Category: 119-61-9

An article Synthesis and characterization of some new Schiff base derivatives of gabapentin, and assessment of their antibacterial, antioxidant and anticonvulsant activities WOS:000614251000021 published article about OXIDATIVE STRESS; MODEL in [Saleem, Muhammad Farrukh; Khan, Mohsin Abbas; Ahmad, Irshad; Khurshid, Umair] Islamia Univ Bahawalpur, Fac Pharm & Alternat Med, Dept Pharmaceut Chem, Bahawalpur, Pakistan; [Aslam, Naveed] Govt Punjab, Primary & Secondary Healthcare Dept, Punjab, Pakistan in 2021.0, Cited 25.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Category: thiomorpholine

Purpose: To synthesize and characterize some new gabapentin Schiff base derivatives, and to assess their antibacterial, antioxidant and antiepileptic activities. Methods: Four Schiff base derivatives of gabapentin, termed G1, G2, G3 and G4, were synthesized by condensation with benzoin, vanillin, acetophenone, and benzophenone, respectively. Their chemical identities were established by FTIR, H-1 NMR and C-13 NMR techniques. The new compounds were screened for antibacterial activity using agar well method, antioxidant activity by DPPH assay, and anticonvulsant activity against pentylenetetrazole (PTZ) induced seizures in mice. Results: All the compounds showed antibacterial activity against the test strains to variable degrees, while the parent drug did not exhibit antibacterial activity. The zones of inhibition of compound G2 against Micrococcus luteus (36.2 +/- 1.0 mm) and Serratia marcescens (28.2 +/- 1.0 mm), and of compound G4 against Stenotrophomonas maltophilia (36.8 +/- 1.0 mm) were larger compared to the standard drug, doxycycline, exhibiting zones of inhibition 28.2 +/- 1.3, 28.2 +/- 0.9 and 20.0 +/- 0.9 mm, respectively. In addition, compounds G1 and G2 possessed significantly greater (p < 0.05) radical scavenging activity (82.3 +/- 1.8 and 92.3 +/- 2.2 %, respectively) than the precursor drug, gabapentin (63.2 +/- 2.6 %). The seizure scores for compounds GI (0.7 +/- 0.06) and G2 (0.9 +/- 0.07) were comparable (p > 0.05) with gabapentin (0.8 +/- 0.06), while compounds G3 and G4 were less active (p < 0.05) than gabapentin. Conclusion: Compounds G1 and G2 exhibit good antibacterial and antioxidant activities while retaining the anticonvulsant activity of the parent drug, gabapentin, thus making them suitable candidates for further development for the treatment of neurodegenerative pathologies associated with bacterial infections. Welcome to talk about 119-61-9, If you have any questions, you can contact Saleem, MF; Khan, MA; Ahmad, I; Aslam, N; Khurshid, U or send Email.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Orooji, Y; Movahedi, A; Liu, ZP; Asadnia, M; Ghasali, E; Ganjkhanlou, Y; Razmjou, A; Karimi-Maleh, H; Kiadeh, NTH in [Orooji, Yasin; Liu, Zhipeng] Nanjing Forestry Univ, Coll Mat Sci & Engn, Nanjing 210037, Jiangsu, Peoples R China; [Orooji, Yasin; Liu, Zhipeng; Ghasali, Ehsan] Nanjing Forestry Univ, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China; [Movahedi, Ali] Nanjing Forestry Univ, Minist Educ, Key Lab Forest Genet & Biotechnol, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China; [Asadnia, Mohsen] Macquarie Univ, Sch Engn, Sydney, NSW 2109, Australia; [Ganjkhanlou, Yadolah] Univ Torino, NIS Ctr, Dept Chem, Via P Giuria 7, I-10125 Turin, Italy; [Ganjkhanlou, Yadolah] Univ Torino, INSTM Ctr, Via P Giuria 7, I-10125 Turin, Italy; [Razmjou, Amir] Univ Technol Sydney UTS, Ctr Technol Water & Wastewater CTWW, Sch Civil & Environm Engn, Sydney, NSW, Australia; [Karimi-Maleh, Hassan] Quchan Univ Technol, Lab Nanotechnol, Dept Chem Engn, Quchan, Iran; [Karimi-Maleh, Hassan] Univ Elect Sci & Technol China, Sch Resources & Environm, Xiyuan Ave,POB 611731, Chengdu, Peoples R China; [Karimi-Maleh, Hassan] Univ Johannesburg, Dept Chem Sci, Doornfontein Campus,POB 17011, ZA-2028 Johannesburg, South Africa; [Kiadeh, Naser Tavajohi Hassan] Umea Univ, Chem Biol Ctr, Dept Chem, Tech Chem, S-90187 Umea, Sweden published Luminescent film: Biofouling investigation of tetraphenylethylene blended polyethersulfone ultrafiltration membrane in 2021.0, Cited 47.0. Application In Synthesis of Benzophenone. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9.

Despite the huge contribution of membrane-based brine and wastewater purification systems in today’s life, biofouling still affects sustainability of membrane engineering. Aimed at reducing membrane modules wastage, the need to study biofouling monitoring as one of contributory factors stemmed from the short time between initial attachment and irreversible biofoulant adhesion. Hence, a membrane for monitoring is introduced to determine the right cleaning time by using fluorescent sensing as a nondestructive and scalable approach. The classical solid-state emissive fluorophore, tetraphenylethylene (TPE), was introduced as a sustainable, safe and sensitive fluorescent indicator in order to show the potential of the method, and polyethersulfone (PES) and non-solvent-induced phase separation method, the most popular material and method, are used to fabricate membrane in industry and academia. Since the employed filler has an aggregation-induced emission (ALE) characteristic, it can track the biofouling throughout the operation. The fabricated membranes have certain characterizations (i.e. morphology assessment, flux, antibiogram, flow cytometry, surface free energy, and protein adsorption) which indicate that hybrid membrane with 5 wt % of TPE has identical biofouling activity compared to neat PES membrane and its optimal luminescence properties make it an appropriate candidate for non-destructive and online biofouling monitoring. (C) 2020 Elsevier Ltd. All rights reserved.

Application In Synthesis of Benzophenone. Welcome to talk about 119-61-9, If you have any questions, you can contact Orooji, Y; Movahedi, A; Liu, ZP; Asadnia, M; Ghasali, E; Ganjkhanlou, Y; Razmjou, A; Karimi-Maleh, H; Kiadeh, NTH or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. Zhang, KY; Lu, GL; Xi, ZS; Li, YQ; Luan, QJ; Huang, XB in [Zhang, Kaiyue; Lu, Guilong; Xi, Zuoshuai; Li, Yaqiong; Luan, Qingjie; Huang, Xiubing] Univ Sci & Technol Beijing, Beijing Adv Innovat Ctr Mat Genome Engn, Sch Mat Sci & Engn, Beijing Key Lab Funct Mat Mol & Struct Construct, Beijing 100083, Peoples R China published Covalent organic framework stabilized CdS nanoparticles as efficient visible-light-driven photocatalysts for selective oxidation of aromatic alcohols in 2021, Cited 34. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9.

Noble-metal-free photocatalysts with high and stable performance provide an environmentally-friendly and cost-efficient route for green organic synthesis. In this work, CdS nanoparticles with small particle size and different amount were successfully deposited on the surface of covalent organic frameworks (COFs). The deposition of suitable content of CdS on COFs could not only modify the light adsorption ability and the intrinsic electronic properties, but also enhance the photocatalytic activity and cycling performance of CdS for the selective oxidation of aromatic alcohols under visible light. Especially, COF/CdS-3 exhibited the highest yield (97.1%) of benzaldehyde which is approximately 2.5 and 15.9 times as that of parental CdS and COF, respectively. The results show that the combination of CdS and COF can improve the utilization of visible light and the separation of photo-generated charge carriers, and COF with the pi-conjugated system as supports for CdS nanoparticles could provide efficient electron transport channels and improve the photocatalytic performance. Therefore, this kind of COF-supported photocatalysts with accelerated photo-induced electrons and charge-carrier separation between semiconductors possesses great potentials in future green organic synthesis. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Welcome to talk about 119-61-9, If you have any questions, you can contact Zhang, KY; Lu, GL; Xi, ZS; Li, YQ; Luan, QJ; Huang, XB or send Email.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. Authors Lan, S; Liu, R; Kong, XW; Liu, JG; Luo, BL; Yang, S; Fang, XQ in AMER CHEMICAL SOC published article about in [Lan, Shouang; Liu, Rui; Kong, Xiangwen; Yang, Shuang; Fang, Xinqiang] Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China; [Lan, Shouang; Liu, Rui; Kong, Xiangwen; Yang, Shuang; Fang, Xinqiang] Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350100, Peoples R China; [Liu, Jinggong] Guangzhou Univ Chinese Med, Orthoped Dept, Guangdong Prov Hosp Tradit Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Peoples R China; [Luo, Benlong] Pingxiang Univ, Pingxiang 337055, Peoples R China in 2021.0, Cited 65.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

A unique deoxygenative cyclodimerization of alkynyl 1,2-diketones facilitated by Ti((OPr)-Pr-i) (4) is achieved, affording a series of highly functionalized furan products. An unusual C-C bond and C=O bond cleavage of the substrates is observed, and Ti(OiPr)(4) plays triplicate roles in the reaction. Furthermore, the products show uncommon fluorescent emission in the solid state, indicating the potential practical applications of this work.

Category: thiomorpholine. Bye, fridends, I hope you can learn more about C13H10O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synergistic bactericidal effects of pairs of photosensitizer molecules activated by ultraviolet A light against bacteria in plasma WOS:000590832300001 published article about PATHOGEN INACTIVATION; RIBOFLAVIN; PLATELET; PRODUCTS; THERAPY; VIRUSES in [Feyissa, Qinati; Xu, Fei; Ibrahim, Zina; Li, Ying; Xu, Kevin L.; Guo, Zihan; Ahmad, Justen; Vostal, Jaroslav G.] US FDA, Lab Cellular Hematol, Div Blood Components & Devices, CBER, Silver Spring, MD USA in 2021.0, Cited 28.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Recommanded Product: Benzophenone

Background The current approach to reducing bacterial contamination in blood transfusion products is through detection or pathogen reduction methods, some of which utilize ultraviolet (UV) light photosensitizers. A small number of photosensitizers are being used as single agents in combination with UV light, but their efficacy can be limited against some pathogens. Benzophenone (BP) and vitamins B1, B6, and K3 have been identified as effective UVA photosensitizers for inactivation of bacteria. We evaluated whether combining pairs of photosensitizers in this group would have synergistic bactericidal effects on Gram-negative and Gram-positive bacteria. Study Design and Methods Bacteria species of Escherichia coli, Bacillus cereus, Staphylococcus aureus, and Klebsiella pneumoniae were mixed with 0 to 100 mM concentrations of photosensitizers and exposed to UVA irradiation at 18 J/cm(2) to assess their bactericidal effects. Results Single photosensitizers irradiated with UVA produced a range of bactericidal activity. When combined in pairs, all demonstrated some synergistic bactericidal effects with up to 4-log reduction above the sum of activities of individual molecules in the pair against bacteria in plasma. Photosensitizer pairs with BP had the highest synergism across all bacteria. With vitamin K3 in the pair, synergism was evident for Gram-positive but not for Gram-negative bacteria. Vitamin B1 and vitamin B6 had the least synergism. These results indicate that a combination approach with multiple photosensitizers may extend effectiveness of pathogen reduction in plasma. Conclusions Combining photosensitizers in pathogen reduction methods could improve bactericidal efficacy and lead to use of lower concentrations of photosensitizers to reduce toxicities and unwanted side effects.

Recommanded Product: Benzophenone. About Benzophenone, If you have any questions, you can contact Feyissa, Q; Xu, F; Ibrahim, Z; Li, Y; Xu, KL; Guo, ZH; Ahmad, J; Vostal, JG or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis and characterization of some new Schiff base derivatives of gabapentin, and assessment of their antibacterial, antioxidant and anticonvulsant activities WOS:000614251000021 published article about OXIDATIVE STRESS; MODEL in [Saleem, Muhammad Farrukh; Khan, Mohsin Abbas; Ahmad, Irshad; Khurshid, Umair] Islamia Univ Bahawalpur, Fac Pharm & Alternat Med, Dept Pharmaceut Chem, Bahawalpur, Pakistan; [Aslam, Naveed] Govt Punjab, Primary & Secondary Healthcare Dept, Punjab, Pakistan in 2021.0, Cited 25.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Category: thiomorpholine

Purpose: To synthesize and characterize some new gabapentin Schiff base derivatives, and to assess their antibacterial, antioxidant and antiepileptic activities. Methods: Four Schiff base derivatives of gabapentin, termed G1, G2, G3 and G4, were synthesized by condensation with benzoin, vanillin, acetophenone, and benzophenone, respectively. Their chemical identities were established by FTIR, H-1 NMR and C-13 NMR techniques. The new compounds were screened for antibacterial activity using agar well method, antioxidant activity by DPPH assay, and anticonvulsant activity against pentylenetetrazole (PTZ) induced seizures in mice. Results: All the compounds showed antibacterial activity against the test strains to variable degrees, while the parent drug did not exhibit antibacterial activity. The zones of inhibition of compound G2 against Micrococcus luteus (36.2 +/- 1.0 mm) and Serratia marcescens (28.2 +/- 1.0 mm), and of compound G4 against Stenotrophomonas maltophilia (36.8 +/- 1.0 mm) were larger compared to the standard drug, doxycycline, exhibiting zones of inhibition 28.2 +/- 1.3, 28.2 +/- 0.9 and 20.0 +/- 0.9 mm, respectively. In addition, compounds G1 and G2 possessed significantly greater (p < 0.05) radical scavenging activity (82.3 +/- 1.8 and 92.3 +/- 2.2 %, respectively) than the precursor drug, gabapentin (63.2 +/- 2.6 %). The seizure scores for compounds GI (0.7 +/- 0.06) and G2 (0.9 +/- 0.07) were comparable (p > 0.05) with gabapentin (0.8 +/- 0.06), while compounds G3 and G4 were less active (p < 0.05) than gabapentin. Conclusion: Compounds G1 and G2 exhibit good antibacterial and antioxidant activities while retaining the anticonvulsant activity of the parent drug, gabapentin, thus making them suitable candidates for further development for the treatment of neurodegenerative pathologies associated with bacterial infections. Welcome to talk about 119-61-9, If you have any questions, you can contact Saleem, MF; Khan, MA; Ahmad, I; Aslam, N; Khurshid, U or send Email.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Orooji, Y; Movahedi, A; Liu, ZP; Asadnia, M; Ghasali, E; Ganjkhanlou, Y; Razmjou, A; Karimi-Maleh, H; Kiadeh, NTH in [Orooji, Yasin; Liu, Zhipeng] Nanjing Forestry Univ, Coll Mat Sci & Engn, Nanjing 210037, Jiangsu, Peoples R China; [Orooji, Yasin; Liu, Zhipeng; Ghasali, Ehsan] Nanjing Forestry Univ, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China; [Movahedi, Ali] Nanjing Forestry Univ, Minist Educ, Key Lab Forest Genet & Biotechnol, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China; [Asadnia, Mohsen] Macquarie Univ, Sch Engn, Sydney, NSW 2109, Australia; [Ganjkhanlou, Yadolah] Univ Torino, NIS Ctr, Dept Chem, Via P Giuria 7, I-10125 Turin, Italy; [Ganjkhanlou, Yadolah] Univ Torino, INSTM Ctr, Via P Giuria 7, I-10125 Turin, Italy; [Razmjou, Amir] Univ Technol Sydney UTS, Ctr Technol Water & Wastewater CTWW, Sch Civil & Environm Engn, Sydney, NSW, Australia; [Karimi-Maleh, Hassan] Quchan Univ Technol, Lab Nanotechnol, Dept Chem Engn, Quchan, Iran; [Karimi-Maleh, Hassan] Univ Elect Sci & Technol China, Sch Resources & Environm, Xiyuan Ave,POB 611731, Chengdu, Peoples R China; [Karimi-Maleh, Hassan] Univ Johannesburg, Dept Chem Sci, Doornfontein Campus,POB 17011, ZA-2028 Johannesburg, South Africa; [Kiadeh, Naser Tavajohi Hassan] Umea Univ, Chem Biol Ctr, Dept Chem, Tech Chem, S-90187 Umea, Sweden published Luminescent film: Biofouling investigation of tetraphenylethylene blended polyethersulfone ultrafiltration membrane in 2021.0, Cited 47.0. Application In Synthesis of Benzophenone. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9.

Despite the huge contribution of membrane-based brine and wastewater purification systems in today’s life, biofouling still affects sustainability of membrane engineering. Aimed at reducing membrane modules wastage, the need to study biofouling monitoring as one of contributory factors stemmed from the short time between initial attachment and irreversible biofoulant adhesion. Hence, a membrane for monitoring is introduced to determine the right cleaning time by using fluorescent sensing as a nondestructive and scalable approach. The classical solid-state emissive fluorophore, tetraphenylethylene (TPE), was introduced as a sustainable, safe and sensitive fluorescent indicator in order to show the potential of the method, and polyethersulfone (PES) and non-solvent-induced phase separation method, the most popular material and method, are used to fabricate membrane in industry and academia. Since the employed filler has an aggregation-induced emission (ALE) characteristic, it can track the biofouling throughout the operation. The fabricated membranes have certain characterizations (i.e. morphology assessment, flux, antibiogram, flow cytometry, surface free energy, and protein adsorption) which indicate that hybrid membrane with 5 wt % of TPE has identical biofouling activity compared to neat PES membrane and its optimal luminescence properties make it an appropriate candidate for non-destructive and online biofouling monitoring. (C) 2020 Elsevier Ltd. All rights reserved.

Application In Synthesis of Benzophenone. Welcome to talk about 119-61-9, If you have any questions, you can contact Orooji, Y; Movahedi, A; Liu, ZP; Asadnia, M; Ghasali, E; Ganjkhanlou, Y; Razmjou, A; Karimi-Maleh, H; Kiadeh, NTH or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. Zhang, KY; Lu, GL; Xi, ZS; Li, YQ; Luan, QJ; Huang, XB in [Zhang, Kaiyue; Lu, Guilong; Xi, Zuoshuai; Li, Yaqiong; Luan, Qingjie; Huang, Xiubing] Univ Sci & Technol Beijing, Beijing Adv Innovat Ctr Mat Genome Engn, Sch Mat Sci & Engn, Beijing Key Lab Funct Mat Mol & Struct Construct, Beijing 100083, Peoples R China published Covalent organic framework stabilized CdS nanoparticles as efficient visible-light-driven photocatalysts for selective oxidation of aromatic alcohols in 2021, Cited 34. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9.

Noble-metal-free photocatalysts with high and stable performance provide an environmentally-friendly and cost-efficient route for green organic synthesis. In this work, CdS nanoparticles with small particle size and different amount were successfully deposited on the surface of covalent organic frameworks (COFs). The deposition of suitable content of CdS on COFs could not only modify the light adsorption ability and the intrinsic electronic properties, but also enhance the photocatalytic activity and cycling performance of CdS for the selective oxidation of aromatic alcohols under visible light. Especially, COF/CdS-3 exhibited the highest yield (97.1%) of benzaldehyde which is approximately 2.5 and 15.9 times as that of parental CdS and COF, respectively. The results show that the combination of CdS and COF can improve the utilization of visible light and the separation of photo-generated charge carriers, and COF with the pi-conjugated system as supports for CdS nanoparticles could provide efficient electron transport channels and improve the photocatalytic performance. Therefore, this kind of COF-supported photocatalysts with accelerated photo-induced electrons and charge-carrier separation between semiconductors possesses great potentials in future green organic synthesis. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Welcome to talk about 119-61-9, If you have any questions, you can contact Zhang, KY; Lu, GL; Xi, ZS; Li, YQ; Luan, QJ; Huang, XB or send Email.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. Authors Lan, S; Liu, R; Kong, XW; Liu, JG; Luo, BL; Yang, S; Fang, XQ in AMER CHEMICAL SOC published article about in [Lan, Shouang; Liu, Rui; Kong, Xiangwen; Yang, Shuang; Fang, Xinqiang] Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China; [Lan, Shouang; Liu, Rui; Kong, Xiangwen; Yang, Shuang; Fang, Xinqiang] Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350100, Peoples R China; [Liu, Jinggong] Guangzhou Univ Chinese Med, Orthoped Dept, Guangdong Prov Hosp Tradit Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Peoples R China; [Luo, Benlong] Pingxiang Univ, Pingxiang 337055, Peoples R China in 2021.0, Cited 65.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

A unique deoxygenative cyclodimerization of alkynyl 1,2-diketones facilitated by Ti((OPr)-Pr-i) (4) is achieved, affording a series of highly functionalized furan products. An unusual C-C bond and C=O bond cleavage of the substrates is observed, and Ti(OiPr)(4) plays triplicate roles in the reaction. Furthermore, the products show uncommon fluorescent emission in the solid state, indicating the potential practical applications of this work.

Category: thiomorpholine. Bye, fridends, I hope you can learn more about C13H10O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synergistic bactericidal effects of pairs of photosensitizer molecules activated by ultraviolet A light against bacteria in plasma WOS:000590832300001 published article about PATHOGEN INACTIVATION; RIBOFLAVIN; PLATELET; PRODUCTS; THERAPY; VIRUSES in [Feyissa, Qinati; Xu, Fei; Ibrahim, Zina; Li, Ying; Xu, Kevin L.; Guo, Zihan; Ahmad, Justen; Vostal, Jaroslav G.] US FDA, Lab Cellular Hematol, Div Blood Components & Devices, CBER, Silver Spring, MD USA in 2021.0, Cited 28.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Recommanded Product: Benzophenone

Background The current approach to reducing bacterial contamination in blood transfusion products is through detection or pathogen reduction methods, some of which utilize ultraviolet (UV) light photosensitizers. A small number of photosensitizers are being used as single agents in combination with UV light, but their efficacy can be limited against some pathogens. Benzophenone (BP) and vitamins B1, B6, and K3 have been identified as effective UVA photosensitizers for inactivation of bacteria. We evaluated whether combining pairs of photosensitizers in this group would have synergistic bactericidal effects on Gram-negative and Gram-positive bacteria. Study Design and Methods Bacteria species of Escherichia coli, Bacillus cereus, Staphylococcus aureus, and Klebsiella pneumoniae were mixed with 0 to 100 mM concentrations of photosensitizers and exposed to UVA irradiation at 18 J/cm(2) to assess their bactericidal effects. Results Single photosensitizers irradiated with UVA produced a range of bactericidal activity. When combined in pairs, all demonstrated some synergistic bactericidal effects with up to 4-log reduction above the sum of activities of individual molecules in the pair against bacteria in plasma. Photosensitizer pairs with BP had the highest synergism across all bacteria. With vitamin K3 in the pair, synergism was evident for Gram-positive but not for Gram-negative bacteria. Vitamin B1 and vitamin B6 had the least synergism. These results indicate that a combination approach with multiple photosensitizers may extend effectiveness of pathogen reduction in plasma. Conclusions Combining photosensitizers in pathogen reduction methods could improve bactericidal efficacy and lead to use of lower concentrations of photosensitizers to reduce toxicities and unwanted side effects.

Recommanded Product: Benzophenone. About Benzophenone, If you have any questions, you can contact Feyissa, Q; Xu, F; Ibrahim, Z; Li, Y; Xu, KL; Guo, ZH; Ahmad, J; Vostal, JG or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem