Category: 88-68-6

In 2020 EUR J MED CHEM published article about BIOLOGICAL EVALUATION; AMPK; ADIPOGENESIS/LIPOGENESIS; DERIVATIVES; INHIBITORS; DESIGN; MICE in [Rao, Yong; Xu, Zhao; Hu, Yu-Tao; Li, Chan; Xu, Yao-Hao; Song, Qin-Qin; Yu, Hong; Song, Bing-Bing; Chen, Shuo-Bin; Li, Qing-Jiang; Huang, Shi-Liang; Tan, Jia-Heng; Ou, Tian-Miao; Wang, Hong-Gen; Huang, Zhi-Shu] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Guangdong, Peoples R China; [Ye, Ji-Ming] RMIT Univ, Sch Hlth & Biomed Sci, Mol Pharmacol Diabet Grp, Melbourne, Vic 3083, Australia; [Zhong, Guo-Ping] Sun Yat Sen Univ, Sch Pharmaceut Sci, Lab Drug Metab & Pharmacokinet, Guangzhou, Peoples R China in 2020, Cited 34. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Name: 2-Aminobenzamide

Discovery of novel anti-obesity agents is a challenging and promising research area. Based on our previous works, we synthesized 40 novel beta-indoloquinazoline analogues by altering the skeleton and introducing preferential side chains, evaluated their lipid-lowering activity and summarized the structure-activity relationships. In combination with an evaluation of the lipid-lowering efficacies, AMP-dependent activated protein kinase (AMPK) activating ability and liver microsomal stability, compound 23 (named as IQZ23) was selected for further studies. IQZ23 exerted a high efficacy in decreasing the triglyceride level (EC50 = 0.033 mu M) in 3T3-L1 adipocytes. Mechanistic studies revealed the lipid-lowering activity of IQZ23 was dependent on the AMPK pathway by modulating ATP synthase activity. This activation was accompanied by mitochondrial biogenesis and oxidation capacity increased, and insulin sensitivity enhanced in pertinent cell models by various interventions. Correspondingly, IQZ23 (20 mg/kg, i.p.) treatment significantly reversed high fat and cholesterol diet (HFC)- induced body weight increases and accompanying clinical symptoms of obesity in mice but without indicative toxicity. These results indicate that IQZ23 could be a useful candidate for the treatment of obesity and related metabolic disorders. (c) 2020 Elsevier Masson SAS. All rights reserved.

Name: 2-Aminobenzamide. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Dandia, A; Bansal, S; Sharma, R; Mahawar, DK; Rathore, KS; Meena, ML; Parewa, V in [Dandia, Anshu; Bansal, Sarika; Sharma, Ruchi; Mahawar, Dinesh Kumar; Meena, Mohan Lal; Parewa, Vijay] Univ Rajasthan, Dept Chem, Ctr Adv Studies, Jaipur, Rajasthan, India; [Rathore, Kuldeep S.] Arya Coll Engn & IT, Dept Phys, Jaipur, Rajasthan, India; [Meena, Mohan Lal] Natl Taiwan Univ, Dept Chem Engn, Taipei, Taiwan published Nanoporous Cu doped ZnS nanoparticles an efficient photo catalyst for the chemoselective synthesis of 2-substituted azoles via C-N arylation/CSp(3)-H oxidation/cyclization/dehydration sequence in visible light in 2020, Cited 91. Recommanded Product: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

ZnS and Cu:ZnS nanoparticles were prepared by aqueous chemical method and characterized by several analytical tools. Nanoparticles have an average size of about similar to 18 nm and possess highly open mesopores, moderate surface area, and uniform morphology. UV-vis spectra designate that doping of Cu shifted the optical response of the ZnS nanoparticles in to a visible region. These Cu:ZnS nanoparticles were employed as a photocatalyst for chemoselective synthesis of 2-substituted azoles by the reaction of benzyl bromides and 1,2-Diaminobenzene or 2-Mercaptoaniline in visible light. Analogous experiments confirmed that the reaction were proceeds through one pot C-N arylation/ CSp(3)- H oxidation/ cyclization/dehydration sequence. The enhanced catalytic activity by doping could be attributed to the presence of trapping level generated by copper doping which augments the relaxation time of electron and holes so that they are easily available for the reaction. The method was also applicable for the synthesis of quinazolin-4(3H)-ones.

Welcome to talk about 88-68-6, If you have any questions, you can contact Dandia, A; Bansal, S; Sharma, R; Mahawar, DK; Rathore, KS; Meena, ML; Parewa, V or send Email.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Substrate Profiling of the Cobalt Nitrile Hydratase from Rhodococcus rhodochrous ATCC BAA 870 WOS:000513770000238 published article about ENANTIOSELECTIVE BIOTRANSFORMATIONS; INDUSTRIAL-PRODUCTION; J1; HYDROLYSIS; REGIOSELECTIVITY; PURIFICATION; BENZONITRILE; DINITRILES; INSIGHTS; AMIDASE in [Mashweu, Adelaide R.; Chhiba-Govindjee, Varsha P.; Bode, Moira L.; Brady, Dean] Univ Witwatersrand, Sch Chem, Mol Sci Inst, ZA-2050 Johannesburg, South Africa; [Chhiba-Govindjee, Varsha P.] CSIR Chem Prod Cluster, POB 395, ZA-0001 Pretoria, South Africa in 2020, Cited 41. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Application In Synthesis of 2-Aminobenzamide

The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ranging in size from small (90 Da) to large (325 Da) were evaluated. Larger compounds included those with a bi-aryl axis, prepared by the Suzuki coupling reaction, Morita-Baylis-Hillman adducts, heteroatom-linked diarylpyridines prepared by Buchwald-Hartwig cross-coupling reactions and imidazo[1,2-a]pyridines prepared by the Groebke-Blackburn-Bienayme multicomponent reaction. The enzyme active site was moderately accommodating, accepting almost all of the small aromatic nitriles, the diarylpyridines and most of the bi-aryl compounds and Morita-Baylis-Hillman products but not the Groebke-Blackburn-Bienayme products. Nitrile conversion was influenced by steric hindrance around the cyano group, the presence of electron donating groups (e.g., methoxy) on the aromatic ring, and the overall size of the compound.

Welcome to talk about 88-68-6, If you have any questions, you can contact Mashweu, AR; Chhiba-Govindjee, VP; Bode, ML; Brady, D or send Email.. Application In Synthesis of 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Crystallography very interesting. Saw the article Synthesis, molecular packing and anti-cholinesterase activity of some new C-2 N-substituted anthranilamide derivatives published in 2019. Product Details of 88-68-6, Reprint Addresses Sarfraz, M; Tariq, MI (corresponding author), Univ Sargodha, Dept Chem, Sargodha 40100, Pakistan.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

Synthesis of C-2 N-substituted anthranilamide derivatives was carried out in a straight forward manner, utilizing 2-aminobenzamide and benzyl chloride as starting materials. Their crystal structures have been established by single crystal X-ray crystallographic method. In the molecules of 2-benzylamino-benzamide (3a), intramolecular hydrogen bonding b/w O atom and proton of -NH and classical intermolecular hydrogen bonding of the type N-H center dot center dot center dot O forming eight membered rings in R-4(2)(8) pattern. In both molecules of 2-(dibenzylamino)benzamide (3b), unlike the molecule in 3a, each H atoms is pointed towards N atom causing intramolecular hydrogen bonding interactions, resulting in S(6) motifs. However, it is interesting to note that both molecules in 3b are lying about inversion centres and form dimers in R-4(2)(8) motifs; the two dimers are linked via non-classical intermolecular hydrogen bonds C-H center dot center dot center dot O resulting in clusters of four molecules in the structure. In vitro assay results revealed that molecule 3b with IC50 values of 3.8 +/- 0.08 mu M (AChE) and 17.6 +/- 1.10 mu M (BChE) possessed better cholinesterase (AChE and BChE) inhibition potential as compared to standard drug galantamine. Preliminary in silico studies showed that more biological active derivatives were also having good pharmacokinetic profile with no AMES toxicity and carcinogenicity.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 2-Aminobenzamide. Authors Vaidya, GN; Nagpure, M; Kumar, D in AMER CHEMICAL SOC published article about in [Vaidya, Gargi Nikhil; Nagpure, Mithilesh; Kumar, Dinesh] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Gandhinagar 382355, Gujarat, India in 2021, Cited 72. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A borrowing carbonate-enabled allylic cross-amination reactions employing allylic alcohol were discovered via merging acyl/allyl C-O bonds activation under nickel catalysis. The key component of this protocol is the ability of nickel [Ni(II)-Ni(0)] to execute a relay process via the nucleophilic trapping of the generated acyl Ni complex, resulting from the acyl C-O bond cleavage of dialkyl carbonates, followed by selective allylic C-O bond activations (allylic C-O vs alkyl C-O vs acyl C-O) to yield pi-allyINi-complexes. The finding truly represents Ni-catalyzed green allylic amination reactions under additive(s)-free conditions with excellent chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) with a wide range of fundamentally challenging N-heterocycles and allylic alcohols. The reaction is scalable, does not require harmful reaction media and a globe box, and is successfully applied to the scale-up synthesis of pharmaceuticals (cinnarizine, flunarizine, and naftifine) with promising yields.

Welcome to talk about 88-68-6, If you have any questions, you can contact Vaidya, GN; Nagpure, M; Kumar, D or send Email.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article One-Pot Synthesis of Diverse Collections of Benzoxazepine and Indolopyrazine Fused to Heterocyclic Systems WOS:000456632800044 published article about HOMOFASCAPLYSIN-B; EVODIAMINE; DERIVATIVES; CASCADE; ROUTE; FASCAPLYSIN; INHIBITORS; ALKALOIDS; ACCESS in [Srinivasulu, Vunnam; Sebastian, Anusha; Al-Tel, Taleb H.] Univ Sharjah, Sharjah Inst Med Res, POB 27272, Sharjah, U Arab Emirates; [Shehadeh, Ihsan; Malik, Omar G.] Univ Sharjah, Coll Sci, Dept Chem, POB 27272, Sharjah, U Arab Emirates; [Tarazi, Hamadeh; Baniowda, Nabil; Al-Tel, Taleb H.] Univ Sharjah, Coll Pharm, POB 27272, Sharjah, U Arab Emirates; [Abu-Yousef, Imad A.] Amer Univ Sharjah, Coll Arts & Sci, Dept Biol Chem & Environm Sci, Sharjah, U Arab Emirates; [Khanfar, Monther A.] Univ Jordan, Dept Chem, Amman 11942, Jordan; [O’Connor, Matthew John] New York Univ Abu Dhabi, POB 129188, Abu Dhabi, U Arab Emirates in 2019, Cited 50. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Recommanded Product: 88-68-6

The development of efficient and modular synthetic methods for the synthesis of diverse collection of privileged substructures needed for a drug design and discovery campaign is highly desirable. Benzoxazepine and indolopyrazine ring systems form the core structures of distinct members of biologically significant molecules. Several members of these families have gained attention due to their broad biological activities, which depend on the type of ring-fusion and peripheral substitution patterns. Despite the potential applications of these privileged substructures in drug discovery, efficient, atom economic, and modular strategies for their access are underdeveloped. Herein, a one-step build/couple/pair strategy that uniquely allows access to diversely functionalized benzoxazepine and indolopyrazine scaffolds is described. The methodology features a one-pot combination of condensation, Mannich, oxidation, and aza-Michael addition reactions, employing a variety of functionalized anilines and aldehydes suitably poised with Micheal acceptor. Scandium triflate (Sc(OTf)(3)) in acetonitrile (ACN) was found to promote the construction of benzoxazepines scaffolds, while sodium metabisulfite (Na2S2O5) in aqueous EtOH rapidly enhanced the cascade reaction that led to diverse collections of indolopyrazine frameworks. These protocols represent modular, efficient, and atom-economic access of constrained benzoxazepine and indolopyrazine systems with more than 10 points of diversity and large substrate tolerance.

Recommanded Product: 88-68-6. Welcome to talk about 88-68-6, If you have any questions, you can contact Srinivasulu, V; Shehadeh, I; Khanfar, MA; Malik, OG; Tarazi, H; Abu-Yousef, IA; Sebastian, A; Baniowda, N; O’Connor, MJ; Al-Tel, TH or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Styryl quinazolinones and its ethynyl derivatives induce myeloid differentiation published in 2019. HPLC of Formula: C7H8N2O, Reprint Addresses Radhakrishnan, S; Tenen, DG; Kobayashi, SS (corresponding author), Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

The tumor suppressor transcription factor CCAAT enhancer-binding protein alpha (C/EBP alpha) expression is down-regulated in myeloid leukemias and enhancement of C/EBP alpha expression induces granulocytic differentiation in leukemic cells. Previously we reported that Styryl quinazolinones induce myeloid differentiation in HL-60 cells by upregulating C/EBP alpha expression. To identify more potent molecule that can induce leukemic cell differentiation we synthesized and evaluated new series of styryl quinazolinones, ethynyl styryl quinazolinones, styryl quinolinones and thienopyrimidinones. Thienopyrimidinones were found toxic and styryl quinolinones were found inactive. Ethynyl styryl quinazolinone 39 and styryl quinazolinone 5 were found active on par with the earlier reported analogues 1 and 2 suggesting that the 5-nitro furan-2-yl styryl quinazolinones find a real promise in leukemic cell differentiation. The improved potency of 5 suggested that further modifications in the 5-nitro furan-2-yl styryl quinazolinones can be at the phenyl substitution at the 3-position of the quinazolinone ring apart from the 5-position of the heteroaryl ring.

HPLC of Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Radhakrishnan, S; Syed, R; Takei, H; Kobayashi, IS; Nakamura, E; Sultana, F; Kamal, A; Tenen, DG; Kobayashi, SS or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Copper-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1 H )-ones from 2-Nitrobenzonitriles and Carbonyl Compounds Mediated by Diboronic Acid in Methanol-Water WOS:000509900900013 published article about AROMATIC O-AMINONITRILE; GREEN SYNTHESIS; COMBINATORIAL SYNTHESIS; COORDINATION POLYMER; FACILE SYNTHESIS; AQUEOUS-MEDIA; QUINAZOLINONES; DERIVATIVES; ALDEHYDES; EFFICIENT in [Liu, Qixing; Sui, Yuebo; Zhang, Yin; Zhang, Kaili; Chen, Yongsheng; Zhou, Haifeng] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Res Ctr Green Pharmaceut Technol & Proc, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China in 2020, Cited 50. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Computed Properties of C7H8N2O

A copper-catalyzed one-pot synthesis of 2,3-dihydroquinazolin-4(1 H )-ones with diboronic acid as a reductant in an aqueous medium is described. Various 2,3-dihydroquinazolin-4(1 H )-ones were prepared with good functional-group tolerance in good yields under mild conditions from readily available 2-nitrobenzonitriles and various carbonyl compounds.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Liu, QX; Sui, YB; Zhang, Y; Zhang, KL; Chen, YS; Zhou, HF or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Photocatalyst-free visible-light-promoted quinazolinone synthesis at room temperature utilizing aldehydes generated in situ via C=C bond cleavage WOS:000632575900022 published article about MOLECULAR-OXYGEN; EFFICIENT; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES; OXIDATION; ALKENES; DERIVATIVES; DESIGN; FACILE; CYCLIZATION; OZONOLYSIS in [Xie, Zongbo; Lan, Jin; Yan, Liyuan; Chen, Xuehua; Li, Qian; Meng, Jia; Le, Zhanggao] East China Univ Technol, Jiangxi Prov Key Lab Synthet Chem, Nanchang 330013, Jiangxi, Peoples R China; [Xie, Zongbo; Lan, Jin; Yan, Liyuan; Chen, Xuehua; Li, Qian; Meng, Jia; Le, Zhanggao] East China Univ Technol, Sch Chem Biol & Mat Sci, Nanchang 330013, Jiangxi, Peoples R China in 2021, Cited 62. SDS of cas: 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

This is the first report on a facile tandem route for synthesizing quinazolinones at room temperature from various aminobenzamides and in situ-generated aldehydes. The latter was formed via C=C bond cleavage, and the overall reaction proceeded using molecular oxygen as a clean oxidant in the absence of a photocatalyst. Visible light, which was indispensable for the entire course of the reaction, played multiple roles. It initially cleaved styrene to an aldehyde, then facilitated its cyclization with an o-substituted aniline, and finally promoted the dehydrogenation of the cyclized intermediate. The previous step provided the feedstock for the next step in the reaction, thereby preventing volatilization, oxidation, and polymerization of the aldehyde. Thus, the overall process is simple, environmentally benign, and economically feasible.

Welcome to talk about 88-68-6, If you have any questions, you can contact Xie, ZB; Lan, J; Yan, LY; Chen, XH; Li, Q; Meng, J; Le, ZG or send Email.. SDS of cas: 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chen, H; Li, P; Qin, RF; Yan, H; Li, G; Huang, HH in [Li, Peng; Qin, Rongfei; Li, Gang; Huang, Haihong] Peking Union Med Coll & Chinese Acad Med Sci, Beijing Key Lab Act Subst Discovery & Druggabil E, Inst Mat Med, Beijing 100050, Peoples R China; [Li, Peng; Qin, Rongfei; Li, Gang; Huang, Haihong] Peking Union Med Coll & Chinese Acad Med Sci, Chinese Acad Med Sci, Key Lab AntiDR TB Innovat Drug Res, Inst Mat Med, Beijing 100050, Peoples R China; [Chen, Hui; Yan, Hong] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing Key Lab Environm & Viral Oncol, Beijing 100124, Peoples R China published DMAP-Catalyzed One-Pot Synthesis of Quinazoline-2,4-diones from 2-Aminobenzamides and Di-tert-butyl Dicarbonate in 2020, Cited 40. Computed Properties of C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The one-pot synthesis of quinazoline-2,4-diones was developed in the presence of 4-dimethylaminopyridine (DMAP) by metal-free catalysis. The commercially available (Boc)(2)O acted as a key precursor in the construction of the 2-position carbonyl of quinazolinediones. The p-methoxybenzyl (PMB)-activated hetero- cyclization could smoothly proceed at room temperature instead of the microwave condition. This strategy is compatible with a variety of substrates with different functional groups. Furthermore, this protocol was utilized to smoothly prepare Zenarestat with a total yield of 70%.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Chen, H; Li, P; Qin, RF; Yan, H; Li, G; Huang, HH or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem