Month: April 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Characteristic group frequencies of bromo- and iodoalkanes in the cesium bromide region, published in 1964, which mentions a compound: 616-14-8, Name is 1-Iodo-2-methylbutane, Molecular C5H11I, SDS of cas: 616-14-8.

The infrared spectra of 74 normal and branched bromo- and iodoalkanes were recorded and studied, 667-286 cm.-1 The number and position of the frequencies characteristic of the C–X stretching vibration are dependent on the rotational isomers present as well as the structure of the alkyl substituents in the vicinity of the C–X group. Conformational structures and representative spectra are presented along with correlation charts which list the C–X stretching vibration for various primary, secondary, and tertiary bromo- and iodoalkanes.

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Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Walden inversion. XIII. The influence of substituting groups on optical rotation in the series of disubstituted acetic acids》. Authors are Levene, P. A.; Mikeska, L. A..The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Recommanded Product: 1-Iodo-2-methylbutane. Through the article, more information about this compound (cas:616-14-8) is conveyed.

cf. C. A. 22, 1953. The conclusion that in the aliphatic series the carbinols and the structurally related halides rotate in opposite directions is substantiated by the study of a series of aliphatic substances derived from disubstituted acetic acids or their corresponding carbinols. Primary halides rotate in the opposite direction to the primary alcs. from which they were derived, while in passing from the corresponding thio to the sulfo derivative the change in rotation is in the same direction, though without change of sign. A decided uniformity was found in the effect on optical rotation of various substitutions of the CO2H group or of the alc. group of the corresponding carbinols, depending upon the position of the subsituting group in the polarity series, C = N > CO2Et > CO2H > CONH2 > COCl > CH2SO3H > CH2X > CH2SH > CH2OH > CH2NH2. The order in this series corresponds with the order of the same groups in polarity series determined by other methods. This relationship holds only for aliphatic substances containing only 1 asym. C atom and only 1 polar group. Active primary amyl alc. was halogenated without marked racemization, while in the rest of the series conversion to the halide from the carbinol by SOCl2, PCl5, HBr, HI, etc., as well as from the amine by NOCl2, led to complete racemization. Optically active halides were obtained in the latter case by the action of NOBr. d-Propylmethylacetic acid, [α]D25 5.58° (Et2O), with SOCl2 gave the d-chloride (I), b15 45-8°; [α]D25 4.06°. I, [α]D25 3.94° (Et2O), with concentrated aqueous NH4OH gave the d-amide, m. 78° (from H2O), [α]D25 5.79° (75% alc.). l-Amide, [α]D25-5.79° (75% alc.), distilled with P2O6 gave l-propylmethylacetonitrile (II), b2 30-2°, [α]D25-13.77°. II with Na-alc. gave d-2-propyl-2-methylethylamine (III), b4 28-30°, [α]D25 3.84°, whose HCl salt had [α]D25 1.51° (50% alc.), l-Propylmethylacetic acid, [α]D25-7.08° (Et2O), with HCl gas in alc. gave the Et ester, b4 78-80°, [α]D25-7.91°. d-Acid Et ester, [α]D25 5.67° (Et2O), with Na-alc. gave l-2-propyl-2-methylethanol (IV), b. 147-7.5°, [α]D25-1.23°. IV with PCl5 or NOCl gave dl-2-propyl-2-methylethyl chloride, b. 110-20°. III with NOBr gave l-2-propyl-2-methylethyl bromide, b10 55-65°, [α]D25-0.94° (Et2O). I with KHS gave d-propylmethylthiolacetic acid, b23 71-2°, [α]D25 7.49°. d-Butylmethylacetic acid (V), [α]D25 5.42° (Et2O), with SOCl2 gave the acid chloride (VI), b9 45-8°, [α]D25 5.06°. VI with NH4OH gave the amide (VII), m. 66° (from H2O), [α]D25 3.86° (75% alc.). VII distilled with P2O5 gave the nitrile (VIII), b9 43-50°, [α]D25 9.40°. In another experiment an amide, [α]D25-11.44°, gave a nitrile, [α]D25-27.09° (Et2O). VIII with Na-alc. gave l-2-butyl-2-methylethylamine, b15 49-54°, [α]D25-3.52° (Et2O), whose HCl salt had [α]D25-2.41° (H2O). V with HCl gas and alc. gave an Et ester, b9 58-62°, [α]D25 6.84°, which with Na-alc. gave d-2-butyl-2-methylethanol, b15 71-2°, [α]D25 2.47° (Et2O). d-Heptylmethylacetic acid (IX), b4 145-7°, [α]D25, whose Na salt, [α]D25 0.84° (H2O), was treated with SOCl2, yielding the acid chloride (X), b1 73-4°, [α]D25 4.89°. X with NH4OH gave the amide (XI), m. 78° (from 50% alc.), [α]D25 7.07° (95% alc.), XI with P2O5 gave the nitrile (XII), b7 85-94°, [α]D25 13.61°. XII with Na-alc. gave 1-2-heptyl-2-methylethylamine (XIII), b24, 103-5°, [α]D25-3.38°, whose HBr salt had [°]D25-4.61° (75% alc.), In another experiment an amine, [α]D25 6.05° (Et2O), was obtained from a nitrile, [α]D25 -15.10° (Et2O). An amine, [α]D25 6.05° (Et2O), was obtained from a HBr salt, [α]D25 5.91°. XIII with HBr (fuming) and NaNO2 gave d-2-heptyl-2-methylethyl bromide, b1 80-5°, [α]D25 2.18° (Et2O). l-Heptylmethylacetic acid, [α]D26 -8.72° (Et2O), with HCl gas and alc. gave the Et ester, b17 122-4°, [α]D25 -8.60°, which with Na-alc, gave d-2-heptyl-2-methylethanol, b0.4 80-2°, [α]D25 3.64°. d-Decylmethylacetic acid, b1 153°, [α]D25 8.47°, showed no rotation when neutralized with NaOH. l-Decylmethylacetic acid (XIV), [α]D25 -6.38° (Et2O), with SOCl2 gave the acid chloride (XV), b0.5 118-25°, [α]D25 -3.5°, which was hydrolyzed, yielding an acid, [α]D25 -5.78° (Et2O). XV with NH4OH gave the amide, m. 77° (from 50% alc.), [α]D25 -3.01° (95% alc.), which with P2O5 gave the nitrile, b0.5 108-10°, [α]D25 -10.87° (Et2O), which with Na-alc. gave d-2-decyl-2-methylethylamine (XVI), [α]D25 4.18°, whose HCl salt, m. 105-18°, [α]D25 3.17° (H2O). XIV with HCl gas and alc. gave an Et ester, b1 141°, [α]D25 -6.48°, which with Na-alc. gave l-2-decyl-2-methylethanol, b1.4 105°, [α]D25 2.34°, XVI with NOBr gave l-2-decyl-2-methylethyl bromide, b0.02 87-90°, [α]D25 -0.39. Primary l-amyl alc., [α]D25 -4.73° (Et2O), with HI gave d-2-ethyl-2-methylethyl iodide, b12 47-50°, [α]D25 3.92° (Et2O), which with KHS gave d-2-ethyl-2-methylethanethiol, b. 116-7°, [α]D25 2.99°. In another experiment an iodide, [α]D25 5.27° (Et2O), gave a mercaptan, [α]D25 6.92°, which with Ba(MnO4)2 gave d-2-ethyl-2-methylethanesulfonic acid, whose Ba salt had [α]D25 5.09° (H2O). A table of mol. rotations of the various derivatives, which do not necessarily agree with the exptl. figures, is appended. These values were calculated on the basis of the parent substance of the highest rotation. There is also a table of d.

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Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Analysis of rotatory dispersions of configurationally related halides》. Authors are Levene, P. A.; Rothen, Alexandre; Marker, R. E..The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).COA of Formula: C5H11I. Through the article, more information about this compound (cas:616-14-8) is conveyed.

Rotatory dispersion curves of halides of the type HMeRC(CH2)nX (X = Cl, Br, I; R = alkyl group; n = 0, 1, 2 or 3) are analyzed in the visible and the ultraviolet regions. The 3 halogen atoms function similarly with respect to the character of this curve in compounds of identical structure. A periodicity in the sign of some of the partial contributions of the halogen atom occurs with increase in n. The course of the rotatory dispersion when n = 1 is anomalous. An attempt is made to apply results when n > 0 to the sign of rotation for compounds where n = 0. When X = COOH, CHO, CN, CHMe2, etc., no complete analogy exists between this group and the group where X is a halogen. [M]D25 maximum (homogeneous) is given for the 16 compounds where X = Br, n = 1, 2, 3, 4, and R = Et, Pr, Bu, pentyl, and for the compound HMeEtC(CH2)5Br. Absorption spectra are given for λ 2100-3300 for 5 iodides. Rotatory dispersion curves are given for the compounds HMeEtCCH2I, HMe(C6H13)CCH2I, HMeEtCCH2Br and HMeEtCCH2Cl. [M]D25 maximum, nD25, d425 (vacuum) and rotatory dispersions (numerical) are given for several other compounds in this series. Differences between the interpretation of the dispersions of the iodides given by the authors (C. A. 27, 951) and that given by Kuhn (C. A. 29, 7159.1) are due to substantial differences between their exptl. data.

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Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called SPME-GC-MS analysis of volatile components in fruits of the frozen Ficus tikoua Bur., published in 2016, which mentions a compound: 616-14-8, mainly applied to SPME GC MS volatile component Ficus, Recommanded Product: 616-14-8.

This thesis developed an SPME-GC-MS method for the aroma components in Ficus tikoua Bur. fruit. At the same time, the solid-phase micro extraction conditions were optimized: extraction temperature was 50°C, the extraction time was 40 min, added 8 g of sodium chloride electrolyte solid extraction Frozen Ficus tikoua Bur. fruit was detected out of 152 kinds of volatile substances, substances detected in 99.03%of the total. The main aroma components were esters, accounting for 33.06%; alcs., accounting for 13.14%; alkanes, accounting for 13.18%; there ketones, aldehydes, acids and other substances. Higher levels of 10 kinds of aroma components were guaiacol (14.71%), cyclobutane carboxylic acid dodecyl ester (13.54%), n-tridecane (6.05%), 2-tridecanone (4.72%), cyclohexasiloxane (4.44%), cyclobutane carboxylic acid decyl ester (4.18%), Me nonyl ketone (3.62%), acetic acid (2.98%), cyclopentanecarboxylic acid thirteen ester (2.48%), 2-tetradecanol (2.31%) and so on.

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Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Two Distinct Thermal Stabilities of DNA and Enzymatic Activities of DNase I in a Multistep Assembly with Carbazole Ligands: Different Binding Characteristics for Duplex and Quadruplex DNA.Electric Literature of C5H11I.

A partially hydrophobic carbazole ligand ((Im+)2Cz: 2,2′-(9-ethyl-9 H-carbazole-3,6-diyl)bis(ethyne-2,1-diyl)bis(1,3-dimethyl-1 H-imidazol-3-ium)) adopts two different binding states (binding states I and II) in its interactions with calf-thymus (ct-) DNA. Two distinct binding states were identified by biphasic UV/Vis and CD spectral changes during the titration of DNA into the carbazole ligand. At low concentrations of ct-DNA, (Im+)2Cz binds to nearly every part of ct-DNA (binding state I). By contrast, an increased concentration of ct-DNA results in a switch in the DNA-binding state, so that the ligands are bound per five DNA base pairs. Similarly, a monocationic carbazole ligand (Im+Cz: 2-((6-bromo-9-ethyl-9 H-carbazol-3-yl)ethynyl)-1,3-dimethyl-1 H-imidazol-3-ium) also shows biphasic UV/Vis spectral changes during the titration of ct-DNA into Im+Cz, which suggests two different binding states of the Im+Cz ligand with ct-DNA. The stepwise equilibrium of the ligand-DNA-complex formation is capable of switching the thermal stability of ct-DNA, as well as the enzymic activity of DNase (DNase I). In binding state I, the (Im+)2Cz ligands interact with nearly every base pair in ct-DNA and stabilize the double-helix structure, which results in a larger increase in the melting temperature of the ct-DNA than that observed with binding state II. On the other hand, the (Im+)2Cz ligand significantly reduces the enzymic activity of DNase I in binding state I, although the enzymic activity is recovered once the binding state of the ligand-DNA complex is changed to binding state II. The (Im+)2Cz ligand was also employed as a binder for G-quadruplex DNA. In contrast to the stepwise complex formation between (Im+)2Cz and ct-DNA, (Im+)2Cz shows a monotonous UV/Vis spectral response during the titration of G-quadruplex DNA into (Im+)2Cz, which suggests a single binding state for (Im+)2Cz with G-quadruplex DNA.

Here is just a brief introduction to this compound(616-14-8)Electric Literature of C5H11I, more information about the compound(1-Iodo-2-methylbutane) is in the article, you can click the link below.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Optical rotation and atomic dimension》. Authors are Brauns, D. H..The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Recommanded Product: 616-14-8. Through the article, more information about this compound (cas:616-14-8) is conveyed.

The 1-F, 1-Cl, 1-Br and 1-I derivatives of 2-methylbutane have [M]D20 -799.1°, 179.1°, 610.1° and 1124.7°, resp. If the F derivative is classified with the other halogen derivatives, the values for the ratio Cl-F, Br-Cl and I-Br are 41:18.1:21.6 which agree well with the ratios of the resp. at. diameters.

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Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Action of ionizing radiation on simple organic compounds》. Authors are Napier, K. H.; Green, J. H..The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Safety of 1-Iodo-2-methylbutane. Through the article, more information about this compound (cas:616-14-8) is conveyed.

I131 in a hydrocarbon was irradiated either with β-rays from a 500 mc. Sr90-Y90 source or with γ-rays from a 5 c. Cs137 source. The distribution of resulting iodinated products were analyzed by gas chromatography. From butane the following percentages of alkyl iodides were obtained: methyl, ethyl, n-propyl, sec-butyl, n-butyl (9, 20, 2, 47, 22, resp.). At some stages in the radiolysis, HI can be as high as 20%.

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Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Diimidazoles. IV. Derivatives of 4,5-diaminoimidazole and their attempted cyclization》. Authors are Schubert, Hermann; Heydenhauss, Dieter.The article about the compound:1-Methyl-4-nitro-1H-imidazol-5-aminecas:4531-54-8,SMILESS:NC1=C([N+]([O-])=O)N=CN1C).Quality Control of 1-Methyl-4-nitro-1H-imidazol-5-amine. Through the article, more information about this compound (cas:4531-54-8) is conveyed.

The preparation of a series of 1-methyl-4-nitro-5-alkylaminoimidazoles (I) is described. The catalytic hydrogenation of I and of 1-methyl-4-nitro-5-aminoimidazole (Ia) (R = H) (II) yielded unstable diamines which could neither be isolated nor cyclized. Acetylation of II gave the di-Ac derivative (III) of II. I were formylated and acetylated smoothly; hydrogenation of the products yielded stable acyl derivatives of 4,5-diaminoimidazole. (CONHMe)2 with PCl5 gave 40.8% 5-chloro-1-methylimidazole (IV), b15 90°. IV (103 g.), 100 cc. concentrated HNO3, and 400 cc. H2O evaporated, the residue added in portions at 10° to 3 times its weight of concentrated H2SO4, and the mixture heated 2 hrs. on a water bath yielded 122 g. 5-Cl analog (V) of II, m. 149-50°. V (13.2g.)in 3.5%absolute NH3EtOH heated 2 hrs. at 130-40° in a sealed tube yielded 6.3 g. II, m. 303° (decomposition) (H2O). II (5 g.) and 200 cc. Ac2O refluxed about 5 hrs. gave 5.2 g. III, m. 149.5-50.5°. V (1.62 g.) in 25 cc. 7% absolute alc. MeNH2 refluxed 3 hrs. yielded 1.45 g. Ia (R = Me) (VI), m. 156-7° (EtOH). VI (5 g.) in 50 cc. HCO2Ac kept 20 hrs. at room temperature and concentrated yielded 5 g. the N-CHO derivative (VII), m. 142.5-3.5° (EtOH). VI (10 g.) in 200 cc. Ac2O heated 1 hr. at 90-100° gave 8.2 g. the N-Ac derivative (VIII), m. 168-9° (BuOH or dioxane). V (1.62 g.) in 37 cc. 7% absolute alc. EtNH2 refluxed 3 hrs. and refrigerated overnight yielded 1.6 g. Ia (R = Et), m. 161-2° (dioxane). In the same manner were prepared the following Ia (R, m.p., and % yield given): Pr, 114-18° (dioxan-epetr. ether), 92; Bu, 101-6° (dioxane-petr. ether), 61; PhCH2, 132-3° (EtOH), 90. Also prepared was the N-Me derivative of VI, m. 94-5.5° (C6H6-petr. ether), 47% yield. II (0.76 g.) in 30 cc. 85% HCO2H hydrogenated 4 hrs. at 17°/756 mm. over 0.2 g. PtO2 yielded a black-brown oil, which treated with dilute aqueous NaOH liberated NH3. III (0.5 g.) in 45 cc. absolute BuOH hydrogenated 40 min. at 17°/770 mm. over 0.2 g. PtO2, and the resulting oily product in C6H6 treated with the stoichiometric amount picric acid yielded 1-methyl-4-amino-5-(N,N-diacetylamino)imidazole picrate, m. 160-1° (decomposition) (BuOH). The BuOH solution from a duplicate run refluxed 1.5 hrs. under argon gave only a brown, flocculent precipitate Hydrogenation of 0.5 g. VI in H2O, dilute HCl, dry dioxane, AcOH, AcOH-HCl, and Ac2O over 0.2 g. PtO2 gave only oily unstable materials. VII (0.6 g.) in 100 cc. Bu0H hydrogenated 50 min. at 18°/763 mm., and the resulting yellow oil treated in EtOH with picric acid gave the picrate of 1-methyl-4-amino-5-(N-methyl-N-formylamino)imidazole (IX), m. 173-70 (decomposition) (H2O); styphnate m. 177-8.5° (decomposition) (H2O). The BuOH solution of the crude IX refluxed 2 hrs. under argon yielded a brown, flocculent precipitate VIII (2 g.) in 120 cc. BuOH hydrogenated 1 hr. at 20°/755 mm. over 0.4 g. PtO2 yielded 1.4 g. 5-AcMeN analog (X) of IX, m. 165-6° ( PhCl); picrate m. 217-21° (decomposition) (H2O); styphnate m. 196-9° (decomposition) (H2O); HCl salt m. 225-6° (decomposition). All attempted cyclizations of X were unsuccessful. X (0.5 g.) in 3 cc. absolute HCO2H refluxed 1.5 hrs. yielded 0.4 g. 1-methyl-4-formyl-amino-5-(N-methyl-N-acetylamino)imidazole (XI), m. 154-5.5° (absolute EtOH-Et2O). X (2.1 g.) in 15 cc. AcOH refluxed 0.5 hr. yielded 1.47 g. 4-AcNH analog of XI, m. 188.5-9.5° (1:1 dioxane-PhCl); picrate m. 166-9° (EtOH); all attempted cyclizations were unsuccessful.

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Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones, Author is Hartmann, Rolf W.; Batzl, Christine, which mentions a compound: 616-14-8, SMILESS is CCC(CI)C, Molecular C5H11I, Computed Properties of C5H11I.

Piperidinediones I (R = H, Me, Et, Pr, CHMe2, CH2CHMe2, CHMeEt, pentyl, isopentyl, CH2CHMeEt, sec-pentyl, hexyl, heptyl) were prepared by alkylating PhCH2CN, addition reaction of PhCHRCN with CH2:CHCN, hydrolysis and ring closure of NCCRPhCH2CH2CN, nitration, and reduction of the nitro group. In vitro I showed a stronger inhibition of human placental aromatase than aminoglutethimide (II). The most active derivative, I (R = isopentyl), showed a 93-fold stronger inhibition than II. I, except I (R = CHMe2, CH2CHMe2, CHMeEt) exhibited equal or lower inhibition of bovine adrenal desmolase than II. Many I showed a stronger inhibition of the plasma estradiol concentration of pregnant mare serum gonadotropin-primed rats than II. They inhibited the testosterone-stimulated tumor growth of ovariectomized 9,10-dimethyl-1,2-benzanthracene tumor-bearing rats more strongly than II. Being stronger and more selective inhibitors of the estrogen biosynthesis than II, some of the newly developed derivatives of II might be better candidates for the treatment of hormone-dependent human breast cancer.

Here is just a brief introduction to this compound(616-14-8)Computed Properties of C5H11I, more information about the compound(1-Iodo-2-methylbutane) is in the article, you can click the link below.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Secondary to normal alkyl group rearrangements in octahedral iridium(III) complexes. 1. Monoalkyl derivatives, the main research direction is alkyl group isomerization iridium complex; solvent effect alkyl isomerization; substituent effect alkyl isomerization; steric hindrance alkyl isomerization.HPLC of Formula: 616-14-8.

sec-Alkyliridium(III) complexes IrYIR(CO)L2 (R = sec-alkyl; Y = Cl, I; L = PMe3, PMe2Ph), formed by oxidative addition of sec-alkyl iodides to IrY(CO)L2, rearrange cleanly by a first-order process to the n-alkyl isomers on dissolution in CH2Cl2 containing protic solvents. The order of efficacy of these solvents in promoting alkyl group rearrangement is CF3CO2H >> CH3OH >> C2H5OH > CH3CO2H ∼ PrOH > (CH3)2CHOH, while in the more strongly coordinating medium of THF the order is H2O >> CH3OH. These orders correlate with the anion-solvating ability of the solvents and, together with the observed retardation by added iodide ion, suggest that the rate-determining step in the rearrangement is dissociation of iodide ion trans to the sec-alkyl group. Rapid, reversible β-hydride elimination in the resulting cation and stereospecific return of iodide ion trans to the resulting n-alkyl group complete the process. The rearrangement is promoted by increasing bulk, both of the alkyl group, up to a certain limit, and of the tertiary phosphine (PMe2Ph > PMe3). Treatment of IrClI{CH(CH3)2}(CO)(PMe2Ph)2 with AgBF4 in MeCN induces immediate alkyl group rearrangement to give the n-propyliridium(III) salt [IrClPr(CO)(NCMe)(PMe2Ph)2]BF4. Studies of analogous CD2CH3 compounds suggest that they, and presumably other n-alkyliridium(III) complexes, undergo reversible β-hydride elimination more slowly than the sec-alkyl complexes. The D labels in the isobutyl-d2 complex IrClI{CD2CH(CH3)2}(CO)(PMe3)2 scramble over all the alkyl C atoms when the compound is heated in CD2Cl2/CD3OD, indicating that a tert-butyliridium(III) species is accessible. Surprisingly, the complexes IrClI{CH2CH(CH3)CH2CH3}(CO)(PMe3)2 and IrClI{CH2CH2CH(CH3)2}(CO)(PMe3)2 do not interconvert under the same conditions, implying that a tert-pentylirdium(III) species cannot be formed. The results are compared with alkyl group rearrangements that occur in other transition-metal systems, especially those promoted by dissociation of Ph3P in (η-C5H5)FeR(CO)(PPh3).

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Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem