Category: 64-10-8

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia published in 2019.0. Product Details of 64-10-8, Reprint Addresses Xiong, B (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China.; Geng, MY; Huang, X (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China.; Geng, MY; Huang, X; Xiong, B (corresponding author), Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China.. The CAS is 64-10-8. Through research, I have a further understanding and discovery of 1-Phenylurea

PRMT4 is a type I protein arginine methyltransferase and plays important roles in various cellular processes. Overexpression of PRMT4 has been found to be involved in several types of cancers. Selective and in vivo effective PRMT4 inhibitors are needed for demonstrating PRMT4 as a promising therapeutic target. On the basis of compound 6, a weak dual PRMT4/6 inhibitor, we constructed a tetrahydroisoquinoline scaffold through a cut-and-sew scaffold hopping strategy. The subsequent SAR optimization efforts employed structure-based approach led to the identification of a novel PRMT4 inhibitor 49. Compound 49 exhibited prominently high potency and selectivity, moderate pharmacokinetic profiles, and good antitumor efficacy in acute myeloid leukemia xenograft model via oral administration, thus demonstrating this compound as a useful pharmacological tool for further target validation and drug development in cancer therapy.

Product Details of 64-10-8. About 1-Phenylurea, If you have any questions, you can contact Guo, ZH; Zhang, ZQ; Yang, H; Cao, DY; Xu, XW; Zheng, XN; Chen, DQ; Wang, Q; Li, YL; Li, J; Du, ZY; Wang, X; Chen, L; Ding, J; Shen, JK; Geng, MY; Huang, X; Xiong, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of 1-Phenylurea. Ozturk, B; Werner, J; Meier-Kolthoff, JP; Bunk, B; Sproer, C; Springael, D in [Ozturk, Basak] Leibniz Inst DSMZ, German Collect Microorganisms & Cell Cultures, Jr Res Grp Microbial Biotechnol, Braunschweig, Germany; [Ozturk, Basak; Springael, Dirk] Katholieke Univ Leuven, Div Soil & Water Management, Leuven, Belgium; [Werner, Johannes] Leibniz Inst Baltic Sea Res, Dept Biol Oceanog, Rostock, Germany; [Meier-Kolthoff, Jan P.; Bunk, Boyke; Sproer, Cathrin] Leibniz Inst DSMZ, Dept Bioinformat & Databases, German Collect Microorganisms & Cell Cultures, Braunschweig, Germany published Comparative Genomics Suggests Mechanisms of Gene is Adaptation toward the Catabolism of the Phenylurea Herbicide Linuron in Variovorax in 2020.0, Cited 84.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

Biodegradation of the phenylurea herbicide linuron appears a specialization within a specific Glade of the Variovorax genus. The linuron catabolic ability is likely acquired by horizontal gene transfer but the mechanisms involved are not known. The full-genome sequences of six linuron-degrading Variovorax strains isolated from geographically distant locations were analyzed to acquire insight into the mechanisms of genetic adaptation toward linuron metabolism. Whole-genome sequence analysis confirmed the phylogenetic position of the linuron degraders in a separate Glade within Variovorax and indicated that they unlikely originate from a common ancestral linuron degrader. The linuron degraders differentiated from Variovorax strains that do not degrade linuron by the presence of multiple plasmids of 20-839 kb, including plasmids of unknown plasmid groups. The linuron catabolic gene clusters showed 1) high conservation and synteny and 2) strain-dependent distribution among the different plasmids. Most of them were bordered by IS1071 elements forming composite transposon structures, often in a multimeric array configuration, appointing IS1071 as a key element in the recruitment of linuron catabolic genes in Variovorax. Most of the strains carried at least one (catabolic) broad host range plasmid that might have been a second instrument for catabolic gene acquisition. We conclude that Glade 1 Variovorax strains, despite their different geographical origin, made use of a limited genetic repertoire regarding both catabolic functions and vehicles to acquire linuron biodegradation.

Safety of 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Ozturk, B; Werner, J; Meier-Kolthoff, JP; Bunk, B; Sproer, C; Springael, D or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2020.0 MEMBRANES-BASEL published article about MOLECULARLY IMPRINTED POLYMERS; PHASE EXTRACTION; POTENTIAL STABILITY; CONDUCTING POLYMERS; CONTROLLED-RELEASE; ELECTRODES; PESTICIDES; SAMPLES in [Kamel, Ayman H.] Ain Shams Univ, Fac Sci, Dept Chem, Cairo 11566, Egypt; [Amr, Abd El-Galil E.; Al-Omar, Mohamed A.; Almehizia, Abdulrahman A.] King Saud Univ, Coll Pharm, Pharmaceut Chem Dept, Drug Explorat & Dev Chair DEDC, Riyadh 11451, Saudi Arabia; [Amr, Abd El-Galil E.] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt in 2020.0, Cited 51.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Application In Synthesis of 1-Phenylurea

Solid-contact ion-selective electrodes (SC-ISEs) have shown great potential for routine and portable ion detection. The introduction of nanomaterials as ion-to-electron transducers and the adoption of different performance-enhancement strategies have significantly promoted the development of SC-ISEs. Herein, new solid-contact ion-selective electrodes, along with the implementation of multiwalled carbon nanotubes (MWCNTs) as ion-to-electron transducers and potassium tetrakis (p-chlorophenyl) borate (KTpClB) as lipophilic ionic additives, were presented for the detection of isoproturon (IPU) and diuron (DU) herbicides. Molecularly imprinted polymers (MIPs), with special molecule recognition properties for isoproturon (IPU) and diuron (DU), were prepared, characterized, and introduced as sensory recognition materials in the presented electrodes. Sensors revealed a near-Nernstian response for both isoproturon (IPU) and diuron (DU) with slopes of 53.1 +/- 1.2 (r(2) = 0.997) and 57.2 +/- 0.3 (r(2) = 0.998) over the linear ranges of 2.2 x 10(-6)-1.0 x 10(-3) M and 3.2 x 10(-6)-1.0 x 10(-3) M with detection limits of 8.3 x 10(-7) and 1.4 x 10(-6) M, respectively. The response time of the presented sensors was found to be <5 s and the lifetime was at least eight weeks. The sensors exhibited good selectivity towards isoproturon (IPU) and diuron (DU) in comparison with some other herbicides, alkali, alkaline earth, and heavy metal ions. The presented sensors were successfully applied for the direct determination of isoproturon (IPU) and diuron (DU) in real water samples. Welcome to talk about 64-10-8, If you have any questions, you can contact Kamel, AH; Amr, AGE; Al-Omar, MA; Almehizia, AA or send Email.. Application In Synthesis of 1-Phenylurea

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Facile construction of magnetic azob enzene-base d framework materials for enrichment and sensitive determination of phenylurea herbicides WOS:000564320000013 published article about SOLID-PHASE EXTRACTION; COVALENT ORGANIC FRAMEWORKS; PERFORMANCE LIQUID-CHROMATOGRAPHY; WATER; ADSORBENT; MICROEXTRACTION; NANOPARTICLES; POLYMER; CARBON; FOOD in [Wang, Qianqian; Wang, Xiaolan; Wang, Junmin; Liu, Weihua; Hao, Lin; Wang, Chun; Wu, Qiuhua; Wang, Zhi] Hebei Agr Univ, Coll Sci, Baoding 071001, Hebei, Peoples R China; [Zhou, Junhong] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China in 2020.0, Cited 35.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Name: 1-Phenylurea

Exploring new material as adsorbent for the efficient enrichment of pollutants is always of great significance in analytical chemistry. In this work, a magnetic azobenzene framework (labeled as MAzo) was constructed as a magnetic solid phase extraction (MSPE) adsorbent by a simple and environmentally benign strategy. The MAzo exhibited the attractive features of strong magnetism, outstanding adsorption performance, as well as good reusability. Combining MAzo-based MSPE with high performance liquid phase chromatography, a simple and effective method was developed for simultaneous determination of four phenylurea herbicides in pear juice and apple juice samples. Under optimized experimental conditions, the method offered low limits of detection of 0.05-0.15 ng mL(-1), high recoveries of 86.7-109.2% with RSD less than 7%. Density functional theory calculation indicated that the good adsorption performance of MAzo for PUHs can be ascribed to the strong H-bonding forces and weak pi-pi interactions. The facile, green, low-cost synthesis method together with the excellent adsorption performance endows the MAzo great application prospect in sample preparation. (c) 2020 Elsevier B.V. All rights reserved.

Welcome to talk about 64-10-8, If you have any questions, you can contact Wang, QQ; Wang, XL; Wang, JM; Liu, WH; Hao, L; Zhou, JH; Wang, C; Wu, QH; Wang, Z or send Email.. Name: 1-Phenylurea

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about SOLID-PHASE EXTRACTION; COVALENT ORGANIC FRAMEWORKS; PERFORMANCE LIQUID-CHROMATOGRAPHY; WATER; ADSORBENT; MICROEXTRACTION; NANOPARTICLES; POLYMER; CARBON; FOOD, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31471643, 31571925, 31671930]; Natural Science Foundation of Hebei ProvinceNatural Science Foundation of Hebei Province [B2020204001, C2020204020, B2017204025]; Scientific and Technological Research Foundation of the Department of Education of Hebei Province [ZD2020196, ZD2016085, QN2019034]. Published in ELSEVIER in AMSTERDAM ,Authors: Wang, QQ; Wang, XL; Wang, JM; Liu, WH; Hao, L; Zhou, JH; Wang, C; Wu, QH; Wang, Z. The CAS is 64-10-8. Through research, I have a further understanding and discovery of 1-Phenylurea. Formula: C7H8N2O

Exploring new material as adsorbent for the efficient enrichment of pollutants is always of great significance in analytical chemistry. In this work, a magnetic azobenzene framework (labeled as MAzo) was constructed as a magnetic solid phase extraction (MSPE) adsorbent by a simple and environmentally benign strategy. The MAzo exhibited the attractive features of strong magnetism, outstanding adsorption performance, as well as good reusability. Combining MAzo-based MSPE with high performance liquid phase chromatography, a simple and effective method was developed for simultaneous determination of four phenylurea herbicides in pear juice and apple juice samples. Under optimized experimental conditions, the method offered low limits of detection of 0.05-0.15 ng mL(-1), high recoveries of 86.7-109.2% with RSD less than 7%. Density functional theory calculation indicated that the good adsorption performance of MAzo for PUHs can be ascribed to the strong H-bonding forces and weak pi-pi interactions. The facile, green, low-cost synthesis method together with the excellent adsorption performance endows the MAzo great application prospect in sample preparation. (c) 2020 Elsevier B.V. All rights reserved.

Formula: C7H8N2O. Welcome to talk about 64-10-8, If you have any questions, you can contact Wang, QQ; Wang, XL; Wang, JM; Liu, WH; Hao, L; Zhou, JH; Wang, C; Wu, QH; Wang, Z or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of 1-Phenylurea. Authors Heriyanto; Pahlevani, F; Sahajwalla, V in ELSEVIER SCI LTD published article about in [Heriyanto; Pahlevani, Farshid; Sahajwalla, Veena] UNSW, Sch Mat Sci & Engn, Ctr Sustainable Mat Res & Technol SMaRT, Sydney, NSW 2052, Australia in 2019.0, Cited 24.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

This study reports an innovative pathway for successfully synthesizing composite panels using various waste input. For this purpose, seven types of powder from waste or widely available filler i.e. Quartz off-cut, sand, waste seashell, dolomite, limestone aggregates, concrete waste and limestone dust were used. The study aims to assess the effectiveness and mechanical properties of the various waste powder in the production of powder-resin composites. The panels were then compared with the novel polymeric glass composite (PGC) in the previous study (Heriyanto et al., 2018). Following the same procedure in PGC, the filler was individually grounded to 64-108 mu m and chemically treated with amino silane coupling agent (CA). The powder filler (untreated or treated) is then mixed with the resin binder with a ratio of 80/20 respectively, followed by hot pressing the mixture at the pressure of 550 bar at 65 degrees C for 1 h. The final composite slab is then further cut for mechanical testing. It was found in the study that when CA was not added, surface roughness of the powder particles affected the flexural strength of the final panel significantly. High surface roughness particles such as in Quartz, sand and seashell adhere effectively with the resin binder which led to higher strength. On the contrary, other factors like smooth particle morphology in glass, dolomite and limestone as well as porous structure in concrete and clump of very fine powder in limestone dust degrade the strength of the final panels. With CA addition, adhesion between resin and powder filler were improved significantly. Flexural strength after the CA treatment was found to be much affected by particle characteristics. Silica-based panels i.e. quartz, sand and glass which consist of high strength and hardness of silica particles perform better compared to that of calcium carbonate-based panels. Compression strength, toughness, stiffness, scratch resistance, density and water absorption were also reported in this study. The properties of all the treated panels are found to be comparable, or if not, much better than natural stones. These new approaches of using waste filler in powder – resin based composites can be a new alternative to produce green materials that deliver economic and environmental benefits. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 64-10-8, If you have any questions, you can contact Heriyanto; Pahlevani, F; Sahajwalla, V or send Email.. Quality Control of 1-Phenylurea

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Evaluation of a series of phenyl-type stationary phases in supercritical fluid chromatography with the linear solvation energy relationship model and its application to the separation of phenolic compounds WOS:000518869100030 published article about LIQUID-CHROMATOGRAPHY; CLASSIFICATION; PURIFICATION; SELECTIVITY; RETENTION; SYSTEM; SFC in [Jiang, Dasen; Ke, Yanxiong; Cai, Jianfeng; Zhang, Huanhuan; Fu, Qing; Jin, Yu; Liang, Xinmiao] East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China; [Liang, Xinmiao] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Key Lab Nat Med, Dalian 116023, Liaoning, Peoples R China in 2020.0, Cited 29.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Computed Properties of C7H8N2O

In recent years, supercritical fluid chromatography (SFC) has become a powerful tool in modern analytical chemistry, and the diversity of stationary phases in SFC promotes phenyl-type phases to confront with a significant resurgence of interest. In this paper, a series of phenyl-type stationary phases with different substituted benzenes involving N-propylbenzamide (PB), 4-fluoro-N-propylbenzamide (PB-F), and 4-ethyl-N-propylbenzamide (PB-ET) were synthesized. Retention mechanism of these phases in SFC was investigated using a linear solvation energy relationship (LSER) model. The phenyl-type stationary phases with all positive parameters can provide all types of interaction, typically involving hydrogen bonding, dipole-dipole and dispersive interactions. The different benzene’s substituents of the stationary phases mainly affected their hydrogen bonding and dipole-dipole interactions, which could be reflected by the angle between the solvation vectors to some extent. The k-k plot showed that the selectivity difference of phenyl-type stationary phases was closely related to the type of solute. Thus, based on twenty-five natural phenolic compounds, two systems with high orthogonality (63.49%) were constructed using three columns, namely phenyl column (PHE) x PB-F and PB x PB-F. Finally, after investigating the influence of chromatographic conditions, ten flavonoids could be separated by using PB, PB-F and PHE columns in SFC. (C) 2019 Published by Elsevier B.V.

Welcome to talk about 64-10-8, If you have any questions, you can contact Jiang, DS; Ke, YX; Cai, JF; Zhang, HH; Fu, Q; Jin, Y; Liang, XM or send Email.. Recommanded Product: 64-10-8

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Racial Disparities in Response to a US Food and Drug Administration Safety Communication Regarding the Use of Power Morcellation for the Treatment of Uterine Leiomyoma WOS:000504342100037 published article about MULTIPLE IMPUTATION; FLEXIBLE TOOL; WOMEN; HYSTERECTOMY; TRENDS in [Matsushita, Tomomi] Johns Hopkins Bloomberg Sch Publ Hlth, 615 North Wolfe St, Baltimore, MD 21205 USA; [Matsushita, Tomomi; Sekizawa, Akihiko] Showa Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan; [Jacobs, Lisa K.] Dept Surg, Tokyo, Japan; Johns Hopkins Univ, Sch Med, Baltimore, MD USA in 2020.0, Cited 25.0. Computed Properties of C7H8N2O. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

Study Objective: To investigate whether the rate of increase in the performance of abdominal myomectomy over a laparoscopic approach after the US Food and Drug Administration (FDA) safety communication regarding morcellator use for myomectomy differs among races. Design: Retrospective cohort study. Setting: The American College of Surgeons National Surgical Quality Improvement data. Patients: Patients aged 18 to 55 years who underwent either laparoscopic or abdominal myomectomy, excluding malignant cases, emergency cases, operations performed by nongynecologic specialists, and cases in which myomectomy was performed during cesarean section. Interventions: None. Measurements and Main Results: The odds ratios of abdominal myomectomy over laparoscopic myomectomy before and after the release of the FDA communication were calculated in 3 race categories: white, African American, and other races. In a logistic regression analysis adjusted for possible confounders, including all races, the odds ratio of abdominal myomectomy before and after the FDA communication was 1.30 (95% confidence interval [CI], 1.20-1.41; p <. 001). In a logistic regression analysis with a product term of FDA communication exposure and race as a possible effect modifier, the African American population showed a significantly greater change in the odds of abdominal myomectomy over laparoscopic myomectomy in comparison with the white population (1.22; 95% CI, 1.02-1.47; p =.03). In contrast, other races showed no significant change (.83; 95% CI,.64-1.08; p =.17). Conclusion: After the FDA communication, the odds ratio of abdominal myomectomy was disproportionately increased in the African American population. (C) 2019 Published by Elsevier Inc. on behalf of AAGL. Computed Properties of C7H8N2O. Welcome to talk about 64-10-8, If you have any questions, you can contact Matsushita, T; Sekizawa, A; Jacobs, LK or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019.0 ACS OMEGA published article about BENZOXAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; DIRECT AMINATION; DESIGN; ANTICANCER; CYANATION in [Slachtova, Veronika; Chasak, Jan; Brulikova, Lucie] Palacky Univ Olomouc, Fac Sci, Dept Organ Chem, 17 Listopadu 12, Olomouc 77146, Czech Republic in 2019.0, Cited 38.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Recommanded Product: 64-10-8

This study reports two synthetic approaches leading to 2-aminobenzoxazoles and their N-substituted analogues. Our first synthetic strategy involves a reaction between various o-aminophenols and N-cyano-N-phenyl-p-toluenesulfonamide as a nonhazardous electrophilic cyanating agent in the presence of Lewis acid. The second synthetic approach uses the Smiles rearrangement upon activation of benzoxazole-2-thiol with chloroacetyl chloride. Both developed synthetic protocols are widely applicable, afford the desired aminobenzoxazoles in good to excellent yields, and use nontoxic and inexpensive starting material.

Recommanded Product: 64-10-8. Welcome to talk about 64-10-8, If you have any questions, you can contact Slachtova, V; Chasak, J; Brulikova, L or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Gong, XX; Li, XF; Xie, WL; Wu, J; Ye, SQ in ROYAL SOC CHEMISTRY published article about QUINOLINE N-OXIDES; H BOND FUNCTIONALIZATION; SULFUR-DIOXIDE; CATALYZED SYNTHESIS; SULFONYL HYDRAZIDES; 1,3-DIPOLAR CYCLOADDITION; STEREOSELECTIVE-SYNTHESIS; POTASSIUM METABISULFITE; 3-COMPONENT SYNTHESIS; DIARYLIODONIUM SALTS in [Gong, Xinxing; Wu, Jie; Ye, Shengqing] Taizhou Univ, Inst Adv Studies, 1139 Shifu Ave, Taizhou 318000, Peoples R China; [Gong, Xinxing; Wu, Jie] Fudan Univ, Dept Chem, 2005 Songhu Rd, Shanghai 200438, Peoples R China; [Li, Xiaofang; Xie, Wenlin] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China in 2019.0, Cited 131.0. Computed Properties of C7H8N2O. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

A photoinduced synthesis of S-aryl thiosulfonates through a three-component reaction of aryldiazonium tetrafluoroborates, sodium metabisulfite, and thiourea is achieved. The reaction scope generality with a range of aryldiazonium tetrafluoroborates is demonstrated. In this transformation, a radical coupling pathway is proposed with the insertion of sulfur dioxide in the presence of a photocatalyst under visible light irradiation. The organic sulfur motifs in S-aryl thiosulfonates originate from the convenient, cheap, and easily available thiourea and sodium metabisulfite.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem