Category: 616-14-8

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Castello, Gianrico; D’Amato, Giuseppina researched the compound: 1-Iodo-2-methylbutane( cas:616-14-8 ).Related Products of 616-14-8.They published the article 《Gas chromatography of alkyl iodides. II. Influence of structure on retention time and sensitivity to electron capture detector》 about this compound( cas:616-14-8 ) in Journal of Chromatography. Keywords: alkyl iodides gas chromatog; iodides alkyl gas chromatog; gas chromatog alkyl iodides; chromatog gas alkyl iodides; electron capture detection alkyl iodides. We’ll tell you more about this compound (cas:616-14-8).

The retention times and indexes observed for 34 alkyl iodides during electron-capture gas-liquid chromatog. on a 15% tricresyl phosphate/Chromosorb W (DMCS-treated)column are examined as functions of the number of C atoms, the I position, and the number and position of branchings in the alkyl iodide mols. The relative molar response of the electron-capture detector is useful for detector standardizations since it depends only on the standing current.

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Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Gas chromatography of isomeric pentyl halides, the main research direction is GAS CHROMATOG PENTYL HALIDE; CHROMATOG GAS PENTYL HALIDE; PENTYL HALIDE GAS CHROMATOG; HALIDE PENTYL GAS CHROMATOG.COA of Formula: C5H11I.

Isomeric pentyl halides were separated by gas chromatog. Two columns were used: a 4 m. × 1/16-in. outer diameter stainless steel column packed with 10% squalane on 80-100-mesh Chromosorb W, N as the carrier at 13-15 ml./min. (column 1), and a 4-m. × 1/8-in. outer diameter stainless steel column packed with 11.5% Bentone 34 + 11.5% silicone MS 555 on 80-100-mesh Chromosorb W, N as the carrier at 25-30 ml./min. (column 2). On column 1, chlorides were analyzed at 20°, bromides and iodides at 40°; on column 2, all analyses were at 40°. A flame ionization detector was used with both columns. tert-Pentyl bromide and iodide decomposed in column 2 although not on column 1. The 3-halogenopentanes were the only isomers that could not be completely separated from all other pentyl structures.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron Letters called Diphosphorus tetraiodide (P2I4). A valuable reagent for regioselective synthesis of iodo alkanes from alcohols, Author is Lauwers, M.; Regnier, B.; Van Eenoo, M.; Denis, J. N.; Krief, A., which mentions a compound: 616-14-8, SMILESS is CCC(CI)C, Molecular C5H11I, Product Details of 616-14-8.

Primary, secondary, and tertiary alkanols and phenylalkanols and secondary and tertiary cycloalkanols were converted in high yields to the resp. alkyl, phenylalkyl, and cycloalkyl iodides by P2I4 in CS2 and at 20°. E.g., ROH [R = Me(CH2)7, Ph(CH2)2, cyclopentyl] gave 80-8% RI in 24 h.

The article 《Diphosphorus tetraiodide (P2I4). A valuable reagent for regioselective synthesis of iodo alkanes from alcohols》 also mentions many details about this compound(616-14-8)Product Details of 616-14-8, you can pay attention to it, because details determine success or failure

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Iodo-2-methylbutane( cas:616-14-8 ) is researched.Name: 1-Iodo-2-methylbutane.Hartmann, Rolf W.; Batzl, Christine published the article 《Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones》 about this compound( cas:616-14-8 ) in Journal of Medicinal Chemistry. Keywords: aminophenylpiperidinedione preparation antitumor; piperidinedione aminophenyl preparation antitumor; aromatase placental inhibition aminophenylpiperidinedione; desmolase adrenal inhibition aminophenylpiperidinedione; estradiol inhibition aminophenylpiperidinedione. Let’s learn more about this compound (cas:616-14-8).

Piperidinediones I (R = H, Me, Et, Pr, CHMe2, CH2CHMe2, CHMeEt, pentyl, isopentyl, CH2CHMeEt, sec-pentyl, hexyl, heptyl) were prepared by alkylating PhCH2CN, addition reaction of PhCHRCN with CH2:CHCN, hydrolysis and ring closure of NCCRPhCH2CH2CN, nitration, and reduction of the nitro group. In vitro I showed a stronger inhibition of human placental aromatase than aminoglutethimide (II). The most active derivative, I (R = isopentyl), showed a 93-fold stronger inhibition than II. I, except I (R = CHMe2, CH2CHMe2, CHMeEt) exhibited equal or lower inhibition of bovine adrenal desmolase than II. Many I showed a stronger inhibition of the plasma estradiol concentration of pregnant mare serum gonadotropin-primed rats than II. They inhibited the testosterone-stimulated tumor growth of ovariectomized 9,10-dimethyl-1,2-benzanthracene tumor-bearing rats more strongly than II. Being stronger and more selective inhibitors of the estrogen biosynthesis than II, some of the newly developed derivatives of II might be better candidates for the treatment of hormone-dependent human breast cancer.

The article 《Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones》 also mentions many details about this compound(616-14-8)Name: 1-Iodo-2-methylbutane, you can pay attention to it, because details determine success or failure

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HPLC of Formula: 616-14-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Synthetic methods and reactions. XIII. Preparation of alkyl halides from alcohols with alkali halides in polyhydrogen fluoride/pyridine solution. Author is Olah, George A.; Welch, John.

Thirty-nine RX (R = C4-8 alkyl, cyclopentyl, cyclohexyl, adamantyl, norbornyl, PhCH2; X = F, Cl, Br, I) were prepared by reaction of the corresponding ROH with MX (M = Na, K, NH4) in polyhydrogen fluoridepyridine. Thus, BuCH2OH was kept 1 hr with 70% HF-pyridine containing NaCl to give 89% BuCH2Cl.

The article 《Synthetic methods and reactions. XIII. Preparation of alkyl halides from alcohols with alkali halides in polyhydrogen fluoride/pyridine solution》 also mentions many details about this compound(616-14-8)HPLC of Formula: 616-14-8, you can pay attention to it, because details determine success or failure

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Optical rotation and atomic dimension》. Authors are Brauns, D. H..The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Category: thiomorpholine. Through the article, more information about this compound (cas:616-14-8) is conveyed.

This is a discussion (without new exptl. data) of a modified Guye’s law using the differences in at. dimensions, F-Cl, Cl-Br, and Br-I. B. tabulates the sp. and mol. rotations of the halogen compounds obtained by replacing the O-acetyl group of the 1st asym. C atom of acetyl sugars by F, Cl, Br, and I and for these and related compounds formulates 2 different rules: (1) when the halogen is attached directly to the asym. C atom the sp. rotations show differences proportional to the differences in at. dimensions, and (2) when the halogen is attached indirectly to the asym. C atom the mol. rotations show differences proportional to the differences in at. dimensions.

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Thiomorpholine – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Asymmetric reductions. VI. The action of the Grignard reagent from (+)-1-chloro-2-methylbutane on a series of alkyl tert-butyl ketones》. Authors are Foley, William M.; Welch, Frank J.; Combe, Edward M. La; Mosher, Harry S..The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Category: thiomorpholine. Through the article, more information about this compound (cas:616-14-8) is conveyed.

cf. C.A. 51, 1828h. Title reactions were carried out with six ketones, and the % asymmetric reduction, i, was determined by comparing the observed rotation of each resulting carbinol with the maximum rotation of pure isomers obtained by resolution. The absolute configurations of the prepared carbinols were determined and R, [α]25D (neat), and i were as follows: Me, 0.63°, 13.4; iso-Pr, -0.38°, 4.6; Et, -2.94°, 10.7; Pr, -3.87°, 11.3; Bu, -3.78°, 11.0; and iso-Bu, -2.56°, 5.9. The results agreed with a reaction mechanism of Grignard reduction involving an intermediate cyclic six-membered transition state in which stereospecificity was controlled by steric interaction of the alkyl and tert-butyl groups of the ketones and the Me and Et groups of the Grignard reagent. The alkyl tert-butyl ketones were prepared by coupling the appropriate acid chloride, RCOCl, with the Grignard reagent from freshly distilled tert-BuCl in the presence of Cu2Cl2 to yield the following products (R, % yield based on Grignard reagent, b.p., and n25D given): Me, 33, 105.2°, 1.3974; Et, 89, 125.0-5.8°, 1.4049-51; Pr, 63, 145.0-5.8°, 1.4109-11; iso-Pr, 36, 135.2-6.7°, 1.4049-68; Bu, 69, 167.0-9.0°, 1.4149-59; and iso-Bu, 40, 155.5-7.0°, 1.4135-42. Only the Me and Pr tert-butylcarbinols were resolved in earlier work, and the resolution of the remaining four, by classical methods (Ingersoll, C.A. 38, 29257), is reported here. Racemic tert-BuCHEtOH (I), b. 136°, n20D 1.4235, was converted to the dl-acid phthalate, m. 88.0-8.3°. By procedures involving brucine and recrystallizations the (-)-acid phthalate (II) was obtained, m. 91.0-1.5°, [α]27D -3.75° (c 20.5, CHCl3), the rotation in CHCl3 being concentration dependent, 2.2° (c 1.5). (+)-I was regenerated from II, n20D 1.4230, α23D 27.40° (neat, l 1); acetate from (+)-I b38 74°, α24D 12.16° (neat, l 0.5), d23 0.856; benzoate from (-)-I b0.8 20°, α25D -3.19° (neat, l 0.5), n20D 1.4912, d23 0.957. Racemic tert-BuCH(OH)Pr-iso (III), b. 150.9-1.1°, n20D 1.4290-9, gave the dl-acid phthalate, m. 114.5-16.0°. The brucine salt was prepared and a less soluble form obtained, m. 173-5°, [α]28D -23°, which on hydrolysis gave an acid phthalate (IV), m. 100.5-3.0°, [α]25D 0.00°, which was hydrolyzed to (-)-III, α28D -7.22° (neat, l 1). Hydrolysis of the more soluble form of the brucine salt, [α]28D -16.1°, gave an acid phthalate (V), [α]28D 0.00°, which on hydrolysis gave (+)-III, α28D 7.22° (neat, l 1). The strychnine salt of IV was also prepared, [α]28D -25.7°, the acid phthalate regenerated, and converted to (-)-III, α28D -8.94° (neat, l 1), n20D 1.4300. The cinchonine salt of V was prepared, m. 144-7° (decomposition), [α]28D 106°, from which an acid phthalate was regenerated, m. 105.5-7.0°, and hydrolyzed to (+)-III, α28D 9.06° (neat, l 1). These latter values of -8.94° for (-)-III and 9.06° for (+)-III were considered best values. Also prepared were acetate of (+)-III, b155 130°, n21D 1.4166, α28D -1.44° (neat, l 1), and benzoate of (+)-III, b32 195°, n19D 1.4969, α25D -0.16° (neat, l 1). Racemic tert-BuCH(OH)Bu-iso (VI), b150 115-16°, n25D 1.4309, m. 17°, gave acid phthalate (VII), m. 83.5-4.5°. Strychnine was used in the resolution and eventually (+)-VII was obtained, m. 75.6-7.5°, [α]23D 8.7° (c 1.5, CHCl3), hydrolyzed to (+)-VI, m. 40-1°, α26D 57.5° (c 20.4, MeOH), and α23D 54.5° (neat, by extrapolation of rotation-concentration curve); acetate of (+)-VI b17 73°, α22D 15.15° (neat, l 0.5), n20D 1.4176, d22 0.852; benzoate of (+)-VI b0.6 88°, α25D 8.24° (neat, l 0.5), n20D 1.4870, d25 0.955. Racemic tert-BuCHBuOH (VIII), n20D 1.4320, was converted to acid phthalate (IX), m. 100.5-2.0°, and then to the strychnine salt. The regenerated (+)-IX was a glass, α23D 4.5° (c 2.8, CHCl3), which was saponified to (+)-VIII, n20D 1.4314, α24D 17.10° (neat, l 0.5). The (-)-phthalate from the more soluble fractions of strychnine salt gave (-)-VIII, α24D -16.39° (neat, l 0.5). The dl-tetrachlorophthalate of VIII was also prepared, m. 126-8°, converted to the strychnine salt, and the less soluble form, [α]25D -12°, hydrolyzed to (-)-acid tetrachlorophthalate, α22D -9.69°, which was saponified to (+)-VIII, α22D 13.70° (neat, l 0.5); 3,5-dinitrobenzoate (X) of (+)-VIII m. 107.5° (MeOH), α25D 10.0° (c 2.4, CHCl3); 3,5-dinitrobcnzoate of dl-VIII, m. 84.0-4.5°. X was saponified to (+)-VIII, b23 76°, α25D 17.12° (neat, l 0.5), n20D 1.4310, d26 0.823. The value for pure (+)-VIII was taken as α25D 34.24° (neat, l 1). From (-)-VIII, α25D -32.8° (neat, l 1), was prepared: acetate, b20 87°, α26D -11.25° (neat, l 0.5), n20D 1.4191, d26 0.851; benzoate, b0.5 98°, α25D -7.29° (neat, l 0.5), n20D 1.4887, d25 0.936; p-nitrobenzoate, b0.5 144-5°, α29D -12.50°, n25D 1.5070. Some work was done with the Grignard reagents of the following prepared compounds: (+)-1-bromo-2-methylbutane, b100 60.8°, n20D 1.4453, α24D 4.22° (neat, l 1), 84% optical purity, a 2nd preparation b100 57-8°, α26.6D 4.66°, 93% optical purity; and (+)-1-iodo-2-methytbutane, n20D 1.4955-69, α21D 8.65° (neat, l 1), 98.5% optical purity, 2nd preparation b53 70°, n20D 1.4969-72, α25D 16.8° (neat, l 2), optical purity 96.5%.

The article 《Asymmetric reductions. VI. The action of the Grignard reagent from (+)-1-chloro-2-methylbutane on a series of alkyl tert-butyl ketones》 also mentions many details about this compound(616-14-8)Category: thiomorpholine, you can pay attention to it, because details determine success or failure

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Thiomorpholine – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Analysis of rotatory dispersions of configurationally related halides》. Authors are Levene, P. A.; Rothen, Alexandre; Marker, R. E..The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Electric Literature of C5H11I. Through the article, more information about this compound (cas:616-14-8) is conveyed.

Rotatory dispersion curves of halides of the type HMeRC(CH2)nX (X = Cl, Br, I; R = alkyl group; n = 0, 1, 2 or 3) are analyzed in the visible and the ultraviolet regions. The 3 halogen atoms function similarly with respect to the character of this curve in compounds of identical structure. A periodicity in the sign of some of the partial contributions of the halogen atom occurs with increase in n. The course of the rotatory dispersion when n = 1 is anomalous. An attempt is made to apply results when n > 0 to the sign of rotation for compounds where n = 0. When X = COOH, CHO, CN, CHMe2, etc., no complete analogy exists between this group and the group where X is a halogen. [M]D25 maximum (homogeneous) is given for the 16 compounds where X = Br, n = 1, 2, 3, 4, and R = Et, Pr, Bu, pentyl, and for the compound HMeEtC(CH2)5Br. Absorption spectra are given for λ 2100-3300 for 5 iodides. Rotatory dispersion curves are given for the compounds HMeEtCCH2I, HMe(C6H13)CCH2I, HMeEtCCH2Br and HMeEtCCH2Cl. [M]D25 maximum, nD25, d425 (vacuum) and rotatory dispersions (numerical) are given for several other compounds in this series. Differences between the interpretation of the dispersions of the iodides given by the authors (C. A. 27, 951) and that given by Kuhn (C. A. 29, 7159.1) are due to substantial differences between their exptl. data.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Cerebrospinal fluid lymphocytes in experimental allergic encephalomyelitis.》. Authors are Wilkerson, L D; Lisak, R P; Zweiman, B.The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Formula: C5H11I. Through the article, more information about this compound (cas:616-14-8) is conveyed.

We report characteristics of the cerebrospinal fluid (CSF) pleocytosis (616+/-148 cells/microliter) that occurred in guinea-pigs with definite clinical experimental allergic encephalomyelitis developing 12 to 16 days after sensitization with homologous myelin basic protein. This pleocytosis was not present in the cerebrospinal fluid of a group of animals studied when still healthy, 9 or 10 days after similar sensitization. Eighty-nine per cent of cells in the CSF pleocytosis were small lymphocytes, 8% were larger lymphocytes and the remainder mostly monocytes. Of the lymphocytes, most were E-rosetting or null cells. B-cell markers were uncommon. The cellular patterns in this CSF pleocytosis appear to be similar to those seen in some delayed hypersensitivity responses.

After consulting a lot of data, we found that this compound(616-14-8)Formula: C5H11I can be used in many types of reactions. And in most cases, this compound has more advantages.

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Thiomorpholine – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Gas chromatographic identification of alkyl radicals formed in plasma radiofrequency discharges by using iodine as a scavenger, the main research direction is alkyl radical identification gas chromatog; iodide alkyl gas chromatog retention; solution heat alkyl iodide.Recommanded Product: 1-Iodo-2-methylbutane.

Alkyl radicals formed in low-pressure radiofrequency plasmas were identified by gas chromatog. using I as a scavenger compound Iodine vapors, injected into the glowing plasma discharge, reacted with active radicals in the gas phase, yielding various saturated alkyl iodides, that were trapped by freezing in an organic solvent and analyzed on Apiezon L and Carbowax 20M columns. Analyses carried out at different temperatures permitted the retention times and indexes to be measured and the relative molar heats of solution to be calculated

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