromethyl-substituted quinazolinones and N-arylquinazoline derivatives via condensation-cyclization reaction of 2-aminobenzamide, 2-amino-N’-arylbenzimidamides and 2-amino-N’-benzylbenzimidamides with trifluoroacetimidoyl chlorides has been developed. noteworthy, this investigation showed the possible of transition-metal-catalyzed activation of trifluoroacetimidoyl chlorides as a carbon trifluoromethylated source for the synthesis of quinazolines and quinazolinone derivatives in good to excellent yields. (C) 2021 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Sajadi, MS; Kazemi, E; Darehkordi, A or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold published in 2019. Product Details of 88-68-6, Reprint Addresses Guglielmi, P (corresponding author), Sapienza Univ Rome, Dipartimento Chim & Tecnol Farmaco, Ple A Moro 5, I-00185 Rome, Italy.; Supuran, CT (corresponding author), Univ Firenze, Sect Pharmaceut & Nutraceut Sci, Neurofarba Dept, Via U Schiff 6, I-50019 Florence, Italy.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives.

Welcome to talk about 88-68-6, If you have any questions, you can contact Rotondi, G; Guglielmi, P; Carradori, S; Secci, D; De Monte, C; De Filippis, B; Maccallini, C; Amoroso, R; Cirilli, R; Akdemir, A; Angeli, A; Supuran, CT or send Email.. Product Details of 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem