Category: 88-68-6

Quality Control of 2-Aminobenzamide. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, Synthesis and Biological Evaluation of the Quinazoline Derivatives as L858R/T790M/C797S Triple Mutant Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors published in 2020, Reprint Addresses Wang, SF (corresponding author), Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Peoples R China.; Zhu, YQ (corresponding author), Jiangsu Chia Tai Fenghai Pharmaceut Co Ltd, 9 Weidi Rd, Nanjing 210046, Peoples R China.; Zhu, YQ (corresponding author), Nanjing Normal Univ, Coll Life Sci, Nanjing 210046, Peoples R China.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide.

Inhibition of the epidermal growth factor receptor (EGFR) has been proved to be one of the most promising strategies for the treatment of non-small cell lung cancers. A series of 2-aryl-4-amino substituted quinazoline derivatives were designed and synthesized with the purpose to overcome L858R/T790M/C797S (CTL) triple mutant drug resistance and the biological activity for inhibition of CTL kinases and EGFR wild type (WT) were evaluated. Three compounds (20, 24 and 27) showed excellent inhibitory activities against EGFR kinases triple mutant CTL (IC50 < 1 mu M) and high selectivity (IC50: WT/CTL >10000). Cell line evaluation showed that the most potent compound 27 was significantly potent against H1975-EGFR L858R/T790M (IC50 = 3.3 mu M) and H1975-EGFR L858R/T790M/C797S (IC50 = 1.2 mu M). Compound 27 also exhibited good microsomes stabilities in human, rat and mouse liver species, but low bioavailability. This work would be very useful for discovering new quinazoline derivatives as tyrosine kinase inhibitors targeting triple mutant L858R/T790M/C797S.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about VISIBLE-LIGHT PHOTOCATALYSIS; ONE-POT SYNTHESIS; OXIDATIVE SYNTHESIS; CATALYZED SYNTHESIS; CASCADE SYNTHESIS; BENZYL ALCOHOLS; 2-AMINOBENZENESULFONAMIDE; DERIVATIVES; CYCLIZATION, Saw an article supported by the IIT Indore; SIC IIT Indore; SAIF; NEHU, Shillong; IIT Kanpur; IIT Bombay; Ministry of Education; DST, Government of IndiaDepartment of Science & Technology (India). Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Sarma, D; Majumdar, B; Deori, B; Jain, S; Sarma, TK. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. SDS of cas: 88-68-6

Catalyst-free photoinduced processes in aqueous medium represent significant advancement toward development of green and sustainable pathways in organic synthesis. tert-Butyl hydroperoxide (TBHP) is a widely used oxidant in organic reactions, where the decomposition of TBHP into its radicals by metal catalysts or other reagents is a key factor for efficient catalytic outcome. Herein, we report a simple and environmentally friendly visible light-promoted synthetic pathway for the synthesis of N-heterocyclic moieties, such as quinazolinones and quinoxalines, in the presence of TBHP as an oxidizing agent in aqueous medium that requires no catalysts/photocatalysts. The enhanced rate of decomposition to generate free radicals from TBHP upon visible light irradiation is the driving force for the domino reaction.

SDS of cas: 88-68-6. Welcome to talk about 88-68-6, If you have any questions, you can contact Sarma, D; Majumdar, B; Deori, B; Jain, S; Sarma, TK or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

HPLC of Formula: C7H8N2O. Chen, CH; Xuejiao, A; Li, X; Huang, GL; Liu, B in [Chen, Chuanhuan; Xuejiao, A.; Li, Xia; Huang, Guoli; Liu, Bo] Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China published Phosphomolybdic Acid (PMA)-catalyzed One-pot Synthesis of 2,3-Dihydroquinazolines in 2019, Cited 34. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

We have developed a new method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yields via phosphomolybdic acid (PMA)-catalyzed cyclocondensation of 2-aminobenzamides with aldehydes or ketones in N,N-dimethylformamide (DMF) at room temperature. The present method proves to be efficient in terms of short reaction time, high yield, simple workup and easy purification.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 J AGR FOOD CHEM published article about BIOLOGICAL EVALUATION; INSECTICIDAL ACTIVITY; FUNGICIDAL ACTIVITIES; DESIGN; ANTIFUNGAL; SERIES; ORYZAE; BASE in [Fan, Zhijiang; Shi, Jun; Luo, Na; Ding, Muhan; Bao, Xiaoping] Guizhou Univ, Ctr Res & Dev Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Guizhou, Peoples R China in 2019, Cited 46. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Application In Synthesis of 2-Aminobenzamide

A total of 22 quinazoline thioether derivatives incorporating a 1,2,4-triazolo[4,3-a]pyridine moiety were designed, synthesized, and evaluated as antimicrobial agents in agriculture. Among these compounds, the chemical structure of compound 61 was further confirmed via single-crystal X-ray diffraction analysis. The bioassay results revealed that some of the compounds possessed noticeable in vitro antibacterial activities against the tested phytopathogenic bacteria. For example, compounds 6b and 6g had EC50 values as low as 10.0 and 24.7 mu g/mL against Xanthomonas axonopodis pv. citri (Xac), respectively, which were significantly better than that of the commercial agrobactericide bismerthiazol (56.9 mu g/mL). Particularly, compound 6b was also found to be capable of suppressing the pathogenic bacterium Xanthomonas oryzae pv. oryzae (Xoo) approximately 12-fold more potent than control bismerthiazol, in terms of their EC 50 values (7.2 versus 89.8 mu g/mL). Importantly, the most active compound 6b turned out to be one with the highest hydrophilicity and the lowest molecular weight within the series. In vivo bioassays further showed the application prospect of 6b as a promising plant bactericide for controlling Xoo. Additionally, in vitro antifungal activities of these compounds were also evaluated at the concentration of 50 mu g/mL. Overall, the present study demonstrated the potential of 1,2,4-triazolo[4,3-a]pyridine-bearing quinazoline thioether derivatives as efficient agricultural antibacterial agents for crop protection.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Al-Sehemi, AG; Irfan, A; Pannipara, M; Assiri, MA; Kalam, A in [Al-Sehemi, Abdullah G.; Irfan, Ahmad; Pannipara, Mehboobali; Assiri, Mohammed A.; Kalam, Abul] King Khalid Univ, Dept Chem, Fac Sci, POB 9004, Abha 61413, Saudi Arabia; [Al-Sehemi, Abdullah G.; Irfan, Ahmad; Pannipara, Mehboobali; Assiri, Mohammed A.; Kalam, Abul] King Khalid Univ, RCAMS, POB 9004, Abha 61413, Saudi Arabia published Anthracene Based AIE Active Probe for Colorimetric and Fluorimetric Detection of Cu2+ Ions in 2019, Cited 37. HPLC of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A novel aggregation induced emission (AIE) active anthracene based dihydroquinazolinone derivative (probe 1) has been synthesized and characterized by means of spectroscopic methods. The photophysical properties of this probe have been investigated in solvents of different polarity display that fluorescence states are of intramolecular charge transfer (ICT) character. Probe 1 show clear AIE behavior in water/THF mixture on reaching water fraction 95%. The AIE behavior of probe 1 have been exploited for the detection of metal ions in aqueous solution which reveals high selectivity and sensitivity towards Cu2+ ions by colorimetrically and function as a chemosensor in a remarkable turn-off fluorescence manner. Further, the experimental results were investigated by computational means by optimizing the ground state geometries of probe 1 and probe 1-Cu complex using density functional theory (DFT) at B3LYP/6-31G** and B3LYP/6-31G**(LANL2DZ) levels of theory. Intra-molecular charge transfer was observed in probe 1 while ligand to metal charge transfer (LMCT) for probe 1-Cu complex.

HPLC of Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Al-Sehemi, AG; Irfan, A; Pannipara, M; Assiri, MA; Kalam, A or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 2-Aminobenzamide. In 2019 CHEMISTRYSELECT published article about CANDIDA-ALBICANS; BACTERIAL BIOFILMS; ANTIBACTERIAL; RESISTANCE; GROWTH in [Ansari, Siddique A.; Alkahtani, Hamad M.; Almehizia, Abdulrahman A.; Al-Tuwajiri, Hanaa M.] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, POB 2454, Riyadh 11451, Saudi Arabia; [Deshmukh, Satish U.] Deogiri Coll, Dept Chem, Aurangabad 431005, Maharashtra, India; [Patil, Rajesh B.] Smt Kashibai Navale Coll Pharm, Sinhgad Tech Educ Societys, Pune 411048, Maharashtra, India; [Damale, Manoj G.] Srinath Coll Pharm, Dept Pharmaceut Med Chem, Aurangabad 431136, Maharashtra, India; [Patil, Rajendra H.] Savitribai Phule Pune Univ, Dept Biotechnol, Pune 411007, Maharashtra, India; [Aleanizy, Fadilah S.; Alqahtani, Fulwah Y.] King Saud Univ, Dept Pharmaceutcs, Coll Pharm, POB 2454, Riyadh 11451, Saudi Arabia; [Pathan, Shahebaaz K.; Sangshetti, Jaiprakash N.] YB Chavan Coll Pharm, Dr Rafiq Zakaria Campus, Aurangabad 431001, Maharashtra, India in 2019, Cited 35. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A library of 2,3-dihydroquinazolin-4(1H)-one derivatives (5 a-k) were synthesized in good yield by using 1-Ethyl-3-Methylimidazolium hydrogen sulphate (10 mol %) as a catalyst and were evaluated for their anti-biofilm, antimicrobial and cytotoxicity potential. Among the synthesized compounds, 2-(4-(1H-1,2,4-triazol-1-yl)phenyl)-2,3-dihydroquinazolin-4(1H)-one (5d) and 2,3-dihydro-2-(2,4,6-trimethoxyphenyl) quinazolin-4(1H)-one (5j) displayed better anti-biofilm activity than fluconazole (IC50 = 40 mu M) with IC50 values less than 30 mu M. Compound 5d also appeared to be fungicidal against C. Albicans having MIC=33.5 mu g/ml comparable with standard fluconazole (50 mu g/ml). All the synthesized compounds were also evaluated for cytotoxic activity by using MTT assay against HeLa, A-549 and MDA-MB-231 cell lines. The compound 5d was found to be more potent against MDA-MB-231 and A549 cell lines (IC50 = 11 +/- 2 mu M and 34 +/- 8 mu M respectively) than 5-fluorouracil (IC50 = 19 +/- 3 mu M and 51 +/- 5 mu M respectively). The compounds substituted with 6-methyl-4-oxo-4H-chromen-3-yl (5a), biphenyl (5c) and 2-hydroxy-5-bromophenyl (5e) were also found to be more potent against MDA-MB-231 cell lines (IC50 = 13 +/- 3 – 14 +/- 4 mu M) than 5-fluorouracil. Molecular docking simulations were also carried out using secreted aspartyl protease (SAP5), pepA enzyme of C. albicans for biofilm inhibition and EGFR tyrosine kinase for cyto-toxicity studies. The study reveals that the compounds 5d and 5e can serve as an important lead moiety for biofilm inhibition and cyto-toxicity against MDA-MB-231 and A549 cancer cell-lines indicating their potential in the treatment of tougher fungal infections and breast and lung cancer.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

HPLC of Formula: C7H8N2O. Authors Akyuz, G in WILEY published article about in [Akyuz, Gulay] Recep Tayyip Erdogan Univ, Art & Sci Fac, Dept Chem, Rize, Turkey in 2021, Cited 18. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

In this study, novel quinazolinones were designed, synthesized, characterized by FT-IR, H-1-NMR, C-13-NMR spectral data, and LC-MS. New compounds inhibitory activities on urease were assessed. All of the compounds exhibited potent urease inhibitory activities. Especially in the synthesized compounds, 2-benzyl-3-({5-[(4-nitrophenyl)amino]-1,3,4-thiadiazol2-yl}methyl)quinazolin-4(3H)-one has the best inhibitory effect against Jack bean urease with IC50 = 3.30 +/- 0.09 mu g/mL. And also, N-(4-nitrophenyl)-2-[(4-oxoquinazolin-3(4H)-yl)acetyl] hydrazinecarbothioamide, N-(4-fluorophenyl)-2-[(4-oxoquinazolin-3(4H)-yl)acetyl] hydrazinecarbothioamide, and 2-benzyl-3-({5-[(4-fluorophenyl)amino]-1,3,4-thiadiazol-2yl} methyl)quinazolin-4(3H)-one have best activities among the synthesized compounds.

HPLC of Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Akyuz, G or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article A Green, Scalable, One-Minute Synthesis of Benzimidazoles WOS:000526543000004 published article about ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; PROMOTED SYNTHESIS; DERIVATIVES; DESIGN; INHIBITORS; SCAFFOLD; BINDING; ACCESS in [Elumalai, Vijayaragavan; Hansen, Jorn H.] UIT Arctic Univ Norway, Dept Chem, Chem Synth & Anal Div, Hansine Nansens Veg 54, N-9037 Tromso, Norway in 2020, Cited 42. Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Herein is reported a substantially improved synthesis of 2-substituted benzimidazoles by condensation of 1,2-diaminoarenes and aldehydes using methanol as the reaction medium. The developed method afforded moderate to excellent yields (33-96%) at ambient temperature, displays high functional group tolerance, is conducted open to air, and requires only one minute reaction time under catalyst- and additive-free conditions. Moreover, the efficient protocol permits scale-up to multi-gram scale synthesis of benzimidazoles and will become a method of choice when constructing such heterocyclic systems.

Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Elumalai, V; Hansen, JH or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Warrier, VG; Nizam, A; Nagaraju, G in [Warrier, Vipul G.; Nizam, Aatika] Christ Univ, Dept Chem, Hosur Rd, Bengaluru 560029, India; [Nagaraju, G.] Siddaganga Inst Technol, Dept Chem, Tumakuru 572103, India published Highly Efficient Photocatalytic Conversion of Amine to Amide and Degradation of Methylene Blue Using BiOCl-TiO2 Nano Heterostructures in 2020, Cited 46. Name: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Facile green synthesis of BiOCl-TiO2 was done using combustion technique by Ixora coccinea leaf extract as fuel source. The said material was characterized using XRD, SEM, EDX, HRTEM, SAED, FTIR, and UV-DRS. The particle size was found to be approximately 60 nm and a crystallite size of 0.3 nm from TEM. The photocatalytic activity of the material was found out using photoluminescence studies, dye degradation and photocatalytic organic conversion. The material showed excellent dye degradation capacity for methylene blue with 80% of the dye degraded under 3 hrs. The stabilisation of electron-hole pair by the heterostructure gave it the ability to perform easy degradation. The degradation kinetics have also been studied. It also showed an excellent organic conversion property with formylation yield reaching up to 96% and total conversion of the reactant molecule. The material is a potent photocatalyst due to its great efficiency and can have a remarkable role in the synthesis of important organic molecules and detoxification of environment.Graphical AbstractThe heterostructure catalyses the conversion of amine to amides and mineralizes methylene blue under visible light condition.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis of 3-indolylmethyl substituted (pyrazolo/benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM) WOS:000487812000051 published article about 1,2,3-BENZOTRIAZIN-4-ONE DERIVATIVES; NEMATOCIDAL ACTIVITIES; INDOLES; 1-ALKYNES; RV1885C; 2-HETEROARYL; DOCKING; PROTEIN; 2-ARYL in [Reddy, Gangireddy Sujeevan; Snehalatha, Ampalam Venkata; Edwin, Rebecca Kristina; Hossain, Kazi Amirul; Misra, Parimal; Pal, Manojit] Dr Reddys Inst Life Sci, Univ Hyderabad Campus, Hyderabad 500046, India; [Reddy, Gangireddy Sujeevan; Giliyaru, Varadaraj Bhat; Hariharapura, Raghu Chandrashekhar; Shenoy, G. Gautham] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India in 2019, Cited 38. HPLC of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria. A series of 3-indolylmethyl substituted pyrazolo-triazinone derivatives were designed and docked into CM in silico as potential inhibitors. These compounds were efficiently synthesized using the Pd/Cu-catalyzed coupling-cyclization in a single pot involving the construction of indole ring. The methodology was later extended to the preparation of corresponding benzo analogs of pyrazolotriazinones i.e. 3-indolylmethyl substituted benzotriazinone derivatives. Several of these novel compounds showed significant inhibition of CM when tested in vitro at 30 mu M. The SAR (Structure-Activity-Relationship) studies suggested that benzotriazinone moiety was more favorable over the pyrazolotriazinone ring. The two best active compounds showed IC50 similar to 0.4-0.9 mu M (better than the reference/known compounds used) and no toxicity till 30 mu M in vitro.

HPLC of Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem