Recently I am researching about COLLISION CROSS-SECTIONS; SIALYL-LEWIS-X; MASS-SPECTROMETRY; N-GLYCANS; LIQUID-CHROMATOGRAPHY; IDENTIFICATION; OLIGOSACCHARIDES; DERIVATIZATION; FRAGMENTATION; GLYCOPROTEINS, Saw an article supported by the German Research FoundationGerman Research Foundation (DFG) [FOR2177/P02]; Max Planck SocietyMax Planck Society. Formula: C7H8N2O. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Manz, C; Grabarics, M; Hoberg, F; Pugini, M; Stuckmann, A; Struwe, WB; Pagel, K. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide
The analysis of complex oligosaccharides is traditionally based on multidimensional workflows where liquid chromatography is coupled to tandem mass spectrometry (LC-MS/MS). Due to the presence of multiple isomers, which cannot be distinguished easily using tandem MS, a detailed structural elucidation is still challenging in many cases. Recently, ion mobility spectrometry (IMS) showed great potential as an additional structural parameter in glycan analysis. While the time-scale of the IMS separation is fully compatible to that of LC-MS-based workflows, there are very few reports in which both techniques have been directly coupled for glycan analysis. As a result, there is little knowledge on how the derivatization with fluorescent labels as common in glycan LC-MS affects the mobility and, as a result, the selectivity of IMS separations. Here, we address this problem by systematically analyzing six isomeric glycans derivatized with the most common fluorescent tags using ion mobility spectrometry. We report >150 collision cross-sections (CCS) acquired in positive and negative ion mode and compare the quality of the separation for each derivatization strategy. Our results show that isomer separation strongly depends on the chosen label, as well as on the type of adduct ion. In some cases, fluorescent labels significantly enhance peak-to-peak resolution which can help to distinguish isomeric species.
About 2-Aminobenzamide, If you have any questions, you can contact Manz, C; Grabarics, M; Hoberg, F; Pugini, M; Stuckmann, A; Struwe, WB; Pagel, K or concate me.. Formula: C7H8N2O
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem