Category: 88-68-6

An article N-Phenylbenzamide derivatives as alternative oxidase inhibitors: Synthesis, molecular properties, H-1-STD NMR, and QSAR WOS:000519189500051 published article about PURIFICATION; PERFORMANCE; INSIGHTS; FEATURES; PATHWAY; ENZYMES; BINDING; IMPACT in [Costa, Paulo C. S.; Evangelista, Joel S.; Miranda, Paulo C. M. L.] Univ Estadual Campinas, UNICAMP, Inst Chem, BR-13083970 Campinas, SP, Brazil; [Barsottini, Mario R. O.; Pires, Barbara A.; Carazzolle, Marcelo F.; Pereira, Goncalo A. G.] Univ Estadual Campinas, UNICAMP, Inst Biol, Lab Genom & BioEnergy, BR-13083862 Campinas, SP, Brazil; [Barsottini, Mario R. O.] Univ Sussex, Biochem & Biomed, Falmer BN1 9QG, England; [Vieira, Maria L. L.; Silva, Jaqueline S.; Sforca, Mauricio L.; Rocco, Silvana A.] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, BR-13083970 Campinas, SP, Brazil; [Zeri, Ana C. M.; Nascimento, Andrey F. Z.] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Synchrotron Light Lab LNLS, BR-13083970 Campinas, SP, Brazil in 2020, Cited 47. Recommanded Product: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

In the present work, 117 N-phenylbenzamides (NPDs) were prepared and evaluated against recombinant AOX from the fungal pathogen Moniliophthora perniciosa. H-1, C-13 NMR, FTIR, and mass spectra provided structural information on NPDs. The library compounds were tested as Alternative Oxidase inhibitors in two different assays using the model yeast Pichia pastoris: cell growth and oxygen consumption assays. The most active compound, 3(FH), was further characterized by DRX and 1H-NMR-STD. Single crystal X-ray diffraction showed intra- and intermolecular interactions of 3(FH) in solid-state and elucidated its 3D structural configuration. 1H-NMR-STD allowed us to derive protein-ligand interactions in a membranemimetic system and evidenced an outstanding interaction of 3(FH) with this enzyme. Results of both biological assays were used as input to Quantitative Structure-Activity Relationship models, which highlighted the more important molecular fragments contributions for protein-ligand interaction. (C) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 2-Aminobenzamide. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C7H8N2O. In 2019 CHINESE J ORG CHEM published article about PRIMARY ALCOHOLS; DERIVATIVES; INHIBITORS; ANTITUMOR; CYCLIZATION; CLEAVAGE; BEARING; AGENTS in [Ju, Huanhuan; Sun, Jiajing; Li, Xiaoliu; Chen, Hua] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China in 2019, Cited 35. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A series of aldo-quinazolinones were synthesized by a one-pot iodine-induced oxidative condensation of the unprotected mono-/di-saccharides and o-aminobenzamides in the yields of 30%similar to 80%, providing an effective protocol for the preparation of aldo-quinazolinones. The amount of iodine has an important effect on the reaction.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Wang, L; Jiang, KC; Zhang, N; Zhang, ZH in WILEY-V C H VERLAG GMBH published article about in [Wang, Liang; Zhang, Nana] Changzhou Vocat Inst Engn, Sch Chem & Pharmaceut Engn, Gehu Rd 33, Changzhou 213164, Jiangsu, Peoples R China; [Jiang, Kuan-chang; Zhang, Zhi-hui] Changzhou Univ, Sch Petrochem Engn, Gehu Rd 1, Changzhou 213164, Jiangsu, Peoples R China in 2021, Cited 43. Product Details of 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A rhodium-catalyzed synthesis of isoquinolino[1,2-b]quinazolines via C-H annulation using vinylene carbonate as an oxidizing acetylene surrogate in biomass-derived gamma-valerolactone (GVL) has been developed. The reactions proceeded smoothly to give the corresponding products in moderate to good yields without any external oxidant and base. This protocol can also be applied for the synthesis of 5,6-dihydro-8H-isoquinolino[1,2-b]quinazolin-8-ones.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

SDS of cas: 88-68-6. Yashwantrao, G; Jejurkar, VP; Kshatriya, R; Saha, S in [Yashwantrao, Gauravi; Jejurkar, Valmik P.; Kshatriya, Rajpratap; Saha, Satyajit] Inst Chem Technol, Dept Dyestuff Technol, Mumbai 400019, Maharashtra, India published Solvent-Free, Mechanochemically Scalable Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Using Bronsted Acid Catalyst in 2019, Cited 76. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Although the synthesis of novel N-heterocyclic molecules is extremely demanding as well as challenging, the involvement of toxic solvents often triggers environmental safety concerns, resulting in process-engineering challenges. Herein, we have demonstrated a rapid, environmentally benign and energy efficient scalable method for the synthesis of 2,3-dihydroquinazolin-4(1H)-one by grinding in a mortar pestle as well as mechanochemically via ball milling using p-TSA catalyst. The ability to accomplish the reaction in the absence of solvent via grinding or milling with p-TSA catalyst, with an immediate reduction in the cost and operational procedures, features the significant advantages of this protocol. The scalability and significance of the operational parameters during mechanochemical milling in the tubular ball mill were also demonstrated. Excellent yield in short duration, large substrate scope, product scalability, and easy recoverability are the prime features of this mechanochemical solvent-free protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-one. The study also demonstrated the significant role of ball diameter to improve the efficiency of the milling operation in this mechanochemical synthesis.

SDS of cas: 88-68-6. Welcome to talk about 88-68-6, If you have any questions, you can contact Yashwantrao, G; Jejurkar, VP; Kshatriya, R; Saha, S or send Email.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article An Efficient Ni/Pd Catalyzed Chemoselective Synthesis of 1,3,2-Benzodiazaborininones from Boronic Acids and Anthranilamides WOS:000486802600001 published article about ONE-POT SYNTHESIS; CRYSTAL-STRUCTURES; BORYLATION; FUNCTIONALIZATION; DERIVATIVES in [Wang, Hao-Jie; Zhang, Mo; Li, Wen-Jing; Ni, Yu; Lin, Jin; Zhang, Zhan-Hui] Hebei Normal Univ, Coll Chem & Mat Sci, Natl Demonstrat Ctr Expt Chem Educ, Hebei Key Lab Organ Funct Mol, Shijiazhuang 050024, Hebei, Peoples R China in 2019, Cited 50. Computed Properties of C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

An efficient Ni/Pd catalyzed chemoselective synthesis of 1,3,2-benzodiazaborininones from boronic acids and anthranilamide has been developed. This protocol allows for the rapid and straightforward access to a wide range of 1,3,2-benzodiazaborininones at roomtemperature with excellent functional group tolerance.

Welcome to talk about 88-68-6, If you have any questions, you can contact Wang, HJ; Zhang, M; Li, WJ; Ni, Y; Lin, J; Zhang, ZH or send Email.. Computed Properties of C7H8N2O

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article omega-Quinazolinonylalkyl aryl ureas as reversible inhibitors of monoacylglycerol lipase WOS:000505596300011 published article about ACID-AMIDE HYDROLASE; MONOGLYCERIDE LIPASE; ENDOCANNABINOID SYSTEM; ACCURATE DOCKING; MAGL; DERIVATIVES; ANALOGS; GLIDE; IDENTIFICATION; PREDICTION in [Dato, Florian M.; Pietsch, Markus] Univ Cologne, Med Fac, Ctr Pharmacol, Inst Pharmacol 2, Gleueler Str 24, D-50931 Cologne, Germany; [Dato, Florian M.; Neudoerfl, Jorg-Martin; Goldfuss, Bernd] Univ Cologne, Inst Organ Chem, Dept Chem, Greinstr 4, D-50939 Cologne, Germany; [Guetschow, Michael] Univ Bonn, Pharmaceut Inst, Pharmaceut Chem 1, Immenburg 4, D-53121 Bonn, Germany in 2020, Cited 60. Category: thiomorpholine. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The serine hydrolase monoacylglycerol lipase (MAGL) is involved in a plethora of pathological conditions, in particular pain and inflammation, various types of cancer, metabolic, neurological and cardiovascular disorders, and is therefore a promising target for drug development. Although a large number of irreversible-acting MAGL inhibitors have been discovered over the past years, there are only few compounds known so far which inhibit the enzyme in a reversible manner. Therefore, much effort is put into the development of novel chemical entities showing reversible inhibitory behavior, which is thought to cause less undesired side effects. To explore a wide range of chemical structures as MAGL binders, we have applied a virtual screening approach by docking small molecules into the crystal structure of human MAGL (hMAGL) and envisaged a library of 45 selected compounds which were then synthesized. Biochemical investigations included the determination of the inhibitory potency on hMAGL and two related hydrolases, i.e. human fatty acid amide hydrolase (hFAAH) and murine cholesterol esterase (mCEase). The most promising candidates from theses analyses, i.e. three w-quinazolinonylalkyl aryl ureas bearing alkyl spacers of three to five methylene groups, exhibited IC50 values of 20-41 mu M and reversible, detergent-insensitive behavior towards hMAGL. Among these compounds, the inhibitor 1-(3,5-bis(tri-fluoromethyl)phenyl)-3-(4-(4-oxo-3,4 dihydroquinazolin-2-yl)butyl)urea (96) was selected for further kinetic characterization, yielding a dissociation constant K-i = 15.4 mu M and a mixed-type inhibition with a pronounced competitive component (alpha = 8.94). This mode of inhibition was further supported by a docking experiment, which suggested that the inhibitor occupies the substrate binding pocket of hMAGL.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Solubility Measurement and Phase Equilibrium Modeling of 2-Aminobenzamide in 15 Pure Solvents WOS:000486361300027 published article about O-AMINOBENZAMIDE; ACID; WATER; OLIGOSACCHARIDES; MIXTURE in [Wu, Kui] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China; [Li, Yajun] Guangdong Acad Sci, Guangzhou Sugarcane Ind Res Inst, Guangdong Prov Bioengn Inst, Guangzhou S10316, Guangdong, Peoples R China in 2019, Cited 24. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Product Details of 88-68-6

The solubility of 2-aminobenzamide in 15 pure organic solvents, including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, n-hexanol, n-octanol, acetone, ethyl acetate, acetonitrile, tetrahydrofuran, and methyl acetate, was measured using a gravimetric method over the temperature range from 273.15 to 324.15 K under atmosphere pressure. Four thermodynamic models, that is, Apelblat equation, 2,11 equation, nonrandom two-liquid equation, and Wilson equation, were applied to correlate the measured solubility data. The correlation results were evaluated by the relative average deviation. The results indicated that the mole fraction solubility increased with the rising of temperature in all 15 solvents, and the Wilson model gave the best fitting results. The experimental data and correlation models would be useful in the purification and synthesis process of 2-aminobenzamide.

Welcome to talk about 88-68-6, If you have any questions, you can contact Wu, K; Li, YJ or send Email.. Product Details of 88-68-6

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of 2-Aminobenzamide. In 2019 TETRAHEDRON LETT published article about CATALYZED DENITROGENATIVE ANNULATION; TERT-BUTYL NITRITE; NEMATOCIDAL ACTIVITIES; SELECTIVE SYNTHESIS; DERIVATIVES; 1,2,3-BENZOTRIAZINE-4-(3H)-ONES; ACID in [Barak, Dinesh S.; Mukhopadhyay, Sushobhan; Dahatonde, Dipak J.; Batra, Sanjay] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Batra, Sanjay] CSIR HRDC, Postal Staff Coll Area, Sect 19, Ghaziabad 201002, India in 2019, Cited 39. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I-2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization. (C) 2018 Elsevier Ltd. All rights reserved.

Safety of 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Barak, DS; Mukhopadhyay, S; Dahatonde, DJ; Batra, S or send Email.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Vyas, KM; Mandal, P; Singh, R; Mobin, SM; Mukhopadhyay, S in [Vyas, Komal M.; Mandal, Poulami; Singh, Rinky; Mobin, Shaikh M.; Mukhopadhyay, Suman] Indian Inst Technol Indore, Sch Basic Sci, Discipline Chem, Khandwa Rd, Indore 453552, India; [Vyas, Komal M.] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India; [Mandal, Poulami] Helmholtz Zensrum Dresden Rossendorf, Dept Resource Ecol, D-01328 Dresden, Germany published Arene-ruthenium(II)-phosphine complexes: Green catalysts for hydration of nitriles under mild conditions in 2020, Cited 86. Name: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Three new arene-ruthenium(II) complexes were prepared by treating [{RuCl(mu-Cl)(eta(6)-arene)}(2)] (eta(6)-arene = p-cymene) dimer with tri(2-furyl)phosphine (PFu(3)) and 1,3,5-triaza-7-phosphaadamantane (PTA), respectively to obtain [RuCl2(eta(6)-arene)PFu(3)] [Ru] -1, (RuCl(eta(6)-arene)(PFu(3))(PTA)]BF4 [Ru] -2 and HtuCl(eta(6)-arene)(PFu(3))(2)]BF4 [Ru] -3. All the complexes were structurally identified using analytical and spectroscopic methods including single-crystal X-ray studies. The effectiveness of resulting complexes as potential homogeneous catalysts for selective hydration of different nitriles into corresponding amides in aqueous medium and air atmosphere was explored. There was a remarkable difference in catalytic activity of the catalysts depending on the nature and number of phosphorus-donor ligands and sites available for catalysis. Experimental studies performed using structural analogues of efficient catalyst concluded a structural-activity relationship for the higher catalytic activity of [Ru] -1, being able to convert huge variety of aromatic, heteroaromatic and aliphatic nitriles. The use of eco-friendly water as a solvent, open atmosphere and avoidance of any organic solvent during the catalytic reactions prove the reported process to be truly green and sustainable.

Welcome to talk about 88-68-6, If you have any questions, you can contact Vyas, KM; Mandal, P; Singh, R; Mobin, SM; Mukhopadhyay, S or send Email.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 2-Aminobenzamide. In 2019 BIOORG MED CHEM LETT published article about C/EBP-ALPHA; INHIBITORS; CYTOTOXICITY; CANCER in [Radhakrishnan, Sridhar; Tenen, Daniel G.] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore; [Syed, Riyaz; Sultana, Farheen; Kamal, Ahmed] Indian Inst Chem Technol, CSIR, Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India; [Syed, Riyaz] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad 500085, India; [Takei, Hisashi; Kobayashi, Ikei S.; Nakamura, Eugene; Kobayashi, Susumu S.] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA; [Takei, Hisashi; Kobayashi, Ikei S.; Nakamura, Eugene; Kobayashi, Susumu S.] Harvard Med Sch, Boston, MA 02215 USA; [Takei, Hisashi] Gunma Univ, Grad Sch Med, Dept Med & Clin Sci, Maebashi, Gunma 3718511, Japan; [Kamal, Ahmed] Janda Harndard, SPER, New Delhi 110062, India; [Tenen, Daniel G.] Harvard Med Sch, Harvard Stem Cell Inst, Boston, MA 02215 USA; [Kobayashi, Susumu S.] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Div Translat Genom, Kashiwa, Chiba 2778577, Japan; [Sultana, Farheen] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA in 2019, Cited 21. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The tumor suppressor transcription factor CCAAT enhancer-binding protein alpha (C/EBP alpha) expression is down-regulated in myeloid leukemias and enhancement of C/EBP alpha expression induces granulocytic differentiation in leukemic cells. Previously we reported that Styryl quinazolinones induce myeloid differentiation in HL-60 cells by upregulating C/EBP alpha expression. To identify more potent molecule that can induce leukemic cell differentiation we synthesized and evaluated new series of styryl quinazolinones, ethynyl styryl quinazolinones, styryl quinolinones and thienopyrimidinones. Thienopyrimidinones were found toxic and styryl quinolinones were found inactive. Ethynyl styryl quinazolinone 39 and styryl quinazolinone 5 were found active on par with the earlier reported analogues 1 and 2 suggesting that the 5-nitro furan-2-yl styryl quinazolinones find a real promise in leukemic cell differentiation. The improved potency of 5 suggested that further modifications in the 5-nitro furan-2-yl styryl quinazolinones can be at the phenyl substitution at the 3-position of the quinazolinone ring apart from the 5-position of the heteroaryl ring.

Recommanded Product: 2-Aminobenzamide. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem