In 2021.0 ORG PROCESS RES DEV published article about COMPLEX; REAGENT; TBN in [Yun, Lei; Zhao, Jingnan; Ma, Cunfei; Yu, Zongyi; Meng, QingWei] Dalian Univ Technol, Dept Pharmaceut Sci, Sch Chem Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China; [Tang, Xiaofei] Xian Modern Chem Res Inst, Xian 710065, Shanxi, Peoples R China; [Meng, QingWei] Dalian Univ Technol, Ningbo Inst, Ningbo 315016, Peoples R China in 2021.0, Cited 33.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Safety of Benzophenone
Selective aerobic oxidation of benzylic sp(3) C-H bonds to generate the corresponding ketones was achieved under continuous-flow conditions. The catalysts N-hydroxyphthalimide (NHPI) and tert-butyl nitrite (TBN) as the precursor of the radical under aerobic conditions motivated this process. Flow microreactors operating under optimized conditions enabled this oxidation with higher efficiency and a shortened reaction time of 54 s (total time was 10 min), which was improved 466 times compared with the batch parallel reaction (7.0 h). Notably, the catalyst and solvent recycling (92.6 and 94.5%) and scale-up experiments (0.87 g h(-1) in 28 h) demonstrated the practicability of the protocol. The high product selectivity and functional group tolerance of the process allowed the production of ketones in yields of 41.2 to 90.3%. To reveal the versatility and applicability of this protocol, the late-stage modification of an antiepileptic drug to obtain oxcarbazepine was further conducted.
Safety of Benzophenone. About Benzophenone, If you have any questions, you can contact Yun, L; Zhao, JN; Tang, XF; Ma, CF; Yu, ZY; Meng, QW or concate me.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem