Category: 88-68-6

Application In Synthesis of 2-Aminobenzamide. I found the field of Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Synthesis, crystal structure and antimicrobial activity of 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives against phytopathogens published in 2019, Reprint Addresses Bao, XP (corresponding author), Guizhou Univ, Ctr Res & Dev Fine Chem, Minist Educ,Key Lab Green Pesticide & Agr Bioengn, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Guizhou, Peoples R China.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide.

A total of eighteen 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives were designed and synthesized, via hybrid pharmacophore approach. Among these compounds, chemical structure of compound 4a was unambiguously confirmed by means of single-crystal X-ray diffraction analysis. All the compounds were evaluated in vitro for their inhibition activity against several important phytopathogenic bacteria and fungi in agriculture. The obtained results indicated that several compounds demonstrated potent antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo). For example, compounds 4c, 4g and 4q had EC50 values of 35.0, 36.5 and 32.4 mu g/mL toward this bacterium, respectively, around 1.5 times more active than commercial bactericide bismerthiazol (EC50 = 89.8 mu g/mL). Additionally, compounds 4j and 4p were found to display comparable antifungal activity against Gloeosporium fructigenum at 50 mu g/mL, to commercial fungicide hymexazol. Finally, the relationships between antibacterial activities and molecular structures of this class of compounds were discussed in detail. [GRAPHICS] .

Application In Synthesis of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Fan, ZJ; Shi, J; Luo, N; Bao, XP or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 2-Aminobenzamide. Meng, GY; Guo, TJ; Ma, TC; Zhang, J; Shen, YC; Sharpless, KB; Dong, JJ in [Meng, Genyi; Guo, Taijie; Ma, Tiancheng; Zhang, Jiong; Shen, Yucheng; Sharpless, Karl Barry; Dong, Jiajia] Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem,Chinese Acad Sci, Shanghai, Peoples R China published Modular click chemistry libraries for functional screens using a diazotizing reagent in 2019, Cited 33. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Click chemistry is a concept in which modular synthesis is used to rapidly find new molecules with desirable properties(1). Copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) triazole annulation and sulfur(VI) fluoride exchange (SuFEx) catalysis are widely regarded as click reactions(2-4), providing rapid access to their products in yields approaching 100% while being largely orthogonal to other reactions. However, in the case of CuAAC reactions, the availability of azide reagents is limited owing to their potential toxicity and the risk of explosion involved in their preparation. Here we report another reaction to add to the click reaction family: the formation of azides from primary amines, one of the most abundant functional groups(5). The reaction uses just one equivalent of a simple diazotizing species, fluorosulfuryl azide(6-11) (FSO2N3), and enables the preparation of over 1,200 azides on 96-well plates in a safe and practical manner. This reliable transformation is a powerful tool for the CuAAC triazole annulation, the most widely used click reaction at present. This method greatly expands the number of accessible azides and 1,2,3-triazoles and, given the ubiquity of the CuAAC reaction, it should find application in organic synthesis, medicinal chemistry, chemical biology and materials science.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Computed Properties of C7H8N2O. Kim, S; Jeoung, D; Kim, K; Lee, SB; Lee, SH; Park, MS; Ghosh, P; Mishra, NK; Hong, S; Kim, IS in [Kim, Saegun; Jeoung, Daeun; Kim, Kunyoung; Lee, Suk Hun; Park, Min Seo; Ghosh, Prithwish; Mishra, Neeraj Kumar; Kim, In Su] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; [Lee, Seok Beom; Hong, Suckchang] Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea published Site-Selective C-H Amidation of 2-Aryl Quinazolinones Using Nitrene Surrogates in 2020, Cited 47. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The site-selective modifications of quinazolinones constitute a pivotal topic in drug discovery and material science. Herein, we describe the rhodium(III)-catalyzed C-H amidation of 2-aryl quinazolin-4(3H)-ones with a range of nitrene surrogates including dioxazolones, organic azides, andN-methoxyamides. Complete site-selectivity and functional group tolerance are observed. Notably, the large-scale reaction and late-stage functionalization highlight the synthetic potential of the developed protocol. Combined mechanistic investigations elucidate a plausible reaction mechanism of this process.

Computed Properties of C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Kim, S; Jeoung, D; Kim, K; Lee, SB; Lee, SH; Park, MS; Ghosh, P; Mishra, NK; Hong, S; Kim, IS or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Novanna, M; Kannadasan, S; Shanmugam, P in [Novanna, Motakatla; Kannadasan, Sathananthan] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India; [Shanmugam, Ponnusamy] CSIR, Organ & Bioorgan Chem Div, Cent Leather Res Inst, Chennai 600020, Tamil Nadu, India published A facile synthesis of (Z)-1, 6-disubstituted-7H-benzo[b][1,5]diazonin-7-one derivatives via arylation-allylation-RCM pathway of anthranilamide and isatoic anhydride in 2019, Cited 46. SDS of cas: 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A facile and efficient method has been developed for the synthesis of (2)-6-allyl-1-phenyl-1,2,5,6tetrahydro-7H-benzo[b][1,5]-diazonin-7-one and (Z)-1,6-diphenyl-1,2,5,6-tetrahydro-7H-benzo[b][1,5]-diazonin-7-one from anthranilamide via N-arylation/N-allylation and from isatoic anhydride via ring opening/N-arylation/N-allylation followed by ring closing metathesis using Grubbs-II catalyst as a key step. Grubbs-II catalyst was found to be superior over Grubbs-I catalyst in terms of reaction time and yield of the product, and the routes developed were suitable to synthesize benzo fused nine membered nitrogen heterocycles. The requirement of diallylated substrates with protected amine and amide nitrogen is suitable for RCM has been established for the synthesis of diazoninone derivatives. (C) 2019 Elsevier Ltd. All rights reserved.

SDS of cas: 88-68-6. Welcome to talk about 88-68-6, If you have any questions, you can contact Novanna, M; Kannadasan, S; Shanmugam, P or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of 2-Aminobenzamide. Recently I am researching about BIOLOGICAL EVALUATION; AMPK; ADIPOGENESIS/LIPOGENESIS; DERIVATIVES; INHIBITORS; DESIGN; MICE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672265, 81930098, 81872732, 81703336]; Special Fund for Science and Technology Development in Guangdong Province [2016A020217004]; Science and Technology Program of Guangzhou [201704020104]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2017A030308003]; 111 ProjectMinistry of Education, China – 111 Project [B16047]; Ministry of Education of ChinaMinistry of Education, China [IRT-17R111]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [31610915]; Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Y093]; Guangdong Provincial Key Laboratory of Construction Foundation [2017B030314030]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Rao, Y; Xu, Z; Hu, YT; Li, C; Xu, YH; Song, QQ; Yu, H; Song, BB; Chen, SB; Li, QJ; Huang, SL; Tan, JH; Ou, TM; Wang, HG; Zhong, GP; Ye, JM; Huang, ZS. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

Discovery of novel anti-obesity agents is a challenging and promising research area. Based on our previous works, we synthesized 40 novel beta-indoloquinazoline analogues by altering the skeleton and introducing preferential side chains, evaluated their lipid-lowering activity and summarized the structure-activity relationships. In combination with an evaluation of the lipid-lowering efficacies, AMP-dependent activated protein kinase (AMPK) activating ability and liver microsomal stability, compound 23 (named as IQZ23) was selected for further studies. IQZ23 exerted a high efficacy in decreasing the triglyceride level (EC50 = 0.033 mu M) in 3T3-L1 adipocytes. Mechanistic studies revealed the lipid-lowering activity of IQZ23 was dependent on the AMPK pathway by modulating ATP synthase activity. This activation was accompanied by mitochondrial biogenesis and oxidation capacity increased, and insulin sensitivity enhanced in pertinent cell models by various interventions. Correspondingly, IQZ23 (20 mg/kg, i.p.) treatment significantly reversed high fat and cholesterol diet (HFC)- induced body weight increases and accompanying clinical symptoms of obesity in mice but without indicative toxicity. These results indicate that IQZ23 could be a useful candidate for the treatment of obesity and related metabolic disorders. (c) 2020 Elsevier Masson SAS. All rights reserved.

About 2-Aminobenzamide, If you have any questions, you can contact Rao, Y; Xu, Z; Hu, YT; Li, C; Xu, YH; Song, QQ; Yu, H; Song, BB; Chen, SB; Li, QJ; Huang, SL; Tan, JH; Ou, TM; Wang, HG; Zhong, GP; Ye, JM; Huang, ZS or concate me.. Quality Control of 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about HISTONE DEACETYLASE SIRT6; GLUCOSE-HOMEOSTASIS; TUMOR-SUPPRESSOR; PROTEIN; CANCER; PROMOTES; PGC-1-ALPHA; ACTIVATION; CHROMAN-4-ONE; ACETYLATION, Saw an article supported by the JST CREST programJapan Science & Technology Agency (JST)Core Research for Evolutional Science and Technology (CREST) [JPMJCR14L2]; JST A-step program [957908]; JSPSMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Mellini, P; Itoh, Y; Elboray, EE; Tsumoto, H; Li, Y; Suzuki, M; Takahashi, Y; Tojo, T; Kurohara, T; Miyake, Y; Miura, Y; Kitao, Y; Kotoku, M; Iida, T; Suzuki, T. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Recommanded Product: 2-Aminobenzamide

The NAD(+)-dependent deacetylase SIRT2 represents an attractive target for drug development. Here, we designed and synthesized drug-like SIRT2-selective inhibitors based on an analysis of the putative binding modes of recently reported SIRT2-selective inhibitors and evaluated their SIRT2-inhibitory activity. This led us to develop a more drug-like diketopiperazine structure as a hydrogen bond (H-bond) hunter to target the substrate-binding site of SIRT2. Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the selectivity pocket of SIRT2, exhibited potent SIRT2-selective inhibition. Inhibition of SIRT2 by 53 was mediated by the formation of a 53-ADP-ribose conjugate, suggesting that 53 is a mechanism-based inhibitor targeting the selectivity pocket, substrate-binding site, and NAD(+)-binding site. Furthermore, 53 showed potent antiproliferative activity toward breast cancer cells and promoted neurite outgrowth of Neuro-2a cells. These findings should pave the way for the discovery of novel therapeutic agents for cancer and neurological disorders.

Welcome to talk about 88-68-6, If you have any questions, you can contact Mellini, P; Itoh, Y; Elboray, EE; Tsumoto, H; Li, Y; Suzuki, M; Takahashi, Y; Tojo, T; Kurohara, T; Miyake, Y; Miura, Y; Kitao, Y; Kotoku, M; Iida, T; Suzuki, T or send Email.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Li, ED; Lin, Q; Meng, YQ; Zhang, LY; Song, PP; Li, N; Xin, JC; Yang, P; Bao, CN; Zhang, DQ; Zhang, Y; Wang, JK; Zhang, QR; Liu, HM in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about BIOLOGICAL EVALUATION; DERIVATIVES; PI3K/AKT/MTOR; GEFITINIB; PATHWAY; DESIGN; GROWTH in [Li, Er-dong; Lin, Qiao; Meng, Ya-qi; Zhang, Lu-ye; Song, Pan-pan; Li, Na; Xin, Jing-chao; Yang, Peng; Bao, Chong-nan; Zhang, Dan-qing; Zhang, Yang; Wang, Ji-kuan; Zhang, Qiu-rong; Liu, Hong-min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China; [Li, Er-dong; Lin, Qiao; Meng, Ya-qi; Zhang, Lu-ye; Song, Pan-pan; Li, Na; Xin, Jing-chao; Yang, Peng; Bao, Chong-nan; Zhang, Dan-qing; Zhang, Yang; Wang, Ji-kuan; Zhang, Qiu-rong; Liu, Hong-min] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 32. Computed Properties of C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A series of novel 2,4-disubstituted quinazolines were synthesized and evaluated for their anti-tumor activity against five human cancer cells (MDA-MB-231, MCF-7, PC-3, HGC-27 and MGC-803) using MIT assay. Among them, compound 9n showed the most potent cytotoxicity against breast cancer cells. Compound 9n also significantly inhibited the colony formation and migration of MDA-MB-231 and MCF-7 cells. Meanwhile, compound 9n induced cell cycle arrest at G1 phase and cell apoptosis, as well as increased accumulation of intracellular ROS. Furthermore, compound 9n exerted anti-tumor effects in vitro via decreasing the expression of anti-apoptotic protein Bcl-2 and increasing the pro-apoptotic protein Bax and p53. Mechanistically, compound 9n markedly decreased p-EGFR and p-PI3K expression, which revealed that compound 9n targeted breast cancer cells via interfering with EGFR-PI3K signaling pathway. Molecular docking suggested that compound 9n could indeed bind into the active pocket of EGFR. All the findings suggest that compound 9n might be a valuable lead compound for anti-tumor agents targeting breast cancer cells. (C) 2019 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 88-68-6, If you have any questions, you can contact Li, ED; Lin, Q; Meng, YQ; Zhang, LY; Song, PP; Li, N; Xin, JC; Yang, P; Bao, CN; Zhang, DQ; Zhang, Y; Wang, JK; Zhang, QR; Liu, HM or send Email.. Computed Properties of C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Kamble, RB; Mane, KD; Rupanawar, BD; Korekar, P; Sudalai, A; Suryavanshi, G in [Kamble, Rohit B.; Mane, Kishor D.; Rupanawar, Bapurao D.; Sudalai, A.; Suryavanshi, Gurunath] CSIR, Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India; [Kamble, Rohit B.; Mane, Kishor D.; Rupanawar, Bapurao D.; Sudalai, A.; Suryavanshi, Gurunath] Acad Sci & Innovat Res, Ghaziabad 201002, UP, India; [Korekar, Pranjal] MES Abasaheb Garware Coll, Dept Chem, Pune 411004, Maharashtra, India published Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: synthesis of primary amides in 2020, Cited 55. Recommanded Product: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.

Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about PHOTOCATALYTIC OXIDATION; CASCADE SYNTHESIS; CATALYSTS; ALCOHOLS; MOF; QUINAZOLINONES; AMINES; FE; HYDROXYLATION; PERFORMANCE, Saw an article supported by the University of Zabol [UOZ-GR-9517-5]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Ghaleno, MR; Ghaffari-Moghaddam, M; Khajeh, M; Oveisi, AR; Bohlooli, M. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Recommanded Product: 88-68-6

A bioinspired iron(III)porphyrinic Zr-MOF, PCN-222(Fe), was modified by post-synthetic cluster metalation with iron(III) chloride, as a cheap, earth-abundant, and environmentally friendly metal precursor, towards formation a new multifunctional MOF, namely Fe@PCN-222(Fe). The MOF consists of bimetallic (Zr-oxo-Fe) nodes linked by Fe(III)porphyrin struts. The cluster metalation and pre-activation treatment of PCN-222(Fe) were performed cooperatively using the FeCl3. The respective MOF was characterized through various techniques, such as FT-IR, PXRD, ICP-AES, BET surface area, SEM, UV-Vis DRS, TGA/DSC, PL, and XPS analyses. The solid showed catalytic activity for one-pot tandem synthesis of quinazolin-4(3H)-ones from alcohols and 2-aminobenzamide through a three-consecutive-step reaction (oxidation-cyclization-oxidation) under visible light irradiation using air or oxygen without adding any additive. In addition, its catalytic performance was superior to that of the bare PCN-222(Fe) and the corresponding homogeneous catalysts. The experiments indicate that the solid MOF acts as both a photoredox and Lewis acid catalyst. Hot-filtration and Fe-leaching tests as well as reusability experiments confirm that the nominal MOF acts as an efficient reusable heterogeneous catalyst for at least three runs without significant decrease in its activity. This work demonstrates the potential of using MOFs as supports for single-site metal species towards preparation of multifunctional MOFs for modern organic transformations combining photocatalysis and catalysis. (C) 2018 Elsevier Inc. All rights reserved.

Recommanded Product: 88-68-6. Welcome to talk about 88-68-6, If you have any questions, you can contact Ghaleno, MR; Ghaffari-Moghaddam, M; Khajeh, M; Oveisi, AR; Bohlooli, M or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Hou, B; Yang, S; Yang, KW; Han, X; Tang, XH; Liu, Y; Jiang, JW; Cui, Y in WILEY-V C H VERLAG GMBH published article about CIRCULARLY-POLARIZED LUMINESCENCE; ASYMMETRIC-SYNTHESIS; BINOL; CRYSTALLINE; CONSTRUCTION; STABILITY; MOLECULES; STRATEGY; PLATFORM; DESIGN in [Hou, Bang; Yang, Shi; Han, Xing; Tang, Xianhui; Liu, Yan; Cui, Yong] Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; [Hou, Bang; Yang, Shi; Han, Xing; Tang, Xianhui; Liu, Yan; Cui, Yong] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China; [Yang, Kuiwei; Jiang, Jianwen] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore in 2021, Cited 78. COA of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

3D covalent organic frameworks (COFs) with well-defined porous channels are shown to be capable of inducing chiral molecular catalysts from non-enantioselective to highly enantioselective in catalyzing organic transformations. By condensations of a tetrahedral tetraamine and two linear dialdehydes derived from enantiopure 1,1 ‘-binaphthol (BINOL), two chiral 3D COFs with a 9-fold or 11-fold interpenetrated diamondoid framework are prepared. Enhanced Bronsted acidity was observed for the chiral BINOL units that are uniformly distributed within the tubular channels compared to the non-immobilized acids. This facilitates the Bronsted acid catalysis of cyclocondensation of aldehydes and anthranilamides to produce 2,3-dihydroquinazolinones. DFT calculations show the COF catalyst provides preferential secondary interactions between the substrate and framework to induce enantioselectivities that are not achievable in homogeneous systems.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem